Detailed information for compound 837644

Basic information

Technical information
  • TDR Targets ID: 837644
  • Name: 1-(4-bromophenyl)-3-(4-fluorophenyl)-5,5-diox o-3a,4,6,6a-tetrahydrothieno[3,4-d]imidazol-2 -one
  • MW: 425.272 | Formula: C17H14BrFN2O3S
  • H donors: 0 H acceptors: 3 LogP: 2.7 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)N1C2CS(=O)(=O)CC2N(C1=O)c1ccc(cc1)Br
  • InChi: 1S/C17H14BrFN2O3S/c18-11-1-5-13(6-2-11)20-15-9-25(23,24)10-16(15)21(17(20)22)14-7-3-12(19)4-8-14/h1-8,15-16H,9-10H2
  • InChiKey: YKCOBHAFBJCQHI-UHFFFAOYSA-N  

Network

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Synonyms

  • 1-(4-bromophenyl)-3-(4-fluorophenyl)-5,5-diketo-3a,4,6,6a-tetrahydrothieno[3,4-d]imidazol-2-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0198 0.1482 1
Mycobacterium tuberculosis Probable dehydrogenase 0.021 0.158 0.2186
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0032 0.0134 0.0111
Echinococcus granulosus RNA directed DNA polymerase 0.0038 0.0185 0.0726
Schistosoma mansoni Smad4 0.0016 0.0004 0.0016
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0004 0.0016
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0 0.0002
Giardia lamblia NADH oxidase lateral transfer candidate 0.0032 0.0134 0.0974
Plasmodium falciparum thioredoxin reductase 0.0032 0.0134 0.0974
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.003 0.0119 0.0662
Echinococcus multilocularis geminin 0.033 0.2554 1
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.021 0.3111
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0041 0.021 0.1634
Brugia malayi MH2 domain containing protein 0.0233 0.1763 1
Echinococcus granulosus Protein kinase C brain isozyme 0.0054 0.031 0.1214
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0023 0.0091
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.003 0.0119 0.0662
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.021 0.119
Loa Loa (eye worm) hypothetical protein 0.0033 0.0146 0.0826
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0018 0.0024 0.0001
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0159 0.1165 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0016
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0032 0.0134 0.0111
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0004 0.0016
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0378 0.2142
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0037 0.018 0.022
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0032 0.0134 0.1854
Brugia malayi Thioredoxin reductase 0.0092 0.0623 0.3534
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0 0.0003
Trypanosoma brucei DNA polymerase eta, putative 0.0062 0.038 0.5956
Giardia lamblia Prenyltransferase 0.003 0.0119 0.0843
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0271 0.1535
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0134 0.1854
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0024 0.0005
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0004 0.0023
Toxoplasma gondii thioredoxin reductase 0.0092 0.0623 0.2216
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0066 0.0373
Mycobacterium tuberculosis Putative ferredoxin reductase 0.021 0.158 0.2186
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0378 0.1478
Schistosoma mansoni smad 0.0016 0.0004 0.0016
Echinococcus granulosus tar DNA binding protein 0.0062 0.0378 0.1478
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.0678
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0023 0.0003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0037 0.018 0.0703
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0198 0.1482 0.5803
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0023 0.0132
Loa Loa (eye worm) hypothetical protein 0.003 0.0119 0.0678
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0066 0.0373
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.018 0.2608
Echinococcus multilocularis GPCR, family 2 0.0015 0 0.0002
Trypanosoma cruzi protein farnesyltransferase, putative 0.003 0.0119 0.1605
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.018 0.2608
Schistosoma mansoni hypothetical protein 0.0033 0.0146 0.057
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.003 0.0119 0.0662
Entamoeba histolytica hypothetical protein 0.0035 0.0161 0.0944
Giardia lamblia Rab geranylgeranyltransferase 0.0159 0.1165 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0 0.0002
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0037 0.018 0.2608
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0161 0.0629
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0032 0.0134 0.0526
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.031 0.1214
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.003 0.0119 0.1605
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0159 0.1165 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0041 0.021 0.3111
Brugia malayi hypothetical protein 0.0035 0.0161 0.0911
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0054 0.031 0.1214
Trichomonas vaginalis mercuric reductase, putative 0.0032 0.0134 0.0765
Loa Loa (eye worm) glutathione reductase 0.0092 0.0623 0.3534
Trypanosoma cruzi trypanothione reductase, putative 0.0092 0.0623 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0271 0.1535
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0041 0.021 0.1281
Entamoeba histolytica hypothetical protein 0.0035 0.0161 0.0944
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0159 0.1165 0.661
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.021 0.3111
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0023
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.004 0.0197 0.1116
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.018 0.0157
Plasmodium vivax thioredoxin reductase, putative 0.0092 0.0623 0.5251
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.003 0.0119 0.0662
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.018 0.2608
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0159 0.1165 0.7828
Leishmania major DNA polymerase eta, putative 0.0062 0.038 0.5956
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0378 0.1478
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1248 1 1
Trypanosoma brucei unspecified product 0.0026 0.0085 0.1033
Schistosoma mansoni protein farnesyltransferase subunit beta 0.003 0.0119 0.0468
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0198 0.1482 0.5803
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0032 0.0134 0.0974
Plasmodium falciparum glutathione reductase 0.0032 0.0134 0.0974
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0041 0.021 0.0821
Mycobacterium tuberculosis Probable oxidoreductase 0.0234 0.1771 0.2453
Schistosoma mansoni hypothetical protein 0.0015 0 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0085 0.1033
Trypanosoma brucei lanosterol synthase 0.003 0.0119 0.1605
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0159 0.1165 0.661
Loa Loa (eye worm) hypothetical protein 0.0015 0 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0023 0.0132
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0 0.0002
Toxoplasma gondii hypothetical protein 0.0041 0.021 0.0689
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1248 1 1
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.003 0.0119 0.0135
Echinococcus multilocularis Smad4 0.0016 0.0004 0.0016
Plasmodium vivax geranylgeranyltransferase, putative 0.003 0.0119 0.0843
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0159 0.1165 0.4562
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0038 0.0185 0.0726
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.003 0.0119 0.0678
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.003 0.0119 0.0356
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0018 0.0024 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.021 0.3111
Loa Loa (eye worm) thioredoxin reductase 0.0092 0.0623 0.3534
Echinococcus granulosus GPCR family 2 0.0015 0 0.0002
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0004 0.0016
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0032 0.0134 0.1854
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0146 0.0826
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0037 0.018 0.1019
Leishmania major trypanothione reductase 0.0092 0.0623 1
Mycobacterium tuberculosis Probable reductase 0.021 0.158 0.2186
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0378 0.1478
Brugia malayi Latrophilin receptor protein 2 0.0015 0 0.0003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0085 0.1033
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0004 0.0016
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0023 0.0091
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.003 0.0119 0.0468
Loa Loa (eye worm) hypothetical protein 0.0044 0.0233 0.1321
Loa Loa (eye worm) hypothetical protein 0.0038 0.0185 0.1052
Entamoeba histolytica hypothetical protein 0.0035 0.0161 0.0944
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0352 0.273 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.021 0.3111
Trypanosoma cruzi lanosterol synthase, putative 0.003 0.0119 0.1605
Leishmania major DNA polymerase eta, putative 0.0036 0.0171 0.2457
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.003 0.0119 0.0678
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0234 0.1771 0.2453
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.031 0.1214
Plasmodium vivax glutathione reductase, putative 0.0092 0.0623 0.5251
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0896 0.7146 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.021 0.158 0.2186
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0023
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0171 0.0544
Loa Loa (eye worm) RNA binding protein 0.0062 0.0378 0.2142
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0041 0.021 0.1634
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0198 0.1482 1
Treponema pallidum NADH oxidase 0.0032 0.0134 0.0111
Echinococcus granulosus dna polymerase kappa 0.0037 0.018 0.0703
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0378 0.2142
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0032 0.0134 0.0526
Trichomonas vaginalis MYB, putative 0.0018 0.0024 0.0005
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0004 0.0016
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0032 0.0134 0.0974
Brugia malayi TAR-binding protein 0.0062 0.0378 0.2142
Loa Loa (eye worm) hypothetical protein 0.0159 0.1165 0.661
Trypanosoma brucei trypanothione reductase 0.0092 0.0623 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.038 0.2158
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0134 0.0111
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.021 0.119
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0159 0.1165 0.4562
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0032 0.0134 0.0111
Echinococcus multilocularis dna polymerase kappa 0.0037 0.018 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Plasmodium falciparum geranylgeranyltransferase, putative 0.003 0.0119 0.0843
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0041 0.021 0.3111
Echinococcus granulosus geminin 0.033 0.2554 1
Brugia malayi MH1 domain containing protein 0.0016 0.0004 0.0023
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0159 0.1165 0.7828
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1248 1 1
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0091
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.021 0.158 0.2186
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.003 0.0119 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0161 0.0629
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0352 0.273 0.2631
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.1763 1
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.003 0.0119 0.0843
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0041 0.021 0.0821
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.003 0.0119 0.0662
Echinococcus multilocularis thioredoxin glutathione reductase 0.0092 0.0623 0.2439
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0171 0.2457
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.021 0.1634
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0032 0.0134 0.0763
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0032 0.0134 0.0974
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.003 0.0119 0.0662
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Trypanosoma brucei unspecified product 0.0037 0.018 0.2608
Plasmodium falciparum protein farnesyltransferase subunit beta 0.003 0.0119 0.0843
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0378 0.2142
Echinococcus granulosus smad 0.0016 0.0004 0.0016
Trypanosoma cruzi DNA polymerase eta, putative 0.0062 0.038 0.5956
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.003 0.0119 0.0843
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.003 0.0119 0.0356
Brugia malayi glutathione reductase 0.0092 0.0623 0.3534
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0378 0.1478
Leishmania major DNA polymerase kappa, putative 0.0037 0.018 0.2608
Schistosoma mansoni hypothetical protein 0.0015 0 0.0002
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.021 0.3111
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.018 0.2608
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0234 0.1771 0.2453
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0032 0.0134 0.1854
Plasmodium falciparum thioredoxin reductase 0.0092 0.0623 0.5251
Giardia lamblia Rab geranylgeranyltransferase 0.003 0.0119 0.0843
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.003 0.0119 0.0468
Leishmania major geranylgeranyltransferase, putative 0.003 0.0119 0.1605
Echinococcus multilocularis RNA directed DNA polymerase 0.0038 0.0185 0.0726
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0004 0.0023
Toxoplasma gondii NADPH-glutathione reductase 0.0032 0.0134 0.0411
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.003 0.0119 0.0662
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0161 0.0629
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.1763 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.018 0.2608
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.021 0.158 0.2186
Trypanosoma cruzi DNA polymerase kappa, putative 0.0037 0.018 0.2608
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0119 0.1605
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0234 0.1771 0.0342
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0378 0.1478
Loa Loa (eye worm) hypothetical protein 0.0049 0.0271 0.1535
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.003 0.0119 0.0662
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0092 0.0623 0.0842
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0134 0.1854
Echinococcus granulosus Smad4 0.0016 0.0004 0.0016
Echinococcus granulosus protein kinase C gamma type 0.0048 0.0262 0.1028
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0159 0.1165 0.7828
Entamoeba histolytica hypothetical protein 0.0035 0.0161 0.0944
Schistosoma mansoni ap endonuclease 0.0018 0.0023 0.0091
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0032 0.0134 0.0111
Brugia malayi ImpB/MucB/SamB family protein 0.0062 0.038 0.2158
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Mycobacterium tuberculosis Conserved hypothetical protein 0.0037 0.018 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Trypanosoma brucei DNA polymerase kappa, putative 0.0026 0.0085 0.1033
Echinococcus granulosus dna polymerase eta 0.0062 0.038 0.1489
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Trypanosoma cruzi trypanothione reductase, putative 0.0032 0.0134 0.1854
Trypanosoma brucei unspecified product 0.0026 0.0085 0.1033
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0032 0.0134 0.0411
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.018 0.2608
Brugia malayi MH2 domain containing protein 0.0016 0.0004 0.0023
Onchocerca volvulus 0.0041 0.021 0.5
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Entamoeba histolytica deoxycytidyl transferase, putative 0.0037 0.018 0.1074
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0041 0.021 0.0821
Echinococcus multilocularis smad 0.0016 0.0004 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0378 0.1478
Schistosoma mansoni hypothetical protein 0.0015 0 0.0002
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.003 0.0119 0.0662
Toxoplasma gondii hypothetical protein 0.0118 0.0831 0.2984
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0032 0.0134 0.0974
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.021 0.3111
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.003 0.0119 0.0678
Trichomonas vaginalis glutathione reductase, putative 0.0032 0.0134 0.0765
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0159 0.1165 0.4562
Schistosoma mansoni hypothetical protein 0.0015 0 0.0002
Leishmania major farnesyltransferase beta subunit 0.003 0.0119 0.1605
Brugia malayi Smad1 0.0016 0.0004 0.0023
Mycobacterium ulcerans DNA polymerase IV 0.0037 0.018 0.0157
Trichomonas vaginalis DNA polymerase eta, putative 0.0037 0.018 0.1074
Schistosoma mansoni hypothetical protein 0.0035 0.0161 0.0629
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.021 0.3111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0032 0.0134 0.0526
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0352 0.273 0.2065
Schistosoma mansoni hypothetical protein 0.033 0.2554 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.021 0.3111
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0198 0.1482 0.5803
Echinococcus multilocularis serine threonine protein kinase 0.0048 0.0262 0.1028
Brugia malayi RNA binding protein 0.0062 0.0378 0.2142
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0119 0.1605
Trypanosoma brucei protein farnesyltransferase beta subunit 0.003 0.0119 0.1605
Trypanosoma cruzi lanosterol synthase, putative 0.003 0.0119 0.1605
Plasmodium falciparum glutathione reductase 0.0092 0.0623 0.5251
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0198 0.1482 0.8408
Echinococcus multilocularis dna polymerase eta 0.0062 0.038 0.1489
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0198 0.1482 0.8408
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.003 0.0119 0.1605
Plasmodium vivax farnesyltransferase beta subunit, putative 0.003 0.0119 0.0843
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0032 0.0134 0.1854
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.021 0.1281
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0159 0.1165 0.7828
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0037 0.018 0.0703
Loa Loa (eye worm) Smad1 0.0016 0.0004 0.0023
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0032 0.0134 0.0156
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0032 0.0134 0.1854
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0037 0.018 0.2608
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0041 0.021 0.0821
Giardia lamblia Myb 1-like protein 0.0018 0.0024 0.0003
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0896 0.7146 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0352 0.273 0.2713
Trypanosoma cruzi protein farnesyltransferase, putative 0.003 0.0119 0.1605
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0032 0.0134 0.1854
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0023 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0 0.0003
Schistosoma mansoni DNA polymerase eta 0.0062 0.038 0.1489
Brugia malayi Protein kinase c protein 2 0.0045 0.0244 0.1385
Echinococcus granulosus protein farnesyltransferase subunit beta 0.003 0.0119 0.0468
Schistosoma mansoni terminal deoxycytidyl transferase 0.0037 0.018 0.0703
Schistosoma mansoni smad1 5 8 and 0.0016 0.0004 0.0016
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0032 0.0134 0.1854
Brugia malayi ImpB/MucB/SamB family protein 0.0037 0.018 0.1019
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.003 0.0119 0.0356
Echinococcus granulosus thioredoxin glutathione reductase 0.0092 0.0623 0.2439
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.003 0.0119 0.0468
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0198 0.1482 0.5803
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0118 0.0831 0.5537
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0037 0.018 0.1074
Giardia lamblia DINP protein human, muc B family 0.0037 0.018 0.1369
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0271 0.1535
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0079 0.0514 0.2012
Schistosoma mansoni hypothetical protein 0.033 0.2554 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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