TDR Targets

Basic information

Technical information

TDR Targets ID: 837682
Name: 3-(3-chlorophenyl)-1-(2-methoxyphenyl)-5,5-di oxo-3a,4,6,6a-tetrahydrothieno[3,4-d]imidazol -2-one
MW: 392.857 | Formula: C18H17ClN2O4S
H donors: 0 H acceptors: 3 LogP: 2.51 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1N1C(=O)N(C2C1CS(=O)(=O)C2)c1cccc(c1)Cl
InChi: 1S/C18H17ClN2O4S/c1-25-17-8-3-2-7-14(17)21-16-11-26(23,24)10-15(16)20(18(21)22)13-6-4-5-12(19)9-13/h2-9,15-16H,10-11H2,1H3
InChiKey: UEDYAEIEYVWGEE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(3-chlorophenyl)-5,5-diketo-1-(2-methoxyphenyl)-3a,4,6,6a-tetrahydrothieno[3,4-d]imidazol-2-one
T5462970

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0123	0.0692	0.0849
Schistosoma mansoni	protein kinase C	0.0148	0.0929	0.0929
Echinococcus granulosus	NDR protein kinase	0.0173	0.1165	0.1165
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1165	0.1384
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Entamoeba histolytica	protein kinase, putative	0.0173	0.1165	1
Echinococcus multilocularis	serine threonine protein kinase	0.0998	0.8857	0.8857
Schistosoma mansoni	rac gtpase activating protein	0.0123	0.0692	0.0692
Echinococcus granulosus	protein kinase c epsilon type	0.0321	0.2545	0.2545
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0126	0.0726	0.0892
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0173	0.1165	0.143
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0173	0.1165	0.143
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0123	0.0692	0.0692
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0123	0.0692	0.0692
Echinococcus multilocularis	N chimaerin	0.0123	0.0692	0.0692
Echinococcus granulosus	serine:threonine protein kinase N2	0.0173	0.1165	0.1165
Schistosoma mansoni	protein kinase C mu	0.0123	0.0692	0.0692
Entamoeba histolytica	protein kinase, putative	0.0173	0.1165	1
Brugia malayi	Variant SH3 domain containing protein	0.0123	0.0692	0.0821
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1165	0.1165
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0173	0.1165	0.143
Loa Loa (eye worm)	hypothetical protein	0.08	0.7004	0.8597
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0321	0.2545	0.3124
Toxoplasma gondii	AGC kinase	0.0173	0.1165	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0929	0.114
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1165	0.1165
Echinococcus granulosus	protein kinase c iota type	0.0296	0.2308	0.2308
Brugia malayi	Pleckstrin Homology Domain	0.0123	0.0692	0.0821
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0148	0.0929	0.0929
Echinococcus granulosus	unc 13 munc13	0.0148	0.0929	0.0929
Schistosoma mansoni	vav2	0.0123	0.0692	0.0692
Brugia malayi	p70 ribosomal S6 kinase beta	0.0173	0.1165	0.1384
Schistosoma mansoni	serine/threonine protein kinase	0.1121	1	1
Brugia malayi	RhoGAP domain containing protein	0.0123	0.0692	0.0821
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0126	0.0726	0.0726
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0126	0.0726	0.0892
Loa Loa (eye worm)	glutaminase	0.0289	0.2245	0.2756
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Trichomonas vaginalis	glutaminase, putative	0.0289	0.2245	1
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0123	0.0692	0.0692
Brugia malayi	diacylglycerol kinase	0.0123	0.0692	0.0821
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0173	0.1165	0.1165
Echinococcus multilocularis	protein kinase c eta type	0.0123	0.0692	0.0692
Echinococcus granulosus	RNA directed DNA polymerase	0.08	0.7004	0.7004
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Brugia malayi	glutaminase DH11.1	0.0289	0.2245	0.2667
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0126	0.0726	0.0726
Echinococcus multilocularis	RNA directed DNA polymerase	0.08	0.7004	0.7004
Brugia malayi	protein kinase C II.	0.0321	0.2545	0.3023
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1165	0.1165
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0126	0.0726	0.0863
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0123	0.0692	0.0849
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0173	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Schistosoma mansoni	atypical protein kinase C	0.0296	0.2308	0.2308
Loa Loa (eye worm)	raf kinase	0.0123	0.0692	0.0849
Echinococcus granulosus	N chimaerin	0.0123	0.0692	0.0692
Schistosoma mansoni	serine/threonine protein kinase	0.1121	1	1
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0123	0.0692	0.0692
Echinococcus granulosus	protein kinase c eta type	0.0123	0.0692	0.0692
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.1121	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Brugia malayi	RhoGEF domain containing protein	0.0123	0.0692	0.0821
Schistosoma mansoni	diacylglycerol kinase theta	0.0123	0.0692	0.0692
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0173	0.1165	0.143
Schistosoma mansoni	serine/threonine protein kinase	0.0321	0.2545	0.2545
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Brugia malayi	protein kinase C3,putative	0.0126	0.0726	0.0863
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0173	0.1165	0.1165
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0173	0.1165	0.143
Brugia malayi	RhoGAP domain containing protein	0.0123	0.0692	0.0821
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0123	0.0692	0.0849
Schistosoma mansoni	serine/threonine protein kinase	0.0173	0.1165	0.1165
Echinococcus multilocularis	unc 13 (munc13)	0.0148	0.0929	0.0929
Brugia malayi	C1-like domain containing protein	0.0126	0.0726	0.0863
Loa Loa (eye worm)	glutaminase 2	0.0289	0.2245	0.2756
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0123	0.0692	0.0692
Schistosoma mansoni	serine/threonine kinase	0.0173	0.1165	0.1165
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Brugia malayi	diacylglycerol kinase	0.0123	0.0692	0.0821
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0173	0.1165	0.1165
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.08	0.7004	0.7004
Brugia malayi	Ras association domain family 1 isoform A	0.0123	0.0692	0.0821
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0123	0.0692	0.0849
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0173	0.1165	0.1165
Brugia malayi	Hr1 repeat family protein	0.0173	0.1165	0.1384
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0173	0.1165	0.143
Loa Loa (eye worm)	hypothetical protein	0.0173	0.1165	0.143
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0173	0.1165	0.5
Schistosoma mansoni	unc-13 (munc13)	0.0148	0.0929	0.0929
Schistosoma mansoni	unc-13 (munc13)	0.0148	0.0929	0.0929
Echinococcus granulosus	protein kinase C gamma type	0.0998	0.8857	0.8857
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0829	0.7276	0.8931
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1165	0.1384
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Mycobacterium ulcerans	glutaminase	0.0289	0.2245	0.5
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Onchocerca volvulus		0.0148	0.0929	1
Entamoeba histolytica	protein kinase, putative	0.0173	0.1165	1
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0173	0.1165	0.1165
Echinococcus granulosus	raf serine:threonine protein kinase	0.0123	0.0692	0.0692
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0173	0.1165	0.143
Schistosoma mansoni	serine/threonine protein kinase	0.0126	0.0726	0.0726
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0692	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0922	0.8146	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0173	0.1165	0.1165
Schistosoma mansoni	glutaminase	0.0289	0.2245	0.2245
Brugia malayi	Protein kinase domain containing protein	0.0173	0.1165	0.1384
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0123	0.0692	0.0692
Echinococcus multilocularis	protein kinase c iota type	0.0296	0.2308	0.2308
Echinococcus multilocularis	myotubularin protein 13	0.0123	0.0692	0.0692
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0148	0.0929	0.0929
Brugia malayi	Protein kinase domain containing protein	0.0126	0.0726	0.0863
Echinococcus granulosus	Rac GTPase activating protein 1	0.0123	0.0692	0.0692
Entamoeba histolytica	protein kinase, putative	0.0173	0.1165	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0321	0.2545	0.2545
Echinococcus granulosus	myotubularin protein 13	0.0123	0.0692	0.0692
Schistosoma mansoni	diacylglycerol kinase theta	0.0123	0.0692	0.0692
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0173	0.1165	0.1165
Schistosoma mansoni	protein kinase C mu	0.0126	0.0726	0.0726
Schistosoma mansoni	serine/threonine protein kinase	0.0123	0.0692	0.0692
Schistosoma mansoni	hypothetical protein	0.0123	0.0692	0.0692
Trichomonas vaginalis	AGC family protein kinase	0.0173	0.1165	0.0313
Echinococcus granulosus	Diacylglycerol kinase theta	0.0123	0.0692	0.0692
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0173	0.1165	0.1165
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0123	0.0692	0.0692
Brugia malayi	Protein kinase c protein 2	0.0951	0.8419	1
Schistosoma mansoni	serine/threonine protein kinase	0.0126	0.0726	0.0726

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 837682