Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0604 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0604 | 0.0822 |
Echinococcus multilocularis | methyl CpG binding domain protein 2 | 0.0037 | 0.0481 | 0.0816 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0602 | 0.1235 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0037 | 0.0481 | 0.0816 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0604 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0604 | 0.1093 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0602 | 0.9121 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0604 | 0.9145 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1801 | 0.3693 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0068 | 0.1801 | 1 |
Onchocerca volvulus | 0.004 | 0.0604 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0602 | 0.1235 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0045 | 0.0821 | 0.1282 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0041 | 0.0649 | 0.1195 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0068 | 0.1801 | 0.3693 |
Echinococcus granulosus | zinc finger protein | 0.0043 | 0.0721 | 0.1359 |
Trypanosoma cruzi | ISWI complex protein | 0.0033 | 0.0314 | 0.3662 |
Trypanosoma cruzi | ISWI complex protein | 0.0033 | 0.0314 | 0.3662 |
Brugia malayi | Bromodomain containing protein | 0.0164 | 0.599 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0604 | 0.0149 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0604 | 0.0149 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0037 | 0.0481 | 0.0987 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.2501 | 0.4055 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0604 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0604 | 0.0883 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0068 | 0.1801 | 0.3805 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2508 | 0.4369 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0604 | 0.0883 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0041 | 0.0649 | 0.3141 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0604 | 0.0149 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0649 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.298 | 0.6475 |
Onchocerca volvulus | 0.004 | 0.0604 | 0.5 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0604 | 0.0149 |
Brugia malayi | hypothetical protein | 0.004 | 0.0602 | 0.082 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0604 | 0.9145 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0604 | 0.9145 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0604 | 0.0149 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0602 | 0.109 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0037 | 0.0481 | 0.0987 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0049 | 0.1003 | 0.1998 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0604 | 0.1238 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0604 | 0.2873 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0649 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.298 | 0.6111 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.298 | 0.6111 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0037 | 0.0481 | 0.0816 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.298 | 0.6111 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.298 | 0.4871 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0131 | 0.4535 | 1 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0079 | 0.2276 | 0.4881 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0039 | 0.0539 | 0.0766 |
Giardia lamblia | Flap structure-specific endonuclease | 0.0029 | 0.0121 | 0.5 |
Schistosoma mansoni | zinc finger protein | 0.0043 | 0.0721 | 0.1479 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0604 | 0.0149 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0037 | 0.0481 | 0.0987 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0604 | 0.0822 |
Loa Loa (eye worm) | inositol-1 | 0.0041 | 0.0649 | 0.0966 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0068 | 0.1801 | 0.1404 |
Plasmodium falciparum | flap endonuclease 1 | 0.0029 | 0.0121 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.298 | 0.6475 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0049 | 0.1003 | 0.2057 |
Brugia malayi | PHD-finger family protein | 0.0055 | 0.1228 | 0.1886 |
Brugia malayi | beta-lactamase | 0.004 | 0.0604 | 0.0822 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0041 | 0.0649 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0041 | 0.0649 | 0.1195 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0604 | 0.0149 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0604 | 0.9145 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1801 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0649 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0604 | 0.1093 |
Echinococcus granulosus | methyl CpG binding domain protein 2 | 0.0037 | 0.0481 | 0.0816 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.2914 | 0.5114 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0604 | 0.9145 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1801 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0314 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0604 | 0.0883 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0604 | 0.1238 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0604 | 0.0822 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0041 | 0.0649 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0602 | 0.109 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0079 | 0.2276 | 0.4881 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0037 | 0.0481 | 0.0987 |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0821 | 0.1685 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0604 | 0.0883 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0604 | 0.9145 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0649 | 0.3141 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0604 | 0.0149 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0068 | 0.1801 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0649 | 0.1331 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0604 | 0.2873 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0602 | 0.9121 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0049 | 0.1003 | 0.1998 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0604 | 0.9145 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0041 | 0.0649 | 0.0377 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0604 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0068 | 0.1801 | 0.3805 |
Schistosoma mansoni | bromodomain containing protein | 0.0138 | 0.4876 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.298 | 0.6475 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0604 | 0.9145 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0604 | 0.0149 |
Schistosoma mansoni | zinc finger protein | 0.0033 | 0.0314 | 0.0645 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0481 | 0.0659 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0068 | 0.1801 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.298 | 0.5233 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.298 | 0.6475 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2733 | 0.4781 |
Leishmania major | hypothetical protein, conserved | 0.0033 | 0.0314 | 0.115 |
Onchocerca volvulus | 0.004 | 0.0604 | 0.5 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0604 | 0.0883 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0602 | 0.9121 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0041 | 0.0649 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0041 | 0.0649 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0604 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.5583 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0604 | 0.9145 |
Brugia malayi | Inositol-1 | 0.0041 | 0.0649 | 0.0899 |
Echinococcus multilocularis | zinc finger protein | 0.0043 | 0.0721 | 0.1359 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.0602 | 0.9121 |
Schistosoma mansoni | inositol monophosphatase | 0.0041 | 0.0649 | 0.1331 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0041 | 0.0649 | 1 |
Trypanosoma brucei | ISWI complex protein | 0.0033 | 0.0314 | 0.3662 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0131 | 0.4535 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0604 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0604 | 0.0883 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.