Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium yoelii | thymidylate synthase, putative | Dihydrofolate reductase | 163 aa | 139 aa | 21.6 % |
Onchocerca volvulus | Putative dihydrofolate reductase | Dihydrofolate reductase | 163 aa | 173 aa | 27.2 % |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Dihydrofolate reductase | 163 aa | 138 aa | 29.7 % |
Babesia bovis | dihydrofolate reductase/thymidilate synthase | Dihydrofolate reductase | 163 aa | 133 aa | 27.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.026 | 0.9883 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.026 | 0.9883 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Schistosoma mansoni | dihydrofolate reductase | 0.026 | 0.9883 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.026 | 0.9883 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.026 | 0.9883 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.026 | 0.9883 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.026 | 0.9883 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.026 | 0.9883 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.026 | 0.9883 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.026 | 0.9883 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0262 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0262 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 7.71 | Inhibitory activity against dihydrofolate reductase | ChEMBL. | 11495588 |
Activity (binding) | = 7.71 | Activity against dihydrofolate reductase of Escherichia coli strain MB 1428 | ChEMBL. | 1507206 |
Ki (binding) | = 4.15 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Ki (binding) | = 6.45 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/C (binding) | = 4.15 | Inhibition of chicken liver dihydrofolate reductase | ChEMBL. | 3701780 |
Log 1/C (binding) | = 4.15 | Inhibition of chicken liver dihydrofolate reductase | ChEMBL. | 3701780 |
Log 1/Ki (binding) | = 4.15 | Inhibitory activity against chicken liver dihydrofolate reductase | ChEMBL. | 2502631 |
Log 1/Ki (binding) | = 6.45 | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | ChEMBL. | 2502631 |
logD (ADMET) | = 1.51 | Partition coefficient (logD) (aqueous phase 0.1 N HCl) | ChEMBL. | 3701780 |
logD (ADMET) | = 1.51 | Partition coefficient (logD) (0.01 N NaOH) | ChEMBL. | 2502631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
4 literature references were collected for this gene.