Detailed information for compound 838048

Basic information

Technical information
  • TDR Targets ID: 838048
  • Name: N-(4-chlorophenyl)-2-[[5-[(1-methylpyrrol-2-y l)methyl]-4-(2-phenylethyl)-1,2,4-triazol-3-y l]sulfanyl]acetamide
  • MW: 465.998 | Formula: C24H24ClN5OS
  • H donors: 1 H acceptors: 3 LogP: 4.43 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Cl)CSc1nnc(n1CCc1ccccc1)Cc1cccn1C
  • InChi: 1S/C24H24ClN5OS/c1-29-14-5-8-21(29)16-22-27-28-24(30(22)15-13-18-6-3-2-4-7-18)32-17-23(31)26-20-11-9-19(25)10-12-20/h2-12,14H,13,15-17H2,1H3,(H,26,31)
  • InChiKey: ZBXFEHHZUZEGHI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-chlorophenyl)-2-[[5-[(1-methyl-2-pyrrolyl)methyl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetamide
  • N-(4-chlorophenyl)-2-[[5-[(1-methylpyrrol-2-yl)methyl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]thio]acetamide
  • N-(4-chlorophenyl)-2-[[5-[(1-methylpyrrol-2-yl)methyl]-4-(2-phenylethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pyruvate kinase 0.007 0.1579 0.1946
Brugia malayi pyruvate kinase 0.0015 0.022 0.0384
Schistosoma mansoni survival motor neuron protein 0.0048 0.1053 0.1053
Brugia malayi hypothetical protein 0.0164 0.3909 0.6832
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0493 0.1439
Echinococcus granulosus alpha 1A adrenergic receptor 0.0074 0.1691 0.1691
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0493 0.2079
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0426 0.1641
Mycobacterium ulcerans hypothetical protein 0.0026 0.0493 0.1439
Loa Loa (eye worm) pyruvate kinase 0.0015 0.022 0.0271
Leishmania major GTP-binding protein, putative 0.0023 0.0426 0.1796
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0847 0.3276
Schistosoma mansoni neuropeptide receptor 0.0074 0.1691 0.1691
Onchocerca volvulus 0.0014 0.0203 0.0258
Trypanosoma brucei 6-phosphogluconolactonase 0.0009 0.0079 0.0324
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0128 0.0158
Brugia malayi ecdysteroid receptor 0.0011 0.0128 0.0223
Echinococcus granulosus transportin 1 0.0006 0.0003 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0128 0.0223
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.1691 0.2085
Onchocerca volvulus 0.0074 0.1691 0.2666
Loa Loa (eye worm) hypothetical protein 0.0049 0.1058 0.1304
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0082
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1485 0.4618
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.0043 0.0082
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0051 0.1106 0.1106
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0128 0.0136
Brugia malayi RNA, U transporter 1 0.0089 0.2055 0.3593
Leishmania major glucosamine-6-phosphate isomerase, putative 0.0009 0.0079 0.0324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.1485 0.4662
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0332 0.0924
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0332 0.0999
Schistosoma mansoni opsin-like receptor 0.0074 0.1691 0.1691
Brugia malayi hypothetical protein 0.0238 0.5721 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.0043 0.0157
Toxoplasma gondii pyruvate kinase PyKII 0.0036 0.0741 0.2862
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1691 0.1691
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0493 0.2925
Schistosoma mansoni inositol monophosphatase 0.004 0.0847 0.0847
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0018 0.0024
Onchocerca volvulus 0.0074 0.1691 0.2666
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0082
Loa Loa (eye worm) hypothetical protein 0.0019 0.0332 0.0409
Loa Loa (eye worm) pyruvate kinase-PB 0.0049 0.1058 0.1304
Schistosoma mansoni hypothetical protein 0.0335 0.8111 0.8111
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0128 0.0223
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0426 0.0426
Loa Loa (eye worm) hypothetical protein 0.0019 0.0332 0.0409
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0128 0.0158
Leishmania major 6-phosphogluconolactonase 0.0009 0.0079 0.0324
Toxoplasma gondii propionate-CoA ligase 0.0008 0.0043 0.0157
Echinococcus multilocularis lamin 0.0027 0.0526 0.0526
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0101 0.2357 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.0043 0.0043
Loa Loa (eye worm) inositol-1 0.004 0.0847 0.1045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Mycobacterium ulcerans hypothetical protein 0.0134 0.3165 1
Echinococcus granulosus lamin 0.0027 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0027 0.0513 0.0633
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0043 0.0076
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Onchocerca volvulus 0.0074 0.1691 0.2666
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0493 0.1439
Loa Loa (eye worm) histone methyltransferase 0.001 0.0107 0.0131
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.1691 0.1691
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0009 0.0079 0.0155
Leishmania major phosphopantetheinyl transferase-like protein 0.0049 0.1064 0.4506
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0484 0.0773
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0128 0.0158
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0043 0.0065
Echinococcus granulosus serotonin receptor 0.0074 0.1691 0.1691
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0026 0.0493 0.0607
Plasmodium vivax SET domain protein, putative 0.0033 0.0673 0.2599
Onchocerca volvulus 0.0074 0.1691 0.2666
Brugia malayi kap beta 3 protein 0.0006 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.007 0.1579 0.1946
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0484 0.0773
Entamoeba histolytica glucosamine-6-phosphate isomerase, putative 0.0009 0.0079 0.0693
Echinococcus multilocularis serotonin receptor 0.0074 0.1691 0.1691
Echinococcus granulosus pyruvate kinase 0.0036 0.0741 0.0741
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.011 0.258 0.4142
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0049 0.1064 0.4116
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.011 0.258 0.4142
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0847 0.3586
Toxoplasma gondii pyruvate kinase PyK1 0.007 0.1579 0.6114
Trypanosoma brucei pyruvate kinase 1, putative 0.007 0.1579 0.6692
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0128 0.0136
Mycobacterium tuberculosis Conserved protein 0.0134 0.3165 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0128 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0128 0.0223
Brugia malayi G-protein coupled receptor 0.0074 0.1691 0.2956
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0847 0.0847
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0673 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Brugia malayi putative neuropeptide receptor NPR1 0.0074 0.1691 0.2956
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0673 0.0673
Loa Loa (eye worm) hypothetical protein 0.0027 0.0526 0.0648
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0128 0.0223
Echinococcus multilocularis pyruvate kinase 0.007 0.1579 0.1579
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.1691 0.1691
Echinococcus granulosus tachykinin peptides receptor 99D 0.0074 0.1691 0.1691
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.0354
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0074 0.1691 0.2085
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0128 0.0128
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.1485 0.6295
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1691 0.1691
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0003 0.0004
Mycobacterium tuberculosis Possible toxin MazF7 0.0134 0.3165 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.1485 0.1485
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.1579 0.6635
Schistosoma mansoni neuropeptide f receptor 76f 0.0074 0.1691 0.1691
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.1691 0.1691
Onchocerca volvulus 0.0074 0.1691 0.2666
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.011 0.258 1
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.1691 0.1691
Mycobacterium tuberculosis Toxin MazF2 0.0134 0.3165 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.0043 0.0366
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0074 0.1691 0.1691
Echinococcus granulosus g-protein coupled receptor 0.0074 0.1691 0.1691
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0049 0.1064 0.4116
Schistosoma mansoni importin beta-1 0.0031 0.063 0.063
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0526 0.0648
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.0043 0.0082
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1691 0.1691
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Schistosoma mansoni hypothetical protein 0.0074 0.1691 0.1691
Echinococcus multilocularis lamin dm0 0.0027 0.0526 0.0526
Schistosoma mansoni pyruvate kinase 0.007 0.1579 0.1579
Entamoeba histolytica Ran family GTPase 0.0023 0.0426 0.3833
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0003 0.0004
Brugia malayi 6-phosphogluconolactonase family protein 0.0009 0.0079 0.0139
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0074 0.1691 0.1691
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0074 0.1691 0.1691
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0426 0.0744
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0306 0.0916
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0076
Echinococcus granulosus g protein coupled receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0426 0.0525
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0031 0.063 0.0777
Onchocerca volvulus 0.0074 0.1691 0.2666
Echinococcus multilocularis importin subunit beta 1 0.0031 0.063 0.063
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0063 0.0063
Brugia malayi RE15519p 0.0074 0.1691 0.2956
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0128 0.0128
Trypanosoma brucei glucosamine-6-phosphate isomerase, putative 0.0009 0.0079 0.0324
Echinococcus granulosus L aminoadipate semialdehyde 0.0174 0.4148 0.4148
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Onchocerca volvulus 0.0011 0.0128 0.0136
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0847 0.1357
Schistosoma mansoni cpg binding protein 0.0031 0.061 0.061
Plasmodium falciparum pyruvate kinase 2 0.0036 0.0741 0.2862
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0493 0.1439
Loa Loa (eye worm) hypothetical protein 0.0014 0.0203 0.025
Echinococcus granulosus somatostatin receptor 0.0074 0.1691 0.1691
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Echinococcus multilocularis sentrin specific protease 7 0.0014 0.0203 0.0203
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0493 0.2079
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.0043 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0128 0.0128
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.0043 0.0172
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0174 0.4148 0.4148
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0049 0.1064 0.4321
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0014 0.0203 0.0848
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Schistosoma mansoni cpg binding protein 0.0029 0.0569 0.0569
Onchocerca volvulus 0.0026 0.0493 0.0727
Echinococcus multilocularis musashi 0.0027 0.0526 0.0526
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Chlamydia trachomatis deubiquitinase/deneddylase Dub1 0.0014 0.0203 0.0541
Echinococcus multilocularis orexin receptor type 2 0.0074 0.1691 0.1691
Schistosoma mansoni hypothetical protein 0.0074 0.1691 0.1691
Entamoeba histolytica pyruvate kinase, putative 0.0049 0.1058 0.9561
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0526 0.0919
Echinococcus multilocularis g-protein coupled receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis translational activator gcn1 0.0006 0.0003 0.0003
Echinococcus granulosus translational activator gcn1 0.0006 0.0003 0.0003
Onchocerca volvulus 0.0074 0.1691 0.2666
Schistosoma mansoni hypothetical protein 0.0074 0.1691 0.1691
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0014 0.0203 0.0321
Schistosoma mansoni 6-phosphogluconolactonase 0.0009 0.0079 0.0079
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0493 0.1509
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0743 0.2306
Brugia malayi follicle stimulating hormone receptor 0.0074 0.1691 0.2956
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus multilocularis pyruvate kinase 0.007 0.1579 0.1579
Mycobacterium tuberculosis Toxin MazF9 0.0134 0.3165 1
Leishmania major importin beta-1 subunit, putative 0.0025 0.0484 0.2042
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0074 0.1691 0.2085
Mycobacterium leprae Probable pyruvate kinase PykA 0.007 0.1579 1
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.1064 0.4506
Echinococcus multilocularis importin 5 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0013 0.0167 0.0206
Brugia malayi Tachykinin-like peptides receptor 99D 0.0074 0.1691 0.2956
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0104 0.0181
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.007 0.1579 0.4959
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.011 0.258 1
Schistosoma mansoni lamin 0.0027 0.0526 0.0526
Echinococcus multilocularis 6 phosphogluconolactonase 0.0009 0.0079 0.0079
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0128 0.0128
Brugia malayi Pre-SET motif family protein 0.0227 0.5453 0.9531
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0035 0.0724 0.2245
Echinococcus granulosus dro:myosuppressin receptor 0.0074 0.1691 0.1691
Schistosoma mansoni biogenic amine receptor 0.0074 0.1691 0.1691
Onchocerca volvulus 0.0029 0.0569 0.085
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0493 0.1439
Trypanosoma cruzi hypothetical protein 0.0014 0.0203 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0128 0.0223
Brugia malayi Dopamine receptor protein 2 0.0074 0.1691 0.2956
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0128 0.0128
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.2357 1
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1691 0.1691
Brugia malayi G protein-coupled receptor 0.0074 0.1691 0.2956
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Brugia malayi sulfakinin receptor protein 0.0074 0.1691 0.2956
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.2357 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0074 0.1691 0.2666
Plasmodium vivax sentrin-specific protease 1, putative 0.0051 0.1106 0.4281
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0074 0.1691 0.1691
Schistosoma mansoni amine GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Echinococcus multilocularis transportin 1 0.0006 0.0003 0.0003
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0034 0.0685 0.2774
Chlamydia trachomatis pyruvate kinase 0.007 0.1579 0.6581
Schistosoma mansoni intermediate filament proteins 0.0027 0.0526 0.0526
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0426 0.1653
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus hypothetical protein 0.0074 0.1691 0.1691
Brugia malayi Pyruvate kinase, M2 isozyme 0.007 0.1579 0.2759
Schistosoma mansoni neuropeptide receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0128 0.0128
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0215 0.0376
Trichomonas vaginalis set domain proteins, putative 0.0258 0.6224 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1485 0.4618
Echinococcus multilocularis sentrin specific protease 1 0.0051 0.1106 0.1106
Brugia malayi steroid hormone receptor 0.0011 0.0128 0.0223
Echinococcus multilocularis neuropeptide Y receptor 0.0074 0.1691 0.1691
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0673 0.0673
Leishmania major pyruvate kinase 0.007 0.1579 0.6692
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1691 0.1691
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0049 0.1064 0.3268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0033 0.0661 0.267
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0493 0.4438
Schistosoma mansoni ran 0.0023 0.0426 0.0426
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0306 0.0916
Mycobacterium leprae Probable 6-phosphogluconolactonase DevB (6PGL) 0.0009 0.0079 0.0234
Onchocerca volvulus 0.0033 0.0673 0.1018
Echinococcus multilocularis sex peptide receptor 0.0074 0.1691 0.1691
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0014 0.0203 0.0688
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0215 0.0265
Schistosoma mansoni glucosamine-6-phosphate isomerase 0.0009 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus multilocularis pyruvate kinase 0.0055 0.1216 0.1216
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1236 0.4783
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.0354
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0074 0.1691 0.2956
Mycobacterium tuberculosis Possible toxin MazF1 0.0134 0.3165 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0673 0.0673
Mycobacterium tuberculosis Toxin MazF3 0.0134 0.3165 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0128 0.0223
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0074 0.1691 0.2956
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0128 0.0128
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Schistosoma mansoni amine GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus lamin dm0 0.0027 0.0526 0.0526
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.1485 0.4618
Echinococcus granulosus 7TM GPCR rhodopsin 0.0074 0.1691 0.1691
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0026 0.0493 0.0607
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.0043 0.0082
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Brugia malayi AKH receptor 0.0074 0.1691 0.2956
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1053 0.184
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0074 0.1691 0.1691
Echinococcus multilocularis neuropeptide s receptor 0.0074 0.1691 0.1691
Giardia lamblia Sentrin specific protease, putative 0.0014 0.0203 0.0493
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0426 0.1385
Echinococcus granulosus snurportin 1 0.0335 0.8111 0.8111
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0101 0.2357 1
Brugia malayi G-protein coupled receptor 0.0074 0.1691 0.2956
Brugia malayi nuclear receptor NHR-88 0.0011 0.0128 0.0223
Schistosoma mansoni amine GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0128 0.0128
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Brugia malayi ORL1-like opioid receptor 0.0074 0.1691 0.2956
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0051 0.1106 0.4281
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0076
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0014 0.0203 0.0688
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0128 0.0223
Echinococcus multilocularis dro:myosuppressin receptor 0.0074 0.1691 0.1691
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.022 0.0384
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.1691 0.2085
Echinococcus granulosus 6 phosphogluconolactonase 0.0009 0.0079 0.0079
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.1579 0.2484
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.0043 0.0082
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.1579 0.2533
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0128 0.0223
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.1691 0.1691
Echinococcus granulosus neuropeptide Y receptor 0.0074 0.1691 0.1691
Plasmodium falciparum importin beta, putative 0.0031 0.063 0.2433
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0051 0.1106 0.1773
Onchocerca volvulus 0.0074 0.1691 0.2666
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0049 0.1064 0.4116
Giardia lamblia Pyruvate kinase 0.007 0.1579 0.5995
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0203 0.0321
Plasmodium vivax sentrin-specific protease 2, putative 0.0014 0.0203 0.0775
Brugia malayi Dopamine receptor protein 1 0.0074 0.1691 0.2956
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0018 0.0024
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0013 0.0167 0.0206
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0128 0.0223
Schistosoma mansoni biogenic amine (5HT) receptor 0.0074 0.1691 0.1691
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.0043 0.0082
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.0043 0.0082
Plasmodium vivax pyruvate kinase, putative 0.007 0.1579 0.6114
Onchocerca volvulus 0.0074 0.1691 0.2666
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0074 0.1691 0.1691
Echinococcus granulosus biogenic amine 5HT receptor 0.0074 0.1691 0.1691
Echinococcus granulosus pyruvate kinase 0.0036 0.0741 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0128 0.0223
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0101 0.2357 0.2357
Onchocerca volvulus 0.0074 0.1691 0.2666
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0074 0.1691 0.1691
Brugia malayi glucose-6-phosphate dehydrogenase 0.0101 0.2357 0.412
Echinococcus granulosus neuropeptide s receptor 0.0074 0.1691 0.1691
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0074 0.1691 0.2956
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0128 0.0158
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0628 0.0628
Onchocerca volvulus 0.0258 0.6224 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0128 0.0158
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Echinococcus multilocularis G protein coupled receptor 139 0.0074 0.1691 0.1691
Echinococcus multilocularis pyruvate kinase 0.0036 0.0741 0.0741
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0074 0.1691 0.1691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus importin subunit beta 1 0.0031 0.063 0.063
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0074 0.1691 0.2956
Schistosoma mansoni coup transcription factor 0.0011 0.0128 0.0128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Echinococcus granulosus orexin receptor type 2 0.0074 0.1691 0.1691
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0074 0.1691 0.1691
Onchocerca volvulus 0.0027 0.0526 0.078
Loa Loa (eye worm) hypothetical protein 0.0174 0.4148 0.5114
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0493 0.0861
Mycobacterium leprae conserved hypothetical protein 0.0049 0.1064 0.6646
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Schistosoma mansoni lamin 0.0027 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0101 0.2357 0.7412
Echinococcus granulosus g protein coupled receptor 0.0074 0.1691 0.1691
Brugia malayi putative neuropeptide receptor 0.0074 0.1691 0.2956
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0128 0.0128
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.0043 0.0157
Mycobacterium tuberculosis Toxin MazF6 0.0134 0.3165 1
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0043 0.0172
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1485 0.1485
Schistosoma mansoni neuropeptide receptor 0.0074 0.1691 0.1691
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0332 0.1108
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0203 0.0203
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1691 0.1691
Brugia malayi G protein-coupled receptor F59B2.13 0.0074 0.1691 0.2956
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0847 0.7653
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0128 0.0128
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0074 0.1691 0.1691
Brugia malayi Pyruvate kinase, muscle isozyme 0.007 0.1579 0.2759
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0128 0.0128
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1691 0.1691
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0128 0.0223
Onchocerca volvulus 0.0074 0.1691 0.2666
Echinococcus multilocularis fmrfamide receptor 0.0074 0.1691 0.1691
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.1579 0.2484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Plasmodium vivax pyruvate kinase 2, putative 0.0036 0.0741 0.2862
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0673 0.0673
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0101 0.2357 0.2357
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0049 0.1064 0.4321
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Brugia malayi Melatonin receptor type 1A 0.0074 0.1691 0.2956
Loa Loa (eye worm) 6-phosphogluconolactonase 0.0009 0.0079 0.0098
Brugia malayi Serotonin receptor 0.0074 0.1691 0.2956
Schistosoma mansoni alpha-1 adrenergic receptor 0.0074 0.1691 0.1691
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Echinococcus multilocularis cpg binding protein 0.0031 0.061 0.061
Trichomonas vaginalis Sentrin-specific protease, putative 0.0014 0.0203 0.0321
Echinococcus multilocularis somatostatin receptor 0.0074 0.1691 0.1691
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0426 0.1796
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.1579 0.2484
Echinococcus multilocularis pyruvate kinase 0.0036 0.0741 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0128 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0128 0.0223
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.1579 0.6635
Loa Loa (eye worm) hypothetical protein 0.0051 0.1106 0.1364
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0484 0.0773
Mycobacterium ulcerans pyruvate kinase 0.007 0.1579 0.4918
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0049 0.1064 0.3324
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0203 0.0203
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0009 0.0079 0.0123
Echinococcus multilocularis neuropeptide FF receptor 2 0.0074 0.1691 0.1691
Schistosoma mansoni hypothetical protein 0.0074 0.1691 0.1691
Schistosoma mansoni opsin-like receptor 0.0074 0.1691 0.1691
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0426 0.1641
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus granulosus pyruvate kinase 0.0036 0.0741 0.0741
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0493 0.4438
Schistosoma mansoni growth hormone secretagogue receptor 0.0074 0.1691 0.1691
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0128 0.0223
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0101 0.2357 0.2357
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0335 0.8111 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0074 0.1691 0.2956
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.5453 0.6723
Loa Loa (eye worm) hypothetical protein 0.0008 0.0043 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0569 0.0702
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.5721 0.5721
Mycobacterium ulcerans 6-phosphogluconolactonase 0.0009 0.0079 0.0115
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0043 0.0054
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis fmrfamide receptor 0.0074 0.1691 0.1691
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0493 0.1439
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0493 0.1439
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0074 0.1691 0.1691
Onchocerca volvulus 0.0164 0.3909 0.6254
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0128 0.0158
Echinococcus granulosus neuropeptide receptor A26 0.0074 0.1691 0.1691
Brugia malayi Importin beta-1 subunit 0.0031 0.063 0.1101
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.0043 0.0172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0673 0.0673
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0128 0.0128
Echinococcus multilocularis allatostatin A receptor 0.0074 0.1691 0.1691
Schistosoma mansoni amine GPCR 0.0074 0.1691 0.1691
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Brugia malayi GnHR receptor homolog 0.0074 0.1691 0.2956
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.0043 0.0082
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0128 0.0128
Brugia malayi neuropeptide F receptor 0.0074 0.1691 0.2956
Giardia lamblia Pyruvate kinase 0.0036 0.0741 0.2644
Loa Loa (eye worm) Ulp1 protease 0.0014 0.0203 0.025
Loa Loa (eye worm) hypothetical protein 0.0026 0.0493 0.0607
Loa Loa (eye worm) pyruvate kinase 0.007 0.1579 0.1946
Echinococcus multilocularis snurportin 1 0.0335 0.8111 0.8111
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0074 0.1691 0.2085
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0493 0.0861
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0493 0.1509
Echinococcus granulosus g protein coupled receptor 0.0074 0.1691 0.1691
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0074 0.1691 0.1691
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0128 0.0223
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0847 0.3586
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0847 0.3474
Echinococcus granulosus neuropeptides capa receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0306 0.0916
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.011 0.258 1
Brugia malayi intermediate filament protein 0.0027 0.0526 0.0919
Echinococcus granulosus sex peptide receptor 0.0074 0.1691 0.1691
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Echinococcus granulosus neuropeptide FF receptor 2 0.0074 0.1691 0.1691
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0203 0.0775
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0493 0.1439
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0493 0.2925
Mycobacterium tuberculosis Possible toxin MazF4 0.0134 0.3165 1
Schistosoma mansoni hypothetical protein 0.0048 0.1053 0.1053
Onchocerca volvulus Neuropeptide F receptor homolog 0.0074 0.1691 0.2666
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Brugia malayi Serotonin receptor 0.0074 0.1691 0.2956
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0847 0.0847
Schistosoma mansoni neuropeptide receptor 0.0074 0.1691 0.1691
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0049 0.1064 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.063 0.2433
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0128 0.0128
Schistosoma mansoni myosin xvIII 0.0074 0.1691 0.1691
Leishmania major pyruvate kinase 0.007 0.1579 0.6692
Onchocerca volvulus 0.0074 0.1691 0.2666
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0128 0.0128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0128 0.0158
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.1691 0.1691
Mycobacterium tuberculosis Possible toxin MazF5 0.0134 0.3165 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.063 0.2663
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0493 0.4438
Loa Loa (eye worm) TYRA-2 protein 0.0074 0.1691 0.2085
Schistosoma mansoni opsin-like receptor 0.0074 0.1691 0.1691
Brugia malayi nuclear hormone receptor 0.0011 0.0128 0.0223
Loa Loa (eye worm) pyruvate kinase 0.007 0.1579 0.1946
Loa Loa (eye worm) melatonin receptor type 1A 0.0074 0.1691 0.2085
Schistosoma mansoni importin-beta 2 0.0006 0.0003 0.0003
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.181
Schistosoma mansoni inositol monophosphatase 0.004 0.0847 0.0847
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.1579 0.2533
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0074 0.1691 0.2085
Echinococcus granulosus sentrin specific protease 7 0.0014 0.0203 0.0203
Echinococcus multilocularis neuropeptide receptor A26 0.0074 0.1691 0.1691
Loa Loa (eye worm) G-protein coupled receptor 0.0074 0.1691 0.2085
Echinococcus multilocularis dnaJ subfamily B 0.0411 1 1
Brugia malayi neuropeptide F receptor 0.0074 0.1691 0.2956
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0043 0.0172
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus granulosus peptide allatostatin:somatostatin 0.0074 0.1691 0.1691
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0076
Brugia malayi Dopamine receptor 0.0074 0.1691 0.2956
Echinococcus granulosus pyruvate kinase 0.007 0.1579 0.1579
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Schistosoma mansoni histamine h1 receptor 0.0074 0.1691 0.1691
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis G-protein coupled receptor, putative 0.0074 0.1691 0.1691
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0493 0.0861
Schistosoma mansoni hypothetical protein 0.0411 1 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0673 0.083
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.0043 0.0054
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0673 0.2599
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0128 0.0128
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0847 0.3474
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0306 0.0916
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0526 0.0648
Echinococcus granulosus sentrin specific protease 1 0.0051 0.1106 0.1106
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0332 0.1276
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0066 0.149 0.4633
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0128 0.0128
Schistosoma mansoni neuropeptide F-like receptor 0.0074 0.1691 0.1691
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0051 0.1106 0.1106
Onchocerca volvulus 0.0174 0.4148 0.6641
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0128 0.0158
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0101 0.2357 0.2906
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0074 0.1691 0.1691
Entamoeba histolytica hypothetical protein 0.0049 0.1064 0.9616
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0074 0.1691 0.1691
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0128 0.0136
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0332 0.1276
Loa Loa (eye worm) oxidoreductase 0.0008 0.0043 0.0054
Schistosoma mansoni 6-phosphogluconolactonase 0.0009 0.0079 0.0079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0847 0.1357
Echinococcus multilocularis pyruvate kinase 0.0036 0.0741 0.0741
Onchocerca volvulus 0.0074 0.1691 0.2666
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0847 0.1357
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Loa Loa (eye worm) hypothetical protein 0.0019 0.0332 0.0409
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.0043 0.0076
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.1485 0.1485
Echinococcus granulosus importin 5 0.0006 0.0003 0.0003
Echinococcus multilocularis sentrin specific protease 8 0.0014 0.0203 0.0203
Schistosoma mansoni pyruvate kinase 0.0036 0.0741 0.0741
Brugia malayi larval opioid receptor 0.0074 0.1691 0.2956
Schistosoma mansoni biogenic amine receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Loa Loa (eye worm) hypothetical protein 0.0019 0.0332 0.0409
Loa Loa (eye worm) hypothetical protein 0.0164 0.3909 0.4819
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0009 0.0079 0.0155
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.0043 0.0157
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.5721 0.5721
Echinococcus granulosus sentrin specific protease 8 0.0014 0.0203 0.0203
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0743 0.456
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0049 0.1064 0.4116
Echinococcus granulosus G protein coupled receptor 139 0.0074 0.1691 0.1691
Plasmodium falciparum sentrin-specific protease 1 0.0051 0.1106 0.4281
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Brugia malayi AMP-binding enzyme family protein 0.0008 0.0043 0.0076
Echinococcus multilocularis neuropeptides capa receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Echinococcus multilocularis g protein coupled receptor 0.0074 0.1691 0.1691
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.0043 0.0043
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0107 0.0107
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.063 0.2663
Brugia malayi CXXC zinc finger family protein 0.0029 0.0569 0.0995
Echinococcus multilocularis neuropeptide receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Echinococcus multilocularis neuropeptide receptor 0.0074 0.1691 0.1691
Brugia malayi Pre-SET motif family protein 0.0033 0.0673 0.1176
Trypanosoma cruzi 6-phosphogluconolactonase, putative 0.0009 0.0079 0.0155
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0063 0.0063
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0074 0.1691 0.1691
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0013 0.018 0.0221
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0074 0.1691 0.1691
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0128 0.0128
Echinococcus granulosus 7tm_1 domain containing protein 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Loa Loa (eye worm) neuropeptide F receptor 0.0074 0.1691 0.2085
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0074 0.1691 0.1691
Schistosoma mansoni biogenic amine receptor 0.0074 0.1691 0.1691
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0426 0.0426
Schistosoma mansoni cpg binding protein 0.0031 0.061 0.061
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0426 0.1653
Echinococcus granulosus neuropeptide receptor 0.0074 0.1691 0.1691
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0128 0.0128
Schistosoma mansoni amine GPCR 0.0074 0.1691 0.1691
Onchocerca volvulus 0.0074 0.1691 0.2666
Brugia malayi Inositol-1 0.004 0.0847 0.1481
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0128 0.0128
Echinococcus multilocularis serotonin receptor 0.0074 0.1691 0.1691
Trichomonas vaginalis helicase, putative 0.0007 0.0018 0.0024
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.0043 0.0172
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0066 0.149 0.577
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0018 0.0024
Trypanosoma cruzi glucosamine-6-phosphate isomerase, putative 0.0009 0.0079 0.0155
Onchocerca volvulus 0.0074 0.1691 0.2666
Schistosoma mansoni pyruvate kinase 0.007 0.1579 0.1579
Loa Loa (eye worm) hypothetical protein 0.0019 0.0332 0.0409
Loa Loa (eye worm) Ulp1 protease 0.0014 0.0203 0.025
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0051 0.1106 1
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0203 0.0354
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.0043 0.0157
Onchocerca volvulus 0.0074 0.1691 0.2666
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0128 0.0128
Echinococcus granulosus tm gpcr rhodopsin 0.0074 0.1691 0.1691
Plasmodium vivax importin-beta 2, putative 0.0031 0.063 0.2433
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0063 0.0063
Echinococcus granulosus cpg binding protein 0.0031 0.061 0.061
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.1485 0.5751
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0174 0.4148 0.725
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0203 0.0775
Loa Loa (eye worm) hypothetical protein 0.0238 0.5721 0.7054
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Schistosoma mansoni adenoreceptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0128 0.0128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0673 0.0673
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0128 0.0128
Trichomonas vaginalis ran, putative 0.0023 0.0426 0.068
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0128 0.0128
Echinococcus multilocularis L aminoadipate semialdehyde 0.0174 0.4148 0.4148
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.0043 0.0065
Echinococcus granulosus rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0011 0.0128 0.0158
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0101 0.2357 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0014 0.0203 0.0321
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0847 0.2575
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1397 0.1397
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0043 0.0043
Echinococcus granulosus intermediate filament protein 0.0027 0.0526 0.0526
Brugia malayi hypothetical protein 0.0074 0.1691 0.2956
Schistosoma mansoni ran 0.0023 0.0426 0.0426
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0378 0.066
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Echinococcus granulosus pyruvate kinase 0.007 0.1579 0.1579
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0074 0.1691 0.1691
Loa Loa (eye worm) hypothetical protein 0.0014 0.0203 0.025
Chlamydia trachomatis deubiquitinase/deneddylase Dub2 0.0014 0.0203 0.0541
Echinococcus multilocularis rhodopsin orphan GPCR 0.0074 0.1691 0.1691
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0107 0.0107
Onchocerca volvulus 0.0027 0.0526 0.078
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0049 0.1064 0.3268
Echinococcus granulosus fmrfamide receptor 0.0074 0.1691 0.1691
Echinococcus granulosus allatostatin A receptor 0.0074 0.1691 0.1691
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0074 0.1691 0.2085
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0426 0.1641
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0128 0.0128
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0493 0.2079
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0484 0.1903
Plasmodium falciparum pyruvate kinase 0.007 0.1579 0.6114
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0074 0.1691 0.1691
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.011 0.258 0.4142
Onchocerca volvulus 0.0074 0.1691 0.2666
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.018 0.018
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.011 0.258 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.1485 0.1485
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0051 0.1106 0.1933
Entamoeba histolytica hypothetical protein 0.0025 0.0484 0.4358
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0074 0.1691 0.1691
Onchocerca volvulus 0.0048 0.1053 0.1633
Trypanosoma brucei pyruvate kinase 1 0.007 0.1579 0.6692
Echinococcus granulosus neuropeptide receptor 0.0074 0.1691 0.1691
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0063 0.0063
Trypanosoma brucei SUMO1/Ulp2, putative 0.0014 0.0203 0.0848

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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