Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | leucyl-tRNA synthetase | 0.0026 | 0.018 | 0.018 |
Plasmodium falciparum | thioredoxin reductase | 0.0066 | 0.2813 | 1 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0026 | 0.018 | 1 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0026 | 0.018 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0026 | 0.018 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0066 | 0.2813 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0066 | 0.2813 | 0.3123 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0026 | 0.018 | 0.02 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0176 | 1 | 0.5 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0026 | 0.018 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0066 | 0.2813 | 1 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0161 | 0.9008 | 1 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0026 | 0.018 | 1 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0026 | 0.018 | 0.064 |
Plasmodium vivax | hypothetical protein, conserved | 0.0026 | 0.018 | 0.064 |
Leishmania major | trypanothione reductase | 0.0066 | 0.2813 | 1 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0026 | 0.018 | 0.02 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0041 | 0.1172 | 0.4166 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0066 | 0.2813 | 0.2983 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0026 | 0.018 | 1 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0026 | 0.018 | 0.064 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0026 | 0.018 | 0.02 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0066 | 0.2813 | 1 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0161 | 0.9008 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0066 | 0.2813 | 0.3123 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0053 | 0.2003 | 0.2065 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0053 | 0.2003 | 0.2224 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0026 | 0.018 | 0.064 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0026 | 0.018 | 0.064 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0026 | 0.018 | 0.064 |
Brugia malayi | glycyl-tRNA synthetase | 0.0053 | 0.2003 | 0.2003 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0053 | 0.2003 | 0.2065 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.015 | 0.8328 | 0.923 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0026 | 0.018 | 1 |
Brugia malayi | protein ZK524.3 | 0.0026 | 0.018 | 0.018 |
Plasmodium vivax | glutathione reductase, putative | 0.0066 | 0.2813 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0066 | 0.2813 | 1 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0026 | 0.018 | 0.064 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0026 | 0.018 | 0.02 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0053 | 0.2003 | 0.2224 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0026 | 0.018 | 0.064 |
Loa Loa (eye worm) | glutathione reductase | 0.0066 | 0.2813 | 0.2983 |
Brugia malayi | Thioredoxin reductase | 0.0066 | 0.2813 | 0.2813 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0053 | 0.2003 | 0.2224 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0053 | 0.2003 | 0.2003 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0026 | 0.018 | 0.064 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0161 | 0.9008 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0066 | 0.2813 | 1 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0026 | 0.018 | 0.02 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0176 | 1 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0066 | 0.2813 | 1 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0026 | 0.018 | 0.064 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0026 | 0.018 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0026 | 0.018 | 0.02 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0026 | 0.018 | 0.064 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0161 | 0.9008 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.9008 | 1 |
Brugia malayi | glutathione reductase | 0.0066 | 0.2813 | 0.2813 |
Brugia malayi | methionyl-tRNA synthetase | 0.0026 | 0.018 | 0.018 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Anti-micrococcus luteus activity was tested for inhibition of isopenicillin N synthetase. | ChEMBL. | 1588566 | |
Activity (binding) | no 0 | Anti-micrococcus luteus activity was tested for inhibition of isopenicillin N synthetase. | ChEMBL. | 1588566 |
Antibiotic activity (functional) | no 0 | The compound was tested for the antibiotic activity against Micrococcus luteus(ATCC 9341 stain); no | ChEMBL. | 1588566 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.