Detailed information for compound 838206

Basic information

Technical information
  • TDR Targets ID: 838206
  • Name: 6-(3,4-dimethylphenoxy)-N,N-diethylhexan-1-am ine
  • MW: 277.445 | Formula: C18H31NO
  • H donors: 0 H acceptors: 0 LogP: 4.82 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCCCCCOc1ccc(c(c1)C)C)CC
  • InChi: 1S/C18H31NO/c1-5-19(6-2)13-9-7-8-10-14-20-18-12-11-16(3)17(4)15-18/h11-12,15H,5-10,13-14H2,1-4H3
  • InChiKey: WXJICJUJUGJIKE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(3,4-dimethylphenoxy)-N,N-diethyl-hexan-1-amine
  • 6-(3,4-dimethylphenoxy)hexyl-diethyl-amine
  • CBMicro_019942
  • BIM-0020085.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0214 0.0813
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1857 0.2887
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.046 0.6429 1
Loa Loa (eye worm) hypothetical protein 0.0348 0.4832 0.7515
Brugia malayi Cell death specification protein 2 0.001 0.0014 0.0022
Echinococcus granulosus GPCR family 2 0.0017 0.0118 0.0182
Trypanosoma brucei trypanothione reductase 0.0047 0.0545 0.3257
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.1408 0.1317
Echinococcus multilocularis geminin 0.0187 0.253 0.3934
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0209 0.0165
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0767 0.1174
Brugia malayi hypothetical protein 0.001 0.0014 0.0022
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.1408 0.1928
Brugia malayi hypothetical protein 0.001 0.0014 0.0022
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0312 0.0483
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1456 1
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0582 0.0885
Schistosoma mansoni hypothetical protein 0.0422 0.5889 0.9158
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.1456 0.1366
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Loa Loa (eye worm) MBCTL1 0.0057 0.0681 0.1056
Brugia malayi Cell death specification protein 2 0.001 0.0014 0.0022
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0214 0.0333
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0112 0.1468 0.2267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.011 0.0005
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0681 0.1056
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0118 0.0182
Onchocerca volvulus 0.0024 0.0209 0.0627
Loa Loa (eye worm) hypothetical protein 0.034 0.4718 0.7337
Schistosoma mansoni hypothetical protein 0.0187 0.253 0.3922
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0046 0.0526 0.3116
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0104 0.016
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0227 0.3107 0.4832
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.1456 0.2138
Schistosoma mansoni cpg binding protein 0.003 0.0294 0.0435
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0163
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Schistosoma mansoni neprilysin 0.012 0.1583 0.2445
Schistosoma mansoni cpg binding protein 0.0031 0.0318 0.0473
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0118 0.0182
Entamoeba histolytica hypothetical protein 0.007 0.0868 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.1857 0.2887
Brugia malayi hypothetical protein 0.001 0.0014 0.0022
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0046 0.0526 0.3116
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0582 0.0903
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.046 0.6429 0.6392
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.1579 0.149
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.1579 0.2203
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0294 0.0454
Loa Loa (eye worm) hypothetical protein 0.003 0.0304 0.047
Onchocerca volvulus 0.0111 0.1456 0.4643
Onchocerca volvulus Huntingtin homolog 0.0134 0.1787 0.5708
Onchocerca volvulus 0.0228 0.312 1
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.046 0.6429 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Echinococcus granulosus protocadherin 11 0.001 0.0014 0.0019
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0112 0.1468 0.2267
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0209 0.2279
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0046 0.0526 0.3116
Loa Loa (eye worm) hypothetical protein 0.0015 0.0084 0.0128
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0189
Echinococcus granulosus X box binding protein 1 0.0317 0.4392 0.683
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0111 0.1456 0.2263
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0214 0.0813
Echinococcus granulosus geminin 0.0187 0.253 0.3934
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0022 0.0182 0.0576
Echinococcus granulosus lamin 0.0031 0.0312 0.0483
Loa Loa (eye worm) hypothetical protein 0.0055 0.0653 0.1014
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0019
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.1408 0.1317
Schistosoma mansoni hypothetical protein 0.012 0.1583 0.2445
Loa Loa (eye worm) bZIP transcription factor family protein 0.001 0.0014 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0209 0.0165
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0681 0.1059
Onchocerca volvulus 0.0031 0.0312 0.0959
Brugia malayi hypothetical protein 0.0134 0.1787 0.278
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0123 0.0019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0672 0.0897
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0232 0.318 0.4935
Loa Loa (eye worm) hypothetical protein 0.0031 0.0312 0.0483
Onchocerca volvulus 0.0111 0.1456 0.4643
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0019
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0209 0.0772
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1456 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0046 0.0526 0.0797
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0242 0.3324 0.5169
Loa Loa (eye worm) hypothetical protein 0.0103 0.1334 0.2072
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1456 1
Schistosoma mansoni hypothetical protein 0.012 0.1583 0.2445
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0123 0.003
Schistosoma mansoni lamin 0.0031 0.0312 0.0464
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0545 0.0845
Entamoeba histolytica hypothetical protein 0.007 0.0868 1
Loa Loa (eye worm) hypothetical protein 0.034 0.4718 0.7337
Trypanosoma cruzi Aminopeptidase M1, putative 0.0046 0.0526 0.3116
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.0014 0.0019
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0545 0.0845
Schistosoma mansoni hypothetical protein 0.012 0.1583 0.2445
Entamoeba histolytica hypothetical protein 0.007 0.0868 1
Brugia malayi Peptidase family M13 containing protein 0.046 0.6429 1
Echinococcus granulosus tumor protein p63 0.0338 0.4686 0.7287
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.5889 0.916
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0209 0.2279
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0209 0.2279
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0582 0.0885
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.1456 0.2265
Plasmodium falciparum glutathione reductase 0.0047 0.0545 1
Echinococcus granulosus aminopeptidase N 0.0127 0.1677 0.2606
Mycobacterium ulcerans zinc metalloprotease 0.046 0.6429 1
Brugia malayi hypothetical protein 0.0046 0.0526 0.0818
Leishmania major trypanothione reductase 0.0047 0.0545 0.3257
Schistosoma mansoni hypothetical protein 0.0187 0.253 0.3922
Loa Loa (eye worm) hypothetical protein 0.0111 0.1456 0.2263
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0112 0.1468 0.2267
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.1456 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0281
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0214 0.0813
Onchocerca volvulus 0.003 0.0294 0.0899
Brugia malayi hypothetical protein 0.0106 0.1381 0.2148
Schistosoma mansoni hypothetical protein 0.007 0.0868 0.1331
Loa Loa (eye worm) hypothetical protein 0.0111 0.1456 0.2263
Schistosoma mansoni hypothetical protein 0.0303 0.4194 0.6516
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0242 0.3324 0.5169
Loa Loa (eye worm) hypothetical protein 0.0038 0.0406 0.0629
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1456 0.2248
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0046 0.0526 0.0797
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0107 0.0164
Schistosoma mansoni hypothetical protein 0.012 0.1583 0.2445
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0118 0.0184
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0209 0.0325
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0209 0.0325
Brugia malayi beta-lactamase 0.0111 0.1456 0.2265
Schistosoma mansoni hypothetical protein 0.012 0.1583 0.2445
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0214 0.0813
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.1579 0.149
Loa Loa (eye worm) hypothetical protein 0.0134 0.1787 0.2778
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0214 0.0331
Echinococcus multilocularis tumor protein p63 0.0338 0.4686 0.7287
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0163
Mycobacterium tuberculosis Conserved protein 0.0111 0.1456 0.1366
Toxoplasma gondii ABC1 family protein 0.0111 0.1456 0.2138
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0582 0.1829
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0681 0.1056
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0214 0.2495
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0582 0.0903
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.001 0.0014 0.0019
Onchocerca volvulus 0.005 0.0582 0.1829
Plasmodium vivax hypothetical protein, conserved 0.0111 0.1456 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0681 0.1056
Onchocerca volvulus 0.0011 0.0025 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0132 0.1744 0.2711
Brugia malayi mbt repeat family protein 0.005 0.0582 0.0905
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.046 0.6429 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0653 0.1014
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.1456 0.2263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0189
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0214 0.0813
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0214 0.0813
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0046 0.0526 0.3116
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0582 0.0903
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0582 0.0885
Loa Loa (eye worm) peptidase family M13 containing protein 0.034 0.4718 0.7337
Brugia malayi Cell death specification protein 2 0.001 0.0014 0.0022
Echinococcus granulosus intermediate filament protein 0.0031 0.0312 0.0483
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.1456 0.2263
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0653 0.1016
Echinococcus granulosus leukotriene A 4 hydrolase 0.0242 0.3324 0.5169
Loa Loa (eye worm) hypothetical protein 0.0111 0.1456 0.2263
Onchocerca volvulus 0.0031 0.0312 0.0959
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0214 0.0312
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0681 0.1039
Trichomonas vaginalis esterase, putative 0.0111 0.1456 1
Onchocerca volvulus Huntingtin homolog 0.0134 0.1787 0.5708
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.001 0.0014 0.0019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0209 0.0165
Echinococcus multilocularis aminopeptidase N 0.0127 0.1677 0.2606
Echinococcus granulosus protocadherin 11 0.001 0.0014 0.0019
Mycobacterium tuberculosis Conserved protein 0.0111 0.1456 0.1366
Mycobacterium ulcerans beta-lactamase 0.0111 0.1456 0.2138
Echinococcus multilocularis X box binding protein 1 0.0317 0.4392 0.683
Onchocerca volvulus 0.0111 0.1456 0.4643
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0214 0.0813
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.001 0.0014 0.0019
Brugia malayi Thioredoxin reductase 0.0047 0.0545 0.0847
Loa Loa (eye worm) hypothetical protein 0.0348 0.4832 0.7515
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0046 0.0526 0.3116
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0312 0.0483
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.011 0.0005
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0209 0.0165
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0582 0.0903
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0214 0.0813
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.1456 0.1366
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0209 0.0772
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.1456 1
Brugia malayi beta-lactamase family protein 0.0111 0.1456 0.2265
Echinococcus granulosus lamin dm0 0.0031 0.0312 0.0483
Brugia malayi TATA binding protein associated factor 0.0024 0.0214 0.0333
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.1456 0.1366
Plasmodium vivax glutathione reductase, putative 0.0047 0.0545 0.3257
Mycobacterium leprae probable zinc metalloprotease 0.046 0.6429 1
Brugia malayi intermediate filament protein 0.0031 0.0312 0.0485
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0123 0.043
Echinococcus multilocularis musashi 0.0031 0.0312 0.0483
Loa Loa (eye worm) cell death specification protein 2 0.001 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.0348 0.4832 0.7515
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0022 0.0182 0.0262
Echinococcus multilocularis lamin 0.0031 0.0312 0.0483
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0115
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0042 0.0066
Echinococcus multilocularis protocadherin 11 0.001 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.046 0.6429 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1857 0.2873
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Brugia malayi glutathione reductase 0.0047 0.0545 0.0847
Brugia malayi peptidase family M13 containing protein 0.0112 0.1468 0.2284
Loa Loa (eye worm) hypothetical protein 0.0134 0.1787 0.2778
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0019
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0197 0.2674 0.4157
Plasmodium falciparum thioredoxin reductase 0.0047 0.0545 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.1408 0.1317
Loa Loa (eye worm) hypothetical protein 0.005 0.0582 0.0903
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0406 0.0631
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0042 0.0066
Loa Loa (eye worm) hypothetical protein 0.0348 0.4832 0.7515
Loa Loa (eye worm) hypothetical protein 0.0024 0.0214 0.0331
Schistosoma mansoni hypothetical protein 0.012 0.1583 0.2445
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0182
Echinococcus multilocularis protocadherin 11 0.001 0.0014 0.0019
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.011 0.0005
Brugia malayi Peptidase family M1 containing protein 0.0046 0.0526 0.0818
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0118 0.0184
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.001 0.0014 0.0019
Loa Loa (eye worm) hypothetical protein 0.034 0.4718 0.7337
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0123 0.014
Echinococcus granulosus cpg binding protein 0.0031 0.0318 0.0492
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0209 0.0772
Brugia malayi hypothetical protein 0.007 0.0868 0.135
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0046 0.0526 0.0815
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0214 0.0331
Brugia malayi hypothetical protein 0.0024 0.0214 0.0333
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.1456 0.1366
Loa Loa (eye worm) peptidase family M13 containing protein 0.034 0.4718 0.7337
Mycobacterium ulcerans lipase LipD 0.0111 0.1456 0.2138
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.1456 0.1366
Loa Loa (eye worm) glutathione reductase 0.0047 0.0545 0.0845
Echinococcus granulosus dnaJ subfamily B 0.0422 0.5889 0.916
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0232 0.318 0.4935
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0189
Onchocerca volvulus 0.0127 0.1677 0.5353
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0214 0.0331
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0214 0.0312
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.1579 0.149
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1456 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0084 0.0128
Loa Loa (eye worm) hypothetical protein 0.0014 0.0076 0.0115
Loa Loa (eye worm) transcription factor SMAD2 0.0132 0.1744 0.2711
Loa Loa (eye worm) hypothetical protein 0.0228 0.312 0.4852
Trypanosoma cruzi aminopeptidase, putative 0.0046 0.0526 0.3116
Echinococcus multilocularis lamin dm0 0.0031 0.0312 0.0483
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.001 0.0014 0.0019
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Onchocerca volvulus 0.0024 0.0214 0.0644
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0214 0.0813
Brugia malayi follicle stimulating hormone receptor 0.0227 0.3107 0.4833
Echinococcus multilocularis endothelin converting enzyme 1 0.046 0.6429 1
Echinococcus granulosus endothelin converting enzyme 1 0.046 0.6429 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0118 0.0182
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0112 0.1468 0.2267
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0123 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.1022 0.1588
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0868 0.1348
Toxoplasma gondii thioredoxin reductase 0.0047 0.0545 0.0696
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0214 0.0174
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0214 0.0813
Brugia malayi mbt repeat family protein 0.005 0.0582 0.0905
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0214 0.2495
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0209 0.0325
Loa Loa (eye worm) hypothetical protein 0.0049 0.0576 0.0893
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.1408 0.1317
Loa Loa (eye worm) beta-lactamase 0.0111 0.1456 0.2263
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.001 0.0014 0.0019
Mycobacterium tuberculosis Conserved protein 0.0111 0.1456 0.1366
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Mycobacterium leprae conserved hypothetical protein 0.0111 0.1456 0.2006
Trypanosoma brucei Aminopeptidase M1, putative 0.0046 0.0526 0.3116
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.1456 0.2263
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0189
Brugia malayi beta-lactamase family protein 0.0111 0.1456 0.2265
Schistosoma mansoni lamin 0.0031 0.0312 0.0464
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0214 0.0174
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0104 0.016
Loa Loa (eye worm) zinc metallopeptidase 4 0.0112 0.1468 0.2282
Leishmania major hypothetical protein, conserved 0.0111 0.1456 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0209 0.0165
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.012 0.1583 0.2445
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.1857 0.2889
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0653 0.1016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1857 0.2873
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0545 0.3257
Loa Loa (eye worm) hypothetical protein 0.034 0.4718 0.7337
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0189
Schistosoma mansoni hypothetical protein 0.0038 0.0406 0.061
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.1456 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0104 0.5
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0163
Loa Loa (eye worm) peptidase family M1 containing protein 0.0105 0.1365 0.2122
Loa Loa (eye worm) hypothetical protein 0.0024 0.0214 0.0331
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0104 0.5
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0112 0.1468 0.2267
Schistosoma mansoni intermediate filament proteins 0.0031 0.0312 0.0464
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.1857 0.2887
Onchocerca volvulus 0.0046 0.0526 0.1647
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0107 0.0167
Echinococcus multilocularis cpg binding protein 0.0031 0.0318 0.0492
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0681 0.1056
Brugia malayi CXXC zinc finger family protein 0.003 0.0294 0.0457
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0209 0.0165
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0576 0.0875
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0104 1
Onchocerca volvulus 0.0049 0.0576 0.1808
Schistosoma mansoni hypothetical protein 0.0317 0.4392 0.6824
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0545 0.0445
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0232 0.318 0.4935
Loa Loa (eye worm) hypothetical protein 0.046 0.6429 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0868 0.1348
Loa Loa (eye worm) hypothetical protein 0.0348 0.4832 0.7515
Toxoplasma gondii peptidase family M13 protein 0.046 0.6429 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0545 0.0845
Schistosoma mansoni hypothetical protein 0.0017 0.0118 0.0163
Loa Loa (eye worm) hypothetical protein 0.0024 0.0209 0.0322
Loa Loa (eye worm) aminopeptidase N 0.0046 0.0526 0.0815
Brugia malayi bZIP transcription factor family protein 0.001 0.0014 0.0022
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0214 0.0813
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1857 0.2887
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.1456 1
Mycobacterium tuberculosis Probable reductase 0.0108 0.1408 0.1317
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0232 0.318 0.4935
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0214 0.0174
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0681 0.1056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0209 0.0105
Loa Loa (eye worm) hypothetical protein 0.0348 0.4832 0.7515
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0104 0.0162
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.1857 0.2887
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.1456 0.2248
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0209 0.0105
Schistosoma mansoni cpg binding protein 0.0031 0.0318 0.0473
Entamoeba histolytica hypothetical protein 0.007 0.0868 1
Brugia malayi MH2 domain containing protein 0.0132 0.1744 0.2713
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.011 0.0005
Schistosoma mansoni endothelin-converting enzyme-related 0.0112 0.1468 0.2267
Loa Loa (eye worm) hypothetical protein 0.0024 0.0209 0.0322
Brugia malayi Peptidase family M1 containing protein 0.0127 0.1677 0.2608
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Loa Loa (eye worm) hypothetical protein 0.0111 0.1456 0.2263
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0209 0.0165
Loa Loa (eye worm) hypothetical protein 0.0024 0.0209 0.0322
Treponema pallidum NADH oxidase 0.0016 0.0104 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0118 0.0182
Loa Loa (eye worm) hypothetical protein 0.0022 0.0182 0.0281
Echinococcus granulosus ccaat enhancer binding protein delta 0.001 0.0014 0.0019
Trypanosoma brucei Aminopeptidase M1, putative 0.0046 0.0526 0.3116
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0104 0.0141
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0545 0.3257
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.1408 0.1317
Loa Loa (eye worm) hypothetical protein 0.0111 0.1456 0.2263
Loa Loa (eye worm) hypothetical protein 0.001 0.0014 0.0019
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0312 0.0485
Mycobacterium ulcerans hypothetical protein 0.0111 0.1456 0.2138
Mycobacterium leprae Probable lipase LipE 0.0111 0.1456 0.2006
Mycobacterium ulcerans aminopeptidase N PepN 0.0046 0.0526 0.0666
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.1857 0.2873
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0022 0.0182 0.0281
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0046 0.0526 0.0815
Schistosoma mansoni neprilysin-2 (M13 family) 0.0232 0.318 0.4935
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0582 0.0903
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0868 0.1331
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0214 0.0174
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0209 0.0165
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0046 0.0526 0.3116
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0197 0.2674 0.4157
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.1456 0.1366
Echinococcus multilocularis GPCR, family 2 0.0017 0.0118 0.0182
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.1456 0.2138
Brugia malayi Hepatic leukemia factor 0.001 0.0014 0.0022
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.1456 0.1366
Loa Loa (eye worm) hypothetical protein 0.0024 0.0214 0.0331
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0084 0.0128
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0118 0.0182
Entamoeba histolytica aminopeptidase, putative 0.0046 0.0526 0.5991
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0242 0.3324 0.5159

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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