TDR Targets

Basic information

Technical information

TDR Targets ID: 838660
Name: 2-(4-chlorophenoxy)propanehydrazide
MW: 214.649 | Formula: C9H11ClN2O2
H donors: 2 H acceptors: 1 LogP: 1.52 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: NNC(=O)C(Oc1ccc(cc1)Cl)C
InChi: 1S/C9H11ClN2O2/c1-6(9(13)12-11)14-8-4-2-7(10)3-5-8/h2-6H,11H2,1H3,(H,12,13)
InChiKey: XNJKEFANLKRJPC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-chlorophenoxy)propionohydrazide
SBB005123
BIM-0020039.P001
CBMicro_020157
Oprea1_028132

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1924	0.347
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0104	0.0227
Schistosoma mansoni	zinc binding dehydrogenase	0.001	0.0092	0.0165
Echinococcus granulosus	mitochondrial trans 2 enoyl coenzyme A reductase	0.001	0.0092	0.0179
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0104	0.0227
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0104	0.0203
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0398	0.0719
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.1284	0.2316
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.1284	0.1204
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0104	0.0187
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0104	0.0227
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.5107	1
Brugia malayi	beta-lactamase family protein	0.0036	0.1284	0.2818
Mycobacterium tuberculosis	Conserved protein	0.0036	0.1284	0.1204
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0037	0.1298	0.1218
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1489	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0104	0.0203
Toxoplasma gondii	Zn-containing alcohol dehydrogenase	0.0078	0.3151	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0104	0.0203
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0104	0.0227
Trichomonas vaginalis	esterase, putative	0.0036	0.1284	0.8533
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0104	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1247	0.2737
Schistosoma mansoni	alcohol dehydrogenase	0.0078	0.3151	0.5684
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0051	0.1924	0.4222
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0104	0.0227
Mycobacterium tuberculosis	Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1	0.0069	0.2726	0.2659
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0104	0.0227
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1979	0.4343
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0104	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1284	0.2818
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0104	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0104	0.0227
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0104	0.0227
Schistosoma mansoni	thyroid hormone receptor	0.0132	0.5544	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0104	0.0227
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.1284	0.1204
Mycobacterium ulcerans	lipase LipD	0.0036	0.1284	0.3898
Toxoplasma gondii	ABC1 family protein	0.0036	0.1284	0.3898
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.1247	0.2737
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0104	0.0227
Schistosoma mansoni	coup transcription factor	0.001	0.0104	0.0187
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0104	0.0187
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0104	0.0227
Mycobacterium leprae	Probable S-nitrosomycothiol reductase MscR	0.0078	0.3151	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0041	0.1489	0.4568
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0051	0.1924	0.347
Brugia malayi	nuclear receptor NHR-88	0.001	0.0104	0.0227
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0104	0.0187
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0104	0.0039
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0104	0.0227
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0104	0.0227
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.1284	0.8533
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1284	0.2818
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1284	0.8533
Mycobacterium ulcerans	beta-lactamase	0.0036	0.1284	0.3898
Trichomonas vaginalis	penicillin-binding protein, putative	0.0036	0.1284	0.8533
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Mycobacterium ulcerans	zinc-containing alcohol dehydrogenase NAD-dependent AdhB	0.0078	0.3151	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0051	0.1924	0.4222
Schistosoma mansoni	inositol monophosphatase	0.0041	0.1489	0.2686
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0104	0.0227
Mycobacterium ulcerans	zinc-dependent alcohol dehydrogenase	0.0078	0.3151	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1924	0.347
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.5107	0.9212
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0398	0.0719
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1284	0.2818
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1284	0.2818
Onchocerca volvulus		0.0036	0.1284	0.3898
Loa Loa (eye worm)	hypothetical protein	0.001	0.0092	0.0201
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0104	0.0187
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.001	0.0092	0.0201
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0104	0.0227
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Schistosoma mansoni	hypothetical protein	0.0016	0.0398	0.0719
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0104	0.0187
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0398	0.0874
Loa Loa (eye worm)	hypothetical protein	0.001	0.0092	0.0201
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1924	0.3767
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0398	0.0719
Brugia malayi	steroid hormone receptor	0.001	0.0104	0.0227
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.1284	0.1204
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1979	0.4343
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Brugia malayi	beta-lactamase family protein	0.0036	0.1284	0.2818
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1284	0.2818
Mycobacterium ulcerans	zinc-type alcohol dehydrogenase AdhD	0.0078	0.3151	1
Loa Loa (eye worm)	inositol-1	0.0041	0.1489	0.3268
Schistosoma mansoni	hypothetical protein	0.0016	0.0398	0.0719
Onchocerca volvulus		0.001	0.0104	0.0039
Schistosoma mansoni	thyroid hormone receptor	0.0132	0.5544	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0104	0.0187
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0398	0.0874
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0104	0.0227
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0398	0.0874
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1489	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0398	0.0719
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0104	0.0039
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0104	0.0227
Onchocerca volvulus	Putative alcohol dehydrogenase	0.0078	0.3151	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0398	0.0719
Echinococcus granulosus	GPCR family 2	0.0016	0.0398	0.078
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.1489	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0104	0.0187
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1924	0.347
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1284	0.8533
Onchocerca volvulus		0.0036	0.1284	0.3898
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0104	0.0203
Loa Loa (eye worm)	alcohol dehydrogenase class III	0.0078	0.3151	0.6915
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.1284	0.1204
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0104	0.0227
Mycobacterium ulcerans	zinc-dependent alcohol dehydrogenase AdhE2	0.0078	0.3151	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0104	0.0187
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.1284	0.3898
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.001	0.0092	0.0201
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1489	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0104	0.0187
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0104	0.0039
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0041	0.1489	1
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.1284	0.3898
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0104	0.0187
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.1284	0.2514
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0132	0.5544	1
Brugia malayi	MH2 domain containing protein	0.0109	0.4557	1
Mycobacterium tuberculosis	Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase)	0.0078	0.3151	0.3088
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0037	0.1298	0.3944
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0104	0.0227
Loa Loa (eye worm)	transcription factor SMAD2	0.0109	0.4557	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.1284	0.1204
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.1284	0.3898
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0041	0.1489	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1284	0.2818
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0104	0.0227
Mycobacterium ulcerans	zinc-containing alcohol dehydrogenase NAD dependent AdhB	0.0078	0.3151	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0104	0.0187
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.1284	0.2316
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0398	0.078
Mycobacterium tuberculosis	Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB	0.0069	0.2726	0.2659
Schistosoma mansoni	hypothetical protein	0.0035	0.1247	0.225
Trichomonas vaginalis	inositol monophosphatase, putative	0.0041	0.1489	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0398	0.078
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0041	0.1489	0.4568
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0104	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1979	0.4343
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1979	0.4343
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0104	0.0203
Loa Loa (eye worm)	hypothetical protein	0.001	0.0104	0.0227
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0104	0.0227
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0104	0.0227
Brugia malayi	Inositol-1	0.0041	0.1489	0.3268
Loa Loa (eye worm)	MH2 domain-containing protein	0.0109	0.4557	1
Mycobacterium leprae	Probable lipase LipE	0.0036	0.1284	0.3898
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0051	0.1924	0.347
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0104	0.0203
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0104	0.0227
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0104	0.0187
Schistosoma mansoni	hypothetical protein	0.0122	0.5107	0.9212
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0041	0.1489	1
Brugia malayi	Alcohol dehydrogenase class III	0.0078	0.3151	0.6915
Brugia malayi	beta-lactamase	0.0036	0.1284	0.2818
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.1284	0.8533
Mycobacterium ulcerans	hypothetical protein	0.0036	0.1284	0.3898
Schistosoma mansoni	inositol monophosphatase	0.0041	0.1489	0.2686
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.1284	0.1204
Leishmania major	hypothetical protein, conserved	0.0036	0.1284	0.8533
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.1284	0.5
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1284	0.8533
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0041	0.1489	1
Echinococcus multilocularis	inositol monophosphatase 1	0.0041	0.1489	0.2686
Loa Loa (eye worm)	hypothetical protein	0.001	0.0092	0.0201
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.1284	0.2316
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0104	0.0187
Loa Loa (eye worm)	beta-lactamase	0.0036	0.1284	0.2818
Mycobacterium tuberculosis	Conserved protein	0.0036	0.1284	0.1204
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.1284	0.2818
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0051	0.1924	0.3767
Echinococcus granulosus	inositol monophosphatase 1	0.0041	0.1489	0.2916
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0104	0.0187
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0104	0.0187
Trichomonas vaginalis	D-aminoacylase, putative	0.0036	0.1284	0.8533
Onchocerca volvulus		0.0036	0.1284	0.3898
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0104	0.0203
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.1284	0.8533
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0398	0.0874
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0104	0.0187
Echinococcus multilocularis	mitochondrial trans 2 enoyl coenzyme A reductase	0.001	0.0092	0.0165
Brugia malayi	ecdysteroid receptor	0.001	0.0104	0.0227
Mycobacterium tuberculosis	Conserved protein	0.0036	0.1284	0.1204
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.1284	0.2818
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0104	0.0227
Brugia malayi	nuclear hormone receptor	0.001	0.0104	0.0227
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.1284	0.1204

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 838660