Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | single minded 2 | 0.0039 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.017 | 0.9674 | 0.9674 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 1 | 1 |
Mycobacterium ulcerans | putative regulatory protein | 0.0039 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.017 | 0.9674 | 0.672 |
Onchocerca volvulus | Bile acid receptor homolog | 0.017 | 0.9674 | 1 |
Brugia malayi | PAS domain containing protein | 0.0052 | 0.0994 | 0.0994 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0052 | 0.0994 | 0.5 |
Schistosoma mansoni | single-minded | 0.0052 | 0.0994 | 0.5 |
Echinococcus multilocularis | transfer RNA-Lys | 0.0039 | 0 | 0.5 |
Brugia malayi | hypoxia-induced factor 1 | 0.0161 | 0.9006 | 0.9006 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.