Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.1725 | 0.1725 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.2574 | 0.2574 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.1725 | 0.1725 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1432 | 0.1432 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.2574 | 0.2574 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.1725 | 0.1725 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Onchocerca volvulus | 0.0033 | 1 | 1 | |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9707 | 0.9707 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.1432 | 0.1432 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 0.7943 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 12.5893 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.