Detailed information for compound 838932

Basic information

Technical information
  • TDR Targets ID: 838932
  • Name: 2-[2-(2-methylbenzoyl)hydrazinyl]-N-(3-methyl phenyl)-2-oxoacetamide
  • MW: 311.335 | Formula: C17H17N3O3
  • H donors: 3 H acceptors: 3 LogP: 3.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cccc(c1)NC(=O)C(=O)NNC(=O)c1ccccc1C
  • InChi: 1S/C17H17N3O3/c1-11-6-5-8-13(10-11)18-16(22)17(23)20-19-15(21)14-9-4-3-7-12(14)2/h3-10H,1-2H3,(H,18,22)(H,19,21)(H,20,23)
  • InChiKey: QNINTZJVJLRFAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[N'-(2-methylbenzoyl)hydrazino]-N-(3-methylphenyl)-2-oxo-acetamide
  • N-(3-methylphenyl)-2-[N'-[(2-methylphenyl)-oxomethyl]hydrazino]-2-oxoacetamide
  • 2-keto-2-[N'-(2-methylbenzoyl)hydrazino]-N-(3-methylphenyl)acetamide
  • N-(3-methylphenyl)-2-[2-(2-methylphenyl)carbonylhydrazinyl]-2-oxo-ethanamide
  • CBMicro_018134
  • BIM-0018066.P001
  • ZINC04992257

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans haloalkane dehalogenase 0.0923 0.6754 0.5
Brugia malayi Protein kinase domain containing protein 0.0055 0.0236 0.0181
Trypanosoma brucei cdc2-related kinase 3 0.0055 0.0236 0.0166
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0171 0.1105 0.1096
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0236 0.0055
Echinococcus multilocularis growth factor receptor bound protein 2 0.0031 0.0056 0.0056
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0168 0.1081 0.1081
Brugia malayi Tyrosine-protein kinase abl-1 0.0037 0.0102 0.0046
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0236 0.0226
Echinococcus granulosus tyrosine protein kinase Src42A 0.0159 0.1019 0.1019
Echinococcus granulosus cyclin dependent kinase 1 0.0055 0.0236 0.0236
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0236 0.0187
Echinococcus granulosus cyclin dependent kinase 5 0.0055 0.0236 0.0236
Mycobacterium tuberculosis Possible haloalkane dehalogenase DhaA (1-chlorohexane halidohydrolase) 0.0923 0.6754 0.5
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0168 0.1081 0.1031
Trichomonas vaginalis CAMK family protein kinase 0.1355 1 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0055 0.0236 0.0236
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.0236 0.0226
Loa Loa (eye worm) DEAH box polypeptide 35 0.0068 0.0334 0.0324
Loa Loa (eye worm) CAMK/CAMKL/NUAK protein kinase 0.0499 0.3569 0.3563
Echinococcus multilocularis tyrosine protein kinase Srms 0.0144 0.0903 0.0903
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0099 0.0567 0.0499
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.1081 0.1081
Echinococcus multilocularis cyclin dependent kinase 0.0055 0.0236 0.0236
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0236 0.0236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0071 0.0015
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0236 0.0236
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0144 0.0903 0.0903
Schistosoma mansoni tyrosine kinase 0.0159 0.1019 0.1019
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0138 0.0857 0.0857
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0037 0.0102 0.0102
Echinococcus granulosus cyclin dependent kinase 0.0055 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0048 0.0184 0.0175
Plasmodium falciparum NIMA related kinase 1 0.0111 0.0653 1
Brugia malayi Protein kinase domain containing protein 0.0168 0.1081 0.1031
Entamoeba histolytica serine/threonine protein kinase, putative 0.1355 1 1
Trichomonas vaginalis CAMK family protein kinase 0.1355 1 1
Schistosoma mansoni serine/threonine protein kinase 0.1355 1 1
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0168 0.1081 0.023
Echinococcus granulosus tyrosine protein kinase Lyn 0.0166 0.107 0.107
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0236 0.0166
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0031 0.0056 0.0046
Trypanosoma brucei cdc2-related kinase 1 0.0055 0.0236 0.0166
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0186 0.1222 0.1222
Giardia lamblia Kinase, CMGC CDK 0.0055 0.0236 0.0055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0085 0.0075
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0236 0.0187
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.0236 0.0166
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.0236 0.0166
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0159 0.1019 0.1019
Schistosoma mansoni tyrosine kinase 0.0159 0.1019 0.1019
Giardia lamblia Kinase, NEK 0.0111 0.0653 0.0481
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0111 0.0653 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0036
Onchocerca volvulus Serine\/threonine kinase homolog 0.1355 1 1
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0025 0.001 0.001
Loa Loa (eye worm) phosphatidylinositol 3 0.0166 0.107 0.1061
Echinococcus granulosus growth factor receptor bound protein 2 0.0031 0.0056 0.0056
Echinococcus granulosus tyrosine protein kinase Blk 0.0144 0.0903 0.0903
Loa Loa (eye worm) TK protein kinase 0.0144 0.0903 0.0894
Trichomonas vaginalis CAMK family protein kinase 0.1355 1 1
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0055 0.0236 0.0236
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0064 0.0304 0.025
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0087 0.0478 0.0424
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0159 0.1019 0.1019
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0056 0.0056
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0064 0.0304 0.0304
Entamoeba histolytica protein kinase, putative 0.0128 0.0785 0.0719
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0186 0.1222 0.1222
Trypanosoma cruzi polo-like protein kinase, putative 0.1355 1 1
Echinococcus multilocularis NCK adaptor protein 0.0031 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0672 0.487 0.4833
Onchocerca volvulus 0.0526 0.3774 0.318
Trichomonas vaginalis CAMK family protein kinase 0.1355 1 1
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0099 0.0567 0.0499
Echinococcus granulosus tyrosine protein kinase Src42A 0.0138 0.0857 0.0857
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0037 0.0102 0.0102
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0159 0.1019 0.1019
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0159 0.1019 0.1019
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.1355 1 1
Schistosoma mansoni growth factor receptor-bound protein 0.0031 0.0056 0.0056
Schistosoma mansoni cell adhesion molecule 0.0025 0.001 0.001
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0068 0.0334 0.0264
Brugia malayi cell division control protein 2 homolog 0.0055 0.0236 0.0181
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0099 0.0567 0.0499
Brugia malayi Immunoglobulin I-set domain containing protein 0.0171 0.1105 0.1054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0056 0.0046
Echinococcus multilocularis roundabout 2 0.003 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase Abl 0.0037 0.0102 0.0102
Echinococcus granulosus c src tyrosine kinase 0.0037 0.0102 0.0102
Echinococcus granulosus tyrosine protein kinase HCK 0.0128 0.0785 0.0785
Brugia malayi Probable ATP-dependent helicase DHX35 0.0068 0.0334 0.028
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0236 0.0236
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0064 0.0304 0.0304
Onchocerca volvulus Tyrosine kinase homolog 0.015 0.0953 0.009
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0099 0.0567 0.0499
Echinococcus granulosus twitchin 0.003 0.0051 0.0051
Trypanosoma cruzi cdc2-related kinase 1 0.0055 0.0236 0.0187
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0079 0.0415 0.0346
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0168 0.1081 0.1072
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0236 0.0166
Echinococcus multilocularis c src tyrosine kinase 0.0037 0.0102 0.0102
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0168 0.1081 0.1072
Trichomonas vaginalis AGC family protein kinase 0.0111 0.0653 0.0586
Brugia malayi SRC-1 0.0159 0.1019 0.0968
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0159 0.1019 0.1019
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0056 0.0046
Loa Loa (eye worm) hypothetical protein 0.0064 0.0304 0.0295
Giardia lamblia Kinase, NEK 0.0111 0.0653 0.0481
Entamoeba histolytica hypothetical protein 0.0079 0.0415 0.0346
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0159 0.1019 0.1019
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0144 0.0903 0.0903
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0068 0.0334 0.0264
Loa Loa (eye worm) TK protein kinase 0.0128 0.0785 0.0776
Giardia lamblia Kinase, NEK 0.0111 0.0653 0.0481
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0159 0.1019 0.1019
Echinococcus multilocularis tyrosine protein kinase Blk 0.0144 0.0903 0.0903
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.1355 1 1
Trichomonas vaginalis CAMK family protein kinase 0.1355 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0159 0.1019 0.1019
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0099 0.0567 0.052
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0159 0.1019 0.1019
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0096 0.0545 0.0477
Trichomonas vaginalis CAMK family protein kinase 0.1355 1 1
Schistosoma mansoni nck2/grb4 0.0031 0.0056 0.0056
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0236 0.0166
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0031 0.0056 0.0056
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0186 0.1222 0.1222
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0037 0.0102 0.0102
Brugia malayi Protein kinase domain containing protein 0.0526 0.3774 0.3739
Loa Loa (eye worm) IKK protein kinase 0.0526 0.3774 0.3768
Echinococcus granulosus roundabout 2 0.003 0.0046 0.0046
Echinococcus granulosus tyrosine protein kinase Fyn 0.0159 0.1019 0.1019
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.0236 0.0236
Schistosoma mansoni adapter molecule crk 0.0031 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0159 0.1019 0.1019
Trypanosoma brucei polo-like protein kinase 0.1355 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0044 0.0152 0.0082
Echinococcus granulosus NCK adaptor protein 0.0031 0.0056 0.0056
Trichomonas vaginalis CAMK family protein kinase 0.0672 0.487 0.4833
Trichomonas vaginalis STE family protein kinase 0.0111 0.0653 0.0586
Trypanosoma cruzi cdc2-related kinase 3 0.0055 0.0236 0.0187
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0055 0.0236 0.0226
Echinococcus multilocularis tyrosine protein kinase HCK 0.0128 0.0785 0.0785
Echinococcus granulosus serine:threonine protein kinase PLK1 0.1355 1 1
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0168 0.1081 0.1081
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0159 0.1019 0.1019
Echinococcus granulosus tyrosine kinase 0.0144 0.0903 0.0903
Schistosoma mansoni kinase 0.069 0.5004 0.5004
Trichomonas vaginalis CAMK family protein kinase 0.1355 1 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0159 0.1019 0.1019
Loa Loa (eye worm) SRC-1 0.0159 0.1019 0.101
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0099 0.0567 0.0513
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0033 0.0071 0.0022
Loa Loa (eye worm) hypothetical protein 0.003 0.0046 0.0036
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0159 0.1019 0.1019
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.1355 1 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0334 0.0324
Trypanosoma cruzi polo-like protein kinase, putative 0.1355 1 1
Schistosoma mansoni tyrosine kinase 0.0037 0.0102 0.0102
Echinococcus granulosus tyrosine protein kinase Src64B 0.0159 0.1019 0.1019
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0033 0.0071 0.0071
Brugia malayi protein-tyrosine kinase 0.0144 0.0903 0.0852
Schistosoma mansoni tyrosine kinase 0.0037 0.0102 0.0102
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0099 0.0567 0.052
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0111 0.0653 1
Giardia lamblia Kinase, PLK 0.1355 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0049 0.0039

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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