Detailed information for compound 838984

Basic information

Technical information
  • TDR Targets ID: 838984
  • Name: (5E)-5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3- yl)methylidene]-2-sulfanylidene-1,3-thiazolid in-4-one
  • MW: 315.413 | Formula: C15H13N3OS2
  • H donors: 1 H acceptors: 2 LogP: 2.93 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1NC(=O)/C(=C/c2cc(n(c2C)c2cccnc2)C)/S1
  • InChi: 1S/C15H13N3OS2/c1-9-6-11(7-13-14(19)17-15(20)21-13)10(2)18(9)12-4-3-5-16-8-12/h3-8H,1-2H3,(H,17,19,20)/b13-7+
  • InChiKey: YISGMOZSGOGYOU-NTUHNPAUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[(2,5-dimethyl-1-pyridin-3-ylpyrrol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5E)-5-[[2,5-dimethyl-1-(3-pyridyl)pyrrol-3-yl]methylene]-2-thioxo-thiazolidin-4-one
  • 5-[[2,5-dimethyl-1-(3-pyridyl)pyrrol-3-yl]methylene]-2-thioxo-thiazolidin-4-one
  • (5E)-5-[[2,5-dimethyl-1-(3-pyridyl)-3-pyrrolyl]methylene]-2-thioxo-4-thiazolidinone
  • 5-[[2,5-dimethyl-1-(3-pyridyl)-3-pyrrolyl]methylene]-2-thioxo-4-thiazolidinone
  • 5-[(2,5-dimethyl-1-pyridin-3-yl-pyrrol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • (5E)-5-[(2,5-dimethyl-1-pyridin-3-yl-pyrrol-3-yl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
  • CBMicro_018200
  • BIM-0018214.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hypothetical protein, conserved 0.0015 0.0007 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0517 0.0995
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0116 0.2212
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0587 0.3263 0.3262
Loa Loa (eye worm) hypothetical protein 0.0933 0.5238 0.5237
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0007 0.0013
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0025 0.0063 0.011
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0015 0.0007 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.0222
Loa Loa (eye worm) hypothetical protein 0.0101 0.0493 0.0491
Echinococcus multilocularis nmda type glutamate receptor 0.0605 0.3369 0.3368
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0116 0.0814
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0166 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0033 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0033 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Echinococcus granulosus neutral amino acid transporter A 0.0908 0.5096 0.5095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.013 0.025
Brugia malayi Regulator of G protein signaling domain containing protein 0.0057 0.0241 0.029
Brugia malayi nuclear receptor NHR-88 0.002 0.0033 0.0038
Echinococcus multilocularis receptor type guanylyl cyclase 0.026 0.1402 0.14
Onchocerca volvulus Poor gastrulation protein homolog 0.0215 0.1146 0.2195
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0076 0.0075
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0282 0.0281
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0908 0.5096 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0355 0.5994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0103 0.0198
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0091 0.0635
Schistosoma mansoni synaptojanin 0.0015 0.0007 0.0006
Echinococcus granulosus synaptojanin 1 0.0015 0.0007 0.0005
Chlamydia trachomatis glutamine binding protein 0.0341 0.1863 0.3555
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0282 0.1975
Schistosoma mansoni ap endonuclease 0.0076 0.0355 0.0414
Brugia malayi SET domain containing protein 0.0016 0.0011 0.0012
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0007 0.0013
Brugia malayi Guanylyl cyclase protein 23 0.026 0.1402 0.1697
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Leishmania major hypothetical protein, conserved 0.0015 0.0007 0.0036
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0282 0.0329
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0033 0.0031
Schistosoma mansoni axis inhibition protein axin 0.0057 0.0241 0.0281
Echinococcus multilocularis musashi 0.0079 0.0369 0.0367
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0057 0.0241 0.0239
Brugia malayi intermediate filament protein 0.0079 0.0369 0.0445
Echinococcus granulosus voltage dependent calcium channel subunit 0.036 0.1972 0.1971
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0015 0.0007 0.0005
Brugia malayi Doublecortin family protein 0.0038 0.0136 0.0163
Brugia malayi hypothetical protein 0.026 0.1402 0.1697
Loa Loa (eye worm) hypothetical protein 0.026 0.1402 0.14
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0076 0.2002
Trichomonas vaginalis rotamase, putative 0.0032 0.0098 0.0189
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0057 0.0241 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0033 0.0031
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0243 0.3941
Loa Loa (eye worm) hypothetical protein 0.026 0.1402 0.14
Entamoeba histolytica hypothetical protein 0.026 0.1402 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0129 0.0127
Trichomonas vaginalis mucin-desulfating sulfatase, putative 0.0025 0.0063 0.0121
Brugia malayi hypothetical protein 0.0101 0.0493 0.0595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.0222
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0007 0.0005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.0355 0.2493
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0282 0.5441
Brugia malayi hypothetical protein 0.0025 0.0063 0.0074
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0076 0.1163
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0057 0.0241 0.0239
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0341 0.1863 0.8413
Treponema pallidum glutamate transporter 0.0403 0.2213 1
Schistosoma mansoni loxhd1 0.0038 0.0136 0.0158
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.026 0.1402 0.2687
Echinococcus multilocularis dnaJ subfamily B 0.0395 0.2171 0.217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0033 0.0031
Brugia malayi Receptor family ligand binding region containing protein 0.0476 0.2629 0.3184
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0015 0.0007 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0606 0.0709
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0105 0.0517 0.1003
Schistosoma mansoni hypothetical protein 0.0215 0.1146 0.1344
Schistosoma mansoni lipoxygenase 0.0038 0.0136 0.0158
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0145 0.028
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0043 0.0166 0.1143
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0033 0.0038
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0136 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0033 0.0038
Echinococcus multilocularis glutamate receptor 2 0.0563 0.3125 0.3124
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0019 0.0037
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0007 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0033 0.0031
Echinococcus granulosus nmda type glutamate receptor 0.026 0.1402 0.14
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0067 0.0128
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0033 0.0031
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0908 0.5096 0.5982
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0007 0.0005
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0043 0.0166 0.1175
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Brugia malayi Metabotropic glutamate receptor precursor. 0.1462 0.8253 1
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.1509 0.8517 1
Onchocerca volvulus 0.0129 0.0652 0.1242
Echinococcus granulosus glutamate receptor 2 0.0823 0.4608 0.4607
Schistosoma mansoni serine-rich repeat protein 0.0085 0.0401 0.0469
Schistosoma mansoni hypothetical protein 0.0327 0.1785 0.2094
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0225 0.12 0.1408
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0007 0.0005
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0428 0.0501
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.008 0.0155
Echinococcus granulosus neutral amino acid transporter A 0.0908 0.5096 0.5095
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.0355 0.252
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0341 0.1863 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.0355 0.0353
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.008 0.0155
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.0355 0.0428
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0028 0.008 0.2119
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0007 0.0005
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0612 0.061
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0098 0.1874
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0033 0.0038
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0105 0.0517 0.2313
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0033 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0241 0.0464
Echinococcus granulosus atrial natriuretic peptide receptor 0.026 0.1402 0.14
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0606 0.3016
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0157 0.0815 0.0955
Schistosoma mansoni protein kinase 0.026 0.1402 0.1644
Echinococcus multilocularis GPCR, family 3, C terminal 0.0215 0.1146 0.1145
Loa Loa (eye worm) RGC/RGC protein kinase 0.026 0.1402 0.14
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0117 0.0587 0.9689
Echinococcus multilocularis expressed protein 0.1102 0.6197 0.6196
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0282 0.0281
Entamoeba histolytica hypothetical protein 0.0057 0.0241 0.168
Schistosoma mansoni lamin 0.0079 0.0369 0.0431
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.0222
Brugia malayi hypothetical protein 0.0038 0.0136 0.0163
Schistosoma mansoni thyroid hormone receptor 0.0142 0.0726 0.0851
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0015 0.0007 0.0036
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0341 0.1863 0.3648
Loa Loa (eye worm) hypothetical protein 0.0476 0.2629 0.2628
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0241 0.0464
Echinococcus multilocularis glutamate receptor 2 0.0559 0.3102 0.3101
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0005
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0355 0.0682
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0007 0.0097
Echinococcus multilocularis neutral amino acid transporter A 0.0908 0.5096 0.5095
Echinococcus multilocularis regulator of G protein signaling 3 0.0057 0.0241 0.0239
Echinococcus multilocularis cpg binding protein 0.0029 0.0086 0.0084
Trichomonas vaginalis DNA helicase recq, putative 0.003 0.0091 0.0174
Entamoeba histolytica hypothetical protein 0.0057 0.0241 0.168
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Echinococcus multilocularis RUN 0.0038 0.0136 0.0134
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0098 0.1529
Schistosoma mansoni glutamate receptor AMPA 0.0519 0.2877 0.3377
Loa Loa (eye worm) hypothetical protein 0.0038 0.0136 0.0134
Schistosoma mansoni thyroid hormone receptor 0.0142 0.0726 0.0851
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0033 0.0037
Leishmania major ATP-dependent phosphofructokinase 0.0105 0.0517 0.3682
Echinococcus granulosus Excitatory amino acid transporter 0.0908 0.5096 0.5095
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0033 0.0031
Loa Loa (eye worm) phosphatidylinositol 3 0.0043 0.0166 0.0164
Loa Loa (eye worm) intermediate filament protein 0.0079 0.0369 0.0367
Loa Loa (eye worm) glutamate receptor 1 0.0563 0.3125 0.3124
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0089 0.0428 0.0426
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.0606 0.0604
Loa Loa (eye worm) hypothetical protein 0.0044 0.0167 0.0165
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0007 0.0013
Schistosoma mansoni hypothetical protein 0.0122 0.0612 0.0717
Trypanosoma brucei RNA editing exonuclease 2 0.0015 0.0007 0.0097
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0043 0.0166 0.1143
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0908 0.5096 1
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0044 0.0167 0.0165
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0079 0.0369 0.0367
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.0131 0.3575
Schistosoma mansoni tyrosine kinase 0.026 0.1402 0.1644
Echinococcus granulosus regulator of G protein signaling 3 0.0057 0.0241 0.0239
Brugia malayi metabotropic GABA-B receptor subtype 2 0.026 0.1402 0.1697
Schistosoma mansoni rab6-interacting 0.0038 0.0136 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0052 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0279 0.0325
Onchocerca volvulus 0.026 0.1402 0.2687
Treponema pallidum glutamate/aspartate transporter 0.0403 0.2213 1
Echinococcus multilocularis lamin dm0 0.0079 0.0369 0.0367
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0033 0.0031
Onchocerca volvulus 0.0101 0.0493 0.0936
Schistosoma mansoni metabotropic glutamate receptor 0.1247 0.7025 0.8248
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0282 0.034
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0145 0.0174
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1102 0.6199 0.6198
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0077 0.0075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0065 0.0125
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0264 0.1425 0.1423
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0225 0.12 0.1199
Echinococcus granulosus RUN 0.0038 0.0136 0.0134
Echinococcus granulosus geminin 0.0327 0.1785 0.1783
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0091 0.0635
Echinococcus multilocularis atrial natriuretic peptide receptor 0.026 0.1402 0.14
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0025 0.0063 0.011
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.026 0.1402 0.14
Plasmodium vivax multidomain scavenger receptor, putative 0.0038 0.0136 0.2225
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0033 0.0031
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0033 0.0037
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0112 0.0559 0.0558
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0606 0.3016
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0007 0.0036
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0517 0.0516
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0038 0.0136 0.0134
Echinococcus granulosus axis inhibition protein axin 0.0057 0.0241 0.0239
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0117 0.0587 0.0585
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0097
Brugia malayi M-phase phosphoprotein, mpp8 0.0101 0.0493 0.0595
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Echinococcus multilocularis lipoxygenase domain containing protein 0.0038 0.0136 0.0134
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0019 0.0037
Loa Loa (eye worm) hypothetical protein 0.0057 0.0241 0.0239
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0043 0.0166 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0103 0.0198
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0098 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0022 0.0384
Brugia malayi 6-phosphofructokinase 0.0105 0.0517 0.0625
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.0241 0.0239
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0928 0.5208 0.5207
Loa Loa (eye worm) hypothetical protein 0.026 0.1402 0.14
Brugia malayi nuclear hormone receptor 0.002 0.0033 0.0038
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0241 0.0281
Echinococcus multilocularis voltage dependent calcium channel subunit 0.036 0.1972 0.1971
Plasmodium falciparum LCCL domain-containing protein 0.0038 0.0136 0.3712
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0136 0.0134
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0308 0.1673 0.1671
Echinococcus multilocularis regulator of G protein signaling 7 0.0057 0.0241 0.0239
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0007 0.0005
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0043 0.0166 0.0164
Brugia malayi Cache domain containing protein 0.0073 0.0332 0.0401
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0007 0.0013
Echinococcus granulosus glutamate receptor subunit protein glur 0.0308 0.1673 0.1671
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0225 0.12 0.1199
Loa Loa (eye worm) hypothetical protein 0.1769 1 1
Trichomonas vaginalis rotamase, putative 0.0032 0.0103 0.0198
Chlamydia trachomatis neutral amino acid transporter 0.0403 0.2213 0.4253
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0033 0.0031
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0403 0.2213 0.2597
Schistosoma mansoni glutamate receptor kainate 0.0519 0.2877 0.3377
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0587 0.3263 0.3262
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.0222
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0007 0.0013
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0051 0.0735
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0403 0.2213 0.2212
Schistosoma mansoni hypothetical protein 0.0264 0.1425 0.1671
Echinococcus granulosus regulator of G protein signaling 3 0.0057 0.0241 0.0239
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0033 0.0038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.0355 0.0684
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0097
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0033 0.0031
Echinococcus granulosus axis inhibition protein axin 0.0057 0.0241 0.0239
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0057 0.0241 0.0239
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0098 0.069
Entamoeba histolytica hypothetical protein 0.0057 0.0241 0.168
Loa Loa (eye worm) hypothetical protein 0.0037 0.0128 0.0126
Giardia lamblia Hypothetical protein 0.0025 0.0063 0.1607
Loa Loa (eye worm) hypothetical protein 0.0057 0.0241 0.0239
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.008 0.0155
Onchocerca volvulus 0.0079 0.0369 0.0697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0103 0.0198
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0129 0.0652 0.0763
Loa Loa (eye worm) glutamate receptor 2 0.0519 0.2877 0.2876
Echinococcus multilocularis excitatory amino acid transporter 2 0.0908 0.5096 0.5095
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.4384 0.4383
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0057 0.0241 0.0464
Echinococcus granulosus lamin dm0 0.0079 0.0369 0.0367
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0028 0.008 0.123
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.0355 1
Onchocerca volvulus 0.0101 0.0493 0.0936
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0043 0.0166 0.0199
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Echinococcus granulosus 6 phosphofructokinase 0.0105 0.0517 0.0516
Echinococcus granulosus histone lysine methyltransferase setb 0.0117 0.0587 0.0585
Schistosoma mansoni hypothetical protein 0.0085 0.0401 0.0469
Brugia malayi Regulator of G protein signaling domain containing protein 0.0057 0.0241 0.029
Schistosoma mansoni nocturnin 0.0015 0.0007 0.0006
Brugia malayi hypothetical protein 0.0358 0.196 0.2373
Leishmania major pantothenate kinase subunit, putative 0.0015 0.0007 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0033 0.0038
Giardia lamblia Hypothetical protein 0.0025 0.0063 0.1607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0052 0.01
Schistosoma mansoni rab6-interacting 0.0038 0.0136 0.0158
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0007 0.0005
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0517 0.3682
Echinococcus multilocularis expressed protein 0.0032 0.0103 0.0101
Echinococcus multilocularis axis inhibition protein axin 0.0057 0.0241 0.0239
Schistosoma mansoni dihydropyridine-sensitive l-type calcium channel 0.0079 0.037 0.0433
Chlamydia trachomatis glutamate symporter 0.0908 0.5096 1
Schistosoma mansoni cpg binding protein 0.0029 0.0086 0.0099
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0079 0.0369 0.0367
Loa Loa (eye worm) hypothetical protein 0.0026 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.026 0.1402 0.14
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0823 0.4608 0.4607
Loa Loa (eye worm) glutamate receptor 0.0522 0.2893 0.2892
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0043 0.0166 0.319
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0587 0.3263 0.3262
Echinococcus multilocularis beta adrenergic receptor kinase 0.0057 0.0241 0.0239
Echinococcus multilocularis Excitatory amino acid transporter 0.0908 0.5096 0.5095
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0057 0.0241 0.0239
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0007 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0332 0.0331
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.0355 0.252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0103 0.0198
Echinococcus multilocularis neutral amino acid transporter A 0.0908 0.5096 0.5095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0103 0.0198
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0028 0.008 0.0334
Loa Loa (eye worm) hypothetical protein 0.026 0.1402 0.14
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Brugia malayi 6-phosphofructokinase 0.0105 0.0517 0.0625
Echinococcus multilocularis axis inhibition protein axin 0.0057 0.0241 0.0239
Brugia malayi CXXC zinc finger family protein 0.0028 0.0077 0.0091
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0036
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.0241 0.0239
Brugia malayi Excitatory amino acid transporter 0.0908 0.5096 0.6174
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0033 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0033 0.0031
Echinococcus multilocularis glutamate receptor 4 0.0044 0.0167 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0166 0.032
Loa Loa (eye worm) RGC/RGC protein kinase 0.026 0.1402 0.14
Echinococcus granulosus tyrosine kinase 0.026 0.1402 0.14
Leishmania major extracellular receptor, putative 0.026 0.1402 1
Echinococcus multilocularis bloom syndrome protein 0.004 0.0145 0.0144
Brugia malayi metabotropic glutamate receptor type 2 0.0782 0.4377 0.5302
Brugia malayi cytoplasmic intermediate filament protein 0.0042 0.016 0.0191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0003
Schistosoma mansoni polycystin 1-related 0.0038 0.0136 0.0158
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.0355 0.0353
Loa Loa (eye worm) hypothetical protein 0.0215 0.1146 0.1145
Loa Loa (eye worm) 6-phosphofructokinase 0.0105 0.0517 0.0516
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0033 0.0031
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0043 0.0166 0.0164
Schistosoma mansoni cript-related 0.0015 0.0007 0.0006
Echinococcus granulosus receptor type guanylyl cyclase 0.026 0.1402 0.14
Echinococcus multilocularis Regulator of G protein signaling 20 0.0057 0.0241 0.0239
Echinococcus multilocularis thyroid hormone receptor alpha 0.0142 0.0726 0.0725
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.0606 1
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0007 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Loa Loa (eye worm) doublecortin family protein 0.0038 0.0136 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0241 0.0281
Schistosoma mansoni hypothetical protein 0.0038 0.0136 0.0158
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.0606 0.0604
Leishmania major endonuclease/exonuclease protein-like protein 0.0015 0.0007 0.0036
Schistosoma mansoni lamin 0.0079 0.0369 0.0431
Brugia malayi steroid hormone receptor 0.002 0.0033 0.0038
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0107 0.0527 0.0525
Schistosoma mansoni glutamate receptor AMPA 0.0519 0.2877 0.3377
Loa Loa (eye worm) RecQ helicase 0.004 0.0145 0.0144
Plasmodium vivax SET domain protein, putative 0.0117 0.0587 1
Brugia malayi hypothetical protein 0.0103 0.0508 0.0614
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0117 0.0587 0.0585
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0136 0.0134
Echinococcus multilocularis regulator of G protein signaling 3 0.0057 0.0241 0.0239
Echinococcus granulosus leukotriene A 4 hydrolase 0.0225 0.12 0.1199
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0036 0.066
Echinococcus granulosus expressed protein 0.0032 0.0103 0.0101
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.0355 0.6845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0116 0.0222
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0033 0.0037
Echinococcus multilocularis neutral amino acid transporter A 0.0908 0.5096 0.5095
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0215 0.1146 0.2195
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0476 0.2629 0.2628
Schistosoma mansoni intermediate filament proteins 0.0079 0.0369 0.0431
Schistosoma mansoni metabotropic glutamate receptor 0.0782 0.4377 0.5138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0103 0.0198
Loa Loa (eye worm) phosphofructokinase 0.0105 0.0517 0.0516
Schistosoma mansoni lipoxygenase 0.0107 0.0527 0.0617
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0341 0.1863 0.8413
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0052 0.0101
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0007 0.0005
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0823 0.4608 0.4607
Brugia malayi Intermediate filament tail domain containing protein 0.0079 0.0369 0.0445
Schistosoma mansoni glutamate receptor NMDA 0.0519 0.2877 0.3377
Echinococcus granulosus excitatory amino acid transporter 3 0.0908 0.5096 0.5095
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1102 0.6199 0.6198
Echinococcus multilocularis regulator of G protein signaling 0.0057 0.0241 0.0239
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Echinococcus granulosus Excitatory amino acid transporter 0.0908 0.5096 0.5095
Schistosoma mansoni ap endonuclease 0.0076 0.0355 0.0414
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0057 0.0241 0.0281
Trypanosoma cruzi extracellular receptor, putative 0.026 0.1402 1
Brugia malayi Sulfatase family protein 0.0025 0.0063 0.0074
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.0355 0.0682
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Echinococcus granulosus glutamate receptor 4 0.0044 0.0167 0.0165
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0057 0.0241 0.029
Brugia malayi Pre-SET motif family protein 0.0814 0.4558 0.5522
Schistosoma mansoni glutamate receptor kainate 0.0842 0.4715 0.5536
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0038 0.0136 0.0134
Brugia malayi CCR4 0.0015 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.026 0.1402 0.14
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0097
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0057 0.0241 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0103 0.0198
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0033 0.0031
Loa Loa (eye worm) hypothetical protein 0.0057 0.0241 0.0239
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0036
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.0606 0.4314
Loa Loa (eye worm) RGS-3 protein 0.0057 0.0241 0.0239
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0517 0.3659
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.008 0.127
Loa Loa (eye worm) hypothetical protein 0.0117 0.0587 0.0585
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0015 0.0007 0.0036
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0036
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0341 0.1863 0.3555
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0089 0.0428 0.0501
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0587 0.0687
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0098 0.0656
Echinococcus granulosus neutral amino acid transporter 0.0908 0.5096 0.5095
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0241 0.0281
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.0355 0.252
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0028 0.008 0.0155
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0043 0.0166 0.319
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0042 0.016 0.0158
Onchocerca volvulus 0.002 0.0033 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Brugia malayi Glutamate receptor 2 precursor 0.0563 0.3125 0.3786
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0116 0.0814
Onchocerca volvulus 0.0028 0.0077 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0052 0.0101
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0033 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0065 0.0074
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0015 0.0007 0.0036
Loa Loa (eye worm) hypothetical protein 0.0025 0.0063 0.0061
Loa Loa (eye worm) excitatory amino acid transporter 0.0908 0.5096 0.5095
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.0007 0.0006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0057 0.0241 0.0281
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0003
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0517 0.0605
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.0606 0.0709
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0091 0.1725
Toxoplasma gondii phosphofructokinase PFKII 0.0028 0.008 0.123
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0043 0.0166 0.1175
Brugia malayi hypothetical protein 0.0057 0.0241 0.029
Schistosoma mansoni cpg binding protein 0.0029 0.0086 0.0099
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0033 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0241 0.0464
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0241 0.0281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0019 0.0037
Trichomonas vaginalis Phosphoglycerol transferase I, putative 0.0025 0.0063 0.0121
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.026 0.1402 0.14
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0052 0.0101
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0282 0.2003
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Echinococcus multilocularis nmda type glutamate receptor 0.026 0.1402 0.14
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0033 0.0031
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0033 0.0037
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0007 0.0013
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0019 0.0037
Loa Loa (eye worm) hypothetical protein 0.0101 0.0493 0.0491
Brugia malayi regulator of G-protein signaling rgs-7 0.0057 0.0241 0.029
Loa Loa (eye worm) hypothetical protein 0.0077 0.036 0.0359
Mycobacterium tuberculosis Probable sulfatase 0.0025 0.0063 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.008 0.0155
Brugia malayi regulator of G-protein signaling egl-10 0.0057 0.0241 0.029
Echinococcus granulosus Polycystic kidney disease protein 0.0038 0.0136 0.0134
Schistosoma mansoni glutamate receptor kainate 0.0842 0.4715 0.5536
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0105 0.0517 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0033 0.0038
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Onchocerca volvulus 0.0079 0.0369 0.0697
Echinococcus granulosus GPCR family 3 C terminal 0.0215 0.1146 0.1145
Schistosoma mansoni z-protein (S1r protein) 0.0057 0.0241 0.0281
Loa Loa (eye worm) hypothetical protein 0.0037 0.0128 0.0126
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0317 0.0315
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.008 0.2119
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0033 0.0031
Echinococcus multilocularis metabotropic glutamate receptor 5 0.1769 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0103 0.0198
Entamoeba histolytica recQ family helicase, putative 0.003 0.0091 0.0601
Brugia malayi Pre-SET motif family protein 0.0117 0.0587 0.0709
Toxoplasma gondii exonuclease III APE 0.0076 0.0355 0.5808
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0033 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0129 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0085 0.0163
Schistosoma mansoni glutamate receptor NMDA 0.0779 0.436 0.5119
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0587 0.0687
Echinococcus granulosus Regulator of G protein signaling 20 0.0057 0.0241 0.0239
Echinococcus multilocularis lamin 0.0079 0.0369 0.0367
Schistosoma mansoni DNA helicase recq5 0.0028 0.0076 0.0088
Brugia malayi PXA domain containing protein 0.0057 0.0241 0.029
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0028 0.008 0.0528
Schistosoma mansoni nuclear hormone receptor 0.002 0.0033 0.0037
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0076 0.2002
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0517 0.0995
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0036
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0476 0.2629 0.2628
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0007 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0241 0.0464
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0015 0.0007 0.0097
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0089 0.0428 0.0426
Echinococcus granulosus beta-adrenergic receptor kinase 0.0057 0.0241 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0067 0.0128
Echinococcus granulosus bloom syndrome protein 0.004 0.0145 0.0144
Echinococcus granulosus intermediate filament protein 0.0079 0.0369 0.0367
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0033 0.0038
Brugia malayi ecdysteroid receptor 0.002 0.0033 0.0038
Loa Loa (eye worm) RGC/RGC protein kinase 0.026 0.1402 0.14
Echinococcus multilocularis synaptojanin 1 0.0015 0.0007 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0019 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0117 0.0587 0.0687
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0019 0.0037
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0282 0.2003
Trichomonas vaginalis set domain proteins, putative 0.0926 0.5198 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0003
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0033 0.0051
Echinococcus granulosus sodium:dicarboxylate symporter 0.0908 0.5096 0.5095
Brugia malayi Glutamate receptor 1 precursor 0.0563 0.3125 0.3786
Loa Loa (eye worm) hypothetical protein 0.0038 0.0136 0.0134
Echinococcus granulosus FTZ F1 alpha 0.002 0.0033 0.0031
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1102 0.6199 0.6198
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0519 0.2877 0.2876
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.0007 0.0006
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0015 0.0007 0.0005
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0033 0.0051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0814 0.4558 0.4557
Echinococcus granulosus cpg binding protein 0.0029 0.0086 0.0084
Brugia malayi hypothetical protein 0.0057 0.0241 0.029
Schistosoma mansoni hypothetical protein 0.0395 0.2171 0.2547
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0033 0.0037
Echinococcus multilocularis 6 phosphofructokinase 0.0105 0.0517 0.0516
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0054 0.0811
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1102 0.6199 0.6198
Onchocerca volvulus 0.0038 0.0136 0.0249
Giardia lamblia GTOR 0.0043 0.0166 0.4584
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0019 0.0037
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0517 0.0995
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0241 0.0281
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0043 0.0166 0.1175
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0103 0.1604
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0007 0.0005
Schistosoma mansoni coup transcription factor 0.002 0.0033 0.0037
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0033 0.0031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0065 0.0125
Echinococcus granulosus dnaJ subfamily B 0.0395 0.2171 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0241 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Schistosoma mansoni cpg binding protein 0.0028 0.0077 0.0088
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0264 0.1425 0.1423
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0076 0.1163
Mycobacterium ulcerans 6-phosphofructokinase 0.0105 0.0517 0.2525
Leishmania major hypothetical protein, conserved 0.0015 0.0007 0.0036
Echinococcus multilocularis NMDA receptor 0.0587 0.3263 0.3262
Echinococcus granulosus lamin 0.0079 0.0369 0.0367
Schistosoma mansoni tyrosine kinase 0.026 0.1402 0.1644
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.0241 0.0281
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0015 0.0007 0.0097
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.0355 0.1576
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0057 0.0241 0.0281
Echinococcus granulosus excitatory amino acid transporter 2 0.0908 0.5096 0.5095
Brugia malayi Cytochrome P450 family protein 0.007 0.0317 0.0382
Echinococcus multilocularis excitatory amino acid transporter 2 0.0908 0.5096 0.5095
Echinococcus granulosus glutamate receptor 2 0.0559 0.3102 0.3101
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0007 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.008 0.0155
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0076 0.009
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0076 0.0075
Schistosoma mansoni 6-phosphofructokinase 0.0105 0.0517 0.0605
Schistosoma mansoni rotamase 0.0032 0.0103 0.0119
Trichomonas vaginalis phosphofructokinase, putative 0.0105 0.0517 0.0995
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0007 0.0005
Echinococcus granulosus expressed protein 0.1102 0.6197 0.6196
Mycobacterium tuberculosis Possible hydrolase 0.0025 0.0063 0.011
Trichomonas vaginalis conserved hypothetical protein 0.0057 0.0241 0.0464
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0007 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0033 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0052 0.01
Brugia malayi PXA domain containing protein 0.0057 0.0241 0.029
Loa Loa (eye worm) hypothetical protein 0.002 0.0033 0.0031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.0606 0.1177
Schistosoma mansoni hypothetical protein 0.0015 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0044 0.0167 0.0165
Brugia malayi hypothetical protein 0.0038 0.0136 0.0163
Loa Loa (eye worm) PXA domain-containing protein 0.0057 0.0241 0.0239
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0033 0.0031
Schistosoma mansoni ATP-binding cassette transporter 0.0519 0.2877 0.3377
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0033 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0098 0.069
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0019 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0076 0.0075
Echinococcus multilocularis metabotropic glutamate receptor 2 0.1247 0.7025 0.7025
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.0355 1
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0003 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0043 0.0166 0.1175
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0103 0.0101
Onchocerca volvulus 0.026 0.1402 0.2687
Brugia malayi A-kinase anchor protein 10, precursor 0.0057 0.0241 0.029
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0076 0.0075
Echinococcus granulosus lipoxygenase domain containing protein 0.0038 0.0136 0.0134
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0107 0.0527 0.0525
Echinococcus multilocularis tyrosine kinase 0.026 0.1402 0.14
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.1102 0.6199 0.6198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0033 0.0031
Echinococcus multilocularis geminin 0.0327 0.1785 0.1783
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0612 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0015 0.0007 0.0036
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0025 0.0063 0.0108
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0241 0.0281
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0908 0.5096 0.9803
Trichomonas vaginalis phosphofructokinase, putative 0.0028 0.008 0.0155
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0028 0.008 0.2119
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0076 0.0075
Echinococcus granulosus glutamate receptor 1 0.0044 0.0167 0.0165
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0007 0.0013
Schistosoma mansoni axis inhibition protein axin 0.0057 0.0241 0.0281
Toxoplasma gondii 6-phosphofructokinase 0.0028 0.008 0.123
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0403 0.2213 0.2597
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.1102 0.6199 0.6198
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0033 0.0038
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0908 0.5096 0.5095
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0033 0.0031
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0033 0.0037
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0007 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0282 0.2003
Schistosoma mansoni DNA helicase recq1 0.0028 0.0076 0.0088
Loa Loa (eye worm) glutamate receptor 0.1462 0.8253 0.8252
Schistosoma mansoni regulator of G protein signaling 0.0057 0.0241 0.0281
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0908 0.5096 0.5095
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0215 0.1146 0.1387
Echinococcus granulosus voltage dependent calcium channel subunit 0.0164 0.0853 0.0851
Echinococcus granulosus glutamate NMDA receptor subunit 0.0519 0.2877 0.2876
Echinococcus multilocularis Excitatory amino acid transporter 0.0908 0.5096 0.5095
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0007 0.0036
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0282 0.0281
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0025 0.0063 0.0061
Echinococcus granulosus nmda type glutamate receptor 0.0605 0.3369 0.3368
Loa Loa (eye worm) hypothetical protein 0.0057 0.0241 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0079 0.0153
Echinococcus multilocularis glutamate receptor 2 0.0823 0.4608 0.4607
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.0007 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0005
Loa Loa (eye worm) hypothetical protein 0.0057 0.0241 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0166 0.032
Echinococcus multilocularis Polycystic kidney disease protein 0.0038 0.0136 0.0134
Onchocerca volvulus 0.0926 0.5198 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0033 0.0051
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0033 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0002 0.0003
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0076 0.0075
Schistosoma mansoni hypothetical protein 0.0327 0.1785 0.2094
Schistosoma mansoni synaptojanin 0.0015 0.0007 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.0606 0.3016
Leishmania major RNA-editing complex protein MP100, putative 0.0015 0.0007 0.0036
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.1202 0.6769 0.8202
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0076 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0033 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0033 0.0031
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0033 0.0031
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0007 0.0036
Echinococcus granulosus metabotropic glutamate receptor 2 0.1247 0.7025 0.7025
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0103 0.0122
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.0355 0.1621
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0517 0.3659
Brugia malayi phosphofructokinase 0.0105 0.0517 0.0625
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0052 0.01
Brugia malayi Receptor family ligand binding region containing protein 0.026 0.1402 0.1697
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0105 0.0517 1
Entamoeba histolytica phosphofructokinase, putative 0.0105 0.0517 0.3659
Echinococcus multilocularis voltage dependent calcium channel subunit 0.0164 0.0853 0.0851
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0015 0.0007 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0063 0.0121
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Plasmodium vivax 6-phosphofructokinase, putative 0.0028 0.008 0.127
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0007 0.0006
Echinococcus granulosus regulator of G protein signaling 7 0.0057 0.0241 0.0239
Echinococcus granulosus excitatory amino acid transporter 2 0.0908 0.5096 0.5095
Echinococcus multilocularis excitatory amino acid transporter 3 0.0908 0.5096 0.5095
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0033 0.0037
Onchocerca volvulus 0.0038 0.0136 0.0249
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0145 0.028
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0403 0.2213 0.2212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0067 0.0128
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.0355 0.0353

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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