Detailed information for compound 839073

Basic information

Technical information
  • TDR Targets ID: 839073
  • Name: (5Z)-5-[[5-(4-nitrophenyl)furan-2-yl]methylid ene]-3-phenyl-1,3-thiazolidine-2,4-dione
  • MW: 392.385 | Formula: C20H12N2O5S
  • H donors: 0 H acceptors: 4 LogP: 4.53 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C(=Cc2ccc(o2)c2ccc(cc2)[N+](=O)[O-])SC(=O)N1c1ccccc1
  • InChi: 1S/C20H12N2O5S/c23-19-18(28-20(24)21(19)14-4-2-1-3-5-14)12-16-10-11-17(27-16)13-6-8-15(9-7-13)22(25)26/h1-12H/b18-12-
  • InChiKey: OWZULGZUIPOZKW-PDGQHHTCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-[[5-(4-nitrophenyl)furan-2-yl]methylidene]-3-phenyl-1,3-thiazolidine-2,4-dione
  • (5Z)-5-[[5-(4-nitrophenyl)-2-furyl]methylene]-3-phenyl-thiazolidine-2,4-dione
  • 5-[[5-(4-nitrophenyl)-2-furyl]methylene]-3-phenyl-thiazolidine-2,4-dione
  • 5-[[5-(4-nitrophenyl)-2-furyl]methylene]-3-phenylthiazolidine-2,4-dione
  • (5Z)-5-[[5-(4-nitrophenyl)-2-furyl]methylene]-3-phenylthiazolidine-2,4-dione
  • 5-[[5-(4-nitrophenyl)-2-furyl]methylene]-3-phenyl-thiazolidine-2,4-quinone
  • (5Z)-5-[[5-(4-nitrophenyl)-2-furyl]methylene]-3-phenyl-thiazolidine-2,4-quinone
  • ZINC01188257
  • CBMicro_020559
  • IBS-0004612
  • BIM-0020660.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0141 0.0845 0.8919
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0659 0.872
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0052 0.0202
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0083 0.0079
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0083 0.0079
Onchocerca volvulus 0.0155 0.0941 1
Brugia malayi hypothetical protein 0.0034 0.009 0.0239
Plasmodium vivax glutathione reductase, putative 0.005 0.0205 0.2394
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0235 0.2699
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0148 0.0399
Echinococcus multilocularis geminin 0.0354 0.2343 0.234
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0196 0.0193
Plasmodium falciparum heat shock protein 90 0.0035 0.0094 0.1115
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0094 0.7839
Loa Loa (eye worm) hypothetical protein 0.0049 0.0196 0.0533
Entamoeba histolytica hypothetical protein 0.0038 0.0119 1
Echinococcus multilocularis lamin dm0 0.0029 0.0053 0.0049
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0148 0.0144
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0083 0.0079
Echinococcus granulosus lamin dm0 0.0029 0.0053 0.0049
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0008 0.0004
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0045 0.1467
Schistosoma mansoni hypothetical protein 0.0038 0.0119 0.0116
Loa Loa (eye worm) hypothetical protein 0.0155 0.0943 0.2599
Schistosoma mansoni endoplasmin 0.0035 0.0094 0.0091
Echinococcus granulosus snurportin 1 0.0315 0.2071 0.2068
Brugia malayi hypothetical protein 0.0022 0.0008 0.0011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0083 0.0929
Echinococcus multilocularis endoplasmin 0.0028 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0083 0.0437 0.1197
Plasmodium vivax multidomain scavenger receptor, putative 0.0141 0.0845 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0659 0.872
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0008 0.0004
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0148 0.0144
Schistosoma mansoni hypothetical protein 0.0049 0.0196 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0148 0.0399
Brugia malayi steroid hormone receptor 0.0042 0.0148 0.0399
Echinococcus multilocularis microtubule associated protein 2 0.1442 1 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0749 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0437 0.517
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0148 0.0144
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0019 0.2043
Trichomonas vaginalis ran, putative 0.0022 0.0004 0.0388
Loa Loa (eye worm) hypothetical protein 0.013 0.0769 0.2116
Onchocerca volvulus Huntingtin homolog 0.013 0.0769 0.8065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0148 0.0144
Plasmodium falciparum glutathione reductase 0.005 0.0205 0.2427
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Brugia malayi Probable ClpP-like protease 0.0083 0.0437 0.1197
Loa Loa (eye worm) hypothetical protein 0.0053 0.0221 0.0602
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.0437 0.0433
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0017 0.0013
Leishmania major trypanothione reductase 0.005 0.0205 0.722
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0148 0.0399
Echinococcus granulosus tissue type plasminogen activator 0.0061 0.0282 0.0279
Brugia malayi hypothetical protein 0.0022 0.0008 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0193 0.019
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0059 0.0643
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0148 0.0399
Schistosoma mansoni hypothetical protein 0.0061 0.0282 0.0279
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0148 0.0399
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0083 0.0079
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Schistosoma mansoni hypothetical protein 0.0049 0.0196 0.0193
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0148 0.0144
Loa Loa (eye worm) TK/ROR protein kinase 0.0079 0.0406 0.1113
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0845 0.5797 0.5795
Loa Loa (eye worm) hypothetical protein 0.0028 0.0049 0.0125
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0196 0.0533
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0196 0.0533
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0052 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0148 0.0399
Echinococcus granulosus importin subunit beta 1 0.003 0.0059 0.0055
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Schistosoma mansoni lipoxygenase 0.0591 0.4007 0.4005
Schistosoma mansoni polycystin 1-related 0.0141 0.0845 0.0841
Brugia malayi Kringle domain containing protein 0.0061 0.0282 0.0771
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.0437 0.0433
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0148 0.0144
Echinococcus granulosus Polycystic kidney disease protein 0.0141 0.0845 0.0841
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0659 0.872
Entamoeba histolytica hypothetical protein 0.0024 0.0019 0.1349
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.2043
Echinococcus multilocularis heat shock protein 0.0035 0.0094 0.0091
Entamoeba histolytica hypothetical protein 0.0038 0.0119 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0061 0.0282 0.3315
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0019 0.0559
Brugia malayi hypothetical protein 0.013 0.0769 0.2116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0196 0.0533
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0094 0.209
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0083 0.0079
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0659 0.872
Schistosoma mansoni loxhd1 0.0141 0.0845 0.0841
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Echinococcus granulosus geminin 0.0354 0.2343 0.234
Echinococcus granulosus heat shock protein 0.0035 0.0094 0.0091
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0148 0.0144
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0094 0.3246
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0749 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0193 0.019
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0205 0.2276
Schistosoma mansoni hypothetical protein 0.0315 0.2071 0.2068
Echinococcus multilocularis neuropeptide s receptor 0.0966 0.6652 0.6651
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0148 0.0399
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0399
Echinococcus multilocularis lipoxygenase domain containing protein 0.0141 0.0845 0.0841
Loa Loa (eye worm) hypothetical protein 0.0536 0.362 1
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0148 0.0144
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0083 0.2844
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0045 0.0041
Brugia malayi nuclear hormone receptor 0.0042 0.0148 0.0399
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0148 0.0144
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0045 0.1467
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0141 0.0845 0.2326
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Toxoplasma gondii hypothetical protein 0.0029 0.0052 0.1128
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0148 0.0144
Echinococcus granulosus heat shock protein 90 0.0035 0.0094 0.0091
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0094 0.106
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0045 0.4732
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0196 0.0193
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0083 0.0219
Brugia malayi Endoplasmin precursor 0.0035 0.0094 0.025
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0437 1
Echinococcus multilocularis heat shock protein 90 0.0028 0.0045 0.0041
Brugia malayi nuclear receptor NHR-88 0.0042 0.0148 0.0399
Loa Loa (eye worm) hypothetical protein 0.013 0.0769 0.2116
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0943 0.2599
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0148 0.0399
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0119 0.0116
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0235 0.0231
Schistosoma mansoni intermediate filament proteins 0.0029 0.0053 0.0049
Echinococcus granulosus endoplasmin 0.0028 0.0045 0.0041
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0205 0.0201
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0083 0.1831
Entamoeba histolytica hypothetical protein 0.0038 0.0119 1
Giardia lamblia Grp94/Hsp90 0.0028 0.0045 0.4519
Schistosoma mansoni hypothetical protein 0.0024 0.0017 0.0013
Brugia malayi Doublecortin family protein 0.0141 0.0845 0.2326
Echinococcus granulosus lipoxygenase domain containing protein 0.0141 0.0845 0.0841
Entamoeba histolytica hypothetical protein 0.0038 0.0119 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0221 0.7806
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0052 0.0622
Brugia malayi hypothetical protein 0.0053 0.0221 0.0602
Schistosoma mansoni importin beta-1 0.003 0.0059 0.0055
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0148 0.0144
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0059 0.0643
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0193 0.019
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0148 0.0399
Echinococcus granulosus lipoxygenase domain containing protein 0.0141 0.0845 0.0841
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0193 0.019
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0008 0.0011
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0094 0.209
Toxoplasma gondii thioredoxin reductase 0.005 0.0205 0.4649
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0148 0.0144
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0749 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0059 0.0055
Leishmania major importin beta-1 subunit, putative 0.0024 0.0019 0.0559
Brugia malayi hypothetical protein 0.0038 0.0119 0.0319
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0011
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0148 0.0144
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0221 0.5027
Echinococcus multilocularis GPCR, family 2 0.0049 0.0196 0.0193
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0083 0.0929
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0053 0.0136
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0045 0.1467
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.0052 0.0113
Brugia malayi isocitrate dehydrogenase 0.0033 0.0083 0.0219
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0659 0.872
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0437 0.5
Leishmania major hypothetical protein, conserved 0.0061 0.0282 1
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0119 0.0116
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0094 0.3246
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0749 1
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0148 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0148 0.0399
Schistosoma mansoni hypothetical protein 0.0106 0.0598 0.0594
Schistosoma mansoni lipoxygenase 0.0845 0.5797 0.5795
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.0437 0.5149
Echinococcus granulosus lamin 0.0029 0.0053 0.0049
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0193 0.019
Echinococcus multilocularis RUN 0.0141 0.0845 0.0841
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0148 0.0399
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0017 0.0013
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0094 0.106
Giardia lamblia Heat shock protein HSP 90-alpha 0.0028 0.0045 0.4519
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0221 0.262
Loa Loa (eye worm) doublecortin family protein 0.0141 0.0845 0.2326
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0148 0.0144
Brugia malayi intermediate filament protein 0.0029 0.0053 0.0136
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0148 0.0144
Entamoeba histolytica heat shock protein 90, putative 0.0035 0.0094 0.7839
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0943 0.2599
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0045 0.4732
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0148 0.0144
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0148 0.1072
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.0437 1
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Schistosoma mansoni hypothetical protein 0.0049 0.0196 0.0193
Brugia malayi nuclear receptor RXR 0.0022 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0011
Echinococcus multilocularis heat shock protein 90 0.0035 0.0094 0.0091
Schistosoma mansoni hypothetical protein 0.0354 0.2343 0.234
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0148 0.0399
Echinococcus multilocularis tissue type plasminogen activator 0.0061 0.0282 0.0279
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0196 0.0193
Schistosoma mansoni lamin 0.0029 0.0053 0.0049
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0148 0.0144
Brugia malayi hypothetical protein 0.0141 0.0845 0.2326
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0193 0.0525
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0148 0.0144
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Schistosoma mansoni heat shock protein 0.0035 0.0094 0.0091
Onchocerca volvulus Huntingtin homolog 0.013 0.0769 0.8065
Loa Loa (eye worm) hypothetical protein 0.0155 0.0941 0.2591
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0845 0.5797 0.5795
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0196 0.0193
Echinococcus multilocularis musashi 0.0029 0.0053 0.0049
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.0437 1
Toxoplasma gondii kringle domain-containing protein 0.0061 0.0282 0.6439
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0148 0.0399
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Echinococcus multilocularis Polycystic kidney disease protein 0.0141 0.0845 0.0841
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0193 0.019
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0094 0.1076
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0008 0.0011
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0083 0.0545
Trypanosoma cruzi hypothetical protein, conserved 0.0061 0.0282 1
Plasmodium falciparum LCCL domain-containing protein 0.0141 0.0845 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0148 0.0399
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0148 0.0144
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0011
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Loa Loa (eye worm) hypothetical protein 0.0029 0.0053 0.0136
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0742 0.2041
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0148 0.1072
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0399
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0008 0.0004
Echinococcus granulosus GPCR family 2 0.0049 0.0196 0.0193
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0437 1
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0053 0.0136
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0019 0.2043
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0205 0.722
Schistosoma mansoni rab6-interacting 0.0141 0.0845 0.0841
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Loa Loa (eye worm) hypothetical protein 0.003 0.0059 0.0152
Echinococcus multilocularis lipoxygenase domain containing protein 0.0141 0.0845 0.0841
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0148 0.0399
Echinococcus granulosus neuropeptide s receptor 0.0966 0.6652 0.6651
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0119 0.0116
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0008 0.0011
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.0437 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0083 0.1831
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0094 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.0437 1
Onchocerca volvulus 0.0061 0.0282 0.2588
Schistosoma mansoni endoplasmin 0.0035 0.0094 0.0091
Onchocerca volvulus 0.0141 0.0845 0.8919
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0011
Mycobacterium tuberculosis Probable reductase 0.0115 0.0659 0.872
Loa Loa (eye worm) hypothetical protein 0.0061 0.0282 0.0771
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0399
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0659 0.872
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0008 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0148 0.0144
Schistosoma mansoni lamin 0.0029 0.0053 0.0049
Brugia malayi glutathione reductase 0.005 0.0205 0.0557
Echinococcus granulosus neuropeptide receptor A26 0.0966 0.6652 0.6651
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0148 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0399
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0148 0.0144
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0148 0.1072
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0094 0.3246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0148 0.0399
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0205 0.0201
Brugia malayi MH2 domain containing protein 0.0127 0.0742 0.2041
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.0437 0.5565
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.0437 0.0433
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0045 0.4732
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0083 0.0079
Schistosoma mansoni hypothetical protein 0.0143 0.0858 0.0854
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0205 0.2394
Plasmodium falciparum thioredoxin reductase 0.005 0.0205 0.2427
Echinococcus granulosus RUN 0.0141 0.0845 0.0841
Brugia malayi Thioredoxin reductase 0.005 0.0205 0.0557
Schistosoma mansoni rab6-interacting 0.0141 0.0845 0.0841
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0148 0.0144
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0235 0.0231
Loa Loa (eye worm) endoplasmin 0.0035 0.0094 0.025
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.0437 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0053 0.0136
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Echinococcus granulosus heat shock protein 90 0.0028 0.0045 0.0041
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0193 0.0525
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0399
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Plasmodium falciparum cysteine repeat modular protein 1 0.0061 0.0282 0.3344
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0221 0.2549
Brugia malayi Protein kinase domain containing protein 0.0079 0.0406 0.1113
Plasmodium falciparum importin beta, putative 0.003 0.0059 0.0693
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Schistosoma mansoni hypothetical protein 0.0354 0.2343 0.234
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0059 0.1268
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0148 0.0144
Plasmodium vivax importin-beta 2, putative 0.003 0.0059 0.0653
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0148 0.0399
Loa Loa (eye worm) hypothetical protein 0.0106 0.0598 0.1642
Echinococcus multilocularis neuropeptide receptor A26 0.0966 0.6652 0.6651
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0148 0.0399
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0193 0.019
Brugia malayi hypothetical protein 0.0141 0.0845 0.2326
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0148 0.0399
Brugia malayi hypothetical protein 0.0155 0.0941 0.2591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0148 0.0399
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0148 0.0399
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0148 0.0144
Schistosoma mansoni coup transcription factor 0.0042 0.0148 0.0144
Brugia malayi RNA, U transporter 1 0.0084 0.0442 0.1212
Trypanosoma brucei RNA helicase, putative 0.0143 0.0858 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0536 0.362 1
Echinococcus multilocularis lamin 0.0029 0.0053 0.0049
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0094 0.025
Leishmania major hypothetical protein, conserved 0.0053 0.0221 0.7806
Brugia malayi ecdysteroid receptor 0.0042 0.0148 0.0399
Brugia malayi heat shock protein 90 0.0035 0.0094 0.025
Schistosoma mansoni microtubule-associated protein tau 0.1442 1 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0004 0.0043
Echinococcus multilocularis snurportin 1 0.0315 0.2071 0.2068
Brugia malayi Importin beta-1 subunit 0.003 0.0059 0.0152
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0094 0.3246
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0083 0.2844
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0235 0.2699
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0148 0.0144
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0094 0.3246
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0205 0.0557
Schistosoma mansoni hypothetical protein 0.0049 0.0196 0.0193
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0083 0.0982
Plasmodium vivax endoplasmin, putative 0.0035 0.0094 0.1076
Leishmania major heat shock protein 83-1 0.0035 0.0094 0.3246
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0148 0.0399
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0094 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0053 0.0049
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0221 0.7806
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0235 0.2699
Loa Loa (eye worm) hypothetical protein 0.0141 0.0845 0.2326
Loa Loa (eye worm) glutathione reductase 0.005 0.0205 0.0557
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0083 0.2844
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.2071 0.5717
Onchocerca volvulus 0.0042 0.0148 0.1072
Trypanosoma brucei trypanothione reductase 0.005 0.0205 0.2357
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0083 0.0219
Loa Loa (eye worm) hypothetical protein 0.0022 0.0008 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0742 0.2041
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0598 0.1642
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0221 0.2588
Trypanosoma brucei heat shock protein, putative 0.0035 0.0094 0.106
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0148 0.0144
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0083 0.0079
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0221 0.262
Schistosoma mansoni hypothetical protein 0.0141 0.0845 0.0841
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0399
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0083 0.0943
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0148 0.0144
Schistosoma mansoni heat shock protein 0.0035 0.0094 0.0091
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0399
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0094 0.106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0148 0.0399
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0943 0.2599

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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