Detailed information for compound 839244

Basic information

Technical information
  • TDR Targets ID: 839244
  • Name: 3-fluoro-N-[4-[4-[(3-fluorobenzoyl)amino]-3-m ethoxyphenyl]-2-methoxyphenyl]benzamide
  • MW: 488.482 | Formula: C28H22F2N2O4
  • H donors: 2 H acceptors: 2 LogP: 5.36 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1NC(=O)c1cccc(c1)F)c1ccc(c(c1)OC)NC(=O)c1cccc(c1)F
  • InChi: 1S/C28H22F2N2O4/c1-35-25-15-17(9-11-23(25)31-27(33)19-5-3-7-21(29)13-19)18-10-12-24(26(16-18)36-2)32-28(34)20-6-4-8-22(30)14-20/h3-16H,1-2H3,(H,31,33)(H,32,34)
  • InChiKey: MVCVKEAMLFNZNS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-fluoro-N-[4-[4-[(3-fluorobenzoyl)amino]-3-methoxy-phenyl]-2-methoxy-phenyl]benzamide
  • 3-fluoro-N-[4-[4-[[(3-fluorophenyl)-oxomethyl]amino]-3-methoxyphenyl]-2-methoxyphenyl]benzamide
  • 3-fluoro-N-[4-[4-[(3-fluorophenyl)carbonylamino]-3-methoxy-phenyl]-2-methoxy-phenyl]benzamide
  • CBMicro_020448
  • Oprea1_320383
  • ST020215
  • BIM-0020317.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin 0.0026 0.0047 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0183 0.068
Schistosoma mansoni alpha-glucosidase 0.0148 0.0521 0.2017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0103 0.0365
Echinococcus granulosus tar DNA binding protein 0.0061 0.0183 0.068
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0053 0.0324
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0242 0.0486
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.0094 0.0182
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.002 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0103 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.011 0.0393
Mycobacterium tuberculosis Conserved protein 0.0076 0.0242 0.0486
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0011 0.0407
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.011 0.0393
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0053 0.2128
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.0011 0.0407
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0103 0.063
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0047 0.0289
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0027 0.0166
Trypanosoma brucei glucosidase, putative 0.0038 0.0094 0.3855
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0053 0.0059
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.002 0.0036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0053 0.4822
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Entamoeba histolytica hypothetical protein 0.0042 0.0108 1
Brugia malayi beta-lactamase 0.0076 0.0242 0.1494
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.002 0.0036
Echinococcus multilocularis survival motor neuron protein 1 0.0273 0.1009 0.0999
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0103 0.0365
Schistosoma mansoni hypothetical protein 0.0667 0.2539 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0027 0.0013
Schistosoma mansoni nuclear hormone receptor 0.0019 0.002 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0103 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0242 1
Toxoplasma gondii ABC1 family protein 0.0076 0.0242 0.0507
Mycobacterium tuberculosis Conserved protein 0.0076 0.0242 0.0486
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0103 0.0637
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.002 0.0117
Echinococcus granulosus muscleblind protein 0.0157 0.0558 0.2165
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0017 0.0011 0.0413
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0027 0.0402
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Loa Loa (eye worm) hypothetical protein 0.0076 0.0242 0.1494
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0103 0.063
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0011 0.0407
Onchocerca volvulus 0.0076 0.0242 0.1488
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.006 0.0107
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0108 0.0382
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0011 0.0407
Echinococcus multilocularis lamin 0.0026 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0179
Brugia malayi tailless protein 0.0019 0.002 0.0124
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0011 0.0068
Echinococcus multilocularis musashi 0.0026 0.0047 0.0036
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0242 1
Brugia malayi Isocitrate dehydrogenase 0.0029 0.006 0.0369
Echinococcus granulosus intermediate filament protein 0.0026 0.0047 0.0142
Brugia malayi ecdysone receptor 0.0019 0.002 0.0124
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0029 0.0072
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0183 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0103 0.0637
Onchocerca volvulus 0.0026 0.0047 0.0282
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0242 0.0915
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0103 0.0092
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0053 0.2128
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0179
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0029 0.006 0.0194
Loa Loa (eye worm) hypothetical protein 0.0273 0.1009 0.6215
Mycobacterium ulcerans lipase LipD 0.0076 0.0242 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Echinococcus granulosus geminin 0.0667 0.2539 1
Brugia malayi RNA binding protein 0.0061 0.0183 0.1127
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.006 0.2435
Onchocerca volvulus 0.0099 0.0332 0.2042
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0029 0.0072
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0094 0.3855
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.002 0.0124
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0242 0.0486
Brugia malayi hypothetical protein 0.0042 0.0108 0.0663
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.002 0.0009
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0094 0.3855
Mycobacterium ulcerans hypothetical protein 0.0027 0.0053 0.0059
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0053 0.4822
Schistosoma mansoni hypothetical protein 0.0667 0.2539 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0103 0.0365
Onchocerca volvulus 0.0019 0.002 0.0117
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0324
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0011 0.0407
Onchocerca volvulus 0.0027 0.0053 0.0317
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0023 0.0035 0.1414
Echinococcus multilocularis isocitrate dehydrogenase 0.0029 0.006 0.0049
Schistosoma mansoni survival motor neuron protein 0.0056 0.0163 0.06
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0103 0.0637
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0011 0.0407
Brugia malayi beta-lactamase family protein 0.0076 0.0242 0.1494
Entamoeba histolytica hypothetical protein 0.0023 0.0035 0.3204
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.0094 0.3855
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0027 0.0016
Mycobacterium leprae Probable lipase LipE 0.0076 0.0242 0.042
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0105 0.4305
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0029 0.006 0.0085
Brugia malayi nuclear receptor NHR-67 0.0019 0.002 0.0124
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0053 0.0324
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.002 0.0009
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0029 0.006 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0179
Loa Loa (eye worm) inositol-1 0.0041 0.0105 0.0647
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0088 0.0079
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0105 0.4305
Brugia malayi nuclear receptor NHR-88 0.0019 0.002 0.0124
Brugia malayi Nuclear hormone receptor E75 0.0019 0.002 0.0124
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.002 0.0009
Brugia malayi hypothetical protein 0.0273 0.1009 0.6215
Mycobacterium ulcerans hypothetical protein 0.0076 0.0242 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0035 0.1414
Mycobacterium ulcerans beta-lactamase 0.0076 0.0242 0.0477
Loa Loa (eye worm) hypothetical protein 0.0076 0.0242 0.1494
Brugia malayi hypothetical protein 0.0019 0.002 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0103 0.0637
Loa Loa (eye worm) beta-lactamase 0.0076 0.0242 0.1494
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0103 0.0092
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0027 0.0063
Brugia malayi nuclear receptor RXR 0.0021 0.0029 0.0179
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.006 0.0049
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Schistosoma mansoni zinc finger protein 0.0019 0.002 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0103 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Toxoplasma gondii FATC domain-containing protein 0.0023 0.0035 0.0053
Echinococcus multilocularis serine protein kinase ATM 0.0023 0.0035 0.0024
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0103 0.0365
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0242 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0614 0.0604
Onchocerca volvulus 0.004 0.0103 0.063
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.002 0.0124
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0158
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0103 0.0365
Leishmania major phosphatidylinositol kinase related protein, putative 0.0017 0.0011 0.0413
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0183 0.1127
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0242 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0053 0.0059
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.002 0.0124
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0242 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0242 0.0486
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0242 0.0477
Schistosoma mansoni nuclear hormone receptor 0.0019 0.002 0.0036
Schistosoma mansoni nuclear receptor 0.0019 0.002 0.0036
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0163 0.1003
Loa Loa (eye worm) hypothetical protein 0.0076 0.0242 0.1494
Toxoplasma gondii exonuclease III APE 0.0021 0.0027 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0047 0.0289
Schistosoma mansoni ap endonuclease 0.0021 0.0027 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0053 0.0069
Brugia malayi hypothetical protein 0.0021 0.0029 0.0179
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0017 0.0011 0.0923
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0242 0.1494
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.0094 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0103 0.0637
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0029 0.006 0.2435
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.002 0.0124
Echinococcus granulosus serine protein kinase ATM 0.0023 0.0035 0.0096
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0158
Schistosoma mansoni alpha-glucosidase 0.0148 0.0521 0.2017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0094 0.3855
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.011 0.01
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0027 0.1069
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0242 1
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0103 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0103 0.0637
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0103 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) RNA binding protein 0.0061 0.0183 0.1127
Schistosoma mansoni lamin 0.0026 0.0047 0.0142
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0053 0.0059
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0011 0.0407
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0242 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0103 0.0365
Loa Loa (eye worm) isocitrate dehydrogenase 0.0029 0.006 0.0369
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0103 0.0637
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0103 0.0092
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0027 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0042 0.011 0.0393
Brugia malayi Glycosyl hydrolases family 31 protein 0.0172 0.0614 0.3783
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0047 0.0289
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1189 0.4573 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0105 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.006 0.0049
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0029 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0053 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0027 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Leishmania major hypothetical protein, conserved 0.0076 0.0242 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0026 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0023 0.014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0103 0.0637
Schistosoma mansoni ap endonuclease 0.0021 0.0027 0.0063
Brugia malayi isocitrate dehydrogenase 0.0029 0.006 0.0369
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0183 0.068
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.002 0.0036
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.006 0.2435
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0103 0.0637
Brugia malayi intermediate filament protein 0.0026 0.0047 0.0289
Loa Loa (eye worm) hypothetical protein 0.0025 0.0045 0.0277
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0242 0.0486
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0029 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Echinococcus granulosus lysosomal alpha glucosidase 0.0172 0.0614 0.2385
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0011 0.0407
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.002 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0103 0.0637
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0029 0.006 0.2435
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0023 0.0035 0.1414
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0027 0.1069
Brugia malayi nuclear receptor NHR-88 0.004 0.0103 0.0637
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0105 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0094 0.3855
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0105 0.4305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.011 0.0393
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.0011 0.0407
Schistosoma mansoni inositol monophosphatase 0.0041 0.0105 0.0372
Brugia malayi beta-lactamase family protein 0.0076 0.0242 0.1494
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0242 0.0915
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0183 0.068
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0027 0.1069
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0027 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0242 0.1494
Loa Loa (eye worm) hypothetical protein 0.0157 0.0558 0.344
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0001 0.0007
Schistosoma mansoni lamin 0.0026 0.0047 0.0142
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.002 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0103 0.0365
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0011 0.0068
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0023 0.0035 0.0096
Brugia malayi conserved hypotetical protein 0.0019 0.002 0.0124
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.002 0.0009
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0324
Onchocerca volvulus 0.0026 0.0047 0.0282
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0053 0.0324
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.0011 0.0407
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0011 0.0407
Brugia malayi Nuclear hormone receptor E75 0.0019 0.002 0.0124
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0103 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0103 0.0092
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0103 0.0365
Toxoplasma gondii isocitrate dehydrogenase 0.0029 0.006 0.0107
Brugia malayi nuclear hormone receptor 0.0019 0.002 0.0124
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.1189 0.4573 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0242 0.0915
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0103 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0179
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0105 0.4305
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0029 0.0072
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0242 0.0477
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Echinococcus granulosus FTZ F1 alpha 0.004 0.0103 0.0365
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0026 0.001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.0011 0.0407
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0027 0.1069
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.002 0.0009
Mycobacterium tuberculosis Conserved protein 0.0076 0.0242 0.0486
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0242 1
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0103 0.0637
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0103 0.0365
Onchocerca volvulus 0.0431 0.1623 1
Brugia malayi nuclear hormone receptor 0.004 0.0103 0.0637
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0242 0.0486
Schistosoma mansoni intermediate filament proteins 0.0026 0.0047 0.0142
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0103 0.0365
Brugia malayi hypothetical protein 0.0019 0.002 0.0124
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0242 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0103 0.0637
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0183 0.1127
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0172 0.0614 0.3783
Schistosoma mansoni hypothetical protein 0.0042 0.0108 0.0382
Schistosoma mansoni inositol monophosphatase 0.0041 0.0105 0.0372
Schistosoma mansoni coup transcription factor 0.004 0.0103 0.0365
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0103 0.0365
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.002 0.0036
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0053 0.4822
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Brugia malayi ecdysteroid receptor 0.004 0.0103 0.0637
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0242 0.042
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0242 0.0486
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0105 0.9754
Loa Loa (eye worm) hypothetical protein 0.0076 0.0242 0.1494
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0105 0.4305
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0103 0.0637
Echinococcus multilocularis muscleblind protein 0.0157 0.0558 0.0548
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0053 0.0059
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0053 0.0069
Echinococcus multilocularis muscleblind protein 1 0.0157 0.0558 0.0548
Schistosoma mansoni alpha glucosidase 0.0038 0.0094 0.0329
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0158
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.0094 0.3855
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0183 0.068
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0103 0.0092
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0027 0.2422
Entamoeba histolytica hypothetical protein 0.0042 0.0108 1
Brugia malayi nuclear receptor RXR 0.0019 0.002 0.0124
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0108 0.0097
Schistosoma mansoni hypothetical protein 0.0056 0.0163 0.06
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.0094 0.058
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0094 0.3855
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0103 0.063
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0011 0.0407
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0029 0.006 0.0049
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0103 0.0637
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0242 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0105 0.4305
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0103 0.0637
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0094 0.8735
Echinococcus multilocularis geminin 0.0667 0.2539 0.2531
Brugia malayi steroid hormone receptor 0.004 0.0103 0.0637
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0242 0.0232
Echinococcus multilocularis lamin dm0 0.0026 0.0047 0.0036
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0029 0.0179
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0027 0.5
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0029 0.006 0.1583
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0029 0.006 0.0049
Brugia malayi TAR-binding protein 0.0061 0.0183 0.1127
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0029 0.0179
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0029 0.006 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.002 0.0009
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0027 0.0003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0103 0.0365
Loa Loa (eye worm) hypothetical protein 0.0027 0.0053 0.0324
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0011 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0103 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0103 0.0637
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0023 0.0035 0.0217
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.002 0.0124
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0053 0.2128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Trichomonas vaginalis esterase, putative 0.0076 0.0242 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0011 0.0407
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0103 0.0365
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0042 0.011 0.0393
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0027 0.1069
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0029 0.006 0.2435
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Onchocerca volvulus 0.0076 0.0242 0.1488
Schistosoma mansoni thyroid hormone receptor 0.004 0.0103 0.0365
Brugia malayi hypothetical protein 0.0021 0.0029 0.0179
Echinococcus granulosus lamin dm0 0.0026 0.0047 0.0142
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0103 0.0365
Schistosoma mansoni nuclear receptor 0.0019 0.002 0.0036
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0011 0.0068
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0105 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0042 0.011 0.0681
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0105 0.4305
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0103 0.0637
Loa Loa (eye worm) hypothetical protein 0.004 0.0103 0.0637
Entamoeba histolytica hypothetical protein 0.0042 0.0108 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0242 0.1494
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.0094 0.3855
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0103 0.0092
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Loa Loa (eye worm) DR-78 0.0019 0.002 0.0124
Echinococcus multilocularis lysosomal alpha glucosidase 0.0172 0.0614 0.0604
Loa Loa (eye worm) hypothetical protein 0.0431 0.1623 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0027 0.0166
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.002 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0053 0.0059
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.0094 0.8735
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.0094 0.3855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0094 0.3855
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0094 0.3855
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.0094 0.058
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.002 0.0124
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0103 0.0092
Loa Loa (eye worm) hypothetical protein 0.0157 0.0558 0.344
Brugia malayi hypothetical protein 0.0431 0.1623 1
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.002 0.0036
Schistosoma mansoni nuclear hormone receptor 0.004 0.0103 0.0365
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Brugia malayi Muscleblind-like protein 0.0157 0.0558 0.344
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0047 0.0289
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0103 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Onchocerca volvulus 0.0019 0.002 0.0117
Toxoplasma gondii pantoate-beta-alanine ligase 0.1189 0.4573 1
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0108 0.0382
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0183 0.1127
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0042 0.011 0.0681
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0088 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.0094 0.3855
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0103 0.0637
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.0094 0.0083
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0103 0.0365
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.002 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0103 0.0637
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0042 0.011 0.01
Onchocerca volvulus 0.0056 0.0163 0.0996
Schistosoma mansoni thyroid hormone receptor 0.004 0.0103 0.0365
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.1189 0.4573 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0105 0.0206
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0124
Brugia malayi Inositol-1 0.0041 0.0105 0.0647
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0158
Onchocerca volvulus 0.0076 0.0242 0.1488
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0105 0.0094
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0487 0.184 0.3997
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0011 0.0068
Echinococcus granulosus survival motor neuron protein 1 0.0273 0.1009 0.3947
Loa Loa (eye worm) hypothetical protein 0.002 0.0026 0.0158
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0053 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0183 0.068
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0017 0.0011 0.0923
Entamoeba histolytica hypothetical protein 0.0042 0.0108 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0023 0.0896
Loa Loa (eye worm) hypothetical protein 0.0076 0.0242 0.1494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0017 0.0011 0.0407
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0029 0.0018

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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