Detailed information for compound 839250

Basic information

Technical information
  • TDR Targets ID: 839250
  • Name: 1-(4-nitrophenyl)-5-phenyl-1,2,4-triazole
  • MW: 266.255 | Formula: C14H10N4O2
  • H donors: 0 H acceptors: 4 LogP: 3.15 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)n1ncnc1c1ccccc1
  • InChi: 1S/C14H10N4O2/c19-18(20)13-8-6-12(7-9-13)17-14(15-10-16-17)11-4-2-1-3-5-11/h1-10H
  • InChiKey: NCJDNNFLOKIFNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ZINC00280758
  • CBMicro_020456
  • BIM-0020302.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0122 0.0267
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0185 0.2745 0.453
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0049 0.0602 0.1342
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0269 0.0269
Giardia lamblia Glutamate synthase 0.0049 0.0602 0.115
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0049 0.0602 0.0889
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.3461 0.7626
Brugia malayi MH2 domain containing protein 0.0016 0.0076 0.0167
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0121
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0049 0.0602 0.1342
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0049 0.0602 0.0602
Leishmania major hypothetical protein, conserved 0.0049 0.0602 0.0602
Schistosoma mansoni gliotactin 0.0047 0.0566 0.0935
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0153 0.0152
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0144 0.0317
Echinococcus granulosus Smad4 0.0016 0.0076 0.0151
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0049 0.0602 0.115
Mycobacterium ulcerans NADH dehydrogenase 0.0049 0.0602 0.2193
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0185 0.2745 0.2744
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Schistosoma mansoni hypothetical protein 0.0048 0.058 0.0957
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0393 0.065
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0038 0.0421 0.0421
Leishmania major ferric reductase, putative 0.0038 0.0421 0.0421
Brugia malayi Pre-SET motif family protein 0.0033 0.0344 0.0766
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0049 0.0602 0.2193
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0122 0.027
Trypanosoma cruzi trypanothione reductase, putative 0.0185 0.2745 0.2744
Trichomonas vaginalis set domain proteins, putative 0.026 0.3923 0.9098
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0393 0.1431
Echinococcus granulosus tar DNA binding protein 0.02 0.2979 0.596
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0285 0.432 0.9633
Echinococcus granulosus acetylcholinesterase 0.0277 0.4197 0.8397
Brugia malayi Blistered cuticle protein 3 0.008 0.1091 0.2433
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0545 0.8404 0.8404
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0049 0.0602 0.1342
Schistosoma mansoni hypothetical protein 0.0048 0.058 0.0957
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0566 0.1262
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.3426 0.7549
Loa Loa (eye worm) Smad1 0.0016 0.0076 0.0165
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0121
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0442
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0144 0.0144
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0068 0.0068
Leishmania major NADH dehydrogenase, putative 0.0049 0.0602 0.0602
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Schistosoma mansoni acetylcholinesterase 0.0047 0.0566 0.0935
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.058 0.116
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0049 0.0602 0.2193
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Schistosoma mansoni BC026374 protein (S09 family) 0.0047 0.0566 0.0935
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0185 0.2745 0.5491
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0049 0.0602 0.1342
Brugia malayi Cytochrome P450 family protein 0.002 0.0144 0.0321
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0076 0.0151
Mycobacterium ulcerans carboxylesterase, LipT 0.0047 0.0566 0.2062
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0049 0.0602 0.1342
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0049 0.0602 0.0602
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0185 0.2745 0.612
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0049 0.0602 0.1393
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0068 0.0137
Schistosoma mansoni glutamate synthase 0.0049 0.0602 0.0994
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0047 0.0566 0.1133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1315 0.217
Plasmodium falciparum thioredoxin reductase 0.0185 0.2745 0.6061
Toxoplasma gondii thioredoxin reductase 0.0296 0.4484 1
Brugia malayi hypothetical protein 0.0047 0.0566 0.1262
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0049 0.0602 0.115
Echinococcus multilocularis para nitrobenzyl esterase 0.0047 0.0566 0.1133
Onchocerca volvulus 0.0033 0.0344 0.0509
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0122 0.027
Schistosoma mansoni tar DNA-binding protein 0.02 0.2979 0.4917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1315 0.263
Leishmania major hypothetical protein, conserved 0.0024 0.0211 0.0211
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0068 0.0113
Echinococcus granulosus BC026374 protein S09 family 0.0047 0.0566 0.1133
Brugia malayi Importin beta-1 subunit 0.0028 0.0269 0.0599
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0153 0.034
Loa Loa (eye worm) hypothetical protein 0.0103 0.1452 0.3199
Toxoplasma gondii selenide, water dikinase 0.0049 0.0602 0.1342
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0602 0.115
Giardia lamblia NADH oxidase lateral transfer candidate 0.0185 0.2745 0.6278
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0049 0.0602 0.1342
Echinococcus multilocularis RUN 0.0021 0.0152 0.0304
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0049 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0033 0.0344 0.0757
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0149 0.2177 0.5039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0149 0.2177 0.4854
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0049 0.0602 0.1393
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0122 0.0201
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.058 0.1277
Mycobacterium tuberculosis Probable oxidoreductase 0.0285 0.432 0.9633
Entamoeba histolytica hypothetical protein 0.0023 0.0186 0.0154
Loa Loa (eye worm) carboxylesterase 0.0277 0.4197 0.9249
Echinococcus multilocularis GPCR, family 2 0.0048 0.058 0.116
Plasmodium vivax ferrodoxin reductase, putative 0.0049 0.0602 0.1209
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0545 0.8404 0.8404
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0185 0.2745 0.5491
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.1247
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.1265 0.1265
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0068 0.0152
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0602 0.0602
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0602 0.115
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.02 0.2979 0.6564
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0393 0.0787
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0137
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.2204 0.4914
Leishmania major DNA polymerase eta, putative 0.0043 0.0509 0.0509
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0211 0.0324
Brugia malayi hypothetical protein 0.0021 0.0152 0.0338
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0153 0.0074
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0344 0.0766
Brugia malayi Inositol-1 0.0036 0.0393 0.0876
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0049 0.0602 0.0602
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.2013 0.4488
Echinococcus granulosus carboxylesterase 5A 0.0277 0.4197 0.8397
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0269 0.0539
Brugia malayi hypothetical protein 0.0021 0.0152 0.0338
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0153 0.0306
Plasmodium vivax SET domain protein, putative 0.0033 0.0344 0.0624
Schistosoma mansoni importin beta-1 0.0028 0.0269 0.0444
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0285 0.432 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Brugia malayi Doublecortin family protein 0.0021 0.0152 0.0338
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0049 0.0602 0.1205
Loa Loa (eye worm) programmed cell death 8 0.0049 0.0602 0.1326
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0049 0.0602 0.115
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0049 0.0602 0.2193
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0049 0.0602 0.115
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.43 1
Trypanosoma brucei NADH dehydrogenase 0.0049 0.0602 0.0602
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.43 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0153 0.0152
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0153 0.034
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0049 0.0602 0.2193
Brugia malayi Smad1 0.0016 0.0076 0.0167
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0334 0.0772
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0393 0.0393
Schistosoma mansoni disulfide oxidoreductase 0.0049 0.0602 0.0994
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0185 0.2745 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0049 0.0602 0.1205
Loa Loa (eye worm) hypothetical protein 0.0277 0.4197 0.9249
Schistosoma mansoni glutamate synthase 0.0049 0.0602 0.0994
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.1247
Brugia malayi MH2 domain containing protein 0.0016 0.0076 0.0167
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0049 0.0602 0.1205
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0122 0.0201
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1315 0.217
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0602 0.0602
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0049 0.0602 0.0602
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0211 0.0211
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0049 0.0602 0.115
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0243
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.1315 0.217
Mycobacterium tuberculosis Probable reductase 0.0149 0.2177 0.4854
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0185 0.2745 0.2744
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0325 0.065
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.1247
Entamoeba histolytica disulphide oxidoreductase, putative 0.0049 0.0602 0.115
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0068 0.0152
Brugia malayi Carboxylesterase family protein 0.0277 0.4197 0.936
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0477 0.7336 0.7336
Brugia malayi glutamate synthase 0.0049 0.0602 0.1342
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1452 0.3238
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0068 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Schistosoma mansoni glutamate synthase 0.0049 0.0602 0.0994
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0269 0.0269
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0149 0.2177 0.4854
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0076 0.0151
Mycobacterium tuberculosis Probable dehydrogenase 0.0149 0.2177 0.4854
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.058 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Schistosoma mansoni polycystin 1-related 0.0021 0.0152 0.0251
Echinococcus granulosus glutamate synthase 0.0049 0.0602 0.1205
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0049 0.0602 0.1205
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0477 0.7336 0.7336
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0152 0.0189
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1265 0.2737
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0152 0.0304
Echinococcus multilocularis neuroligin 0.0047 0.0566 0.1133
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.1265 0.2787
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0049 0.0602 0.1393
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0393 0.065
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0539 0.1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0211 0.0465
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0049 0.0602 0.1342
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0185 0.2745 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0068 0.015
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0211 0.0211
Mycobacterium ulcerans ferredoxin reductase 0.0049 0.0602 0.2193
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1265 0.2737
Loa Loa (eye worm) hypothetical protein 0.0048 0.058 0.1277
Leishmania major importin beta-1 subunit, putative 0.0023 0.0186 0.0185
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1265 0.1265
Schistosoma mansoni neuroligin 3 (S09 family) 0.0047 0.0566 0.0935
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0153 0.0191
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1265 0.2737
Echinococcus granulosus geminin 0.0328 0.4999 1
Echinococcus granulosus cytochrome P450 2K1 0.0011 0 0.0001
Brugia malayi Thioredoxin reductase 0.0296 0.4484 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.1265 0.2821
Loa Loa (eye worm) glutathione reductase 0.0296 0.4484 0.9881
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.2204 0.4914
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0646 1 1
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0049 0.0602 0.0602
Loa Loa (eye worm) hypothetical protein 0.0151 0.2204 0.4856
Schistosoma mansoni hypothetical protein 0.0299 0.4538 0.749
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0185 0.2745 0.612
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0137
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0539 0.1
Brugia malayi hypothetical protein 0.0146 0.2127 0.4743
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0049 0.0602 0.1342
Schistosoma mansoni hypothetical protein 0.0328 0.4999 0.825
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0545 0.8404 0.8404
Plasmodium falciparum glutathione reductase 0.0296 0.4484 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.1247
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0136 0.1971 0.4394
Echinococcus granulosus acetylcholinesterase 0.0277 0.4197 0.8397
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0646 1 1
Echinococcus multilocularis dna polymerase eta 0.0043 0.0509 0.1019
Echinococcus granulosus thioredoxin glutathione reductase 0.0296 0.4484 0.8971
Schistosoma mansoni smad1 5 8 and 0.0016 0.0076 0.0125
Brugia malayi RNA recognition motif domain containing protein 0.02 0.2979 0.6643
Schistosoma mansoni rab6-interacting 0.0021 0.0152 0.0251
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1265 0.2737
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0211 0.0471
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0122 0.0243
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0152 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0344 0.0568
Trichomonas vaginalis apoptosis inducing factor, putative 0.0049 0.0602 0.115
Onchocerca volvulus 0.0047 0.0566 0.1098
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0393 0.065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0344 0.0568
Trypanosoma brucei ferric reductase transmembrane protein, putative 0.0038 0.0421 0.0421
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0049 0.0602 0.1342
Schistosoma mansoni tar DNA-binding protein 0.02 0.2979 0.4917
Schistosoma mansoni rab6-interacting 0.0021 0.0152 0.0251
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0185 0.2745 1
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0602 0.0602
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1265 0.2737
Brugia malayi Cytochrome P450 family protein 0.002 0.0144 0.0321
Loa Loa (eye worm) carboxylesterase 0.0047 0.0566 0.1247
Echinococcus multilocularis carboxylesterase 5A 0.0277 0.4197 0.8397
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0049 0.0602 0.1393
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0152 0.0304
Schistosoma mansoni lipoxygenase 0.0123 0.1766 0.2915
Loa Loa (eye worm) acetylcholinesterase 1 0.0277 0.4197 0.9249
Loa Loa (eye worm) hypothetical protein 0.0146 0.2127 0.4686
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0122 0.0243
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0186 0.0185
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0049 0.0602 0.115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0477 0.7336 0.7336
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0211 0.0211
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0602 0.0602
Trypanosoma cruzi ferric reductase transmembrane protein, putative 0.0038 0.0421 0.0421
Echinococcus granulosus snurportin 1 0.0299 0.4538 0.9078
Plasmodium vivax glutathione reductase, putative 0.0296 0.4484 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.058 0.1292
Trypanosoma brucei unspecified product 0.0019 0.0122 0.0121
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0149 0.2177 0.4854
Trichomonas vaginalis glutathione reductase, putative 0.0185 0.2745 0.6278
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.1315 0.263
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0509 0.0509
Onchocerca volvulus 0.026 0.3923 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0393 0.0876
Echinococcus granulosus para nitrobenzyl esterase 0.0047 0.0566 0.1133
Schistosoma mansoni Smad4 0.0016 0.0076 0.0125
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0122 0.0442
Onchocerca volvulus 0.0146 0.2127 0.5237
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0049 0.0602 0.1205
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0049 0.0602 0.0889
Brugia malayi isocitrate dehydrogenase 0.0015 0.0068 0.0152
Loa Loa (eye worm) hypothetical protein 0.0043 0.0509 0.1121
Trypanosoma cruzi DNA polymerase eta, putative 0.003 0.0307 0.0306
Echinococcus granulosus importin subunit beta 1 0.0028 0.0269 0.0539
Giardia lamblia Kinase, PLK 0.0091 0.1265 0.2737
Schistosoma mansoni ran 0.0021 0.0153 0.0252
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.1315 0.2931
Echinococcus granulosus RUN 0.0021 0.0152 0.0304
Brugia malayi Pre-SET motif family protein 0.0228 0.3426 0.764
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0049 0.0602 0.2193
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0049 0.0602 0.1209
Onchocerca volvulus 0.0049 0.0602 0.1194
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.1247
Echinococcus granulosus smad 0.0016 0.0076 0.0151
Echinococcus granulosus dna polymerase kappa 0.0019 0.0122 0.0243
Trypanosoma brucei trypanothione reductase 0.0296 0.4484 0.4484
Schistosoma mansoni inositol monophosphatase 0.0036 0.0393 0.0649
Brugia malayi MH1 domain containing protein 0.0016 0.0076 0.0167
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0049 0.0602 0.0602
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0602 0.115
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0049 0.0602 0.115
Mycobacterium ulcerans dehydrogenase 0.0049 0.0602 0.2193
Mycobacterium ulcerans glutamate synthase subunit beta 0.0049 0.0602 0.2193
Schistosoma mansoni tar DNA-binding protein 0.02 0.2979 0.4917
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0049 0.0602 0.1205
Echinococcus granulosus dna polymerase eta 0.0043 0.0509 0.1019
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0185 0.2745 0.6061
Leishmania major hypothetical protein, conserved 0.0049 0.0602 0.0602
Trichomonas vaginalis ran, putative 0.0021 0.0153 0.0074
Brugia malayi Latrophilin receptor protein 2 0.0048 0.058 0.1292
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Echinococcus multilocularis 0.0011 0 0.0001
Brugia malayi glutathione reductase 0.0296 0.4484 1
Brugia malayi RNA binding protein 0.02 0.2979 0.6643
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0049 0.0602 0.1205
Echinococcus multilocularis glutamate synthase 0.0049 0.0602 0.1205
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0185 0.2745 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0076 0.0165
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0068 0.0068
Mycobacterium ulcerans monoxygenase 0.0049 0.0602 0.2193
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1265 0.2737
Echinococcus multilocularis acetylcholinesterase 0.0277 0.4197 0.8397
Loa Loa (eye worm) thioredoxin reductase 0.0296 0.4484 0.9881
Trypanosoma cruzi trypanothione reductase, putative 0.0296 0.4484 0.4484
Trypanosoma cruzi NADH dehydrogenase, putative 0.0049 0.0602 0.0602
Schistosoma mansoni hypothetical protein 0.0103 0.1452 0.2397
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0153 0.0306
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0152 0.0304
Onchocerca volvulus 0.0047 0.0566 0.1098
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0393 0.065
Entamoeba histolytica thioredoxin reductase, putative 0.0049 0.0602 0.115
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0566 0.0935
Plasmodium vivax thioredoxin reductase, putative 0.0296 0.4484 1
Schistosoma mansoni DNA polymerase eta 0.0043 0.0509 0.084
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0049 0.0602 0.1209
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0566 0.0935
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0123 0.1766 0.3533
Plasmodium vivax importin-beta 2, putative 0.0028 0.0269 0.0455
Brugia malayi TAR-binding protein 0.02 0.2979 0.6643
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0049 0.0602 0.0889
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.1265 0.1265
Schistosoma mansoni hypothetical protein 0.0021 0.0152 0.0251
Brugia malayi hypothetical protein 0.0016 0.0076 0.0168
Echinococcus multilocularis snurportin 1 0.0299 0.4538 0.9078
Echinococcus multilocularis thioredoxin glutathione reductase 0.0296 0.4484 0.8971
Loa Loa (eye worm) blistered cuticle protein 3 0.008 0.1091 0.2404
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0393 0.0787
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0149 0.2177 0.4854
Loa Loa (eye worm) hypothetical protein 0.0277 0.4197 0.9249
Brugia malayi Carboxylesterase family protein 0.0277 0.4197 0.936
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0123 0.1766 0.3533
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0049 0.0602 0.1205
Trypanosoma brucei hypothetical protein, conserved 0.0049 0.0602 0.0602
Plasmodium falciparum importin beta, putative 0.0028 0.0269 0.0455
Treponema pallidum NADH oxidase 0.0185 0.2745 0.5794
Trypanosoma cruzi NADH dehydrogenase, putative 0.0049 0.0602 0.0602
Schistosoma mansoni cytochrome P450 0.0011 0 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1315 0.263
Echinococcus multilocularis geminin 0.0328 0.4999 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0393 0.0393
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.2013 0.7332
Schistosoma mansoni loxhd1 0.0021 0.0152 0.0251
Schistosoma mansoni hypothetical protein 0.0011 0 0.0001
Schistosoma mansoni smad1 5 8 and 0.0016 0.0076 0.0125
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0509 0.0509
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0185 0.2745 0.2744
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0049 0.0602 0.1342
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0049 0.0602 0.1342
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.43 1
Echinococcus granulosus GPCR family 2 0.0048 0.058 0.116
Schistosoma mansoni kinase 0.0046 0.0558 0.0922
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0285 0.432 0.9633
Leishmania major cytochrome p450-like protein 0.002 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.1247
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0122 0.0121
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.1265 0.2531
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0152 0.0189
Schistosoma mansoni sulfide quinone reductase 0.0049 0.0602 0.0994
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.1265 0.2737
Schistosoma mansoni smad 0.0016 0.0076 0.0125
Trichomonas vaginalis glutamate synthase, putative 0.0049 0.0602 0.115
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0334
Loa Loa (eye worm) hypothetical protein 0.0021 0.0152 0.0334
Brugia malayi Carboxylesterase family protein 0.0047 0.0566 0.1262
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0049 0.0602 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0049 0.0602 0.1205
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0049 0.0602 0.1342
Trypanosoma brucei unspecified product 0.0013 0.003 0.003
Plasmodium falciparum ferrodoxin reductase-like protein 0.0049 0.0602 0.1209
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0122 0.0121
Trypanosoma cruzi cytochrome P450, putative 0.002 0.0144 0.0144
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0049 0.0602 0.1205
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.003
Brugia malayi follicle stimulating hormone receptor 0.0233 0.3499 0.7801
Loa Loa (eye worm) RNA binding protein 0.02 0.2979 0.6564
Leishmania major DNA polymerase eta, putative 0.003 0.0307 0.0306
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0185 0.2745 0.612
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.1265 0.2531
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0477 0.7336 0.7336
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0344 0.0688
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0049 0.0602 0.115
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.1265 0.2088
Mycobacterium tuberculosis Carboxylesterase LipT 0.0047 0.0566 0.1262
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0068 0.0137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0344 0.0568
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0296 0.4484 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0076 0.0125
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0344 0.0688
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0602 0.115
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0277 0.4197 0.6927
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0185 0.2745 0.6061
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0602 0.0602
Schistosoma mansoni hypothetical protein 0.0048 0.058 0.0957
Onchocerca volvulus 0.0047 0.0566 0.1098
Schistosoma mansoni hypothetical protein 0.0328 0.4999 0.825
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0509 0.1135
Schistosoma mansoni sulfide quinone reductase 0.0049 0.0602 0.0994
Schistosoma mansoni hypothetical protein 0.0049 0.0602 0.0994
Toxoplasma gondii ImpB/MucB/SamB family protein 0.003 0.0307 0.0683
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0185 0.2745 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0122 0.027
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0049 0.0602 0.0602
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0068 0.0068
Echinococcus multilocularis smad 0.0016 0.0076 0.0151
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0076 0.0165
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0602 0.115
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0153 0.0152
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0068 0.0137
Schistosoma mansoni hypothetical protein 0.0048 0.058 0.0957
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0152 0.0304
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0185 0.2745 0.2744
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0153 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.003
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0566 0.1262
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0185 0.2745 0.6061
Echinococcus multilocularis BC026374 protein (S09 family) 0.0047 0.0566 0.1133
Onchocerca volvulus 0.0047 0.0566 0.1098
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0049 0.0602 0.115
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.002 0.0144 0.0525
Loa Loa (eye worm) hypothetical protein 0.0028 0.0269 0.0592
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0152 0.0304
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0068 0.0152
Loa Loa (eye worm) carboxylesterase 0.0047 0.0566 0.1247
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0344 0.0688
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0049 0.0602 0.1209
Plasmodium falciparum glutathione reductase 0.0185 0.2745 0.6061
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.058 0.116
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0646 1 1
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0047 0.0566 0.1064
Trichomonas vaginalis mercuric reductase, putative 0.0185 0.2745 0.6278
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.003 0.003
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.1315 0.2896
Brugia malayi MH1 domain containing protein 0.0016 0.0076 0.0167
Brugia malayi RNA, U transporter 1 0.008 0.1083 0.2414
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0049 0.0602 0.1342
Leishmania major trypanothione reductase 0.0296 0.4484 0.4484
Onchocerca volvulus Dual oxidase homolog 0.008 0.1091 0.2491
Leishmania major hypothetical protein, conserved 0.0049 0.0602 0.0602
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0049 0.0602 0.115
Loa Loa (eye worm) hypothetical protein 0.0047 0.0566 0.1247
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.1315 0.263
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0186 0.0154
Loa Loa (eye worm) hypothetical protein 0.0049 0.0602 0.1326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0344 0.0568
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0136 0.1971 0.4394
Entamoeba histolytica Ran family GTPase 0.0021 0.0153 0.0074
Schistosoma mansoni ran 0.0021 0.0153 0.0252
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0049 0.0602 0.2193
Trypanosoma brucei polo-like protein kinase 0.0091 0.1265 0.1265
Echinococcus granulosus neuroligin 0.0047 0.0566 0.1133
Mycobacterium ulcerans hypothetical protein 0.0049 0.0602 0.2193
Trypanosoma brucei unspecified product 0.0013 0.003 0.003
Loa Loa (eye worm) CYP4Cod1 0.002 0.0144 0.0317
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.43 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0049 0.0602 0.1342
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0153 0.0191
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0049 0.0602 0.1205
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0186 0.0154
Loa Loa (eye worm) cytochrome P450 family protein 0.002 0.0144 0.0317
Schistosoma mansoni tar DNA-binding protein 0.02 0.2979 0.4917
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0566 0.0935
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0299 0.4538 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.1265 0.2737
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0076 0.0151
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0393 0.0393
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0049 0.0602 0.1205
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0068 0.0068
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.1265 0.2951
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0334 0.0744
Brugia malayi Carboxylesterase family protein 0.0047 0.0566 0.1262
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.3461 0.7626
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0393 0.0393
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.43 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0122 0.0121
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0211 0.0324
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0185 0.2745 0.6061
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0076 0.0125
Trypanosoma brucei cytochrome P450, putative 0.002 0.0144 0.0144
Trichomonas vaginalis spcc417.12 protein, putative 0.0047 0.0566 0.1064
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0047 0.0566 0.1133
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0186 0.0154
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0545 0.8404 0.8404
Schistosoma mansoni inositol monophosphatase 0.0036 0.0393 0.0649
Echinococcus multilocularis tar DNA binding protein 0.02 0.2979 0.596
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.2013 0.4659
Leishmania major GTP-binding protein, putative 0.0021 0.0153 0.0152
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0269 0.0599
Loa Loa (eye worm) inositol-1 0.0036 0.0393 0.0866
Giardia lamblia Thioredoxin reductase 0.0049 0.0602 0.115
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0049 0.0602 0.2193
Trichomonas vaginalis glutamate synthase, putative 0.0049 0.0602 0.115
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0049 0.0602 0.115
Echinococcus multilocularis acetylcholinesterase 0.0277 0.4197 0.8397
Loa Loa (eye worm) hypothetical protein 0.0043 0.0498 0.1098
Schistosoma mansoni tar DNA-binding protein 0.02 0.2979 0.4917
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0152 0.0334
Plasmodium falciparum thioredoxin reductase 0.0296 0.4484 1
Brugia malayi Carboxylesterase family protein 0.0047 0.0566 0.1262
Onchocerca volvulus 0.0047 0.0566 0.1098
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.058 0.116
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0185 0.2745 1
Schistosoma mansoni lipoxygenase 0.0086 0.1183 0.1953
Brugia malayi Carboxylesterase family protein 0.0047 0.0566 0.1262
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0049 0.0602 0.1326
Echinococcus multilocularis Smad4 0.0016 0.0076 0.0151
Brugia malayi hypothetical protein 0.0024 0.0211 0.0471
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.2204 0.4856
Loa Loa (eye worm) TAR-binding protein 0.02 0.2979 0.6564
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0211 0.0324
Brugia malayi MH2 domain containing protein 0.0231 0.3461 0.7717
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.3499 0.7709
Toxoplasma gondii NADPH-glutathione reductase 0.0185 0.2745 0.612
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0068 0.0068
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0076 0.0151

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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