Detailed information for compound 839261

Basic information

Technical information
  • TDR Targets ID: 839261
  • Name: 3-[(3,4-dichlorophenyl)methyl]-2-sulfanyliden e-1,3-thiazolidin-4-one
  • MW: 292.205 | Formula: C10H7Cl2NOS2
  • H donors: 0 H acceptors: 1 LogP: 3.6 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CSC(=S)N1Cc1ccc(c(c1)Cl)Cl
  • InChi: 1S/C10H7Cl2NOS2/c11-7-2-1-6(3-8(7)12)4-13-9(14)5-16-10(13)15/h1-3H,4-5H2
  • InChiKey: QIBBZBPBPUWUEK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(3,4-dichlorophenyl)methyl]-2-thioxo-thiazolidin-4-one
  • 3-[(3,4-dichlorophenyl)methyl]-2-thioxo-4-thiazolidinone
  • 3-(3,4-dichlorobenzyl)-2-thioxo-thiazolidin-4-one
  • 34392-98-8
  • BIM-0020699.P001
  • ZINC01217123
  • CBMicro_020787
  • NSC139712

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0022 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0022 0.0057 0.0086
Echinococcus multilocularis RUN 0.002 0.0032 0.0032
Brugia malayi Pyridoxal-dependent decarboxylase, pyridoxal binding domain containing protein 0.0213 0.2849 0.2849
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Echinococcus granulosus RUN 0.002 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Echinococcus granulosus cathepsin l cysteine peptidase 0.0022 0.0057 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0057 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Schistosoma mansoni polycystin 1-related 0.002 0.0032 0.0032
Schistosoma mansoni rab6-interacting 0.002 0.0032 0.0032
Onchocerca volvulus 0.002 0.0032 0.0081
Leishmania major cysteine peptidase A (CPA) 0.0022 0.0057 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0291 0.3986 0.3986
Brugia malayi Cathepsin L-like precursor 0.0022 0.0057 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0057 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0057 0.0057
Trichomonas vaginalis pyridoxal-dependent decarboxylase, putative 0.0213 0.2849 1
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0057 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Loa Loa (eye worm) doublecortin family protein 0.002 0.0032 0.0032
Loa Loa (eye worm) pyridoxal-dependent decarboxylase 0.0213 0.2849 0.2849
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Onchocerca volvulus 0.0291 0.3986 1
Onchocerca volvulus 0.0022 0.0057 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Onchocerca volvulus 0.0022 0.0057 0.0142
Loa Loa (eye worm) ShTK domain-containing protein 0.0291 0.3986 0.3986
Giardia lamblia Ornithine decarboxylase 0.0213 0.2849 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Loa Loa (eye worm) cysteine protease 0.0022 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Onchocerca volvulus 0.0291 0.3986 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.0057 0.0057
Brugia malayi Doublecortin family protein 0.002 0.0032 0.0032
Entamoeba histolytica ornithine decarboxylase, putative 0.0213 0.2849 1
Echinococcus multilocularis cysteine protease 0.0022 0.0057 0.0057
Brugia malayi Papain family cysteine protease containing protein 0.0022 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Onchocerca volvulus 0.0291 0.3986 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Onchocerca volvulus 0.0022 0.0057 0.0142
Mycobacterium ulcerans diaminopimelate decarboxylase LysA 0.0213 0.2849 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0213 0.2849 1
Onchocerca volvulus 0.0022 0.0057 0.0142
Schistosoma mansoni hypothetical protein 0.002 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0022 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0057 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Brugia malayi hypothetical protein 0.002 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Onchocerca volvulus 0.0291 0.3986 1
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0291 0.3986 0.3986
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0057 0.0199
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0057 0.0199
Brugia malayi Common central domain of tyrosinase family protein 0.0291 0.3986 0.3986
Entamoeba histolytica cysteine protease, putative 0.0022 0.0057 0.0199
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0057 0.0057
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0032 0.0032
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0022 0.0057 0.0057
Onchocerca volvulus 0.0022 0.0057 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.094 0.3298
Schistosoma mansoni tyrosinase precursor 0.0291 0.3986 0.3986
Plasmodium vivax vivapain-2 0.0022 0.0057 0.0086
Trichomonas vaginalis ornithine decarboxylase, putative 0.0076 0.085 0.2985
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Schistosoma mansoni tyrosinase precursor 0.0291 0.3986 0.3986
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0291 0.3986 0.3986
Trichomonas vaginalis diaminopimelate decarboxylase, putative 0.0213 0.2849 1
Brugia malayi Cathepsin L-like precursor 0.0022 0.0057 0.0057
Plasmodium vivax vivapain-2 0.0022 0.0057 0.0086
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0032 0.0032
Brugia malayi Cathepsin L-like precursor 0.0022 0.0057 0.0057
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0213 0.2849 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0057 0.0057
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0057 0.0199
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Brugia malayi ShTK domain containing protein 0.0291 0.3986 0.3986
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0022 0.0057 0.0057
Echinococcus granulosus cathepsin l1 0.0022 0.0057 0.0057
Toxoplasma gondii diaminopimelate decarboxylase 0.0213 0.2849 1
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Loa Loa (eye worm) ctsf protein 0.0022 0.0057 0.0057
Trypanosoma brucei ornithine decarboxylase 0.0213 0.2849 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0032
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0291 0.3986 0.3986
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Onchocerca volvulus 0.0022 0.0057 0.0142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0213 0.2849 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0702 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0022 0.0057 0.0057
Echinococcus multilocularis cysteine protease 0.0022 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0022 0.0057 0.0199
Echinococcus granulosus cathepsin L cysteine proteinase 0.0022 0.0057 0.0057
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0022 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Brugia malayi hypothetical protein 0.002 0.0032 0.0032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0702 1 1
Onchocerca volvulus Cathepsin L homolog 0.0022 0.0057 0.0142
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0702 1 1
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0291 0.3986 0.3986
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Loa Loa (eye worm) tyrosinase 1 0.0291 0.3986 0.3986
Onchocerca volvulus 0.0022 0.0057 0.0142
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0032 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0022 0.0057 1
Schistosoma mansoni loxhd1 0.002 0.0032 0.0032
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0022 0.0057 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0022 0.0057 0.0199
Schistosoma mansoni lipoxygenase 0.002 0.0032 0.0032
Loa Loa (eye worm) fibroinase 0.0022 0.0057 0.0057
Onchocerca volvulus 0.002 0.0032 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Trichomonas vaginalis ornithine decarboxylase, putative 0.0213 0.2849 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Trypanosoma cruzi cruzipain precursor, putative 0.0022 0.0057 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0702 1 1
Onchocerca volvulus Cathepsin F homolog 0.0022 0.0057 0.0142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0057 0.0057
Onchocerca volvulus 0.0213 0.2849 0.7149
Loa Loa (eye worm) hypothetical protein 0.0291 0.3986 0.3986
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0022 0.0057 0.0199
Trichomonas vaginalis ornithine decarboxylase, putative 0.0213 0.2849 1
Leishmania major cathepsin L-like protease 0.0022 0.0057 0.0199
Mycobacterium tuberculosis Diaminopimelate decarboxylase LysA (DAP decarboxylase) 0.0213 0.2849 0.5
Schistosoma mansoni rab6-interacting 0.002 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.002 0.0032 0.0032
Loa Loa (eye worm) ShTK domain-containing protein 0.0291 0.3986 0.3986
Leishmania major ornithine decarboxylase, putative 0.0213 0.2849 1
Mycobacterium leprae PROBABLE DIAMINOPIMELATE DECARBOXYLASE LYSA (DAP DECARBOXYLASE) 0.0082 0.094 0.5
Plasmodium falciparum cysteine proteinase falcipain 3 0.0022 0.0057 0.0086
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0057 0.0199

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.