Detailed information for compound 839376

Basic information

Technical information
  • TDR Targets ID: 839376
  • Name: N-(anthracen-9-ylmethylideneamino)-2-(3-methy lphenoxy)acetamide
  • MW: 368.428 | Formula: C24H20N2O2
  • H donors: 1 H acceptors: 1 LogP: 5.47 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COc1cccc(c1)C)N/N=C/c1c2ccccc2cc2c1cccc2
  • InChi: 1S/C24H20N2O2/c1-17-7-6-10-20(13-17)28-16-24(27)26-25-15-23-21-11-4-2-8-18(21)14-19-9-3-5-12-22(19)23/h2-15H,16H2,1H3,(H,26,27)/b25-15+
  • InChiKey: HDQNNNKKFOYSRI-MFKUBSTISA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(9-anthrylmethyleneamino)-2-(3-methylphenoxy)acetamide
  • N-(anthracen-9-ylmethylideneamino)-2-(3-methylphenoxy)ethanamide
  • BIM-0021059.P001
  • CBMicro_020942

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Echinococcus multilocularis lamin dm0 0.0032 0.0175 0.0175
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0026 0.0109 0.0128
Echinococcus granulosus carboxylesterase 5A 0.0075 0.0639 0.0753
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0096 0.0862 0.232
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0343 0.35 1
Schistosoma mansoni zinc finger protein 0.0027 0.0125 0.0114
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.012
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0628 0.074
Echinococcus granulosus acetylcholinesterase 0.0075 0.0639 0.0753
Loa Loa (eye worm) hypothetical protein 0.003 0.0152 0.0544
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.002 0.0051 0.0063
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.0175 0.0565
Schistosoma mansoni hypothetical protein 0.0024 0.0095 0.0079
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0043 0.03 0.1298
Schistosoma mansoni terminal deoxycytidyl transferase 0.004 0.026 0.0274
Loa Loa (eye worm) hypothetical protein 0.0176 0.1709 0.6113
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0096 0.0862 0.232
Trypanosoma cruzi trypanothione reductase, putative 0.0096 0.0862 0.232
Trypanosoma brucei DNA topoisomerase ii 0.0053 0.0397 0.1026
Brugia malayi Muscleblind-like protein 0.0176 0.1709 0.6088
Leishmania major hypothetical protein, conserved 0.0026 0.0109 0.0224
Loa Loa (eye worm) hypothetical protein 0.0045 0.0315 0.1127
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0369 0.0948
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0033 0.0013
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0051 0.0026
Leishmania major cytochrome p450-like protein 0.0023 0.008 0.0142
Brugia malayi hypothetical protein 0.0144 0.1372 0.4876
Treponema pallidum thioredoxin reductase (trxB) 0.0026 0.0109 0.011
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0026 0.0109 0.0476
Loa Loa (eye worm) hypothetical protein 0.0044 0.0302 0.1079
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0026 0.0109 0.0274
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0026 0.0109 0.0138
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0109 0.0224
Schistosoma mansoni bromodomain containing protein 0.0078 0.0673 0.0762
Trichomonas vaginalis flap endonuclease-1, putative 0.0031 0.0163 0.0265
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0096 0.0862 0.232
Giardia lamblia DINP protein human, muc B family 0.0047 0.0343 0.0789
Loa Loa (eye worm) hypothetical protein 0.0032 0.0175 0.0626
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0026 0.0109 0.0109
Trypanosoma cruzi DNA polymerase eta, putative 0.007 0.0579 0.1533
Brugia malayi Carboxylesterase family protein 0.0075 0.0639 0.2237
Trichomonas vaginalis DNA topoisomerase II, putative 0.0067 0.055 0.1392
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0073 0.0142
Brugia malayi MH2 domain containing protein 0.014 0.1333 0.4735
Toxoplasma gondii hypothetical protein 0.0057 0.0447 0.1499
Loa Loa (eye worm) hypothetical protein 0.0024 0.0097 0.0346
Leishmania major NADH dehydrogenase, putative 0.0026 0.0109 0.0224
Schistosoma mansoni hypothetical protein 0.0199 0.1961 0.2284
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0095 0.0342
Echinococcus granulosus flap endonuclease 1 0.0031 0.0163 0.0192
Onchocerca volvulus 0.0032 0.0175 0.0521
Loa Loa (eye worm) bromodomain containing protein 0.0023 0.0081 0.0288
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.0109 0.0224
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0209 0.0748
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0096 0.0862 0.232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0078 0.0664 0.2376
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0026 0.0109 0.0128
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.0288 0.072
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0043 0.03 0.2888
Echinococcus multilocularis carboxylesterase 5A 0.0075 0.0639 0.0639
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0028 0.0132 0.0289
Giardia lamblia DNA topoisomerase II 0.0064 0.0518 0.13
Loa Loa (eye worm) voltage-dependent calcium channel 0.0028 0.0132 0.0474
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.0109 0.0128
Loa Loa (eye worm) hypothetical protein 0.005 0.037 0.1322
Echinococcus granulosus thioredoxin glutathione reductase 0.0277 0.2796 0.3295
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0022 0.0071 0.0137
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0078 0.0664 0.0664
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.0109 0.0224
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0664 0.1769
Giardia lamblia Flap structure-specific endonuclease 0.0031 0.0163 0.0265
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0026 0.0109 0.0138
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0354 0.1937
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0026 0.0109 0.0224
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.014 0.0165
Echinococcus granulosus lamin 0.0032 0.0175 0.0206
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0096 0.0862 0.4495
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0048 0.0354 0.1937
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0211 0.0509
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.008 0.0685 0.0808
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0369 0.0948
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0168 0.1626 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.005 0.0369 0.0948
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0109 0.0106
Loa Loa (eye worm) hypothetical protein 0.0083 0.0723 0.2587
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0287 0.0287
Brugia malayi jmjC domain containing protein 0.0018 0.0033 0.0056
Plasmodium vivax flap endonuclease 1, putative 0.0031 0.0163 0.047
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.0618 0.0729
Trypanosoma brucei DNA polymerase eta, putative 0.007 0.0579 0.1533
Echinococcus granulosus dna polymerase eta 0.007 0.0579 0.0683
Loa Loa (eye worm) glutathione reductase 0.0277 0.2796 1
Echinococcus multilocularis zinc finger protein 0.0027 0.0125 0.0125
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0026 0.0109 0.0106
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Schistosoma mansoni inositol monophosphatase 0.0043 0.03 0.0321
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0639 0.0722
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0109 0.0224
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0033 0.012
Leishmania major DNA topoisomerase ii 0.006 0.0478 0.125
Loa Loa (eye worm) hypothetical protein 0.0144 0.1372 0.4909
Leishmania major trypanothione reductase 0.0277 0.2796 0.77
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.0574 0.0574
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0026 0.0109 0.0476
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0862 0.2903
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0026 0.0109 0.0109
Onchocerca volvulus Huntingtin homolog 0.0144 0.1372 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0026 0.0109 0.0138
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0197 0.0704
Entamoeba histolytica deoxycytidyl transferase, putative 0.004 0.026 0.0547
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.012
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.004 0.026 0.0931
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.03 0.03
Loa Loa (eye worm) MH2 domain-containing protein 0.014 0.1333 0.4769
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0073 0.0015
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.008 0.0685 0.0685
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0355 0.3622 1
Brugia malayi jmjC domain containing protein 0.0069 0.0574 0.2002
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0618 0.0697
Echinococcus granulosus muscleblind protein 0.0176 0.1709 0.2014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0058 0.0035
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.0175 0.0626
Schistosoma mansoni sulfide quinone reductase 0.0026 0.0109 0.0095
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.006 0.0478 0.125
Echinococcus granulosus phd:f box containing protein 0.0018 0.0033 0.0039
Schistosoma mansoni glutamate synthase 0.0026 0.0109 0.0095
Plasmodium falciparum glutathione reductase 0.0277 0.2796 1
Schistosoma mansoni cpg binding protein 0.0038 0.0241 0.0251
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0109 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.1628 0.4452
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0355 0.3622 1
Brugia malayi jmjC domain containing protein 0.0018 0.0033 0.0056
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0026 0.0109 0.0214
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0051 0.006
Plasmodium vivax ferrodoxin reductase, putative 0.0026 0.0109 0.0274
Loa Loa (eye worm) hypothetical protein 0.003 0.0152 0.0544
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0073 0.0007
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0096 0.0862 0.0862
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0026 0.0109 0.0106
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0755
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0073 0.0197
Mycobacterium ulcerans hypothetical protein 0.0187 0.1831 1
Echinococcus granulosus acetylcholinesterase 0.0075 0.0639 0.0753
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0302 0.0759
Mycobacterium ulcerans glutamate synthase subunit beta 0.0026 0.0109 0.0214
Echinococcus granulosus geminin 0.0199 0.1961 0.2311
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0026 0.0109 0.0224
Echinococcus granulosus dna polymerase kappa 0.0071 0.0593 0.0699
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.008 0.0285
Brugia malayi Inositol-1 0.0043 0.03 0.1015
Trichomonas vaginalis apoptosis inducing factor, putative 0.0026 0.0109 0.0106
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0078 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Echinococcus multilocularis acetylcholinesterase 0.0075 0.0639 0.0639
Schistosoma mansoni ap endonuclease 0.0022 0.0073 0.0052
Loa Loa (eye worm) programmed cell death 8 0.0026 0.0109 0.039
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0033 0.0013
Echinococcus multilocularis CREB binding protein 0.002 0.0045 0.0045
Loa Loa (eye worm) acetylcholinesterase 1 0.0075 0.0639 0.2287
Brugia malayi Bromodomain containing protein 0.0047 0.0339 0.1156
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0026 0.0109 0.0214
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0071 0.059 0.206
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.014 0.0132
Loa Loa (eye worm) hypothetical protein 0.0144 0.1372 0.4909
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0073 0.0086
Brugia malayi Cytochrome P450 family protein 0.0023 0.008 0.0223
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0058 0.0058
Brugia malayi glutathione reductase 0.0277 0.2796 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.008 0.0047
Loa Loa (eye worm) hypothetical protein 0.0018 0.0033 0.012
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.0109 0.0224
Loa Loa (eye worm) transcription factor SMAD2 0.014 0.1333 0.4769
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0026 0.0109 0.0328
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0302 0.0759
Plasmodium falciparum ferrodoxin reductase-like protein 0.0026 0.0109 0.0274
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0073 0.0122
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0168 0.1626 0.8838
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0026 0.0109 0.0214
Trypanosoma brucei unspecified product 0.0027 0.0129 0.0279
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0033 0.0006
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0033 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0071 0.0593 0.1572
Leishmania major DNA polymerase eta, putative 0.0042 0.0288 0.072
Schistosoma mansoni disulfide oxidoreductase 0.0026 0.0109 0.0095
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0058 0.0035
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0033 0.0033
Onchocerca volvulus 0.0034 0.0197 0.0695
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0122 0.1137 0.131
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0026 0.0109 0.0138
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.03 0.0663
Echinococcus multilocularis glutamate synthase 0.0026 0.0109 0.0109
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Echinococcus granulosus CREB binding protein 0.002 0.0045 0.0053
Onchocerca volvulus 0.0032 0.0175 0.0521
Toxoplasma gondii exonuclease III APE 0.0022 0.0073 0.0142
Schistosoma mansoni lamin 0.0032 0.0175 0.0173
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0026 0.0109 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.03 0.0663
Mycobacterium ulcerans ferredoxin reductase 0.0026 0.0109 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0862 0.2903
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0078 0.0664 0.0783
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.0109 0.0106
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0073 0.0073
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0109 0.0106
Trypanosoma brucei unspecified product 0.0063 0.0511 0.1342
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0039 0.0251 0.0938
Brugia malayi jmjC domain containing protein 0.0018 0.0033 0.0056
Plasmodium falciparum DNA gyrase subunit B 0.0022 0.0071 0.0137
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0078 0.0664 0.1726
Mycobacterium tuberculosis Probable dehydrogenase 0.0026 0.0109 0.0138
Schistosoma mansoni glutamate synthase 0.0026 0.0109 0.0095
Trypanosoma brucei cytochrome P450, putative 0.0023 0.008 0.0142
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0026 0.0109 0.0138
Echinococcus multilocularis thioredoxin glutathione reductase 0.0277 0.2796 0.2796
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0069 0.0574 0.0676
Loa Loa (eye worm) hypothetical protein 0.0075 0.0639 0.2287
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0755
Echinococcus multilocularis CREB binding protein 0.0084 0.0738 0.0738
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0096 0.0862 0.2903
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0031 0.0163 0.047
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0026 0.0109 0.0128
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0109 0.0106
Schistosoma mansoni cpg binding protein 0.0038 0.0241 0.0251
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0031 0.0163 0.0375
Schistosoma mansoni lamin 0.0032 0.0175 0.0173
Leishmania major hypothetical protein, conserved 0.0026 0.0109 0.0224
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0053 0.0397 0.1026
Echinococcus granulosus CREB binding protein 0.0076 0.065 0.0766
Plasmodium vivax DNA topoisomerase II, putative 0.0067 0.055 0.1869
Leishmania major mitochondrial DNA topoisomerase II 0.0053 0.0397 0.1026
Brugia malayi glutamate synthase 0.0026 0.0109 0.0328
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0109 0.0274
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0069 0.0574 0.0574
Plasmodium vivax thioredoxin reductase, putative 0.0277 0.2796 1
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0026 0.0109 0.0274
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0026 0.0109 0.0138
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Trichomonas vaginalis DNA polymerase eta, putative 0.0071 0.0593 0.152
Mycobacterium ulcerans NADH dehydrogenase 0.0026 0.0109 0.0214
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0664 0.1769
Leishmania major DNA polymerase eta, putative 0.007 0.0579 0.1533
Trypanosoma cruzi DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0071 0.0593 0.152
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.004 0.026 0.0307
Trypanosoma brucei unspecified product 0.0027 0.0129 0.0279
Trypanosoma cruzi trypanothione reductase, putative 0.0277 0.2796 0.77
Loa Loa (eye worm) intermediate filament protein 0.0032 0.0175 0.0626
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0078 0.0664 0.2327
Loa Loa (eye worm) hypothetical protein 0.008 0.0685 0.2452
Schistosoma mansoni hypothetical protein 0.0199 0.1961 0.2284
Echinococcus multilocularis voltage dependent calcium channel 0.008 0.0685 0.0685
Brugia malayi Thioredoxin reductase 0.0277 0.2796 1
Brugia malayi Bromodomain containing protein 0.0092 0.082 0.2886
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0343 0.0874
Toxoplasma gondii transporter, cation channel family protein 0.0028 0.0132 0.0359
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.004 0.026 0.026
Echinococcus granulosus zinc finger protein 0.0027 0.0125 0.0147
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0109 0.0224
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0211 0.0509
Echinococcus multilocularis dna polymerase eta 0.007 0.0579 0.0579
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0039 0.0251 0.066
Loa Loa (eye worm) TOPoisomerase family member 0.0067 0.055 0.1966
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0109 0.0106
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.0109 0.0328
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0018 0.0064
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0096 0.0862 0.3
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0026 0.0109 0.0214
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0026 0.0109 0.0274
Onchocerca volvulus Huntingtin homolog 0.0144 0.1372 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0051 0.0026
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.008 0.0685 0.0808
Echinococcus granulosus cpg binding protein 0.0038 0.0241 0.0284
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0051 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0026 0.0109 0.0106
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.008 0.0685 0.0685
Mycobacterium tuberculosis Conserved hypothetical protein 0.004 0.026 0.0693
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0026 0.0109 0.0476
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0096 0.0862 0.1016
Loa Loa (eye worm) calcium channel 0.008 0.0685 0.2452
Trypanosoma brucei DNA polymerase IV, putative 0.0063 0.0511 0.1342
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0096 0.0862 0.3
Trypanosoma brucei DNA topoisomerase II beta, putative 0.006 0.0478 0.125
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0026 0.0109 0.0274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Mycobacterium tuberculosis Probable reductase 0.0026 0.0109 0.0138
Plasmodium falciparum glutathione reductase 0.0096 0.0862 0.3
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0168 0.1628 0.4452
Mycobacterium ulcerans hypothetical protein 0.0026 0.0109 0.0214
Toxoplasma gondii NADPH-glutathione reductase 0.0096 0.0862 0.3
Echinococcus granulosus microtubule associated protein 2 0.0811 0.8486 1
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0067 0.055 0.055
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0862 0.2903
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0078 0.0092
Schistosoma mansoni hypothetical protein 0.0026 0.0109 0.0095
Schistosoma mansoni sulfide quinone reductase 0.0026 0.0109 0.0095
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0033 0.0039
Trypanosoma brucei NADH dehydrogenase 0.0026 0.0109 0.0224
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0033 0.0006
Treponema pallidum oxidoreductase 0.0026 0.0109 0.011
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0026 0.0109 0.0128
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0026 0.0109 0.0224
Brugia malayi PHD-finger family protein 0.0033 0.0192 0.0626
Plasmodium vivax glutathione reductase, putative 0.0277 0.2796 1
Schistosoma mansoni voltage-gated cation channel 0.008 0.0685 0.0777
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0033 0.0006
Schistosoma mansoni DNA topoisomerase II 0.0067 0.055 0.0616
Giardia lamblia Thioredoxin reductase 0.0026 0.0109 0.0106
Trypanosoma brucei DNA polymerase beta thumb, putative 0.005 0.0369 0.0948
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0033 0.012
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0026 0.0109 0.0106
Echinococcus multilocularis musashi 0.0032 0.0175 0.0175
Leishmania major hypothetical protein, conserved 0.0026 0.0109 0.0224
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0026 0.0109 0.0109
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0033 0.012
Loa Loa (eye worm) hypothetical protein 0.0045 0.0315 0.1127
Mycobacterium ulcerans monoxygenase 0.0026 0.0109 0.0214
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0026 0.0109 0.0106
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0067 0.055 0.0648
Brugia malayi TAZ zinc finger family protein 0.0122 0.1137 0.4028
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0033 0.0033
Echinococcus granulosus CREB binding protein 0.002 0.0045 0.0053
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0571 0.1945
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.008 0.0685 0.2403
Loa Loa (eye worm) hypothetical protein 0.0075 0.0639 0.2287
Echinococcus granulosus intermediate filament protein 0.0032 0.0175 0.0206
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0026 0.0109 0.039
Toxoplasma gondii hypothetical protein 0.0024 0.0097 0.0229
Loa Loa (eye worm) hypothetical protein 0.0028 0.0132 0.0474
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0096 0.0862 0.3
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0033 0.0033
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0096 0.0862 0.3
Echinococcus multilocularis CREB binding protein 0.002 0.0045 0.0045
Echinococcus multilocularis lamin 0.0032 0.0175 0.0175
Toxoplasma gondii selenide, water dikinase 0.0026 0.0109 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0109 0.0224
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0073 0.0122
Echinococcus multilocularis geminin 0.0199 0.1961 0.1961
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.008 0.0685 0.0777
Echinococcus granulosus voltage dependent calcium channel 0.0028 0.0132 0.0156
Schistosoma mansoni glutamate synthase 0.0026 0.0109 0.0095
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0031 0.0163 0.0375
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.008 0.0142
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0073 0.0004
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0053 0.0397 0.1026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0187 0.1831 0.6458
Trypanosoma cruzi DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0026 0.0109 0.0138
Brugia malayi jmjC domain containing protein 0.0018 0.0033 0.0056
Loa Loa (eye worm) inositol-1 0.0043 0.03 0.1072
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0755
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0026 0.0109 0.0214
Schistosoma mansoni intermediate filament proteins 0.0032 0.0175 0.0173
Trichomonas vaginalis mercuric reductase, putative 0.0096 0.0862 0.2304
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0026 0.0109 0.0106
Brugia malayi polk-prov protein 0.0044 0.0302 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0343 0.0874
Loa Loa (eye worm) hypothetical protein 0.0031 0.0169 0.0603
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0058 0.0069
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0026 0.0109 0.0274
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0618 0.2212
Loa Loa (eye worm) hypothetical protein 0.0045 0.0318 0.1137
Giardia lamblia NADH oxidase lateral transfer candidate 0.0096 0.0862 0.2304
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0026 0.0109 0.0106
Echinococcus multilocularis muscleblind protein 0.0176 0.1709 0.1709
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Chlamydia trachomatis thioredoxin reductase 0.0026 0.0109 0.0476
Loa Loa (eye worm) carboxylesterase 0.0075 0.0639 0.2287
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0033 0.0033
Giardia lamblia Fructose-bisphosphate aldolase 0.0343 0.35 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Brugia malayi Probable DNA topoisomerase II 0.0067 0.055 0.1914
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0026 0.0109 0.0138
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.0109 0.0109
Echinococcus multilocularis CREB binding protein 0.002 0.0045 0.0045
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.0109 0.0106
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.03 0.0663
Brugia malayi Flap endonuclease-1 0.0031 0.0163 0.0523
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0026 0.0109 0.0224
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.008 0.0685 0.0685
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0109 0.0274
Entamoeba histolytica Flap nuclease, putative 0.0031 0.0163 0.0265
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0026 0.0109 0.0128
Trichomonas vaginalis glutamate synthase, putative 0.0026 0.0109 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0061 0.0486 0.1272
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0048 0.0354 0.1937
Echinococcus granulosus lamin dm0 0.0032 0.0175 0.0206
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Schistosoma mansoni inositol monophosphatase 0.0043 0.03 0.0321
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0096 0.0862 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0096 0.0862 0.4495
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.03 0.0755
Mycobacterium ulcerans dehydrogenase 0.0026 0.0109 0.0214
Loa Loa (eye worm) hypothetical protein 0.0176 0.1709 0.6113
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0096 0.0862 1
Echinococcus multilocularis acetylcholinesterase 0.0075 0.0639 0.0639
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0096 0.0862 0.232
Schistosoma mansoni jumonji domain containing protein 0.0069 0.0574 0.0645
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0073 0.0122
Schistosoma mansoni cpg binding protein 0.0034 0.0197 0.0199
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0096 0.0862 0.4495
Loa Loa (eye worm) hypothetical protein 0.0021 0.0058 0.0209
Loa Loa (eye worm) hypothetical protein 0.0056 0.0433 0.155
Giardia lamblia Glutamate synthase 0.0026 0.0109 0.0106
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.004 0.026 0.0274
Loa Loa (eye worm) flap endonuclease-1 0.0031 0.0163 0.0584
Schistosoma mansoni CREB-binding protein 2 0.0122 0.1137 0.131
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0073 0.0122
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0033 0.0039
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0026 0.0109 0.0109
Plasmodium falciparum thioredoxin reductase 0.0096 0.0862 0.3
Entamoeba histolytica DNA topoisomerase II, putative 0.0067 0.055 0.1392
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0862 0.4964
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0026 0.0109 0.0106
Brugia malayi ImpB/MucB/SamB family protein 0.004 0.026 0.0872
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0026 0.0109 0.0138
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0026 0.0109 0.0214
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0073 0.026
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0343 0.35 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0026 0.0109 0.0328
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0096 0.0862 0.232
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0078 0.0664 0.0752
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0067 0.055 0.1914
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0168 0.1626 0.5708
Brugia malayi Carboxylesterase family protein 0.0075 0.0639 0.2237
Trypanosoma cruzi DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Echinococcus multilocularis cpg binding protein 0.0038 0.0241 0.0241
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0287 0.0338
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0109 0.0224
Leishmania major mitochondrial DNA polymerase beta 0.0355 0.3622 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0026 0.0109 0.0109
Toxoplasma gondii DNA topoisomerase 2, putative 0.0067 0.055 0.1869
Leishmania major hypothetical protein, conserved 0.0018 0.0033 0.0013
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0071 0.059 0.206
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0096 0.0862 0.232
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0033 0.0013
Treponema pallidum NADH oxidase 0.0096 0.0862 0.2306
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0028 0.0132 0.0289
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0628 0.0628
Trypanosoma cruzi DNA topoisomerase II, putative 0.006 0.0478 0.125
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.03 0.0353
Echinococcus multilocularis muscleblind protein 1 0.0176 0.1709 0.1709
Echinococcus granulosus voltage dependent calcium channel 0.008 0.0685 0.0808
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0067 0.055 0.1914
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0026 0.0109 0.0138
Schistosoma mansoni flap endonuclease-1 0.0028 0.0132 0.0122
Toxoplasma gondii thioredoxin reductase 0.0277 0.2796 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0078 0.0664 0.1769
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0026 0.0109 0.0214
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0026 0.0109 0.0274
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0096 0.0862 0.0986
Loa Loa (eye worm) CBP-B 0.0085 0.0749 0.2678
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0026 0.0109 0.0224
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0033 0.0006
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.008 0.0685 0.0777
Loa Loa (eye worm) hypothetical protein 0.0024 0.0097 0.0346
Loa Loa (eye worm) thioredoxin reductase 0.0277 0.2796 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0071 0.0593 0.1572
Loa Loa (eye worm) hypothetical protein 0.0054 0.0414 0.1481
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.03 0.0964
Echinococcus multilocularis dna polymerase kappa 0.0071 0.0593 0.0593
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.008 0.0142
Brugia malayi Cytochrome P450 family protein 0.0023 0.008 0.0223
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.03 0.0663
Plasmodium falciparum thioredoxin reductase 0.0277 0.2796 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.039
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0031 0.0163 0.0375
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0343 0.0996
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.008 0.0685 0.0808
Plasmodium falciparum DNA topoisomerase 2 0.0067 0.055 0.1869
Schistosoma mansoni microtubule-associated protein tau 0.0811 0.8486 1
Entamoeba histolytica thioredoxin reductase, putative 0.0026 0.0109 0.0106
Echinococcus multilocularis flap endonuclease 1 0.0031 0.0163 0.0163
Echinococcus granulosus transcription factor Dp 1 0.0045 0.0316 0.0372
Brugia malayi intermediate filament protein 0.0032 0.0175 0.0565
Loa Loa (eye worm) hypothetical protein 0.007 0.0579 0.2073
Brugia malayi Cytochrome P450 family protein 0.0035 0.0209 0.0688
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0078 0.0664 0.1769
Trypanosoma brucei DNA polymerase kappa, putative 0.0035 0.0211 0.0509
Echinococcus multilocularis transcription factor Dp 1 0.0045 0.0316 0.0316
Leishmania major DNA polymerase kappa, putative 0.0047 0.0343 0.0874
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.014 0.014
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.008 0.0685 0.0685
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0277 0.2796 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0026 0.0109 0.0106
Loa Loa (eye worm) CYP4Cod1 0.0023 0.008 0.0285
Brugia malayi CXXC zinc finger family protein 0.0034 0.0197 0.0644
Trypanosoma cruzi NADH dehydrogenase, putative 0.0026 0.0109 0.0224
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.06 0.0676
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0096 0.0862 0.232
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0026 0.0109 0.0106
Treponema pallidum fructose-bisphosphate aldolase 0.0343 0.35 1
Brugia malayi ImpB/MucB/SamB family protein 0.007 0.0579 0.2021
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0096 0.0862 0.3039
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0355 0.3622 1
Schistosoma mansoni DNA polymerase eta 0.007 0.0579 0.0651
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0168 0.1628 0.4452
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.0618 0.0697
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0073 0.0142
Trypanosoma brucei trypanothione reductase 0.0277 0.2796 0.77
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.008 0.0285
Brugia malayi jmjC domain containing protein 0.0073 0.0618 0.2162
Trichomonas vaginalis glutathione reductase, putative 0.0096 0.0862 0.2304
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0343 0.35 1
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0026 0.0109 0.0274
Echinococcus granulosus glutamate synthase 0.0026 0.0109 0.0128
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0096 0.0862 0.3
Plasmodium vivax DNA gyrase subunit B, putative 0.0022 0.0071 0.0137
Schistosoma mansoni ap endonuclease 0.0022 0.0073 0.0052
Mycobacterium ulcerans DNA polymerase IV 0.0071 0.0593 0.2967
Plasmodium falciparum flap endonuclease 1 0.0031 0.0163 0.047
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0073 0.0003
Mycobacterium ulcerans DNA polymerase IV 0.0071 0.0593 0.2967
Echinococcus multilocularis microtubule associated protein 2 0.0811 0.8486 0.8486
Trypanosoma brucei DNA polymerase IV, putative 0.0071 0.0593 0.1572
Chlamydia trachomatis DNA gyrase subunit B 0.0036 0.0224 0.1926
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0033 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0109 0.0224
Echinococcus multilocularis voltage dependent calcium channel 0.008 0.0685 0.0685
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.0288 0.092
Echinococcus granulosus CREB binding protein 0.0122 0.1137 0.134
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0096 0.0862 0.232
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0096 0.0862 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.006 0.0478 0.125
Entamoeba histolytica disulphide oxidoreductase, putative 0.0026 0.0109 0.0106

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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