Detailed information for compound 839488

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 434.387 | Formula: C21H18F4N4O2
  • H donors: 3 H acceptors: 3 LogP: 4.57 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)C1Nc2cc(nn2C(C1)C(F)(F)F)C(=O)Nc1cc(C)ccc1O
  • InChi: 1S/C21H18F4N4O2/c1-11-2-7-17(30)15(8-11)27-20(31)16-10-19-26-14(12-3-5-13(22)6-4-12)9-18(21(23,24)25)29(19)28-16/h2-8,10,14,18,26,30H,9H2,1H3,(H,27,31)
  • InChiKey: UEJMYYPUMYVQFN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0297 0.0297
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0645 0.0623
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.008 0.002
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0439 0.0381
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.017 0.0205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0029
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0027 0.0297 0.0667
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0144 0.0146
Schistosoma mansoni lamin 0.0054 0.0796 0.0775
Plasmodium vivax SET domain protein, putative 0.0029 0.0326 0.4694
Echinococcus multilocularis geminin 0.0338 0.6168 0.6159
Brugia malayi conserved hypotetical protein 0.0013 0.0024 0.0024
Plasmodium vivax glutathione reductase, putative 0.0046 0.0645 1
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0053 0.0053
Leishmania major hypothetical protein, conserved 0.0035 0.0439 0.0381
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Loa Loa (eye worm) hypothetical protein 0.0035 0.0439 0.0416
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.008 0.002
Brugia malayi nuclear hormone receptor 0.0013 0.0024 0.0024
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0479 0.0901
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0645 0.0623
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0645 0.1446
Echinococcus multilocularis bloom syndrome protein 0.0021 0.017 0.0147
Onchocerca volvulus 0.0054 0.0796 0.1889
Loa Loa (eye worm) glutathione reductase 0.0046 0.0645 0.0623
Plasmodium falciparum thioredoxin reductase 0.0046 0.0645 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0144 0.0144
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0326 0.0303
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.4507 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0326 0.0303
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0144 1
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0201 0.358 0.3542
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0081
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0027 0.0297 0.0274
Trichomonas vaginalis set domain proteins, putative 0.0229 0.4116 0.9116
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0024 0.0024
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.106 0.1039
Brugia malayi nuclear hormone receptor family member nhr-6 0.0013 0.0024 0.0024
Schistosoma mansoni intermediate filament proteins 0.0054 0.0796 0.0775
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0297 0.0274
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0479 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0027 0.0297 0.0297
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0105 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0027 0.0297 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.4507 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0144 0.0166
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0479 0.365
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0029
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0105 0.0064
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0306 0.0283
Loa Loa (eye worm) hypothetical protein 0.0016 0.0091 0.0068
Mycobacterium tuberculosis Probable reductase 0.0104 0.1754 0.4282
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0027 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.008 0.0596
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0105 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0014 0.0053 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0027 0.0297 0.0297
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.008 0.002
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0324 0.0301
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0796 0.0796
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.4109 0.4095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0252 0.0229
Toxoplasma gondii exonuclease III APE 0.0019 0.0144 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.008 0.002
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.106 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.008 0.002
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0439 0.0918
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0297 0.0297
Trichomonas vaginalis esterase, putative 0.0035 0.0439 0.0811
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0439 0.9001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0439 0.0918
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0439 0.0416
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1754 0.4282
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2881 0.6328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0027 0.0297 0.0274
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0105 0.1011
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0541 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0027 0.0297 0.0274
Schistosoma mansoni zinc finger protein 0.0015 0.006 0.0036
Brugia malayi Steroid receptor seven-up type 2 0.0027 0.0297 0.0297
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1974 0.4845
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.4507 1
Schistosoma mansoni hypothetical protein 0.0338 0.6168 0.6159
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0479 0.0421
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.027 0.0247
Echinococcus granulosus lamin 0.0054 0.0796 0.0775
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.106 0.1006
Brugia malayi ecdysteroid receptor 0.0027 0.0297 0.0297
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0439 0.9001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0045 0.0638 0.0616
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0027 0.0297 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.4507 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2881 0.6328
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.106 0.1006
Brugia malayi hypothetical protein 0.0014 0.0053 0.0053
Brugia malayi Nuclear hormone receptor E75 0.0013 0.0024 0.0024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0638 0.0616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0645 0.0623
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0105 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0027 0.0297 0.0297
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0144 0.1625
Brugia malayi Pre-SET motif family protein 0.0202 0.3589 0.3589
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0541 1 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.4507 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0645 0.0645
Brugia malayi Pre-SET motif family protein 0.0029 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.0035 0.0439 0.0416
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1754 0.8596
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0092 0.0068
Schistosoma mansoni hypothetical protein 0.0122 0.2084 0.2065
Brugia malayi isocitrate dehydrogenase 0.0017 0.0105 0.0105
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Brugia malayi tailless protein 0.0013 0.0024 0.0024
Mycobacterium tuberculosis Conserved protein 0.0035 0.0439 0.0918
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0192 0.0169
Echinococcus granulosus lamin dm0 0.0054 0.0796 0.0775
Toxoplasma gondii ABC1 family protein 0.0035 0.0439 0.04
Onchocerca volvulus Bile acid receptor homolog 0.0027 0.0297 0.0667
Brugia malayi follicle stimulating hormone receptor 0.0229 0.4109 0.4109
Toxoplasma gondii thioredoxin reductase 0.0046 0.0645 0.0607
Schistosoma mansoni RAR-like nuclear receptor 0.0027 0.0297 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2881 0.6328
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0201 0.358 0.3542
Echinococcus granulosus bloom syndrome protein 0.0021 0.017 0.0147
Mycobacterium leprae Probable lipase LipE 0.0035 0.0439 0.0213
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0029
Loa Loa (eye worm) hypothetical protein 0.0054 0.0796 0.0775
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0014 0.0053 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0027 0.0297 0.0297
Echinococcus multilocularis ecdysone induced protein 78C 0.0027 0.0297 0.0274
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0027 0.0297 0.0274
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0105 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.3589 0.3574
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0645 0.0623
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0103 0.008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0439 0.0416
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.2084 0.2065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0645 0.0623
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.106 0.106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Schistosoma mansoni thyroid hormone receptor 0.0149 0.2601 0.2584
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0324 0.0324
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0105 0.0081
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0439 0.0918
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1754 0.4282
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0541 1 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0326 0.0287
Onchocerca volvulus 0.0027 0.0297 0.0667
Echinococcus granulosus ecdysone induced protein 78C 0.0027 0.0297 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0439 0.0381
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0479 0.0421
Schistosoma mansoni lamin 0.0054 0.0796 0.0775
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0521 0.0498
Mycobacterium tuberculosis Conserved protein 0.0035 0.0439 0.0918
Brugia malayi nuclear hormone receptor family member odr-7 0.0013 0.0024 0.0024
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.4507 0.4507
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0123 0.0764
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0645 0.0623
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0439 0.0811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0645 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0027 0.0297 0.0297
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0027 0.0297 0.0297
Toxoplasma gondii fructose-bisphospatase II 0.0541 1 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.1074 0.1053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0144 0.0085
Brugia malayi Bromodomain containing protein 0.0037 0.0481 0.0481
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0088 0.0065
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0541 1 1
Onchocerca volvulus 0.0054 0.0796 0.1889
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0014 0.0053 0.0029
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0081
Echinococcus multilocularis musashi 0.0054 0.0796 0.0775
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.106 0.1039
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.106 0.1039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0144 0.1146
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0027 0.0297 0.0274
Plasmodium falciparum glutathione reductase 0.0046 0.0645 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0439 0.0416
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0479 0.0456
Brugia malayi PHD-finger family protein 0.0024 0.0236 0.0236
Loa Loa (eye worm) hypothetical protein 0.0026 0.027 0.0247
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.008 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Onchocerca volvulus Protein ultraspiracle homolog 0.0027 0.0297 0.0667
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0541 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0326 0.0303
Mycobacterium ulcerans hypothetical protein 0.0035 0.0439 0.9001
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0201 0.358 0.3542
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0105 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0439 0.0811
Echinococcus granulosus intermediate filament protein 0.0054 0.0796 0.0775
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0027 0.0297 0.0274
Onchocerca volvulus 0.0229 0.4116 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0873 0.0851
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0144 0.0085
Echinococcus granulosus geminin 0.0338 0.6168 0.6159
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1974 0.4845
Toxoplasma gondii fructose-bisphospatase I 0.0201 0.358 0.3554
Schistosoma mansoni ap endonuclease 0.0019 0.0144 0.0121
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.008 0.008
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.008 0.0056
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0105 0.0081
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0027 0.0297 0.0274
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0105 0.0105
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0092 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2881 0.6328
Schistosoma mansoni hypothetical protein 0.002 0.0157 0.0134
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0645 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0439 0.0381
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0479 0.0421
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0439 0.0918
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.2084 0.2065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0045 0.0638 0.0616
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0201 0.358 0.3554
Brugia malayi intermediate filament protein 0.0054 0.0796 0.0796
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0439 0.0416
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0105 0.0081
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1754 0.4282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0027 0.0297 0.0274
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0157 0.0134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0027 0.0297 0.0274
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0144 0.0121
Loa Loa (eye worm) hypothetical protein 0.0053 0.0778 0.0756
Brugia malayi ecdysone receptor 0.0013 0.0024 0.0024
Loa Loa (eye worm) inositol-1 0.0037 0.0479 0.0456
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0479 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0027 0.0297 0.0274
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0027 0.0297 0.0274
Schistosoma mansoni ap endonuclease 0.0019 0.0144 0.0121
Echinococcus multilocularis lamin 0.0054 0.0796 0.0775
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0144 0.0085
Loa Loa (eye worm) hypothetical protein 0.0035 0.0439 0.0416
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0405 0.0833
Leishmania major trypanothione reductase 0.0046 0.0645 0.0589
Brugia malayi Inositol-1 0.0037 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0041 0.056 0.0538
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0013 0.0024 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0796 0.0775
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0092 0.0068
Echinococcus multilocularis lamin dm0 0.0054 0.0796 0.0775
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.027 0.0247
Schistosoma mansoni inositol monophosphatase 0.0037 0.0479 0.0456
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0027 0.0297 0.0274
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0105 0.0081
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.008 0.002
Brugia malayi nuclear receptor RXR 0.0013 0.0024 0.0024
Echinococcus multilocularis thyroid hormone receptor alpha 0.0149 0.2601 0.2584
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0144 0.0085
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1974 0.4845
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0027 0.0297 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0027 0.0297 0.0297
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0873 0.0851
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2881 0.6328
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.3048 0.6706
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0027 0.0297 0.0274
Brugia malayi nuclear hormone receptor 0.0027 0.0297 0.0297
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.4507 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0144 0.0121
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0105 0.0045
Onchocerca volvulus 0.0035 0.0439 0.1015
Brugia malayi hypothetical protein 0.0164 0.2887 0.2887
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0144 0.0121
Loa Loa (eye worm) hypothetical protein 0.0039 0.0525 0.0503
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0437 0.0415
Loa Loa (eye worm) RecQ helicase 0.0021 0.017 0.0147
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0479 0.044
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0014 0.0053 0.0029
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0092 0.0068
Onchocerca volvulus 0.0029 0.0326 0.0739
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.008 0.5
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.008 0.0056
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1754 0.4282
Schistosoma mansoni hypothetical protein 0.0015 0.006 0.0036
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0645 1
Brugia malayi nuclear receptor NHR-67 0.0013 0.0024 0.0024
Brugia malayi nuclear receptor NHR-88 0.0027 0.0297 0.0297
Onchocerca volvulus 0.0035 0.0439 0.1015
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1754 0.4282
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.399 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0192 0.0169
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.008 0.002
Brugia malayi beta-lactamase family protein 0.0035 0.0439 0.0439
Brugia malayi Bromodomain containing protein 0.0073 0.1153 0.1153
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.4507 0.4494
Loa Loa (eye worm) hypothetical protein 0.0045 0.0638 0.0616
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0521 0.0498
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.008 0.002
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0027 0.0297 0.0274
Schistosoma mansoni steroid hormone receptor ad4bp 0.0027 0.0297 0.0274
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0479 0.0456
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0144 1
Brugia malayi nuclear receptor RXR 0.0014 0.0053 0.0053
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0479 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0014 0.0053 0.0029
Mycobacterium tuberculosis Conserved protein 0.0035 0.0439 0.0918
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0297 0.0297
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0645 0.0623
Brugia malayi beta-lactamase family protein 0.0035 0.0439 0.0439
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2881 0.6328
Brugia malayi beta-lactamase 0.0035 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Echinococcus granulosus FTZ F1 alpha 0.0027 0.0297 0.0274
Schistosoma mansoni bromodomain containing protein 0.0061 0.0938 0.0917
Brugia malayi hypothetical protein 0.0013 0.0024 0.0024
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0439 0.0416
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0439 0.0416
Schistosoma mansoni nuclear hormone receptor 0.0027 0.0297 0.0274
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0027 0.0297 0.0274
Mycobacterium ulcerans lipase LipD 0.0035 0.0439 0.9001
Echinococcus multilocularis FTZ F1 alpha 0.0027 0.0297 0.0274
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.017 0.0205
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0144 0.0146
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0027 0.0297 0.0274
Brugia malayi nuclear receptor NHR-88 0.0013 0.0024 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0439 0.6567
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0027 0.0297 0.0274
Schistosoma mansoni retinoic acid receptor RXR 0.0027 0.0297 0.0274
Schistosoma mansoni hypothetical protein 0.0338 0.6168 0.6159
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0645 0.0623
Echinococcus granulosus zinc finger protein 0.0019 0.0138 0.0115
Brugia malayi glutathione reductase 0.0046 0.0645 0.0645
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0439 0.0918
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Echinococcus granulosus histone lysine methyltransferase setb 0.0045 0.0638 0.0616
Onchocerca volvulus 0.0035 0.0439 0.1015
Schistosoma mansoni inositol monophosphatase 0.0037 0.0479 0.0456
Schistosoma mansoni hypothetical protein 0.0056 0.0843 0.0822
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0014 0.0053 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0297 0.0274
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0144 0.1674
Loa Loa (eye worm) hypothetical protein 0.0014 0.0053 0.0029
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0796 0.0775
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0297 0.0274
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.106 0.1006
Schistosoma mansoni zinc finger protein 0.0019 0.0138 0.0115
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0541 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.3048 0.6706
Brugia malayi photoreceptor-specific nuclear receptor 0.0027 0.0297 0.0297
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0439 0.0918
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0252 0.0229
Brugia malayi orphan nuclear receptor NR2E1 0.0013 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0027 0.0297 0.0274
Schistosoma mansoni thyroid hormone receptor 0.0149 0.2601 0.2584
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0027 0.0297 0.0297
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0105 0.0045
Brugia malayi Thioredoxin reductase 0.0046 0.0645 0.0645
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0437 0.0415
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.106 0.1039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0479 0.0901
Brugia malayi steroid hormone receptor 0.0027 0.0297 0.0297
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.008 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0027 0.0297 0.0274
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0105 0.0081
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0541 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0439 0.0811
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.008 0.0596
Leishmania major 0.0541 1 1
Trypanosoma brucei trypanothione reductase 0.0046 0.0645 0.0589
Loa Loa (eye worm) hypothetical protein 0.0027 0.0297 0.0274
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1974 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.106 0.1006
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0297 0.0297
Brugia malayi hypothetical protein 0.0014 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0164 0.2887 0.287
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.2881 0.6984
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0479 0.0901
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0439 0.0213
Loa Loa (eye worm) beta-lactamase 0.0035 0.0439 0.0416
Mycobacterium ulcerans beta-lactamase 0.0035 0.0439 0.9001
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0144 0.1625
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0439 0.0439
Brugia malayi hypothetical protein 0.0013 0.0024 0.0024
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.008 0.0039
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0439 0.0811
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.008 0.002
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0645 0.0589
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0192 0.0169
Echinococcus multilocularis zinc finger protein 0.0019 0.0138 0.0115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0439 0.0416
Loa Loa (eye worm) hypothetical protein 0.0037 0.0482 0.046
Loa Loa (eye worm) hypothetical protein 0.0035 0.0439 0.0416
Loa Loa (eye worm) steroid hormone receptor 0.0027 0.0297 0.0274
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.002
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0439 0.0918
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0439 0.0811
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0105 0.0441
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.2881 0.6328
Schistosoma mansoni coup transcription factor 0.0027 0.0297 0.0274
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0645 0.0623
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0027 0.0297 0.0274
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0027 0.0297 0.0274
Onchocerca volvulus 0.0164 0.2887 0.6998

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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