Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0033 | 0.1061 | 0.3622 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0025 | 0.0713 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0526 | 0.185 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0183 | 0.7845 | 1 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0025 | 0.0713 | 0.2412 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0025 | 0.0713 | 0.1424 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0017 | 0.036 | 0.1157 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0034 | 0.1126 | 0.3962 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0037 | 0.1279 | 0.4391 |
Plasmodium falciparum | glutathione reductase | 0.0025 | 0.0713 | 0.2412 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0017 | 0.0361 | 0.127 |
Plasmodium falciparum | thioredoxin reductase | 0.0025 | 0.0713 | 0.2412 |
Trypanosoma brucei | trypanothione reductase | 0.0072 | 0.2842 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.1279 | 0.4501 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.1279 | 0.4501 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0037 | 0.1237 | 0.4244 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0037 | 0.1237 | 0.1206 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0072 | 0.2842 | 0.3164 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0025 | 0.0713 | 0.2412 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0021 | 0.0526 | 0.5 |
Plasmodium vivax | glutathione reductase, putative | 0.0072 | 0.2842 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0017 | 0.036 | 0.1157 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0526 | 0.1746 |
Toxoplasma gondii | hypothetical protein | 0.0017 | 0.036 | 0.1157 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0037 | 0.1237 | 0.4354 |
Echinococcus granulosus | intermediate filament protein | 0.0017 | 0.0361 | 0.1149 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0037 | 0.1237 | 0.5423 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.005 | 0.1838 | 0.6423 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0361 | 0.127 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0036 | 0.0126 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.005 | 0.1838 | 0.1809 |
Echinococcus multilocularis | lamin dm0 | 0.0017 | 0.0361 | 0.1149 |
Brugia malayi | jmjC domain containing protein | 0.001 | 0.0036 | 0.0126 |
Plasmodium falciparum | thioredoxin reductase | 0.0072 | 0.2842 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0036 | 0.0126 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0164 | 0.7016 | 0.8867 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0526 | 0.1746 |
Echinococcus multilocularis | lamin | 0.0017 | 0.0361 | 0.1149 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0037 | 0.1237 | 0.4282 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0021 | 0.0526 | 0.1731 |
Loa Loa (eye worm) | intermediate filament protein | 0.0017 | 0.0361 | 0.127 |
Schistosoma mansoni | lamin | 0.0017 | 0.0361 | 0.0326 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0021 | 0.0526 | 0.1746 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0025 | 0.0713 | 0.2412 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 0.6365 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0037 | 0.1237 | 0.4244 |
Echinococcus granulosus | lamin | 0.0017 | 0.0361 | 0.1149 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.1279 | 0.4391 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0033 | 0.1061 | 0.0732 |
Toxoplasma gondii | thioredoxin reductase | 0.0072 | 0.2842 | 1 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0025 | 0.0713 | 0.2412 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0072 | 0.2842 | 1 |
Echinococcus multilocularis | musashi | 0.0017 | 0.0361 | 0.1149 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0025 | 0.0713 | 0.2412 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0025 | 0.0713 | 0.0255 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0183 | 0.7845 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.1279 | 0.4391 |
Schistosoma mansoni | intermediate filament proteins | 0.0017 | 0.0361 | 0.0326 |
Brugia malayi | jmjC domain containing protein | 0.001 | 0.0036 | 0.0126 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1838 | 0.6468 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.001 | 0.0036 | 0.0126 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0025 | 0.0713 | 0.1424 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0021 | 0.0526 | 0.1731 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0025 | 0.0713 | 0.2508 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0025 | 0.0713 | 0.2412 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0526 | 0.0492 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0164 | 0.7016 | 0.8867 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.1279 | 0.1248 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0526 | 0.1746 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 0.6423 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 0.6365 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0037 | 0.1279 | 0.4391 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0037 | 0.1237 | 0.5423 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0017 | 0.0361 | 0.127 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0025 | 0.0713 | 0.1424 |
Plasmodium falciparum | glutathione reductase | 0.0072 | 0.2842 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.001 | 0.0036 | 0.0126 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0073 | 0.2867 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0526 | 0.1746 |
Onchocerca volvulus | 0.0017 | 0.0361 | 0.5 | |
Plasmodium vivax | thioredoxin reductase, putative | 0.0072 | 0.2842 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0164 | 0.7016 | 0.8892 |
Brugia malayi | Probable ClpP-like protease | 0.005 | 0.1838 | 0.6468 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Brugia malayi | jmjC domain containing protein | 0.001 | 0.0036 | 0.0126 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0183 | 0.7845 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0025 | 0.0713 | 0.2412 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0037 | 0.1237 | 0.0972 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.005 | 0.1838 | 0.6423 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.1279 | 0.4501 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0025 | 0.0713 | 0.2391 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0526 | 0.1746 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0072 | 0.2842 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0037 | 0.1279 | 0.1248 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0025 | 0.0713 | 0.2412 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0025 | 0.0713 | 0.2412 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0025 | 0.0713 | 0.0679 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0033 | 0.1061 | 0.0937 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.005 | 0.1838 | 0.1974 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 1 |
Brugia malayi | intermediate filament protein | 0.0017 | 0.0361 | 0.127 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0025 | 0.0713 | 0.2412 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0713 | 0.1424 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0036 | 0.0126 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0073 | 0.2867 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.1279 | 0.1248 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0025 | 0.0713 | 0.2412 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0025 | 0.0713 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0526 | 0.185 |
Toxoplasma gondii | exonuclease III APE | 0.0021 | 0.0526 | 0.1746 |
Loa Loa (eye worm) | glutathione reductase | 0.0072 | 0.2842 | 1 |
Onchocerca volvulus | 0.0017 | 0.0361 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0017 | 0.0361 | 0.1149 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0164 | 0.7016 | 0.8867 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0164 | 0.7016 | 0.8867 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0183 | 0.7845 | 1 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0164 | 0.7016 | 0.8867 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0025 | 0.0713 | 0.1424 |
Treponema pallidum | NADH oxidase | 0.0025 | 0.0713 | 0.2385 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0025 | 0.0713 | 0.2412 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0025 | 0.0713 | 0.2391 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0025 | 0.0713 | 0.2412 |
Mycobacterium tuberculosis | Probable reductase | 0.0164 | 0.7016 | 0.8867 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.001 | 0.0036 | 0.0126 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0033 | 0.1061 | 0.3622 |
Brugia malayi | Thioredoxin reductase | 0.0072 | 0.2842 | 1 |
Brugia malayi | jmjC domain containing protein | 0.001 | 0.0036 | 0.0126 |
Schistosoma mansoni | lamin | 0.0017 | 0.0361 | 0.0326 |
Schistosoma mansoni | ap endonuclease | 0.0021 | 0.0526 | 0.0492 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0033 | 0.1061 | 0.0732 |
Leishmania major | trypanothione reductase | 0.0072 | 0.2842 | 1 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0018 | 0.0413 | 0.1453 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.005 | 0.1838 | 1 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0018 | 0.0413 | 0.1453 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0025 | 0.0713 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.005 | 0.1838 | 0.6423 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0347 | 0.122 |
Brugia malayi | glutathione reductase | 0.0072 | 0.2842 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0025 | 0.0713 | 0.2412 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0526 | 0.112 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.