Detailed information for compound 839642

Basic information

Technical information
  • TDR Targets ID: 839642
  • Name: N-[(2,4-dimethoxyphenyl)methylideneamino]-2-( 4-methylphenyl)quinazolin-4-amine
  • MW: 398.457 | Formula: C24H22N4O2
  • H donors: 1 H acceptors: 2 LogP: 5.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(OC)ccc1C=NNc1nc(nc2c1cccc2)c1ccc(cc1)C
  • InChi: 1S/C24H22N4O2/c1-16-8-10-17(11-9-16)23-26-21-7-5-4-6-20(21)24(27-23)28-25-15-18-12-13-19(29-2)14-22(18)30-3/h4-15H,1-3H3,(H,26,27,28)/b25-15+
  • InChiKey: ALTHSGHPTSPSFL-MFKUBSTISA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(2,4-dimethoxyphenyl)methyleneamino]-2-(4-methylphenyl)quinazolin-4-amine
  • N-[(2,4-dimethoxyphenyl)methyleneamino]-2-(4-methylphenyl)-4-quinazolinamine
  • [(2,4-dimethoxybenzylidene)amino]-[2-(4-methylphenyl)quinazolin-4-yl]amine
  • CBMicro_020924
  • Neuro1_000620
  • BIM-0020882.P001

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.124
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0075 0.0674
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0075 0.0674
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0001 0.0009
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0026 0.0088
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0001 0.0002
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0174 0.0208
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0075 0.0531
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0075 0.0531
Echinococcus multilocularis geminin 0.017 0.1107 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0111 0.4894
Brugia malayi beta-lactamase family protein 0.0035 0.0174 0.124
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0003 0.0021
Loa Loa (eye worm) glutathione reductase 0.0039 0.02 0.1424
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0075 0.0674
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0057
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0008 0.0072
Brugia malayi ecdysteroid receptor 0.002 0.0075 0.0531
Schistosoma mansoni cpg binding protein 0.0029 0.0136 0.1226
Trichomonas vaginalis MYB, putative 0.001 0.0001 0.0002
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0075 0.0674
Onchocerca volvulus 0.0151 0.098 0.6099
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0075 0.0674
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0203 0.1838
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0609 0.0817
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0057
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0075 0.0464
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0026 0.0183
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0212 0.1403 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0075 0.0674
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0251 0.2269
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0174 0.0208
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0174 0.8522
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0008 0.0057
Onchocerca volvulus 0.0035 0.0174 0.1084
Schistosoma mansoni cpg binding protein 0.0031 0.0147 0.133
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0026 0.0154
Trypanosoma brucei trypanothione reductase 0.0039 0.02 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0075 0.0531
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0075 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0075 0.0531
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0174 0.8522
Brugia malayi hypothetical protein 0.0151 0.098 0.6979
Echinococcus granulosus FTZ F1 alpha 0.002 0.0075 0.0674
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.041 0.2771 0.2753
Plasmodium falciparum thioredoxin reductase 0.0039 0.02 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.0151 0.098 0.6979
Mycobacterium tuberculosis Conserved protein 0.0035 0.0174 0.0208
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0148 0.1338
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0075 0.0674
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0174 0.1078
Plasmodium vivax SET domain protein, putative 0.0031 0.0148 0.7027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0075 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0075 0.0531
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0075 0.0531
Mycobacterium ulcerans lipase LipD 0.0035 0.0174 0.0149
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0001 0.5
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0001 0.0002
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0008 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0075 0.0674
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0075 0.0531
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0174 0.0149
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0324 0.1166
Schistosoma mansoni hypothetical protein 0.0012 0.0013 0.0118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0075 0.0674
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0174 0.1078
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0251 0.2269
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Loa Loa (eye worm) hypothetical protein 0.0026 0.0111 0.079
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0111 0.4894
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0013 0.0118
Loa Loa (eye worm) hypothetical protein 0.0031 0.0148 0.1055
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.1471 0.2025
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0075 0.0674
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.02 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0075 0.0531
Trichomonas vaginalis esterase, putative 0.0035 0.0174 0.1078
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1455 1 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0075 0.0674
Brugia malayi glutathione reductase 0.0039 0.02 0.1424
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0609 0.0622
Brugia malayi hypothetical protein 0.0017 0.0048 0.0342
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0001 0.0009
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0111 0.4894
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0004 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0174 0.8522
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0541 0.0722
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0609 0.0817
Mycobacterium tuberculosis Probable reductase 0.0088 0.0541 0.0722
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0111 0.4894
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0026 0.0233
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0075 0.0674
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.124
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0136 0.0967
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0075 0.0531
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0075 0.0674
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0026 0.0233
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0075 0.0674
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0001 0.5
Trichomonas vaginalis set domain proteins, putative 0.0242 0.1606 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.124
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0251 0.2269
Brugia malayi Pre-SET motif family protein 0.0031 0.0148 0.1055
Onchocerca volvulus 0.0031 0.0148 0.0922
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0174 0.0208
Brugia malayi beta-lactamase family protein 0.0035 0.0174 0.124
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.02 0.0244
Schistosoma mansoni hypothetical protein 0.017 0.1107 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0075 0.0531
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0251 0.1788
Brugia malayi CXXC zinc finger family protein 0.0029 0.0136 0.0967
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0075 0.0674
Schistosoma mansoni cpg binding protein 0.0031 0.0147 0.133
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0136 0.1228
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0148 0.1338
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0075 0.0674
Brugia malayi hypothetical protein 0.0011 0.0008 0.0057
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.041 0.2771 1
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1045 0.7162 1
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.041 0.2771 0.2753
Brugia malayi nuclear hormone receptor 0.002 0.0075 0.0531
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0057
Echinococcus multilocularis cpg binding protein 0.0031 0.0147 0.133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0075 0.0531
Mycobacterium tuberculosis Conserved protein 0.0035 0.0174 0.0208
Loa Loa (eye worm) beta-lactamase 0.0035 0.0174 0.124
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0075 0.0674
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0075 0.0674
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0001 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0174 0.1078
Schistosoma mansoni hypothetical protein 0.017 0.1107 1
Onchocerca volvulus 0.0035 0.0174 0.1084
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0541 0.0525
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0609 0.0817
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1045 0.7162 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0174 0.1078
Toxoplasma gondii thioredoxin reductase 0.0039 0.02 0.0716
Onchocerca volvulus 0.002 0.0075 0.0464
Leishmania major hypothetical protein, conserved 0.0035 0.0174 0.8522
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0075 0.0674
Schistosoma mansoni coup transcription factor 0.002 0.0075 0.0674
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0174 0.1573
Brugia malayi Pre-SET motif family protein 0.0212 0.1403 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0148 0.053
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0174 0.124
Onchocerca volvulus 0.0035 0.0174 0.1084
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0174 0.0208
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0026 0.0233
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0008 0.0072
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.02 0.1424
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0013 0.0118
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0057
Leishmania major hypothetical protein, conserved 0.0026 0.0111 0.4894
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0111 0.4894
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0203 0.1838
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0001 0.5
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0026 0.0154
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0008 0.0057
Leishmania major trypanothione reductase 0.0039 0.02 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0541 0.0722
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0148 0.1338
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.124
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0541 0.0722
Schistosoma mansoni thyroid hormone receptor 0.002 0.0075 0.0674
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0075 0.0531
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0008 0.0057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.124
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0075 0.0464
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0075 0.0674
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0004 0.0034
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0174 0.124
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0174 0.1573
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0251 0.1788
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0541 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0075 0.0531
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0026 0.0088
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0075 0.0464
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0075 0.0531
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0075 0.0531
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0174 0.0208
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0057
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0075 0.0674
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0075 0.0531
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0174 0.0208
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0148 0.1338
Loa Loa (eye worm) hypothetical protein 0.0035 0.0174 0.124
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1455 1 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0004 0.0027
Brugia malayi steroid hormone receptor 0.002 0.0075 0.0531
Plasmodium vivax glutathione reductase, putative 0.0039 0.02 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0026 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.037 0.3345
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0174 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0148 0.1338
Schistosoma mansoni thyroid hormone receptor 0.002 0.0075 0.0674
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0251 0.2269
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0075 0.0531
Echinococcus granulosus geminin 0.017 0.1107 1
Brugia malayi nuclear receptor RXR 0.0011 0.0008 0.0057
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0008 0.0072
Brugia malayi hypothetical protein 0.0011 0.0008 0.0057
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0075 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0075 0.0531
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0148 0.1338
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0075 0.0531
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0251 0.2269
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0075 0.0531
Mycobacterium ulcerans hypothetical protein 0.0035 0.0174 0.0149
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1455 1 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.041 0.2771 0.3717
Onchocerca volvulus 0.0242 0.1606 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0541 0.0722
Toxoplasma gondii ABC1 family protein 0.0035 0.0174 0.0623
Mycobacterium tuberculosis Conserved protein 0.0035 0.0174 0.0208
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0251 0.2269
Brugia malayi beta-lactamase 0.0035 0.0174 0.124
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0075 0.0674
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.02 1
Plasmodium falciparum glutathione reductase 0.0039 0.02 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0075 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0075 0.0531
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0111 0.0395
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0174 0.8522
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0075 0.0674
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0174 0.1573
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0075 0.0674
Mycobacterium ulcerans beta-lactamase 0.0035 0.0174 0.0149
Echinococcus granulosus cpg binding protein 0.0031 0.0147 0.133
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0251 0.2269
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0075 0.0531
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0174 0.1573
Brugia malayi hypothetical protein 0.0026 0.0111 0.079
Onchocerca volvulus 0.0029 0.0136 0.0845
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0075 0.0531
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0174 0.1078
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0111 0.4894
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0174 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0148 0.1338
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0075 0.0674
Brugia malayi Thioredoxin reductase 0.0039 0.02 0.1424

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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