Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0124 | 0.2663 | 0.8755 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0026 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0026 | 0.0298 | 0.0948 |
Brugia malayi | ecdysteroid receptor | 0.0026 | 0.0298 | 0.0948 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.1291 | 0.4243 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0017 | 0.0082 | 0.0261 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0026 | 0.0298 | 0.0298 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.1291 | 0.1291 |
Schistosoma mansoni | nuclear hormone receptor | 0.0026 | 0.0298 | 0.0298 |
Echinococcus multilocularis | protein patched | 0.0055 | 0.0986 | 0.2993 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0026 | 0.0298 | 0.0948 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0883 | 0.2682 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.0298 | 0.0948 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.0298 | 0.0978 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.0298 | 0.0903 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0026 | 0.0298 | 0.0948 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0017 | 0.0082 | 0.0261 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0529 | 0.4113 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0026 | 0.0298 | 0.0903 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 0.287 | 1 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0529 | 0.1686 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.2663 | 0.2663 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0055 | 0.0986 | 0.314 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.1291 | 0.4243 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Schistosoma mansoni | patched 1 | 0.0055 | 0.0986 | 0.0986 |
Brugia malayi | CHE-14 protein | 0.0055 | 0.0986 | 0.314 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0529 | 0.174 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.1291 | 0.3919 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0529 | 0.1686 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0529 | 0.1686 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0017 | 0.0082 | 0.0261 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.0883 | 0.2814 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0055 | 0.0986 | 0.2993 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0026 | 0.0298 | 0.0948 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0026 | 0.0298 | 0.0903 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0529 | 0.1686 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0082 | 0.0261 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0151 | 0.3294 | 1 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0017 | 0.0082 | 0.0269 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0082 | 0.0261 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0026 | 0.0298 | 0.0903 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0688 | 1 |
Onchocerca volvulus | 0.0036 | 0.0529 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0082 | 0.0261 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0529 | 0.1686 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0529 | 0.0529 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0529 | 0.4113 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0026 | 0.0298 | 0.0948 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.0298 | 0.0948 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0529 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.0298 | 0.0978 |
Echinococcus granulosus | FTZ F1 alpha | 0.0026 | 0.0298 | 0.0978 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1291 | 0.4112 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0026 | 0.0298 | 0.0298 |
Brugia malayi | nuclear hormone receptor | 0.0026 | 0.0298 | 0.0948 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0055 | 0.0986 | 0.2993 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.5177 | 1 |
Onchocerca volvulus | 0.0036 | 0.0529 | 1 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0529 | 0.1686 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0082 | 0.0261 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0017 | 0.0082 | 0.0261 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 0.287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0688 | 0.5571 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 0.287 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0688 | 0.2262 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0055 | 0.0986 | 0.3241 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0026 | 0.0298 | 0.0298 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0055 | 0.0986 | 0.8308 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0529 | 0.1686 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0529 | 0.4113 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.1291 | 0.4112 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0529 | 0.4113 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0026 | 0.0298 | 0.0948 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0026 | 0.0298 | 0.0903 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0017 | 0.0082 | 0.0261 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.0298 | 0.0903 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0144 | 0.3139 | 0.3139 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.0298 | 0.0978 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0026 | 0.0298 | 0.0948 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0026 | 0.0298 | 0.0298 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.1291 | 0.4112 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0017 | 0.0082 | 0.0248 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0055 | 0.0986 | 0.3241 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0026 | 0.0298 | 0.0948 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0133 | 0.287 | 0.9438 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0026 | 0.0298 | 0.0978 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0026 | 0.0298 | 0.0298 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.117 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0026 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0529 | 0.7384 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0529 | 0.1686 |
Brugia malayi | nuclear receptor NHR-88 | 0.0026 | 0.0298 | 0.0948 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.117 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.1291 | 0.4112 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.0883 | 0.0883 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0026 | 0.0298 | 0.0978 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0017 | 0.0082 | 0.0261 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0529 | 0.4113 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0688 | 0.5571 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0603 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.0986 | 0.314 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0529 | 0.1686 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0026 | 0.0298 | 0.0948 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0133 | 0.287 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0082 | 0.0261 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.0883 | 0.2814 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1291 | 0.4112 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.1291 | 0.4243 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0883 | 0.2904 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0529 | 0.4113 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0026 | 0.0298 | 0.0298 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.3294 | 0.3294 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0529 | 0.1686 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.1291 | 0.3919 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.287 | 0.9145 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0133 | 0.287 | 0.8715 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0026 | 0.0298 | 0.4821 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0026 | 0.0298 | 0.0948 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0133 | 0.287 | 0.287 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0026 | 0.0298 | 0.0978 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 0.287 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0026 | 0.0298 | 0.4821 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0688 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0055 | 0.0986 | 0.3241 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.0986 | 0.2993 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.1291 | 0.3919 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0062 | 0.117 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0026 | 0.0298 | 0.0903 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0055 | 0.0986 | 0.0986 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0144 | 0.3139 | 0.953 |
Schistosoma mansoni | coup transcription factor | 0.0026 | 0.0298 | 0.0298 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0529 | 0.1686 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0026 | 0.0298 | 0.0948 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0124 | 0.2663 | 0.8085 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.1291 | 0.4112 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0688 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0026 | 0.0298 | 0.0948 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0026 | 0.0298 | 0.0948 |
Onchocerca volvulus | 0.0026 | 0.0298 | 0.4821 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0132 | 0.2842 | 0.9054 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0062 | 0.117 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.0883 | 0.2682 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0026 | 0.0298 | 0.0948 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0026 | 0.0298 | 0.0978 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0026 | 0.0298 | 0.0298 |
Brugia malayi | MH2 domain containing protein | 0.0132 | 0.2842 | 0.9054 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.0883 | 0.2904 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0026 | 0.0298 | 0.0978 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0133 | 0.287 | 0.9145 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0603 | 1 |
Onchocerca volvulus | 0.0036 | 0.0529 | 1 | |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0529 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0026 | 0.0298 | 0.0948 |
Brugia malayi | Pepsin A precursor | 0.0017 | 0.0082 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0529 | 0.1686 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0529 | 0.0529 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.014 | 0.3041 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0151 | 0.3294 | 0.3294 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0144 | 0.3139 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0144 | 0.3139 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0026 | 0.0298 | 0.0903 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0017 | 0.0082 | 0.0082 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0026 | 0.0298 | 0.4821 |
Brugia malayi | steroid hormone receptor | 0.0026 | 0.0298 | 0.0948 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0132 | 0.2842 | 0.9054 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0026 | 0.0298 | 0.0948 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0529 | 0.1607 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0529 | 0.7384 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.