Detailed information for compound 840076

Basic information

Technical information
  • TDR Targets ID: 840076
  • Name: 1-(4-chlorophenyl)-5-[1-[(2-methylpropan-2-yl )oxycarbonyl]piperidin-4-yl]pyrazole-4-carbox ylic acid
  • MW: 405.875 | Formula: C20H24ClN3O4
  • H donors: 1 H acceptors: 4 LogP: 3.51 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1cnn(c1C1CCN(CC1)C(=O)OC(C)(C)C)c1ccc(cc1)Cl
  • InChi: 1S/C20H24ClN3O4/c1-20(2,3)28-19(27)23-10-8-13(9-11-23)17-16(18(25)26)12-22-24(17)15-6-4-14(21)5-7-15/h4-7,12-13H,8-11H2,1-3H3,(H,25,26)
  • InChiKey: LJCLZGWBEQIEML-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(1-tert-butoxycarbonyl-4-piperidyl)-1-(4-chlorophenyl)pyrazole-4-carboxylic acid
  • 5-[1-(tert-butoxy-oxomethyl)-4-piperidinyl]-1-(4-chlorophenyl)-4-pyrazolecarboxylic acid
  • 5-[1-(tert-butoxycarbonyl)piperidin-4-yl]-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylic acid
  • MLS000045831
  • SMR000028228

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Giardia intestinalis Putative fructose-1,6-bisphosphate aldolase Starlite/ChEMBL No references
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Giardia lamblia Fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative Get druggable targets OG5_129214 All targets in OG5_129214
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum fructose-bisphosphate aldolase Get druggable targets OG5_129214 All targets in OG5_129214
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.5 %
Candida albicans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 358 aa 22.6 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 25.8 %
Mycobacterium ulcerans fructose-bisphosphate aldolase Putative fructose-1,6-bisphosphate aldolase   323 aa 361 aa 26.9 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0256 0.0452
Mycobacterium tuberculosis Conserved protein 0.0035 0.0325 0.059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0456 0.0813
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0061 0.0104
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0061 0.0058
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0009 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0004 0.0002
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0009 0.0004 0.0002
Echinococcus granulosus sodium leak channel non selective protein 0.0009 0.0004 0.0002
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0256 0.0254
Echinococcus granulosus thymidylate synthase 0.0224 0.2664 0.3906
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0082 0.0116
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0189 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0325 0.0586
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Brugia malayi hypothetical protein 0.0461 0.5608 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0004 0.0007
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0169 0.0301
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0153 0.1783 0.2613
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0256 0.0452
Brugia malayi conserved hypotetical protein 0.0014 0.0061 0.0104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0082 0.0132
Echinococcus granulosus dihydrofolate reductase 0.0449 0.5462 0.8012
Schistosoma mansoni pyruvate kinase 0.0017 0.0093 0.0151
Loa Loa (eye worm) DR-78 0.0014 0.0061 0.0109
Brugia malayi thymidylate synthase 0.0224 0.2664 0.4748
Brugia malayi Cytochrome P450 family protein 0.0016 0.0091 0.0158
Schistosoma mansoni nuclear receptor 0.0014 0.0061 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0256 0.0452
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0009 0.0003 0.0005
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0009 0.0004 0.0002
Leishmania major hypothetical protein, conserved 0.0009 0.0004 0.0002
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.0441 0.0782
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0256 0.0422
Brugia malayi beta-lactamase 0.0035 0.0325 0.0574
Schistosoma mansoni lipoxygenase 0.0057 0.06 0.0993
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0061 0.0058
Brugia malayi nuclear receptor NHR-67 0.0014 0.0061 0.0104
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.0441 0.0643
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0256 0.0452
Echinococcus granulosus shaker cognate 0.0009 0.0004 0.0002
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0009 0.0004 0.0001
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0009 0.0004 0.0002
Brugia malayi hypothetical protein 0.0016 0.0082 0.0142
Schistosoma mansoni lozenge 0.0058 0.0604 0.1001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0441 0.1028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0441 0.0798
Onchocerca volvulus 0.0021 0.0141 0.0248
Echinococcus granulosus pyruvate kinase 0.0017 0.0093 0.0133
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0325 0.0755
Brugia malayi olfactory channel protein osm-9 0.0009 0.0004 0.0002
Toxoplasma gondii hypothetical protein 0.0046 0.0456 0.0825
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Echinococcus multilocularis pyruvate kinase 0.0017 0.0093 0.0091
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0256 0.0254
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0256 0.0457
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.1079
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Leishmania major hypothetical protein, conserved 0.0035 0.0325 0.0586
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0082 0.0132
Brugia malayi Cyclic-nucleotide gated cation channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0579
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0169 0.0302
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0091 0.0163
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0074 0.0804 0.1431
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0256 0.0372
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0169 0.0389
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Schistosoma mansoni thyroid hormone receptor 0.003 0.0256 0.0422
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0061 0.0097
Echinococcus granulosus neuropeptide s receptor 0.0558 0.6817 1
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0009 0.0004 0.0002
Schistosoma mansoni voltage-dependent calcium channel 0.0009 0.0004 0.0002
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0224 0.2664 0.4426
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Schistosoma mansoni lipoxygenase 0.0021 0.0141 0.0231
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.0289 0.0525
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0361 0.4364 0.7253
Schistosoma mansoni coup transcription factor 0.003 0.0256 0.0422
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0004 0.0002
Brugia malayi nuclear receptor NHR-88 0.0014 0.0061 0.0104
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Brugia malayi nuclear hormone receptor 0.003 0.0256 0.0452
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0325 0.059
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.1587 0.2325
Brugia malayi steroid hormone receptor 0.003 0.0256 0.0452
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0325 0.059
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0745 0.1352
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0671 0.1224
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0009 0.0004 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0671 0.1112
Leishmania major hypothetical protein, unknown function 0.0009 0.0004 0.0002
Brugia malayi TAR-binding protein 0.0062 0.0651 0.1157
Mycobacterium ulcerans pyruvate kinase 0.0032 0.0289 0.0525
Echinococcus multilocularis kinesin family 1 0.0415 0.5033 0.5032
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0009 0.0004 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0256 0.0452
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0289 0.0672
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0045 0.0441 0.1028
Loa Loa (eye worm) hypothetical protein 0.0046 0.0456 0.0813
Loa Loa (eye worm) hypothetical protein 0.0041 0.04 0.0714
Echinococcus granulosus tar DNA binding protein 0.0062 0.0651 0.0952
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0256 0.0452
Brugia malayi cation channel family protein 0.0009 0.0004 0.0002
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0441 0.0798
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0153 0.1783 0.2613
Schistosoma mansoni loxhd1 0.0021 0.0141 0.0231
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0141 0.0204
Echinococcus granulosus transient receptor potential cation channel 0.0009 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0002
Echinococcus granulosus kinesin family 1 0.0415 0.5033 0.7382
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0401 0.0726
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0009 0.0004 0.0001
Echinococcus multilocularis pyruvate kinase 0.0026 0.0205 0.0202
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0169 0.0389
Echinococcus granulosus voltage gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0579
Schistosoma mansoni sodium/solute symporter 0.0038 0.0354 0.0585
Echinococcus granulosus sodium channel protein 0.0009 0.0004 0.0002
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0651 0.1157
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0325 0.0586
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0267 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0256 0.0452
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0009 0.0004 0.0001
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0267 0.0264
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0169 0.0302
Echinococcus multilocularis pyruvate kinase 0.0032 0.0289 0.0287
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0004 0.0002
Schistosoma mansoni rab6-interacting 0.0021 0.0141 0.0231
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0267 0.0471
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.1136 0.1885
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.074 0.0737
Echinococcus granulosus potassium voltage gated channel protein 0.0009 0.0004 0.0002
Onchocerca volvulus 0.0035 0.0325 0.0574
Toxoplasma gondii transporter, cation channel family protein 0.0055 0.0573 0.1038
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0401 0.0935
Schistosoma mansoni dihydrofolate reductase 0.0449 0.5462 0.9078
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0009 0.0004 0.0002
Echinococcus multilocularis pyruvate kinase 0.0017 0.0093 0.0091
Echinococcus granulosus potassium voltage gated channel protein 0.0009 0.0004 0.0002
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0141 0.0204
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0189 0.0273
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0256 0.0422
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.002 0.0026
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0651 0.1161
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Loa Loa (eye worm) CYP4Cod1 0.0016 0.0091 0.0163
Echinococcus granulosus potassium voltage gated channel protein 0.0009 0.0004 0.0002
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0061 0.0104
Loa Loa (eye worm) hypothetical protein 0.0032 0.0283 0.0505
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.0354 0.0516
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0009 0.0004 0.0002
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0141 0.0253
Brugia malayi Cytochrome P450 family protein 0.0016 0.0091 0.0158
Loa Loa (eye worm) RNA binding protein 0.0062 0.0651 0.1161
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0141 0.0252
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0804 0.1469
Schistosoma mansoni voltage-gated ion channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Brugia malayi Dihydrofolate reductase 0.0449 0.5462 0.974
Onchocerca volvulus 0.003 0.0256 0.0452
Brugia malayi beta-lactamase family protein 0.0035 0.0325 0.0574
Brugia malayi ion channel NompC 0.0009 0.0004 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0045 0.0441 0.0786
Echinococcus multilocularis RUN 0.0021 0.0141 0.0139
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Schistosoma mansoni hypothetical protein 0.0031 0.0267 0.0439
Loa Loa (eye worm) ion channel NompC 0.0009 0.0004 0.0007
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0289 0.0516
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0061 0.0058
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.0441 0.1028
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0141 0.0139
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0325 0.0755
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0252
Echinococcus multilocularis sodium channel protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Schistosoma mansoni voltage-gated cation channel 0.0153 0.1783 0.2961
Leishmania major pyruvate kinase 0.0032 0.0289 0.0522
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Onchocerca volvulus 0.0014 0.0061 0.0104
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0082 0.0079
Chlamydia trachomatis dihydrofolate reductase 0.0449 0.5462 1
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0325 0.059
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0256 0.0254
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0354 0.0352
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0256 0.0254
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0325 0.059
Loa Loa (eye worm) hypothetical protein 0.0055 0.0573 0.1022
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0325 0.0586
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0004 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.1079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0168 0.0299
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0452 0.5495 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.08 0.1325
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0009 0.0004 0.0002
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0289 0.0512
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0146
Brugia malayi hypothetical protein 0.0021 0.0141 0.0248
Giardia lamblia Pyruvate kinase 0.0032 0.0289 0.0672
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0009 0.0004 0.0002
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.4267 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0093 0.0133
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0256 0.0452
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0093 0.0165
Echinococcus multilocularis voltage gated potassium channel 0.0009 0.0004 0.0001
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.2026 0.3707
Echinococcus granulosus cpg binding protein 0.0037 0.0342 0.0498
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0082 0.0146
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0358 0.0648
Loa Loa (eye worm) hypothetical protein 0.0059 0.0622 0.111
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0009 0.0004 0.0002
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.04 0.0398
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0061 0.0097
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0189 0.0186
Plasmodium falciparum pyruvate kinase 0.0032 0.0289 0.0522
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0009 0.0004 0.0002
Mycobacterium ulcerans hypothetical protein 0.0035 0.0325 0.059
Loa Loa (eye worm) dehydrogenase 0.0009 0.0003 0.0005
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0804 0.0802
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0256 0.0452
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.1079
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0009 0.0004 0.0002
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0256 0.0422
Toxoplasma gondii hypothetical protein 0.0009 0.0004 0.0002
Echinococcus multilocularis sodium leak channel non selective protein 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0169 0.0302
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0325 0.059
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0004 0.0003
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0168 0.0387
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0169 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.2026 0.3707
Loa Loa (eye worm) cytochrome P450 family protein 0.0016 0.0091 0.0163
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Schistosoma mansoni nuclear receptor 0.0014 0.0061 0.0097
Mycobacterium tuberculosis Conserved protein 0.0035 0.0325 0.059
Brugia malayi beta-lactamase family protein 0.0035 0.0325 0.0574
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0256 0.0452
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0325 0.0579
Schistosoma mansoni hypothetical protein 0.0335 0.4045 0.6721
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.1636 0.1634
Echinococcus granulosus transient receptor potential ion channel A 0.0091 0.1019 0.1492
Echinococcus multilocularis geminin 0.0335 0.4045 0.4043
Echinococcus multilocularis ryanodine receptor 44f 0.0009 0.0004 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0325 0.059
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0579
Echinococcus granulosus pyruvate kinase 0.0017 0.0093 0.0133
Loa Loa (eye worm) hypothetical protein 0.0031 0.0267 0.0475
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0256 0.0372
Loa Loa (eye worm) voltage-dependent calcium channel 0.0055 0.0573 0.1022
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0055 0.0573 0.1038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0256 0.0452
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0061 0.0109
Loa Loa (eye worm) hypothetical protein 0.0461 0.5608 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1087 0.1935
Toxoplasma gondii hypothetical protein 0.0009 0.0004 0.0002
Echinococcus multilocularis Protein lozenge 0.0058 0.0604 0.0602
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0009 0.0004 0.0003
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0168 0.0299
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0441 0.0439
Echinococcus multilocularis GPCR, family 2 0.0031 0.0267 0.0264
Brugia malayi GH02984p 0.0038 0.0354 0.0628
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0061 0.0086
Schistosoma mansoni pyruvate kinase 0.0032 0.0289 0.0477
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Schistosoma mansoni kinesin eg-5 0.0054 0.0555 0.0919
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4267 1
Onchocerca volvulus 0.0038 0.0354 0.0628
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0494 0.6017 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0671 0.1224
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0146
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Schistosoma mansoni cpg binding protein 0.0035 0.0317 0.0523
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.2026 0.3707
Plasmodium vivax pyruvate kinase, putative 0.0032 0.0289 0.0522
Toxoplasma gondii transporter, cation channel family protein 0.0009 0.0004 0.0002
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0061 0.0086
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0061 0.0086
Schistosoma mansoni pyruvate kinase 0.0032 0.0289 0.0477
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Echinococcus granulosus transient receptor potential cation channel 0.0009 0.0004 0.0002
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0009 0.0004 0.0001
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0004 0.0002
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0289 0.0512
Schistosoma mansoni thyroid hormone receptor 0.003 0.0256 0.0422
Echinococcus multilocularis thymidylate synthase 0.0224 0.2664 0.2662
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0061 0.0086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0256 0.0422
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0074 0.0804 0.1469
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0169 0.0304
Schistosoma mansoni inositol transporter 0.0038 0.0354 0.0585
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0449 0.5462 1
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0009 0.0004 0.0002
Loa Loa (eye worm) thymidylate synthase 0.0224 0.2664 0.4751
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0354 0.0516
Brugia malayi ecdysone receptor 0.0014 0.0061 0.0104
Brugia malayi nuclear receptor RXR 0.0014 0.0061 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0256 0.0457
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Echinococcus granulosus voltage dependent calcium channel 0.0055 0.0573 0.0837
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0325 0.0322
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.0441 0.1028
Schistosoma mansoni polycystin 1-related 0.0021 0.0141 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0256 0.0452
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.4267 1
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0009 0.0004 0.0001
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.04 0.0584
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0009 0.0004 0.0002
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0401 0.0726
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0009 0.0004 0.0001
Echinococcus multilocularis shaker cognate 0.0009 0.0004 0.0001
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0009 0.0004 0.0001
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Plasmodium vivax kinesin-5 0.0054 0.0555 0.1006
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.0004 0.0001
Echinococcus granulosus GPCR family 2 0.0031 0.0267 0.0387
Mycobacterium ulcerans lipase LipD 0.0035 0.0325 0.059
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0061 0.0097
Schistosoma mansoni transient receptor potential channel 0.0069 0.074 0.1225
Trichomonas vaginalis chaperonin, putative 0.0024 0.0189 0.0437
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0009 0.0004 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0325 0.0535
Onchocerca volvulus 0.0224 0.2664 0.4748
Echinococcus granulosus hypothetical protein 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0325 0.059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0671 0.1224
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) voltage-gated potassium channel 0.0009 0.0004 0.0007
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.0289 0.0672
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0579
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0074 0.0804 0.1469
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0267 0.0387
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0256 0.0254
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0004 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0256 0.0372
Mycobacterium tuberculosis Conserved protein 0.0035 0.0325 0.059
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0256 0.0457
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0267 0.0475
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.0004 0.0001
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0651 0.1161
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0169 0.0302
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.1079
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Brugia malayi dihydrofolate reductase family protein 0.0449 0.5462 0.974
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Brugia malayi ecdysteroid receptor 0.003 0.0256 0.0452
Schistosoma mansoni rab6-interacting 0.0021 0.0141 0.0231
Echinococcus granulosus solute carrier family 5 0.0038 0.0354 0.0516
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0707 0.1257
Schistosoma mansoni hypothetical protein 0.0335 0.4045 0.6721
Onchocerca volvulus 0.0035 0.0317 0.0561
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0354 0.064
Echinococcus multilocularis potassium voltage gated channel protein 0.0009 0.0004 0.0001
Toxoplasma gondii kinesin motor domain-containing protein 0.0054 0.0555 0.1006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.002 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0256 0.0452
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1327 0.2367
Loa Loa (eye worm) hypothetical protein 0.0153 0.1783 0.318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0061 0.0097
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.0441 0.0729
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0354 0.0516
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0256 0.0372
Echinococcus granulosus calcium activated potassium channel 0.0009 0.0004 0.0002
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.6017 0.6015
Toxoplasma gondii exonuclease III APE 0.0023 0.0169 0.0302
Schistosoma mansoni calcium-activated potassium channel 0.0009 0.0004 0.0002
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0009 0.0004 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0325 0.0535
Echinococcus multilocularis pyruvate kinase 0.0032 0.0289 0.0287
Brugia malayi Kinesin motor domain containing protein 0.0054 0.0555 0.0986
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.06 0.0597
Mycobacterium ulcerans thymidylate synthase 0.0224 0.2664 0.4875
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0038 0.0354 0.0632
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0651 0.0649
Schistosoma mansoni vesicular amine transporter 0.0009 0.0004 0.0002
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0004 0.0002
Brugia malayi hypothetical protein 0.0021 0.0141 0.0248
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0452 0.5495 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0074 0.0804 0.1333
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0082 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0256 0.0457
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0141 0.0139
Mycobacterium ulcerans beta-lactamase 0.0035 0.0325 0.059
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0189 0.0339
Loa Loa (eye worm) hypothetical protein 0.0101 0.1136 0.2026
Echinococcus multilocularis solute carrier family 5 0.0038 0.0354 0.0352
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.1636 0.2716
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0009 0.0004 0.0002
Brugia malayi hypothetical protein 0.0014 0.0061 0.0104
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0256 0.0372
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0061 0.0104
Loa Loa (eye worm) calcium channel 0.0153 0.1783 0.318
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0256 0.0254
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.0289 0.0522
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0189 0.0332
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0009 0.0004 0.0002
Schistosoma mansoni cpg binding protein 0.0037 0.0342 0.0564
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Leishmania major cytochrome p450-like protein 0.0016 0.0091 0.0162
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.0289 0.0512
Loa Loa (eye worm) hypothetical protein 0.0097 0.1087 0.1938
Schistosoma mansoni ryanodine receptor related 0.0009 0.0004 0.0002
Schistosoma mansoni inositol transporter 0.0038 0.0354 0.0585
Mycobacterium tuberculosis Hypothetical protein 0.0106 0.1208 0.2208
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0055 0.0573 0.1038
Echinococcus multilocularis voltage dependent calcium channel 0.0153 0.1783 0.1781
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0256 0.0254
Echinococcus granulosus geminin 0.0335 0.4045 0.5932
Onchocerca volvulus 0.0035 0.0325 0.0574
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1087 0.1938
Loa Loa (eye worm) voltage-gated potassium channel 0.0009 0.0004 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.1208 0.2827
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0009 0.0004 0.0002
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0317 0.0566
Schistosoma mansoni hypothetical protein 0.0031 0.0267 0.0439
Schistosoma mansoni transient receptor potential channel 0.0101 0.1136 0.1885
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0325 0.059
Schistosoma mansoni 60S ribosomal protein L21 0.0009 0.0004 0.0002
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0009 0.0004 0.0007
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0358 0.0834
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0189 0.0339
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0169 0.0389
Schistosoma mansoni hypothetical protein 0.0031 0.0267 0.0439
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0189 0.031
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0009 0.0004 0.0002
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0671 0.0669
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0256 0.0452
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0256 0.0452
Toxoplasma gondii transporter, cation channel family protein 0.0009 0.0004 0.0002
Mycobacterium leprae Probable lipase LipE 0.0035 0.0325 0.059
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0169 0.0302
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0061 0.0058
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0009 0.0004 0.0001
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0189 0.031
Echinococcus multilocularis cpg binding protein 0.0037 0.0342 0.0339
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0061 0.0104
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1327 0.2367
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0153 0.1783 0.3177
Brugia malayi MH2 domain containing protein 0.0116 0.1327 0.2364
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0325 0.059
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0671 0.1224
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0009 0.0004 0.0002
Loa Loa (eye worm) cytochrome P450 family protein 0.0027 0.0225 0.0401
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0061 0.0097
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.0441 0.0643
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.0289 0.0522
Echinococcus multilocularis neuropeptide s receptor 0.0558 0.6817 0.6816
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.0441 0.0798
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0256 0.0372
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0091 0.0162
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0016 0.0091 0.0163
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.0441 0.0439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0146
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1087 0.1935
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0189 0.0339
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0461 0.5608 1
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0141 0.0253
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0009 0.0004 0.0002
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0153 0.1783 0.1781
Entamoeba histolytica kinesin, putative 0.0054 0.0555 0.1296
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0009 0.0004 0.0002
Trypanosoma brucei cytochrome P450, putative 0.0016 0.0091 0.0162
Loa Loa (eye worm) kinesin-like protein KLP2 0.0054 0.0555 0.099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0146
Echinococcus multilocularis dihydrofolate reductase 0.0449 0.5462 0.5461
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0224 0.2664 0.4875
Echinococcus granulosus transient receptor potential cation channel 0.0009 0.0004 0.0002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0401 0.0935
Echinococcus granulosus dnaJ subfamily B 0.0494 0.6017 0.8826
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0153 0.1783 0.2961
Brugia malayi Transient-receptor-potential like protein 0.0041 0.04 0.071
Echinococcus granulosus two pore calcium channel protein 2 0.0009 0.0004 0.0002
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0452 0.5495 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0169 0.0296
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0009 0.0004 0.0002
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0009 0.0004 0.0002
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0009 0.0004 0.0002
Echinococcus multilocularis transient receptor potential ion channel A 0.0091 0.1019 0.1017
Brugia malayi cation channel family protein 0.0009 0.0004 0.0002
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.0004 0.0001
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0141 0.0204
Giardia lamblia Kinesin-5 0.0054 0.0555 0.1296
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Echinococcus granulosus pyruvate kinase 0.0032 0.0289 0.0421
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0169 0.0244
Giardia lamblia Pyruvate kinase 0.0017 0.0093 0.0213
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0009 0.0004 0.0002
Schistosoma mansoni transient receptor potential channel 0.0069 0.074 0.1225
Echinococcus granulosus voltage gated potassium channel 0.0009 0.0004 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0671 0.1112
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0256 0.0372
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0325 0.0574
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0579
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0289 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0651 0.1079
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0289 0.0516
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Echinococcus granulosus transient receptor potential cation channel 0.0009 0.0004 0.0002
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0401 0.0726
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0267 0.0387
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0325 0.0473
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0009 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0031 0.0267 0.0439
Schistosoma mansoni two-pore calcium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0189 0.0337
Schistosoma mansoni high-affinity choline transporter 0.0038 0.0354 0.0585
Echinococcus multilocularis neuropeptide receptor A26 0.0558 0.6817 0.6816
Loa Loa (eye worm) hypothetical protein 0.0066 0.0707 0.1261
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0325 0.0755
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0256 0.0457
Loa Loa (eye worm) hypothetical protein 0.0035 0.0325 0.0579
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0449 0.5462 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0256 0.0254
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0082 0.0142
Trypanosoma cruzi cytochrome P450, putative 0.0016 0.0091 0.0162
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0441 0.0439
Brugia malayi CXXC zinc finger family protein 0.0035 0.0317 0.0561
Schistosoma mansoni cpg binding protein 0.0037 0.0342 0.0564
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.0441 0.0729
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0093 0.0165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Echinococcus multilocularis voltage gated potassium channel 0.0009 0.0004 0.0001
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0061 0.0104
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0009 0.0004 0.0002
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.074 0.1082
Echinococcus granulosus RUN 0.0021 0.0141 0.0204
Echinococcus multilocularis transfer RNA-Gly 0.0009 0.0004 0.0001
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.074 0.1082
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0153 0.1783 0.1781
Echinococcus granulosus FTZ F1 alpha 0.003 0.0256 0.0372
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0256 0.0457
Echinococcus multilocularis two pore calcium channel protein 2 0.0009 0.0004 0.0001
Brugia malayi RNA binding protein 0.0062 0.0651 0.1157
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0061 0.0058
Brugia malayi Cytochrome P450 family protein 0.0027 0.0225 0.0396
Loa Loa (eye worm) histone methyltransferase 0.0011 0.002 0.0036
Echinococcus multilocularis potassium voltage gated channel protein 0.0009 0.0004 0.0001
Echinococcus granulosus potassium voltage gated channel protein 0.0009 0.0004 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0256 0.0452
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Brugia malayi hypothetical protein 0.0014 0.0061 0.0104
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.0289 0.0525
Echinococcus granulosus two pore calcium channel protein 1 0.0009 0.0004 0.0002
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0189 0.0437
Brugia malayi tailless protein 0.0014 0.0061 0.0104
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0325 0.0755
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0189 0.0437
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0354 0.0352
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0061 0.0104
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0671 0.0981
Loa Loa (eye worm) oxidoreductase 0.0009 0.0003 0.0005
Loa Loa (eye worm) dihydrofolate reductase 0.0449 0.5462 0.9741
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0009 0.0004 0.0002
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.0289 0.0512
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0189 0.0339
Echinococcus granulosus voltage dependent calcium channel 0.0153 0.1783 0.2613
Loa Loa (eye worm) voltage-gated calcium channel 0.0009 0.0004 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0169 0.0166
Schistosoma mansoni ap endonuclease 0.0023 0.0169 0.0276
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0061 0.0086
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.0004 0.0001
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0189 0.0339
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0061 0.0104
Schistosoma mansoni hypothetical protein 0.0021 0.0141 0.0231
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0256 0.0422
Loa Loa (eye worm) hypothetical protein 0.0016 0.0082 0.0146
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.1136 0.1663
Loa Loa (eye worm) hypothetical protein 0.0038 0.0354 0.0632
Echinococcus granulosus neuropeptide receptor A26 0.0558 0.6817 1
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Echinococcus multilocularis potassium large conductance calcium activated 0.0009 0.0004 0.0001
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0256 0.0452
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0153 0.1783 0.1781
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.2684 0.4911
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.1636 0.2914
Echinococcus multilocularis transient receptor potential cation channel 0.0009 0.0004 0.0001
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0256 0.0254
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0452 0.5495 1
Brugia malayi nuclear receptor NHR-88 0.003 0.0256 0.0452
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0354 0.0628
Echinococcus granulosus hyperpolarization activated cyclic 0.0009 0.0004 0.0002
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0074 0.0804 0.1177
Echinococcus granulosus ryanodine receptor 44f 0.0009 0.0004 0.0002
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0354 0.0516
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0009 0.0004 0.0002
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0671 0.1217
Echinococcus granulosus potassium large conductance calcium activated 0.0009 0.0004 0.0002
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0106 0.1208 0.2195
Echinococcus granulosus pyruvate kinase 0.0032 0.0289 0.0421
Schistosoma mansoni ap endonuclease 0.0023 0.0169 0.0276
Loa Loa (eye worm) ryanodine receptor 0.0009 0.0004 0.0007
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.074 0.0737
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0141 0.0252
Loa Loa (eye worm) acetyltransferase 0.0141 0.1636 0.2917
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0061 0.0104
Leishmania major pyruvate kinase 0.0032 0.0289 0.0522
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0061 0.0058
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0671 0.1217
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.0441 0.0798
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0224 0.2664 0.4875
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0009 0.0004 0.0002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0256 0.0422
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0005
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0256 0.0422
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0153 0.1783 0.2961
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0009 0.0004 0.0001
Brugia malayi nuclear hormone receptor 0.0014 0.0061 0.0104
Onchocerca volvulus 0.0461 0.5608 1
Echinococcus granulosus transient receptor potential cation channel 0.0009 0.0004 0.0002
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0189 0.0437
Onchocerca volvulus 0.0021 0.0141 0.0248
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0354 0.0352
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0401 0.0585
Trypanosoma brucei pyruvate kinase 1 0.0032 0.0289 0.0522
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0009 0.0004 0.0001
Loa Loa (eye worm) pyruvate kinase 0.0032 0.0289 0.0516
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0169 0.0304
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0009 0.0004 0.0002
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0169 0.0302
Schistosoma mansoni nuclear hormone receptor 0.003 0.0256 0.0422
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0358 0.0834
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0452 0.5495 1
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0449 0.5462 1
Schistosoma mansoni zinc finger protein 0.0014 0.0061 0.0097
Loa Loa (eye worm) runx1 0.0058 0.0604 0.1078
Echinococcus multilocularis two pore calcium channel protein 1 0.0009 0.0004 0.0001
Brugia malayi Doublecortin family protein 0.0021 0.0141 0.0248
Echinococcus multilocularis hyperpolarization activated cyclic 0.0009 0.0004 0.0001
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0009 0.0004 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0441 0.1028
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0452 0.5495 1
Echinococcus multilocularis potassium voltage gated channel protein 0.0009 0.0004 0.0001
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.4267 1
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0189 0.0339
Echinococcus granulosus potassium voltage gated channel protein 0.0009 0.0004 0.0002
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0153 0.1783 0.1781
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0009 0.0004 0.0002
Trichomonas vaginalis esterase, putative 0.0035 0.0325 0.0755
Plasmodium falciparum kinesin-5 0.0054 0.0555 0.1006
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0169 0.0389
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0009 0.0004 0.0002
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0074 0.0804 0.146
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Loa Loa (eye worm) dehydrogenase 0.0009 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0325 0.059
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Brugia malayi hypothetical protein 0.0106 0.1208 0.2151
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0189 0.0332
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0325 0.0755
Schistosoma mansoni voltage-gated potassium channel 0.0009 0.0004 0.0002
Echinococcus multilocularis calcium activated potassium channel 0.0009 0.0004 0.0001
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.0289 0.0522
Echinococcus granulosus transient receptor potential cation channel 0.0009 0.0004 0.0002
Brugia malayi voltage-dependent calcium channel 0.0009 0.0004 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0256 0.0452
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Onchocerca volvulus 0.0035 0.0325 0.0574
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Loa Loa (eye worm) beta-lactamase 0.0035 0.0325 0.0579
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0061 0.0109
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0256 0.0422
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0009 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.0441 0.0643
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0009 0.0004 0.0002
Toxoplasma gondii ABC1 family protein 0.0035 0.0325 0.0586
Echinococcus multilocularis pyruvate kinase 0.0017 0.0093 0.0091
Brugia malayi hypothetical protein 0.0016 0.0082 0.0142
Onchocerca volvulus 0.0009 0.0004 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0267 0.0264
Echinococcus granulosus voltage gated hydrogen channel 1 0.0009 0.0004 0.0002
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0256 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0256 0.0452
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0065 0.0689 0.1228
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.4267 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457
Brugia malayi nuclear receptor RXR 0.0016 0.0082 0.0142
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0256 0.0422
Loa Loa (eye worm) hypothetical protein 0.0032 0.0289 0.0516
Onchocerca volvulus 0.0014 0.0061 0.0104
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.1136 0.1134
Echinococcus multilocularis voltage dependent calcium channel 0.0153 0.1783 0.1781
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0061 0.0109
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0256 0.0372
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0093 0.0165
Loa Loa (eye worm) hypothetical protein 0.0009 0.0004 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0256 0.0457
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.0289 0.0512
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.06 0.0877
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0009 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0066 0.0707 0.1172
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.0354 0.0352
Loa Loa (eye worm) hypothetical protein 0.0014 0.0061 0.0109
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0153 0.1783 0.2613
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0061 0.0086
Echinococcus multilocularis conserved hypothetical protein 0.0009 0.0004 0.0001
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0354 0.0516
Echinococcus multilocularis potassium voltage gated channel protein 0.0009 0.0004 0.0001
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0141 0.0139
Brugia malayi hypothetical protein 0.0009 0.0004 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0325 0.0586
Loa Loa (eye worm) hypothetical protein 0.003 0.0256 0.0457

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8114 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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