Detailed information for compound 840090

Basic information

Technical information
  • TDR Targets ID: 840090
  • Name: 6-(4-nitrophenyl)pyrrolo[3,4-b]pyrazine-5,7-d ione
  • MW: 270.2 | Formula: C12H6N4O4
  • H donors: 0 H acceptors: 6 LogP: 0.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccc(cc1)N1C(=O)c2c(C1=O)nccn2
  • InChi: 1S/C12H6N4O4/c17-11-9-10(14-6-5-13-9)12(18)15(11)7-1-3-8(4-2-7)16(19)20/h1-6H
  • InChiKey: ZYDGXFXBTQZJCD-UHFFFAOYSA-N  

Network

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Synonyms

  • 6-(4-nitrophenyl)pyrrolo[3,4-b]pyrazine-5,7-quinone
  • Oprea1_843520

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0023 0.0877
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0234
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.1445
Plasmodium vivax SET domain protein, putative 0.0031 0.02 0.7027
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0238 0.1244
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0038 0.1445
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0364 0.2789 0.2744
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0926 0.7169 1
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0364 0.2789 1
Trichomonas vaginalis MYB72, putative 0.001 0.0034 0.0135
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.1445
Brugia malayi hypothetical protein 0.0026 0.0158 0.0977
Onchocerca volvulus 0.0029 0.0186 0.0819
Brugia malayi hypothetical protein 0.0017 0.0087 0.0538
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0238 0.1244
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0234
Brugia malayi Pre-SET motif family protein 0.0213 0.1619 1
Onchocerca volvulus 0.0036 0.0238 0.1105
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0186 0.1149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.1445
Brugia malayi beta-lactamase family protein 0.0036 0.0238 0.147
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0038 0.1445
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.02 0.2171
Brugia malayi MH2 domain containing protein 0.0122 0.0909 0.5616
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0238 0.0177
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0238 0.0248
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0644 0.0586
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0399 0.1324
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0926 0.7169 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0238 0.1244
Brugia malayi MH2 domain containing protein 0.0008 0.0022 0.0138
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0038 0.1445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0234
Schistosoma mansoni Smad4 0.0008 0.0022 0.0242
Trichomonas vaginalis pc-MYB2, putative 0.001 0.0034 0.0135
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0242
Trichomonas vaginalis MYB, putative 0.001 0.0035 0.0137
Toxoplasma gondii ABC1 family protein 0.0036 0.0238 0.0739
Brugia malayi glutathione reductase 0.0039 0.0259 0.1597
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0158 0.4894
Echinococcus granulosus Smad4 0.0008 0.0022 0.0851
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0034 0.0135
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0062 0.0286
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0062 0.0099
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0238 0.2582
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0022 0.0851
Brugia malayi Smad1 0.0008 0.0022 0.0138
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0238 0.0177
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0238 0.1244
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.02 0.7619
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0035 0.0137
Brugia malayi nuclear hormone receptor 0.001 0.0038 0.0234
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0037 0.1408
Echinococcus multilocularis cpg binding protein 0.0031 0.0199 0.7582
Echinococcus granulosus FTZ F1 alpha 0.001 0.0038 0.1445
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0238 0.8952
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.02 0.0601
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0263 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0644 0.0819
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0034 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0038 0.0234
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0038 0.1445
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0034 0.0135
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0038 0.0412
Brugia malayi MH1 domain containing protein 0.0008 0.0022 0.0138
Mycobacterium ulcerans hypothetical protein 0.0036 0.0238 0.0177
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0038 0.1445
Brugia malayi steroid hormone receptor 0.001 0.0038 0.0234
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0022 0.0851
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0238 0.0248
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0451 0.4894
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0412
Leishmania major hypothetical protein, conserved 0.0026 0.0158 0.4894
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0234
Plasmodium vivax glutathione reductase, putative 0.0039 0.0259 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0122 0.0909 0.5616
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0038 0.1445
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0035 0.0137
Brugia malayi MH1 domain containing protein 0.0008 0.0022 0.0138
Loa Loa (eye worm) glutathione reductase 0.0039 0.0259 0.1597
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.02 0.7619
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0023 0.0877
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.147
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0238 0.0248
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0186 0.7096
Leishmania major hypothetical protein, conserved 0.0036 0.0238 0.8952
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Onchocerca volvulus 0.0243 0.1848 1
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0364 0.2789 0.2744
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0644 0.0819
Echinococcus granulosus cpg binding protein 0.0031 0.0199 0.7582
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0037 0.1408
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0234
Trypanosoma brucei trypanothione reductase 0.0039 0.0259 1
Brugia malayi Pre-SET motif family protein 0.0031 0.02 0.1236
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0234
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0038 0.0412
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.02 0.2171
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0242
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.1445
Leishmania major trypanothione reductase 0.0039 0.0259 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0038 0.0412
Mycobacterium tuberculosis Conserved protein 0.0036 0.0238 0.0248
Onchocerca volvulus 0.0031 0.02 0.0896
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0238 0.8952
Brugia malayi nuclear receptor NHR-88 0.001 0.0038 0.0234
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0238 0.9062
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.0034 0.0211
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0062 0.0671
Brugia malayi beta-lactamase family protein 0.0036 0.0238 0.147
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0038 0.1445
Loa Loa (eye worm) histone methyltransferase 0.001 0.0037 0.0228
Trichomonas vaginalis esterase, putative 0.0036 0.0238 0.1244
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.02 0.2171
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0259 1
Onchocerca volvulus 0.0036 0.0238 0.1105
Trichomonas vaginalis C-MYB, putative 0.001 0.0034 0.0135
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0047 0.1808
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0158 0.4894
Loa Loa (eye worm) beta-lactamase 0.0036 0.0238 0.147
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0038 0.0234
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0238 0.2582
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0234
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0238 0.147
Schistosoma mansoni cpg binding protein 0.0031 0.0199 0.216
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0062 0.0382
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0158 0.4894
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0038 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0038 0.0234
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0062 0.2355
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0022 0.0138
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.147
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0023 0.0877
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0038 0.0234
Schistosoma mansoni nuclear hormone receptor 0.001 0.0038 0.0412
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0022 0.0138
Loa Loa (eye worm) transcription factor SMAD2 0.0122 0.0909 0.5616
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0034 0.0135
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.02 0.7619
Schistosoma mansoni hypothetical protein 0.0012 0.0047 0.0515
Schistosoma mansoni thyroid hormone receptor 0.001 0.0038 0.0412
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0034 0.0135
Mycobacterium ulcerans beta-lactamase 0.0036 0.0238 0.0177
Trichomonas vaginalis pc-MYB2, putative 0.001 0.0034 0.0135
Brugia malayi MH2 domain containing protein 0.0008 0.0022 0.0138
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0022 0.0851
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0038 0.1445
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0238 0.0248
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0038 0.0412
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0238 0.9062
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0259 1
Schistosoma mansoni cpg binding protein 0.0031 0.0199 0.216
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.147
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0038 0.1445
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.1445
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0034 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0158 0.4894
Mycobacterium ulcerans lipase LipD 0.0036 0.0238 0.0177
Echinococcus granulosus smad 0.0008 0.0022 0.0851
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0038 0.1445
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0034 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1619 1
Brugia malayi ecdysteroid receptor 0.001 0.0038 0.0234
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0038 0.0234
Plasmodium falciparum thioredoxin reductase 0.0039 0.0259 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0038 0.0234
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0721 0.0927
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0644 0.0819
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0038 0.1445
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0036 0.0223
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0238 0.8952
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0022 0.0851
Schistosoma mansoni smad1 5 8 and 0.0008 0.0022 0.0242
Onchocerca volvulus 0.0036 0.0238 0.1105
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Brugia malayi CXXC zinc finger family protein 0.0029 0.0186 0.1149
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0038 0.0412
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0038 0.0234
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0022 0.0242
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0721 0.0927
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0238 0.0248
Echinococcus multilocularis Smad4 0.0008 0.0022 0.0851
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0158 0.0449
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0038 0.0412
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.1236
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0721 0.0927
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0038 0.0234
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0364 0.2789 0.368
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0034 0.0135
Trichomonas vaginalis MYB3r3, putative 0.001 0.0034 0.0135
Brugia malayi beta-lactamase 0.0036 0.0238 0.147
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0238 0.8952
Brugia malayi Thioredoxin reductase 0.0039 0.0259 0.1597
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0038 0.0234
Loa Loa (eye worm) hypothetical protein 0.001 0.0038 0.0234
Schistosoma mansoni smad 0.0008 0.0022 0.0242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0038 0.0234
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.1749 0.2374
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0038 0.0412
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0062 0.0099
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.02 0.2171
Trichomonas vaginalis C-MYB, putative 0.001 0.0034 0.0135
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0038 0.1445
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0047 0.1808
Toxoplasma gondii thioredoxin reductase 0.0039 0.0259 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0234
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0062 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0023 0.0877
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0238 0.1244
Schistosoma mansoni coup transcription factor 0.001 0.0038 0.0412
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0034 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0644 0.0819
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.147
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0023 0.025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0038 0.0234
Mycobacterium tuberculosis Conserved protein 0.0036 0.0238 0.0248
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1289 1 1
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0259 0.1597
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0038 0.0234
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0062 0.2355
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.0034 0.0211
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0038 0.0234
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0238 0.0248
Mycobacterium tuberculosis Probable reductase 0.0088 0.0644 0.0819
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0062 0.0286
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0263 1
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.0034 0.5
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0644 0.0819
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0158 0.4894
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0038 0.0412
Loa Loa (eye worm) Smad1 0.0008 0.0022 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0038 0.0234
Plasmodium falciparum glutathione reductase 0.0039 0.0259 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0158 0.4894
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0238 0.0248
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0259 0.0277
Loa Loa (eye worm) hypothetical protein 0.0026 0.0158 0.0977
Schistosoma mansoni cpg binding protein 0.0029 0.0186 0.2019
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.147
Mycobacterium tuberculosis Conserved protein 0.0036 0.0238 0.0248
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0721 0.0697
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0238 0.147
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.0034 0.0135
Echinococcus multilocularis smad 0.0008 0.0022 0.0851
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0038 0.0412
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1848 1

Activities

Activity type Activity value Assay description Source Reference
-logMIC (functional) = 4.41 Antibacterial activity against Escherichia coli assessed as growth inhibition after 24 hr by two-fold serial dilution method ChEMBL. No reference
MIC (functional) = 10.5 ug ml-1 Antibacterial activity against Escherichia coli assessed as growth inhibition after 24 hr by two-fold serial dilution method ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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