Detailed information for compound 840092

Basic information

Technical information
  • TDR Targets ID: 840092
  • Name: 7-[[4-chloro-3-(trifluoromethyl)phenyl]amino] -6-(thiophen-2-ylmethyl)-7H-pyrrolo[4,3-b]pyr idin-5-one
  • MW: 423.839 | Formula: C19H13ClF3N3OS
  • H donors: 1 H acceptors: 2 LogP: 4.45 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(Cc2cccs2)C(c2c1cccn2)Nc1ccc(c(c1)C(F)(F)F)Cl
  • InChi: 1S/C19H13ClF3N3OS/c20-15-6-5-11(9-14(15)19(21,22)23)25-17-16-13(4-1-7-24-16)18(27)26(17)10-12-3-2-8-28-12/h1-9,17,25H,10H2
  • InChiKey: KVNQTAQIENKXCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-6-(2-thienylmethyl)-7H-pyrrolo[4,3-b]pyridin-5-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0068 0.0101 0.0119
Mycobacterium ulcerans dehydrogenase/reductase 0.0098 0.0155 0.0155
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0098 0.0155 0.0457
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0098 0.0155 0.0155
Leishmania major hypothetical protein, conserved 0.0098 0.0155 0.0457
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Leishmania major quinonoid dihydropteridine reductase 0.0098 0.0155 0.0457
Echinococcus multilocularis carbonyl reductase 1 0.0098 0.0155 0.5493
Mycobacterium ulcerans short-chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short-chain dehydrogenase 0.0098 0.0155 0.0155
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0098 0.0155 0.0457
Echinococcus granulosus histone deacetylase 6 0.0043 0.0057 0.2026
Mycobacterium ulcerans ketoacyl reductase 0.0098 0.0155 0.0155
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Leishmania major quinonoid dihydropteridine reductase 0.0098 0.0155 0.0457
Onchocerca volvulus 0.0098 0.0155 1
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.0176
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0155 0.0457
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0057 0.0163
Loa Loa (eye worm) hypothetical protein 0.0037 0.0046 0.0054
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0098 0.0155 0.5493
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0098 0.0155 0.0457
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0098 0.0155 0.0155
Echinococcus granulosus histone deacetylase 8 0.0013 0.0003 0.0097
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0098 0.0155 0.0457
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0098 0.0155 0.0457
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Mycobacterium ulcerans ketoacyl reductase 0.0098 0.0155 0.0155
Brugia malayi putative malonyl-CoA decarboxylase 0.4745 0.8518 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0057 0.0163
Leishmania major hypothetical protein, conserved 0.0098 0.0155 0.0457
Echinococcus granulosus WW domain containing oxidoreductase 0.0098 0.0155 0.5502
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0098 0.0155 0.5493
Schistosoma mansoni histone deacetylase hda2 0.005 0.0069 0.2502
Leishmania major short chain dehydrogenase-like protein 0.0098 0.0155 0.0457
Plasmodium vivax histone deacetylase, putative 0.0043 0.0057 0.3569
Toxoplasma gondii histone deacetylase HDAC1 0.0043 0.0057 0.3569
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.4745 0.8518 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0098 0.0155 0.0457
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0098 0.0155 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0098 0.0155 0.0457
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 1
Brugia malayi Dehydrogenases, short chain protein 30 0.0098 0.0155 0.0182
Mycobacterium ulcerans short chain dehydrogenase 0.5569 1 1
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0098 0.0155 1
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0098 0.0155 0.5493
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0101 0.3597
Schistosoma mansoni histone deacetylase 1 2 3 0.0013 0.0003 0.0099
Mycobacterium leprae Probable oxidoreductase 0.0098 0.0155 0.5
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Brugia malayi histone deacetylase 11 0.0013 0.0003 0.0003
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0098 0.0155 1
Brugia malayi histone deacetylase 3 (HD3) 0.0013 0.0003 0.0003
Leishmania major quinonoid dihydropteridine reductase 0.0098 0.0155 0.0457
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 1
Echinococcus multilocularis ankyrin repeat protein 0.0165 0.0275 0.977
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 1
Toxoplasma gondii oxidoreductase, putative 0.0098 0.0155 1
Echinococcus multilocularis carbonyl reductase 1 0.0098 0.0155 0.5493
Trypanosoma cruzi short chain dehydrogenase, putative 0.0098 0.0155 0.0457
Onchocerca volvulus 0.0098 0.0155 1
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Onchocerca volvulus 0.0098 0.0155 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0098 0.0155 1
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0057 0.2023
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Onchocerca volvulus 0.0098 0.0155 1
Toxoplasma gondii carbonyl reductase 1, putative 0.0098 0.0155 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0098 0.0155 0.0155
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0098 0.0155 0.0457
Toxoplasma gondii histone deacetylase HDAC5 0.0013 0.0003 0.003
Toxoplasma gondii oxidoreductase, putative 0.0098 0.0155 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0098 0.0155 0.0155
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0098 0.0155 1
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Trypanosoma brucei short-chain dehydrogenase, putative 0.0098 0.0155 0.0457
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0155 0.0457
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0098 0.0155 0.0457
Brugia malayi histone deacetylase 1 (HD1) 0.0013 0.0003 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0098 0.0155 0.0457
Leishmania major pteridine reductase 1 0.0098 0.0155 0.0457
Loa Loa (eye worm) histone deacetylase 1 0.0013 0.0003 0.0003
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Onchocerca volvulus 0.0098 0.0155 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0098 0.0155 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0155 0.0457
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0098 0.0155 0.0457
Echinococcus multilocularis histone deacetylase 0.0043 0.0057 0.2023
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0003 0.0176
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0098 0.0155 0.0457
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0155 0.0155
Echinococcus multilocularis histone deacetylase 1 0.0013 0.0003 0.0097
Echinococcus granulosus carbonyl reductase 1 0.0098 0.0155 0.5502
Leishmania major quinonoid dihydropteridine reductase 0.0098 0.0155 0.0457
Trypanosoma brucei histone deacetylase 4 0.0043 0.0057 0.0163
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0057 0.207
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0155 0.0155
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Onchocerca volvulus 0.0098 0.0155 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0098 0.0155 1
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0098 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0101 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0098 0.0155 0.0182
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0098 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Plasmodium vivax histone deacetylase 2, putative 0.0043 0.0057 0.3569
Brugia malayi Histone deacetylase family protein 0.0043 0.0057 0.0067
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Brugia malayi Histone deacetylase family protein 0.0043 0.0057 0.0067
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0098 0.0155 0.5622
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0003 0.0176
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0098 0.0155 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.0155 0.0155
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0098 0.0155 0.0457
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0098 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Leishmania major hypothetical protein, conserved 0.0098 0.0155 0.0457
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0098 0.0155 0.0457
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Giardia lamblia Hypothetical protein 0.0098 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Leishmania major oxidoreductase-like protein 0.0098 0.0155 0.0457
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0098 0.0155 1
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0098 0.0155 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Echinococcus multilocularis carbonyl reductase 1 0.0098 0.0155 0.5493
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.0176
Entamoeba histolytica short chain dehydrogenase family protein 0.0098 0.0155 1
Onchocerca volvulus 0.0098 0.0155 1
Echinococcus granulosus histone deacetylase 3 0.0013 0.0003 0.0097
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Plasmodium vivax hypothetical protein, conserved 0.0098 0.0155 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0098 0.0155 0.0155
Plasmodium falciparum steroid dehydrogenase, putative 0.0098 0.0155 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0098 0.0155 0.5493
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0098 0.0155 0.0155
Trypanosoma brucei oxidoreductase-like protein 0.0098 0.0155 0.0457
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Onchocerca volvulus 0.0098 0.0155 1
Leishmania major hypothetical protein, conserved 0.0098 0.0155 0.0457
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0098 0.0155 0.0457
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Echinococcus multilocularis transient receptor potential cation channel 0.0098 0.0155 0.5493
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Mycobacterium tuberculosis Possible oxidoreductase 0.0098 0.0155 0.0155
Echinococcus granulosus carbonyl reductase 1 0.0098 0.0155 0.5502
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Loa Loa (eye worm) dehydrogenase 0.0098 0.0155 0.0182
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Entamoeba histolytica hypothetical protein, conserved 0.0098 0.0155 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Leishmania major histone deacetylase, putative 0.0043 0.0057 0.0163
Trypanosoma brucei histone deacetylase 3 0.0043 0.0057 0.0163
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0098 0.0155 1
Brugia malayi hypothetical protein 0.0098 0.0155 0.0182
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0098 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0101 0.0119
Schistosoma mansoni carbonyl reductase 0.0098 0.0155 0.5622
Echinococcus granulosus acetylcholinesterase 0.0068 0.0101 0.3603
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1865 0.3334 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.0155 0.0182
Echinococcus granulosus acetylcholinesterase 0.0068 0.0101 0.3603
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Mycobacterium ulcerans short-chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0098 0.0155 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Loa Loa (eye worm) histone deacetylase 0.0043 0.0057 0.0067
Echinococcus granulosus retinol dehydrogenase 11 0.0098 0.0155 0.5502
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Giardia lamblia Reductase, putative 0.0098 0.0155 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Echinococcus granulosus ankyrin repeat protein 0.0165 0.0275 0.9786
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0098 0.0155 0.0155
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Echinococcus granulosus oxidoreductase 0.0098 0.0155 0.5502
Echinococcus granulosus hypothetical protein 0.0098 0.0155 0.5502
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0098 0.0155 1
Loa Loa (eye worm) hypothetical protein 0.4745 0.8518 1
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0057 0.207
Echinococcus granulosus carbonyl reductase 1 0.0098 0.0155 0.5502
Onchocerca volvulus Histone deacetylase 10 homolog 0.0013 0.0003 0.0176
Echinococcus multilocularis histone deacetylase 6 0.005 0.0069 0.2445
Entamoeba histolytica hypothetical protein, conserved 0.0098 0.0155 1
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0098 0.0155 0.5493
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0098 0.0155 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Schistosoma mansoni carbonyl reductase 0.0098 0.0155 0.5622
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0057 0.2023
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0098 0.0155 0.0457
Echinococcus multilocularis retinol dehydrogenase 11 0.0098 0.0155 0.5493
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0098 0.0155 0.0155
Echinococcus granulosus retinol dehydrogenase 11 0.0098 0.0155 0.5502
Echinococcus multilocularis conserved hypothetical protein 0.0098 0.0155 0.5493
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0098 0.0155 0.0457
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0155 0.0155
Echinococcus granulosus histone deacetylase 1 0.0013 0.0003 0.0097
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0098 0.0155 0.0182
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Plasmodium falciparum histone deacetylase, putative 0.0043 0.0057 0.3569
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Brugia malayi Dehydrogenases, short chain protein 2 0.0098 0.0155 0.0182
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1865 0.3334 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0098 0.0155 0.0457
Schistosoma mansoni carbonyl reductase 0.0098 0.0155 0.5622
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0155 0.0457
Loa Loa (eye worm) carboxylesterase 0.0068 0.0101 0.0119
Mycobacterium ulcerans carveol-like dehydrogenase 0.0098 0.0155 0.0155
Onchocerca volvulus 0.0098 0.0155 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0098 0.0155 0.5622
Leishmania major quinonoid dihydropteridine reductase 0.0098 0.0155 0.0457
Leishmania major histone deacetylase, putative 0.0043 0.0057 0.0163
Echinococcus granulosus steroid dehydrogenase 0.0098 0.0155 0.5502
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Leishmania major quinonoid dihydropteridine reductase 0.0098 0.0155 0.0457
Leishmania major quinonoid dihydropteridine reductase 0.0098 0.0155 0.0457
Onchocerca volvulus Sepiapterin reductase homolog 0.0098 0.0155 1
Leishmania major dehydrogenase-like protein 0.0098 0.0155 0.0457
Leishmania major malonyl-coa decarboxylase-like protein 0.1865 0.3334 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0013 0.0003 0.0176
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.0176
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0098 0.0155 0.5502
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0155 0.0155
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Leishmania major hypothetical protein, conserved 0.0098 0.0155 0.0457
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0098 0.0155 0.5622
Brugia malayi Carboxylesterase family protein 0.0068 0.0101 0.0119
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0098 0.0155 0.0155
Brugia malayi Carboxylesterase family protein 0.0068 0.0101 0.0119
Leishmania major 3-keto-dihydrosphingosine reductase 0.0098 0.0155 0.0457
Trypanosoma brucei short-chain dehydrogenase, putative 0.0098 0.0155 0.0457
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Echinococcus granulosus histone deacetylase 6 0.005 0.0069 0.2449
Schistosoma mansoni histone deacetylase 0.0013 0.0003 0.0099
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0057 0.0067
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0101 0.3682
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0098 0.0155 0.5502
Echinococcus multilocularis carbonyl reductase 1 0.0098 0.0155 0.5493
Entamoeba histolytica short chain dehydrogenase family protein 0.0098 0.0155 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0098 0.0155 0.0457
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Brugia malayi Retinol dehydrogenase 12 0.0098 0.0155 0.0182
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0098 0.0155 0.0457
Giardia lamblia Short-chain dehydrogenase, putative 0.0098 0.0155 1
Schistosoma mansoni retinal dehydrogenase 0.0098 0.0155 0.5622
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Echinococcus multilocularis transient receptor potential cation channel 0.0168 0.0282 1
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0098 0.0155 1
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0098 0.0155 0.0457
Echinococcus multilocularis steroid dehydrogenase 0.0098 0.0155 0.5493
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Loa Loa (eye worm) histone deacetylase 3 0.0013 0.0003 0.0003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Echinococcus multilocularis histone deacetylase 3 0.0013 0.0003 0.0097
Loa Loa (eye worm) histone deacetylase 11 0.0013 0.0003 0.0003
Mycobacterium ulcerans oxidoreductase 0.0098 0.0155 0.0155
Onchocerca volvulus 0.0098 0.0155 1
Trichomonas vaginalis steroid dehydrogenase, putative 0.0098 0.0155 1
Leishmania major short chain dehydrogenase, putative 0.0098 0.0155 0.0457
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0101 0.3597
Onchocerca volvulus 0.0098 0.0155 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0098 0.0155 1
Loa Loa (eye worm) dehydrogenase 0.0098 0.0155 0.0182
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0098 0.0155 0.5502
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.1865 0.3334 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0098 0.0155 0.0457
Loa Loa (eye worm) hypothetical protein 0.003 0.0034 0.004
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0098 0.0155 0.0155
Echinococcus granulosus transient receptor potential cation channel 0.0168 0.0281 1
Entamoeba histolytica hypothetical protein 0.0098 0.0155 1
Echinococcus granulosus hypothetical protein 0.0098 0.0155 0.5502
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Echinococcus granulosus histone deacetylase 6 0.0043 0.0057 0.2026
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Brugia malayi oxidoreductase 0.0098 0.0155 0.0182
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Mycobacterium ulcerans oxidoreductase 0.0098 0.0155 0.0155
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0057 0.0163
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0101 0.3603
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0098 0.0155 0.0155
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Echinococcus granulosus carbonyl reductase 1 0.0098 0.0155 0.5502
Mycobacterium ulcerans ketoacyl reductase 0.0098 0.0155 0.0155
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0155 0.0457
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0098 0.0155 0.0155
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.0176
Plasmodium falciparum histone deacetylase 2 0.0043 0.0057 0.3569
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0098 0.0155 0.0155
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0098 0.0155 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0098 0.0155 0.0457
Echinococcus granulosus histone deacetylase 0.0043 0.0057 0.2026
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Leishmania major short chain dehydrogenase, putative 0.0098 0.0155 0.0457
Onchocerca volvulus 0.0098 0.0155 1
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0098 0.0155 0.0155
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Brugia malayi dehydrogenases, short chain protein 2 0.0098 0.0155 0.0182
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0057 0.2023
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0098 0.0155 0.5622
Schistosoma mansoni histone deacetylase 0.0013 0.0003 0.0099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0101 0.3597
Plasmodium vivax steroid dehydrogenase, putative 0.0098 0.0155 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Loa Loa (eye worm) oxidoreductase 0.0098 0.0155 0.0182
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0098 0.0155 0.0182
Echinococcus multilocularis retinol dehydrogenase 13 0.0098 0.0155 0.5493
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0098 0.0155 1
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.0176
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0098 0.0155 0.0155
Trichomonas vaginalis histone deacetylase, putative 0.0013 0.0003 0.0176
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0098 0.0155 0.5502
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Schistosoma mansoni short chain dehydrogenase 0.0098 0.0155 0.5622
Trypanosoma brucei short-chain dehydrogenase, putative 0.0098 0.0155 0.0457
Brugia malayi Histone deacetylase 1 0.0013 0.0003 0.0003
Trypanosoma cruzi hypothetical protein, conserved 0.0098 0.0155 0.0457
Mycobacterium ulcerans short-chain dehydrogenase 0.0098 0.0155 0.0155
Echinococcus granulosus histone deacetylase 7 0.0043 0.0057 0.2026
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0098 0.0155 0.0182
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0098 0.0155 0.0457
Echinococcus multilocularis oxidoreductase 0.0098 0.0155 0.5493
Echinococcus multilocularis histone deacetylase 8 0.0013 0.0003 0.0097
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0165 0.0275 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0098 0.0155 1
Onchocerca volvulus 0.0098 0.0155 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0098 0.0155 0.5493
Mycobacterium ulcerans short-chain type oxidoreductase 0.0098 0.0155 0.0155
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Mycobacterium ulcerans short chain dehydrogenase 0.0098 0.0155 0.0155
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0098 0.0155 0.0457
Echinococcus multilocularis steroid dehydrogenase 0.0098 0.0155 0.5493
Schistosoma mansoni histone deacetylase hda2 0.0013 0.0003 0.0099
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0098 0.0155 0.0182
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0098 0.0155 0.0457
Brugia malayi hypothetical protein 0.0098 0.0155 0.0182
Mycobacterium ulcerans dehydrogenase 0.0098 0.0155 0.0155
Schistosoma mansoni steroid dehydrogenase 0.0098 0.0155 0.5622
Trypanosoma brucei histone deacetylase, putative 0.0043 0.0057 0.0163
Brugia malayi dehydrogenases, short chain protein 9 0.0098 0.0155 0.0182

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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