Detailed information for compound 840472

Basic information

Technical information
  • TDR Targets ID: 840472
  • Name: N-(2-chlorophenyl)-2-[1-oxo-4-(pyridin-3-ylme thyl)phthalazin-2-yl]acetamide
  • MW: 404.849 | Formula: C22H17ClN4O2
  • H donors: 1 H acceptors: 3 LogP: 3.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cn1nc(Cc2cccnc2)c2c(c1=O)cccc2)Nc1ccccc1Cl
  • InChi: 1S/C22H17ClN4O2/c23-18-9-3-4-10-19(18)25-21(28)14-27-22(29)17-8-2-1-7-16(17)20(26-27)12-15-6-5-11-24-13-15/h1-11,13H,12,14H2,(H,25,28)
  • InChiKey: DJNXYRUBEQMXMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-chlorophenyl)-2-[1-oxo-4-(3-pyridylmethyl)phthalazin-2-yl]acetamide
  • N-(2-chlorophenyl)-2-[1-oxo-4-(3-pyridylmethyl)-2-phthalazinyl]acetamide
  • N-(2-chlorophenyl)-2-[1-keto-4-(3-pyridylmethyl)phthalazin-2-yl]acetamide
  • N-(2-chlorophenyl)-2-[1-oxo-4-(pyridin-3-ylmethyl)phthalazin-2-yl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0124 0.0112
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0124 0.1257
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0881 0.3468
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0278 0.304
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0238 0.023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0005
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0124 0.0486
Echinococcus granulosus peptidase Clp S14 family 0.0041 0.0705 0.2773
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0063 0.1194 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0063 0.1194 0.5
Schistosoma mansoni terminal deoxycytidyl transferase 0.0011 0.0015 0.0058
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0238 0.0938
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0123 0.2542 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0238 0.0938
Trypanosoma cruzi trans-sialidase, putative 0.0031 0.0465 0.5199
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0124 0.1257
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0881 1
Trypanosoma cruzi trans-sialidase, putative 0.0031 0.0465 0.5198
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.018 0.191
Schistosoma mansoni peptidase Clp (S14 family) 0.0063 0.1194 0.4698
Brugia malayi nuclear hormone receptor 0.0021 0.0238 0.023
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0278 0.1444
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0005
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0063 0.1194 0.4698
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0238 0.0938
Echinococcus granulosus dna polymerase kappa 0.003 0.0457 0.1798
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0881 1
Leishmania major DNA polymerase kappa, putative 0.0016 0.0124 0.1266
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0238 0.023
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0016 0.0124 0.159
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0124 0.0112
Brugia malayi nuclear hormone receptor 0.0442 0.9755 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0063 0.1194 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0123 0.2542 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0457 0.273
Brugia malayi isocitrate dehydrogenase 0.0015 0.0124 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0238 0.023
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0063 0.1194 0.5
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0238 0.023
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0063 0.1194 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0457 0.5104
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0238 0.0938
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0238 0.0938
Brugia malayi hypothetical protein 0.0011 0.0019 0.0005
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0238 0.0938
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0124 0.1266
Trypanosoma brucei protein kinase, putative 0.0049 0.0881 1
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0238 0.0938
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0238 0.0938
Trypanosoma cruzi trans-sialidase, putative 0.0031 0.0465 0.5199
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0022 0.0263 0.1304
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0238 0.0938
Trypanosoma brucei trans-sialidase, putative 0.0031 0.0465 0.5199
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0486
Trypanosoma brucei unspecified product 0.0025 0.0347 0.3838
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0238 0.0938
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0486
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.3188
Brugia malayi ecdysteroid receptor 0.0021 0.0238 0.023
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0238 0.023
Trypanosoma cruzi trans-sialidase, putative 0.0031 0.0465 0.5198
Schistosoma mansoni coup transcription factor 0.0021 0.0238 0.0938
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.018 0.0529
Echinococcus multilocularis peptidase Clp (S14 family) 0.0041 0.0705 0.2773
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0457 0.5104
Loa Loa (eye worm) hypothetical protein 0.0023 0.0291 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0238 0.023
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0881 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0124 0.1257
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.003 0.0457 0.3948
Trypanosoma cruzi trans-sialidase, putative 0.0031 0.0465 0.5198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0238 0.023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0881 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0011 0.0015 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0238 0.0938
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0123 0.2542 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0486
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0881 0.3468
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0123 0.2542 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0019 0.0076
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0881 0.3468
Trypanosoma cruzi trans-sialidase, putative 0.0031 0.0465 0.5199
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0457 0.5104
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0005
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.005 0.0404
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0881 1
Trypanosoma brucei trans-sialidase, putative 0.0031 0.0465 0.5199
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0457 0.5104
Trypanosoma brucei trans-sialidase 0.0031 0.0465 0.5199
Trypanosoma brucei DNA polymerase IV, putative 0.003 0.0457 0.5104
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0238 0.0938
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.018 0.191
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0238 0.0938
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0041 0.0705 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.018 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0238 0.023
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0881 1
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0123 0.2542 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0238 0.023
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0238 0.0938
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0238 0.023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0238 0.0938
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0881 0.089
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Trypanosoma brucei trans-sialidase, putative 0.0031 0.0465 0.5199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0238 0.023
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0124 0.0486
Echinococcus multilocularis dna polymerase kappa 0.003 0.0457 0.1798
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0124 0.1257
Plasmodium falciparum ataxin-2 like protein, putative 0.0022 0.0278 0.1444
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0124 0.1266
Brugia malayi nuclear receptor RXR 0.0011 0.0019 0.0005
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0063 0.1194 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0123 0.2542 0.2595
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0881 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.018 0.0738
Brugia malayi steroid hormone receptor 0.0021 0.0238 0.023
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0881 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0881 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0123 0.2542 0.2595
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0238 0.023
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0238 0.023
Loa Loa (eye worm) hypothetical protein 0.0432 0.9535 0.9775
Trypanosoma brucei trans-sialidase, putative 0.0031 0.0465 0.5199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0238 0.023
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0238 0.0938
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0076
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0238 0.0938
Brugia malayi polk-prov protein 0.0023 0.0291 0.0284
Trichomonas vaginalis DNA polymerase eta, putative 0.003 0.0457 0.3948
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0063 0.1194 0.4698
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0238 0.023
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0238 0.0938
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0238 0.0938
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0238 0.0938
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0881 0.7079
Schistosoma mansoni ap endonuclease 0.0018 0.018 0.0709
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0124 0.0486
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0041 0.0705 0.4744
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0041 0.0705 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.018 0.0709
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0123 0.2542 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0011 0.0015 0.0058
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Brugia malayi hypothetical protein 0.0014 0.0099 0.0087
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.018 0.191
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0238 0.0938
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.018 0.017
Brugia malayi Probable ClpP-like protease 0.0063 0.1194 0.1211
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0238 0.023
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0063 0.1194 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0123 0.2542 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0291 0.3188
Brugia malayi hypothetical protein 0.0011 0.0019 0.0005
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0238 0.0938
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.018 0.0529
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.018 0.191
Loa Loa (eye worm) hypothetical protein 0.0063 0.1194 0.1211
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0238 0.0938
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.005 0.0404
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0063 0.1194 1
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0881 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.018 0.0709
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0238 0.0938
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.018 0.2399
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0238 0.0938
Trypanosoma cruzi DNA polymerase kappa, putative 0.003 0.0457 0.5104
Mycobacterium ulcerans DNA polymerase IV 0.003 0.0457 0.273
Plasmodium vivax ataxin-2 like protein, putative 0.0022 0.0278 0.1444
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0019 0.0005
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0124 0.1257
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.018 0.017
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0063 0.1194 1
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0881 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0238 0.023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0238 0.023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0238 0.0938
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0881 0.3468
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.005 0.0404
Trypanosoma brucei PAB1-binding protein , putative 0.0022 0.0278 0.304
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0022 0.0263 0.1304
Brugia malayi MAP kinase sur-1 0.0049 0.0881 0.089
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0011 0.0015 0.0058
Echinococcus multilocularis dna polymerase eta 0.0011 0.0015 0.0058
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0063 0.1194 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0019 0.0005
Trypanosoma cruzi PAB1-binding protein , putative 0.0022 0.0278 0.304
Schistosoma mansoni ap endonuclease 0.0018 0.018 0.0709
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0442 0.9755 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0238 0.023
Toxoplasma gondii hypothetical protein 0.0022 0.0263 0.1304
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0019 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0238 0.023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0238 0.023
Toxoplasma gondii LsmAD domain-containing protein 0.0022 0.0278 0.1444
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0881 0.3468
Loa Loa (eye worm) hypothetical protein 0.0022 0.0278 0.0271
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0019 0.0076
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0238 0.0938
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0881 1
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0238 0.0938
Leishmania major hypothetical protein, conserved 0.0022 0.0278 0.304
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0063 0.1194 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0238 0.0938
Trypanosoma brucei DNA polymerase IV, putative 0.0025 0.0347 0.3838
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0238 0.023
Echinococcus granulosus dna polymerase eta 0.0011 0.0015 0.0058
Trypanosoma brucei trans-sialidase, putative 0.0031 0.0465 0.5199
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0124 0.1578
Trypanosoma brucei DNA polymerase kappa, putative 0.003 0.0457 0.5104
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Trypanosoma cruzi trans-sialidase, Group I, putative 0.0031 0.0465 0.5199
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0124 0.0486
Trypanosoma cruzi trans-sialidase, putative 0.0031 0.0465 0.5198
Brugia malayi nuclear receptor NHR-88 0.0021 0.0238 0.023
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0238 0.023
Loa Loa (eye worm) hypothetical protein 0.0011 0.0019 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0238 0.023
Brugia malayi hypothetical protein 0.0022 0.0278 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0238 0.023
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0238 0.0938
Toxoplasma gondii exonuclease III APE 0.0018 0.018 0.0529
Schistosoma mansoni DNA polymerase eta 0.0011 0.0015 0.0058
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0022 0.0263 0.0818

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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