TDR Targets

Basic information

Technical information

TDR Targets ID: 840664
Name: N-(4-fluorophenyl)-2-[1-oxo-4-(pyridin-3-ylme thyl)phthalazin-2-yl]-N-propylacetamide
MW: 430.474 | Formula: C25H23FN4O2
H donors: 0 H acceptors: 3 LogP: 3.81 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(C(=O)Cn1nc(Cc2cccnc2)c2c(c1=O)cccc2)c1ccc(cc1)F
InChi: 1S/C25H23FN4O2/c1-2-14-29(20-11-9-19(26)10-12-20)24(31)17-30-25(32)22-8-4-3-7-21(22)23(28-30)15-18-6-5-13-27-16-18/h3-13,16H,2,14-15,17H2,1H3
InChiKey: CYSITHXCZSBMPL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-fluorophenyl)-2-[1-oxo-4-(3-pyridylmethyl)phthalazin-2-yl]-N-propyl-acetamide
N-(4-fluorophenyl)-2-[1-oxo-4-(3-pyridylmethyl)-2-phthalazinyl]-N-propylacetamide
N-(4-fluorophenyl)-2-[1-keto-4-(3-pyridylmethyl)phthalazin-2-yl]-N-propyl-acetamide
N-(4-fluorophenyl)-2-[1-oxo-4-(pyridin-3-ylmethyl)phthalazin-2-yl]-N-propyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	thyroid hormone receptor	0.0141	0.0764	0.1263
Schistosoma mansoni	lamin	0.0053	0.0196	0.0324
Schistosoma mansoni	inositol monophosphatase	0.0073	0.0325	0.0538
Schistosoma mansoni	hypothetical protein	0.0131	0.0697	0.1152
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0325	0.1031
Echinococcus multilocularis	geminin	0.0164	0.0909	0.0909
Leishmania major	hypothetical protein, conserved	0.005	0.0177	0.0561
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0053	0.0196	0.1023
Echinococcus multilocularis	lamin dm0	0.0053	0.0196	0.0196
Schistosoma mansoni	intermediate filament proteins	0.0053	0.0196	0.0324
Giardia lamblia	CDC8	0.0148	0.0808	0.2561
Schistosoma mansoni	thymidylate kinase	0.0148	0.0808	0.1336
Onchocerca volvulus		0.0053	0.0196	0.2423
Trypanosoma cruzi	thymidine kinase, putative	0.0514	0.3156	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0082	0.0244
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0152	0.025
Echinococcus granulosus	snurportin 1	0.03	0.1782	0.2944
Treponema pallidum	thymidylate kinase (tmk)	0.0148	0.0808	1
Echinococcus granulosus	thymidine kinase	0.0965	0.6051	1
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0005	0.0015
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0057	0.0433
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0039	0.0123
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0056	0.0219	0.1154
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0325	0.1031
Schistosoma mansoni	hypothetical protein	0.0031	0.0057	0.0095
Trypanosoma brucei	thymidylate kinase, putative	0.0148	0.0808	0.2561
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0056	0.0219	0.271
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0065	0.0276	0.2679
Schistosoma mansoni	hypothetical protein	0.0022	0.0001	0.0002
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0082	0.0377
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0152	0.1144
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0082	0.0259
Schistosoma mansoni	hypothetical protein	0.0104	0.0524	0.0865
Loa Loa (eye worm)	intermediate filament protein	0.0053	0.0196	0.1023
Echinococcus multilocularis	thymidine kinase	0.0965	0.6051	0.6051
Onchocerca volvulus		0.0035	0.0082	0.1012
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0098	0.0487	0.3676
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0082	0.0259
Plasmodium vivax	thymidylate kinase, putative	0.0148	0.0808	1
Onchocerca volvulus		0.0035	0.0082	0.1012
Toxoplasma gondii	ABC1 family protein	0.0035	0.0082	0.1012
Brugia malayi	hypothetical protein	0.0035	0.0082	0.0616
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0082	0.0135
Trichomonas vaginalis	thymidine kinase, putative	0.0514	0.3156	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0158	0.119
Entamoeba histolytica	thymidine kinase, putative	0.0514	0.3156	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0082	0.0259
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0177	0.1798
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0082	0.0135
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0073	0.0325	0.4025
Brugia malayi	RNA, U transporter 1	0.008	0.0371	0.28
Echinococcus multilocularis	transfer RNA-Ile	0.0965	0.6051	0.6051
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0028	0.0039	0.0136
Trypanosoma brucei	thymidylate kinase, putative	0.0148	0.0808	0.2561
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0082	0.0377
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0057	0.0057
Leishmania major	thymidylate kinase-like protein	0.0148	0.0808	0.2561
Brugia malayi	hypothetical protein	0.0228	0.1324	1
Brugia malayi	cytoplasmic intermediate filament protein	0.0028	0.0039	0.0296
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0152	0.0772
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.1324	0.2189
Entamoeba histolytica	hypothetical protein	0.0035	0.0082	0.0244
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0325	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0082	0.0377
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0152	0.025
Trichomonas vaginalis	ap endonuclease, putative	0.0056	0.0219	0.0694
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0025	0.0021	0.0021
Trichomonas vaginalis	thymidine kinase, putative	0.0514	0.3156	1
Trypanosoma brucei	RNA helicase, putative	0.022	0.1273	0.4033
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0082	0.0135
Plasmodium falciparum	ataxin-2 like protein, putative	0.005	0.0177	0.1798
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0152	0.025
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0082	0.0259
Schistosoma mansoni	hypothetical protein	0.0164	0.0909	0.1502
Brugia malayi	latrophilin 2 splice variant baaae	0.0067	0.0288	0.2175
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0056	0.0219	0.0694
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0058	0.0231	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0082	0.0377
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0057	0.0239
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0005	0.0015
Toxoplasma gondii	exonuclease III APE	0.0056	0.0219	0.271
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0056	0.0219	0.0694
Brugia malayi	Importin beta-1 subunit	0.0028	0.0039	0.0292
Brugia malayi	beta-lactamase family protein	0.0035	0.0082	0.0617
Toxoplasma gondii	thymidylate kinase	0.0148	0.0808	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0152	0.0152
Schistosoma mansoni	hypothetical protein	0.0164	0.0909	0.1502
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0196	0.1023
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0082	0.0377
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.03	0.1782	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0056	0.0219	0.2343
Schistosoma mansoni	thymidine kinase	0.0965	0.6051	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0082	0.0244
Brugia malayi	intermediate filament protein	0.0053	0.0196	0.1479
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0005	0.0015
Echinococcus multilocularis	snurportin 1	0.03	0.1782	0.1782
Trypanosoma brucei	unspecified product	0.0027	0.0032	0.0101
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0022	0.0001	0.0001
Brugia malayi	thymidylate kinase	0.0148	0.0808	0.6102
Trypanosoma brucei	ingi protein (ORF1)	0.0027	0.0032	0.0101
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0082	0.0259
Echinococcus multilocularis	thymidylate kinase	0.0148	0.0808	0.0808
Schistosoma mansoni	ap endonuclease	0.0056	0.0219	0.0362
Schistosoma mansoni	lipoxygenase	0.0053	0.0201	0.0332
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0056	0.0219	0.0694
Loa Loa (eye worm)	hypothetical protein	0.0052	0.019	0.0988
Schistosoma mansoni	ap endonuclease	0.0056	0.0219	0.0362
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0056	0.0219	0.1141
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0082	0.0082
Mycobacterium ulcerans	thymidylate kinase	0.0148	0.0808	1
Brugia malayi	Inositol-1	0.0073	0.0325	0.2456
Trypanosoma brucei	importin beta-1 subunit, putative	0.0028	0.0039	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0487	0.267
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0025	0.0021	0.0035
Leishmania major	hypothetical protein, conserved	0.0035	0.0082	0.0259
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0056	0.0219	0.0362
Schistosoma mansoni	hypothetical protein	0.0035	0.0082	0.0135
Schistosoma mansoni	hypothetical protein	0.022	0.1273	0.2103
Echinococcus multilocularis	musashi	0.0053	0.0196	0.0196
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0022	0.0001	0.0002
Onchocerca volvulus		0.0053	0.0196	0.2423
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0053	0.0201	0.0332
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0131	0.0697	0.0697
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0057	0.0095
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0098	0.0487	0.267
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0141	0.0764	0.0764
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0056	0.0219	0.2343
Trypanosoma brucei	ingi protein (ORF1)	0.0027	0.0032	0.0101
Trichomonas vaginalis	esterase, putative	0.0035	0.0082	0.0259
Trypanosoma brucei	PAB1-binding protein , putative	0.005	0.0177	0.0561
Brugia malayi	beta-lactamase family protein	0.0035	0.0082	0.0617
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0056	0.0219	0.0219
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0057	0.0057
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0148	0.0808	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0028	0.0039	0.0479
Onchocerca volvulus		0.0047	0.0158	0.195
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0056	0.0219	0.0694
Trichomonas vaginalis	thymidylate kinase, putative	0.0148	0.0808	0.2561
Schistosoma mansoni	hypothetical protein	0.0031	0.0057	0.0095
Echinococcus granulosus	GPCR family 2	0.0031	0.0057	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0082	0.0377
Trypanosoma brucei	hypothetical protein, conserved	0.0027	0.0032	0.0101
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0222	0.1285	1
Loa Loa (eye worm)	hypothetical protein	0.0228	0.1324	0.7412
Schistosoma mansoni	thyroid hormone receptor	0.0141	0.0764	0.1263
Entamoeba histolytica	Thymidylate kinase, putative	0.0148	0.0808	0.255
Schistosoma mansoni	hypothetical protein	0.0031	0.0057	0.0095
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0098	0.0487	0.3676
Onchocerca volvulus		0.0035	0.0082	0.1012
Giardia lamblia	Thymidine kinase	0.0514	0.3156	1
Trichomonas vaginalis	inositol monophosphatase, putative	0.0073	0.0325	0.1031
Echinococcus granulosus	intermediate filament protein	0.0053	0.0196	0.0324
Schistosoma mansoni	inositol monophosphatase	0.0073	0.0325	0.0538
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.1324	0.1324
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0056	0.0219	0.0694
Brugia malayi	Intermediate filament tail domain containing protein	0.0053	0.0196	0.1479
Entamoeba histolytica	hypothetical protein	0.0035	0.0082	0.0244
Trypanosoma cruzi	thymidine kinase, putative	0.0514	0.3156	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0152	0.025
Trypanosoma cruzi	thymidylate kinase, putative	0.0148	0.0808	0.2561
Echinococcus granulosus	Thymidine kinase 2 mitochondrial	0.0965	0.6051	1
Schistosoma mansoni	importin beta-1	0.0028	0.0039	0.0064
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0057	0.0433
Plasmodium vivax	ataxin-2 like protein, putative	0.005	0.0177	0.1798
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0057	0.0057
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0148	0.0808	0.604
Echinococcus multilocularis	inositol monophosphatase 1	0.0073	0.0325	0.0325
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0152	0.0152
Trypanosoma cruzi	thymidylate kinase, putative	0.0148	0.0808	0.2561
Echinococcus multilocularis	thymidine kinase	0.0965	0.6051	0.6051
Schistosoma mansoni	hypothetical protein	0.03	0.1782	0.2944
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0005	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0082	0.0377
Giardia lamblia	Deoxynucleoside kinase	0.0391	0.2366	0.7495
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0057	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0288	0.1545
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.0325	0.1031
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.0604	0.3336
Brugia malayi	hypothetical protein	0.005	0.0177	0.1337
Chlamydia trachomatis	thymidylate kinase	0.0148	0.0808	0.5
Toxoplasma gondii	LsmAD domain-containing protein	0.005	0.0177	0.2191
Brugia malayi	hypothetical protein	0.0032	0.0064	0.0485
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0005	0.0015
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0082	0.0135
Trypanosoma brucei	thymidine kinase	0.0514	0.3156	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0082	0.0617
Trichomonas vaginalis	ap endonuclease, putative	0.0056	0.0219	0.0694
Echinococcus granulosus	lamin	0.0053	0.0196	0.0324
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0056	0.0219	0.068
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0082	0.056
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0131	0.0697	0.1152
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0082	0.0259
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0073	0.0325	0.3352
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0082	0.0082
Echinococcus granulosus	lamin dm0	0.0053	0.0196	0.0324
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0056	0.0219	0.271
Schistosoma mansoni	hypothetical protein	0.0031	0.0057	0.0095
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0177	0.0561
Schistosoma mansoni	lamin	0.0053	0.0196	0.0324
Brugia malayi	exodeoxyribonuclease III family protein	0.0056	0.0219	0.1654
Echinococcus multilocularis	importin subunit beta 1	0.0028	0.0039	0.0039
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0073	0.0325	0.1017
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0158	0.026
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0073	0.0325	0.1031
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0056	0.0219	0.1889
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0148	0.0808	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0082	0.0135
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0082	0.0259
Plasmodium falciparum	thymidylate kinase	0.0148	0.0808	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0177	0.0917
Echinococcus multilocularis	lamin	0.0053	0.0196	0.0196
Echinococcus granulosus	thymidylate kinase	0.0148	0.0808	0.1336
Echinococcus granulosus	inositol monophosphatase 1	0.0073	0.0325	0.0538
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0065	0.0276	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0039	0.0133
Schistosoma mansoni	hypothetical protein	0.0148	0.0808	0.1336
Echinococcus granulosus	thymidine kinase	0.0965	0.6051	1
Schistosoma mansoni	thymidylate kinase	0.0148	0.0808	0.1336
Trichomonas vaginalis	thymidine kinase, putative	0.0514	0.3156	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0057	0.0239
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0073	0.0325	0.4025
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0021	0.0035
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0073	0.0325	0.1031
Loa Loa (eye worm)	inositol-1	0.0073	0.0325	0.1756
Leishmania major	hypothetical protein, conserved	0.0058	0.0231	0.0733
Brugia malayi	MH2 domain containing protein	0.0116	0.0604	0.4563
Echinococcus granulosus	importin subunit beta 1	0.0028	0.0039	0.0064
Loa Loa (eye worm)	thymidylate kinase	0.0148	0.0808	0.449
Trypanosoma cruzi	UMP-CMP kinase, mitochondrial, putative	0.0058	0.0231	0.0733
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.0604	0.3336
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0027	0.0032	0.0101
Trichomonas vaginalis	thymidylate kinase, putative	0.0148	0.0808	0.2561
Brugia malayi	beta-lactamase	0.0035	0.0082	0.0617
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0082	0.0259
Trypanosoma cruzi	PAB1-binding protein , putative	0.005	0.0177	0.0561
Leishmania major	thymidine kinase, putative	0.0514	0.3156	1
Schistosoma mansoni	hypothetical protein	0.0067	0.0288	0.0476
Echinococcus granulosus	geminin	0.0164	0.0909	0.1502
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0053	0.0201	0.0201
Schistosoma mansoni	hypothetical protein	0.0047	0.0158	0.026
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0152	0.025
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0082	0.0377
Onchocerca volvulus	Putative thymidylate kinase	0.0148	0.0808	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 840664