TDR Targets

Basic information

Technical information

TDR Targets ID: 840730
Name: N-(2,4-dimethoxyphenyl)-3-[(4-ethoxybenzoyl)a mino]-1-benzofuran-2-carboxamide
MW: 460.479 | Formula: C26H24N2O6
H donors: 2 H acceptors: 2 LogP: 5.16 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccc(cc1)C(=O)Nc1c(oc2c1cccc2)C(=O)Nc1ccc(cc1OC)OC
InChi: 1S/C26H24N2O6/c1-4-33-17-11-9-16(10-12-17)25(29)28-23-19-7-5-6-8-21(19)34-24(23)26(30)27-20-14-13-18(31-2)15-22(20)32-3/h5-15H,4H2,1-3H3,(H,27,30)(H,28,29)
InChiKey: UTNWXQHXAYXNMG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2,4-dimethoxyphenyl)-3-[(4-ethoxybenzoyl)amino]benzofuran-2-carboxamide
N-(2,4-dimethoxyphenyl)-3-[[(4-ethoxyphenyl)-oxomethyl]amino]-2-benzofurancarboxamide
N-(2,4-dimethoxyphenyl)-3-[(4-ethoxyphenyl)carbonylamino]-1-benzofuran-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	Tubulin beta 2C chain	0.001	0.0338	0.0338
Echinococcus granulosus	Tubulin beta 2C chain	0.001	0.0338	0.0338
Echinococcus granulosus	Tubulin beta 2C chain	0.001	0.0338	0.0338
Echinococcus multilocularis	tubulin gamma 1 chain	0.001	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Loa Loa (eye worm)	tubulin beta chain	0.001	0.0338	0.0338
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.9752	0.9752
Echinococcus granulosus	tubulin gamma 1 chain	0.001	0.0338	0.0338
Echinococcus granulosus	tubulin subunit beta	0.001	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0014	0.5111	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Echinococcus multilocularis	Tubulin beta 2C chain	0.001	0.0338	0.0338
Echinococcus granulosus	tubulin subunit TubB	0.0018	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0018	0.9752	0.9752
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0018	0.9752	0.9752
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.9752	0.9752
Schistosoma mansoni	alpha tubulin	0.0018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Brugia malayi	Tubulin gamma chain	0.001	0.0338	0.0338
Loa Loa (eye worm)	steroid hormone receptor	0.0018	0.9752	0.9752
Loa Loa (eye worm)	tubulin alpha 2	0.0014	0.5111	0.5111
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0018	0.9752	0.9752
Echinococcus granulosus	peroxisome assembly protein 26	0.0018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	1	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0018	0.9752	0.9752
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0018	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.001	0.0338	0.0338
Brugia malayi	steroid hormone receptor	0.0018	0.9752	0.9752
Echinococcus granulosus	tubulin alpha chain	0.0018	1	1
Schistosoma mansoni	alpha tubulin	0.0018	1	1
Leishmania major	alpha tubulin	0.0018	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0018	0.9752	0.9752
Schistosoma mansoni	coup transcription factor	0.0018	0.9752	0.9752
Trypanosoma brucei	alpha tubulin	0.0018	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0018	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0018	0.9752	0.9752
Echinococcus multilocularis	ecdysone induced protein 78C	0.0018	0.9752	0.9752
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Echinococcus multilocularis	Tubulin beta 2C chain	0.001	0.0338	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0018	0.9752	0.9752
Brugia malayi	photoreceptor-specific nuclear receptor	0.0018	0.9752	0.9752
Trypanosoma cruzi	alpha tubulin, putative	0.0018	1	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0018	0.9752	0.9752
Loa Loa (eye worm)	BEN-1 protein	0.001	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0013	0.3629	0.3629
Leishmania major	alpha tubulin	0.0018	1	1
Echinococcus multilocularis	tubulin subunit beta	0.001	0.0338	0.0338
Loa Loa (eye worm)	tubulin beta-4 chain	0.001	0.0338	0.0338
Echinococcus multilocularis	tubulin alpha 3 chain	0.0018	1	1
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0013	0.3629	0.3629
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.9752	0.9752
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0018	1	1
Echinococcus granulosus	alpha tubulin	0.0018	1	1
Echinococcus granulosus	tubulin alpha 3 chain	0.0018	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0014	0.5111	0.494
Echinococcus granulosus	tubulin alpha 3 chain	0.0018	1	1
Brugia malayi	beta-tubulin, identical	0.001	0.0338	0.0338
Brugia malayi	Tubulin beta-1 chain	0.001	0.0338	0.0338
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0018	0.9752	0.9752
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	1	1
Brugia malayi	Tubulin alpha chain	0.0018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	1	1
Schistosoma mansoni	tubulin subunit beta	0.001	0.0338	0.0338
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0018	0.9752	0.5
Echinococcus multilocularis	tubulin alpha 3 chain	0.0018	1	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Leishmania major	alpha tubulin	0.0018	1	1
Echinococcus multilocularis	beta tubulin	0.001	0.0338	0.0338
Leishmania major	alpha tubulin	0.0018	1	1
Brugia malayi	alpha-tubulin	0.0018	1	1
Schistosoma mansoni	tubulin subunit beta	0.001	0.0338	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0018	0.9752	0.9752
Echinococcus multilocularis	tubulin alpha chain	0.0018	1	1
Echinococcus granulosus	tubulin alpha chain	0.0018	1	1
Leishmania major	alpha tubulin	0.0018	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	1	1
Echinococcus granulosus	tubulin alpha chain	0.0018	1	1
Schistosoma mansoni	tubulin subunit epsilon	0.001	0.0338	0.0338
Loa Loa (eye worm)	alpha-tubulin	0.0018	1	1
Trypanosoma brucei	alpha tubulin	0.0018	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.9752	0.9752
Entamoeba histolytica	tubulin alpha-1 chain	0.0018	1	1
Loa Loa (eye worm)	BEN-1 protein	0.001	0.0338	0.0338
Brugia malayi	nuclear receptor NHR-88	0.0018	0.9752	0.9752
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0018	0.9752	0.9752
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.001	0.0338	0.0338
Echinococcus granulosus	tubulin alpha 1C chain	0.0018	1	1
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0014	0.5111	0.5111
Trypanosoma brucei	alpha tubulin	0.0018	1	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0018	1	1
Loa Loa (eye worm)	beta-tubulin	0.001	0.0338	0.0338
Schistosoma mansoni	alpha tubulin	0.0018	1	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0018	0.9752	0.9752
Echinococcus granulosus	Tubulin beta 2C chain	0.001	0.0338	0.0338
Brugia malayi	nuclear hormone receptor	0.0018	0.9752	0.9752
Echinococcus multilocularis	tubulin alpha chain	0.0018	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0018	0.9752	0.9752
Echinococcus multilocularis	tubulin alpha chain	0.0018	1	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0018	0.9752	0.9752
Plasmodium falciparum	alpha tubulin 2	0.0018	1	1
Plasmodium falciparum	alpha tubulin 1	0.0018	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.001	0.0338	0.0338
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.9752	0.9752
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0018	0.9752	0.9752
Schistosoma mansoni	tubulin subunit beta	0.001	0.0338	0.0338
Toxoplasma gondii	alpha-tubulin I, putative	0.0018	1	1
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0018	1	1
Echinococcus granulosus	beta tubulin	0.001	0.0338	0.0338
Echinococcus granulosus	tubulin alpha chain	0.0018	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0018	0.9752	0.9752
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0018	0.9752	0.9752
Schistosoma mansoni	tubulin subunit beta	0.001	0.0338	0.0338
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Loa Loa (eye worm)	tubulin alpha 2	0.0014	0.5111	0.5111
Schistosoma mansoni	RAR-like nuclear receptor	0.0018	0.9752	0.9752
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0018	0.9752	0.9752
Echinococcus granulosus	tubulin alpha chain	0.0018	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0018	0.9752	0.9752
Schistosoma mansoni	tubulin subunit beta	0.001	0.0338	0.0338
Entamoeba histolytica	tubulin alpha chain, putative	0.0018	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0018	1	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0018	0.9752	0.9752
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0018	0.9752	0.9752
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0018	0.9752	0.9752
Schistosoma mansoni	tubulin subunit beta	0.001	0.0338	0.0338
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0018	0.9752	0.9752
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0018	0.9752	0.9752
Loa Loa (eye worm)	tubulin beta-1 chain	0.001	0.0338	0.0338
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.9752	0.9752
Schistosoma mansoni	retinoic acid receptor RXR	0.0018	0.9752	0.9752
Schistosoma mansoni	tubulin subunit alpha	0.0018	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0018	0.9752	0.9752
Echinococcus granulosus	Tubulin beta 2C chain	0.001	0.0338	0.0338
Trypanosoma brucei	alpha tubulin	0.0018	1	1
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.9752	0.9752
Loa Loa (eye worm)	hypothetical protein	0.0018	0.9752	0.9752
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0018	0.9752	0.9752
Leishmania major	alpha tubulin	0.0018	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.001	0.0338	0.0338
Echinococcus multilocularis	beta tubulin	0.001	0.0338	0.0338
Plasmodium vivax	tubulin alpha chain, putative	0.0018	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0018	1	1
Loa Loa (eye worm)	tubulin alpha chain	0.0018	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.001	0.0338	0.0338
Giardia lamblia	Alpha-tubulin	0.0018	1	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0018	0.9752	0.9752
Onchocerca volvulus		0.0018	0.9752	0.5
Leishmania major	alpha tubulin	0.0018	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0018	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0018	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.001	0.0338	0.0338
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0013	0.3629	0.3406
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0018	0.9752	0.9752
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.001	0.0338	0.0338
Schistosoma mansoni	nuclear hormone receptor	0.0018	0.9752	0.9752
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0018	0.9752	0.9752
Leishmania major	alpha tubulin	0.0018	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0018	1	1
Echinococcus granulosus	Tubulin alpha 1 chain	0.0018	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.001	0.0338	0.0338
Echinococcus granulosus	tubulin epsilon chain	0.001	0.0338	0.0338
Echinococcus multilocularis	FTZ F1 alpha	0.0018	0.9752	0.9752
Leishmania major	alpha tubulin	0.0018	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0018	0.9752	0.9752
Brugia malayi	Tubulin alpha-2 chain	0.0018	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0018	0.9752	0.9752
Leishmania major	alpha tubulin	0.0018	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0018	0.9752	0.9752
Echinococcus multilocularis	tubulin subunit TubB	0.0018	1	1
Echinococcus granulosus	beta tubulin	0.001	0.0338	0.0338
Brugia malayi	tubulin alpha chain - mouse	0.0018	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0018	0.9752	0.9752
Echinococcus multilocularis	hypothetical protein	0.0018	1	1
Echinococcus granulosus	tubulin beta 4A class IVa	0.001	0.0338	0.0338
Brugia malayi	Steroid receptor seven-up type 2	0.0018	0.9752	0.9752
Schistosoma mansoni	tubulin subunit gamma	0.001	0.0338	0.0338
Brugia malayi	Tubulin alpha-2 chain	0.0018	1	1
Echinococcus granulosus	tubulin alpha	0.001	0.0338	0.0338
Echinococcus multilocularis	tubulin alpha chain	0.0018	1	1
Giardia lamblia	Alpha-tubulin	0.0018	1	1
Schistosoma mansoni	tubulin subunit alpha	0.0018	1	1
Echinococcus granulosus	FTZ F1 alpha	0.0018	0.9752	0.9752
Schistosoma mansoni	thyroid hormone receptor	0.0018	0.9752	0.9752
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0018	0.9752	0.9752
Leishmania major	alpha tubulin	0.0018	1	1
Echinococcus multilocularis	tubulin epsilon chain	0.001	0.0338	0.0338
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.9752	0.9752
Echinococcus multilocularis	tubulin alpha	0.001	0.0338	0.0338
Brugia malayi	ecdysteroid receptor	0.0018	0.9752	0.9752
Onchocerca volvulus	Bile acid receptor homolog	0.0018	0.9752	0.5
Onchocerca volvulus	Protein ultraspiracle homolog	0.0018	0.9752	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0018	0.9752	0.9752
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0018	0.9752	0.9752
Leishmania major	alpha tubulin	0.0018	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0018	1	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0018	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0018	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0018	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0018	1	1
Toxoplasma gondii	alpha tubulin TUBA1	0.0018	1	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 840730