Detailed information for compound 841162

Basic information

Technical information
  • TDR Targets ID: 841162
  • Name: N-(3-acetamido-5,7-dimethyl-1-adamantyl)aceta mide
  • MW: 278.39 | Formula: C16H26N2O2
  • H donors: 2 H acceptors: 2 LogP: 1.58 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)NC12CC3(NC(=O)C)CC(C2)(CC(C1)(C3)C)C
  • InChi: 1S/C16H26N2O2/c1-11(19)17-15-6-13(3)5-14(4,7-15)9-16(8-13,10-15)18-12(2)20/h5-10H2,1-4H3,(H,17,19)(H,18,20)
  • InChiKey: MSQGNHPUFDAVHW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-acetamido-5,7-dimethyl-1-adamantyl)ethanamide
  • BIM-0018437.P001
  • Oprea1_324219
  • CBMicro_018423
  • ZINC04020642

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0506 0.0976
Echinococcus multilocularis neuroligin 0.006 0.077 0.0768
Echinococcus multilocularis RUN 0.0039 0.0454 0.0452
Echinococcus multilocularis expressed conserved protein 0.0094 0.1261 0.126
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0073 0.0953 0.0838
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0052 0.01
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0533
Brugia malayi Carboxylesterase family protein 0.0358 0.5189 1
Brugia malayi nuclear hormone receptor 0.0031 0.0336 0.0647
Brugia malayi hypothetical protein 0.0039 0.0454 0.0874
Onchocerca volvulus Bile acid receptor homolog 0.0066 0.0856 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0392 0.0755
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0953 0.0952
Echinococcus multilocularis microtubule associated protein 2 0.0682 1 1
Echinococcus granulosus acetylcholinesterase 0.0358 0.5189 0.5188
Onchocerca volvulus 0.0039 0.0454 0.4491
Echinococcus granulosus para nitrobenzyl esterase 0.006 0.077 0.0768
Brugia malayi Nuclear hormone receptor-like 1 0.0066 0.0856 0.165
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0358 0.5189 0.5127
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0066 0.0856 0.0855
Brugia malayi EGF-like domain containing protein 0.0027 0.0277 0.0533
Schistosoma mansoni cpg binding protein 0.0028 0.0293 0.0169
Schistosoma mansoni steroid hormone receptor ad4bp 0.0066 0.0856 0.074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0151 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.011 0.1502 0.1501
Loa Loa (eye worm) carboxylesterase 0.0358 0.5189 1
Brugia malayi Cytochrome P450 family protein 0.0012 0.0052 0.01
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0035 0.0392 0.039
Brugia malayi aspartic protease BmAsp-2, identical 0.0017 0.0126 0.0242
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0533
Brugia malayi Doublecortin family protein 0.0039 0.0454 0.0874
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0336 0.0213
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Schistosoma mansoni neuroligin 3 (S09 family) 0.006 0.077 0.0652
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0392 0.0755
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0151 0.1099
Echinococcus multilocularis slit 2 protein 0.0027 0.0277 0.0275
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0454 0.0452
Schistosoma mansoni gliotactin 0.006 0.077 0.0652
Mycobacterium ulcerans carboxylesterase, LipT 0.006 0.077 1
Schistosoma mansoni ap endonuclease 0.0019 0.0151 0.0026
Schistosoma mansoni retinoic acid receptor RXR 0.0066 0.0856 0.074
Loa Loa (eye worm) hypothetical protein 0.0017 0.0126 0.0242
Schistosoma mansoni hypothetical protein 0.0368 0.5335 0.5276
Echinococcus granulosus BC026374 protein S09 family 0.006 0.077 0.0768
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0506 0.0505
Schistosoma mansoni zinc finger protein 0.0031 0.0336 0.0213
Echinococcus granulosus cpg binding protein 0.003 0.0317 0.0315
Echinococcus granulosus pikachurin 0.0027 0.0277 0.0275
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0506 0.0505
Brugia malayi hypothetical protein 0.0035 0.0392 0.0755
Brugia malayi tailless protein 0.0031 0.0336 0.0647
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1351 0.135
Brugia malayi hypothetical protein 0.0035 0.0392 0.0755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0066 0.0856 0.1651
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0066 0.0856 0.165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0066 0.0856 0.074
Schistosoma mansoni hypothetical protein 0.0368 0.5335 0.5276
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1351 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0336 0.0648
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0336 0.0334
Schistosoma mansoni RAR-like nuclear receptor 0.0066 0.0856 0.074
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0073 0.0953 1
Schistosoma mansoni BC026374 protein (S09 family) 0.006 0.077 0.0652
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0953 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0151 0.1099
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0454 1
Brugia malayi nuclear receptor NHR-88 0.0066 0.0856 0.165
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1484
Schistosoma mansoni loxhd1 0.0039 0.0454 0.0332
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0066 0.0856 0.1651
Onchocerca volvulus 0.0066 0.0856 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0066 0.0856 0.1651
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Brugia malayi orphan nuclear receptor NR2E1 0.0031 0.0336 0.0647
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0856 0.165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0336 0.0334
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Loa Loa (eye worm) carboxylesterase 0.006 0.077 0.1484
Brugia malayi Eukaryotic aspartyl protease family protein 0.0017 0.0126 0.0242
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0031 0.0336 0.0647
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1986 0.1985
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0506 0.0505
Schistosoma mansoni hypothetical protein 0.0041 0.0484 0.0362
Brugia malayi Cytochrome P450 family protein 0.0012 0.0052 0.01
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0336 0.0647
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0066 0.0856 0.0855
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0151 0.0149
Onchocerca volvulus 0.0039 0.0454 0.4491
Echinococcus granulosus tumor protein p63 0.0329 0.4754 0.4753
Schistosoma mansoni rab6-interacting 0.0039 0.0454 0.0332
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0953 0.0952
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0066 0.0856 0.1651
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0336 0.0334
Echinococcus granulosus slit 2 protein 0.0027 0.0277 0.0275
Loa Loa (eye worm) hypothetical protein 0.0017 0.0126 0.0242
Echinococcus multilocularis para nitrobenzyl esterase 0.006 0.077 0.0768
Loa Loa (eye worm) hypothetical protein 0.0358 0.5189 1
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1484
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0031 0.0336 0.0213
Onchocerca volvulus 0.0031 0.0336 0.2879
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1351 0.135
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0066 0.0856 0.0855
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Onchocerca volvulus 0.0028 0.0293 0.2289
Schistosoma mansoni nuclear receptor 0.0031 0.0336 0.0213
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0066 0.0856 0.0855
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0073 0.0953 0.6684
Schistosoma mansoni polycystin 1-related 0.0039 0.0454 0.0332
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0027 0.0277 0.0533
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0017 0.0126 0.0242
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0454 0.0452
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.5875 0.5874
Echinococcus multilocularis carboxylesterase 5A 0.0358 0.5189 0.5188
Loa Loa (eye worm) hypothetical protein 0.01 0.1351 0.2604
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0875
Onchocerca volvulus 0.006 0.077 0.8815
Echinococcus multilocularis acetylcholinesterase 0.0358 0.5189 0.5188
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1484
Brugia malayi nuclear hormone receptor family member odr-7 0.0031 0.0336 0.0647
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0073 0.0953 0.0952
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Brugia malayi hypothetical protein 0.006 0.077 0.1483
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.0875
Brugia malayi nuclear receptor RXR 0.0035 0.0392 0.0755
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0151 0.1099
Echinococcus granulosus ubiquitin specific protease 41 0.0073 0.0953 0.0952
Brugia malayi hypothetical protein 0.0039 0.0454 0.0874
Trichomonas vaginalis spcc417.12 protein, putative 0.006 0.077 0.7784
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0066 0.0856 0.165
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0336 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0066 0.0856 0.165
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0035 0.0392 0.027
Schistosoma mansoni slit 0.0027 0.0277 0.0153
Loa Loa (eye worm) steroid hormone receptor 0.0066 0.0856 0.1651
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0066 0.0856 1
Brugia malayi hypothetical protein 0.0017 0.0126 0.0242
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0017 0.0126 0.0242
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0052 0.01
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.0277 0.0275
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0066 0.0856 0.0855
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0151 0.077
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0066 0.0856 0.165
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0073 0.0953 0.0838
Loa Loa (eye worm) hypothetical protein 0.0035 0.0392 0.0755
Schistosoma mansoni lipoxygenase 0.011 0.1502 0.1394
Loa Loa (eye worm) hypothetical protein 0.0035 0.0392 0.0755
Brugia malayi hypothetical protein 0.0017 0.0126 0.0242
Loa Loa (eye worm) abnormal epIthelia family member 0.0027 0.0277 0.0533
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0856 0.165
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.006 0.077 1
Echinococcus granulosus arachidonate 5 lipoxygenase 0.011 0.1502 0.1501
Loa Loa (eye worm) hypothetical protein 0.0048 0.0586 0.113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0392 0.0755
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0151 0.5
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Schistosoma mansoni cell polarity protein 0.0027 0.0277 0.0153
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1484
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0586 0.0466
Brugia malayi steroid hormone receptor 0.0066 0.0856 0.165
Echinococcus granulosus carboxylesterase 5A 0.0358 0.5189 0.5188
Brugia malayi conserved hypotetical protein 0.0031 0.0336 0.0647
Onchocerca volvulus 0.006 0.077 0.8815
Echinococcus granulosus FTZ F1 alpha 0.0066 0.0856 0.0855
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0336 0.0334
Schistosoma mansoni lipoxygenase 0.0039 0.0454 0.0332
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1484
Loa Loa (eye worm) hypothetical protein 0.0358 0.5189 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0372 0.54 0.5342
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0953 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Onchocerca volvulus 0.006 0.077 0.8815
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0336 0.0334
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0953 1
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Schistosoma mansoni rab6-interacting 0.0039 0.0454 0.0332
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0151 0.0291
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Brugia malayi Pepsin A precursor 0.0017 0.0126 0.0242
Brugia malayi hypothetical protein 0.0031 0.0336 0.0647
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0066 0.0856 0.074
Brugia malayi ecdysteroid receptor 0.0066 0.0856 0.165
Echinococcus granulosus geminin 0.0368 0.5335 0.5334
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0506 0.4601
Echinococcus granulosus RUN 0.0039 0.0454 0.0452
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0073 0.0953 0.0952
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0336 0.0334
Echinococcus multilocularis tumor protein p63 0.0329 0.4754 0.4753
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0052 0.01
Schistosoma mansoni acetylcholinesterase 0.006 0.077 0.0652
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0017 0.0126 0.0124
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0454 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Loa Loa (eye worm) aspartyl protease 6 0.0017 0.0126 0.0242
Echinococcus multilocularis FTZ F1 alpha 0.0066 0.0856 0.0855
Echinococcus granulosus expressed conserved protein 0.0094 0.1261 0.126
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0454 0.0452
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0073 0.0953 0.1837
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0151 0.1099
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0073 0.0953 1
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0336 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0066 0.0856 0.165
Echinococcus multilocularis thyroid hormone receptor alpha 0.0191 0.2704 0.2703
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0151 0.0305
Schistosoma mansoni nuclear receptor 0.0031 0.0336 0.0213
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1351 0.2604
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0073 0.0953 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0066 0.0856 0.074
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0336 0.2879
Brugia malayi hypothetical protein 0.0031 0.0336 0.0647
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0066 0.0856 0.0855
Brugia malayi nuclear receptor RXR 0.0031 0.0336 0.0647
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0856 0.0855
Loa Loa (eye worm) hypothetical protein 0.0027 0.0277 0.0533
Schistosoma mansoni hypothetical protein 0.0039 0.0454 0.0332
Echinococcus granulosus dnaJ subfamily B 0.0404 0.5875 0.5874
Schistosoma mansoni hypothetical protein 0.0124 0.1719 0.1614
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0035 0.0392 0.0755
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0293 0.0565
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0066 0.0856 0.074
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0336 0.0334
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1374 0.1264
Loa Loa (eye worm) carboxylesterase 0.006 0.077 0.1484
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0454 0.0875
Loa Loa (eye worm) DR-78 0.0031 0.0336 0.0648
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0151 0.1379
Brugia malayi nuclear hormone receptor 0.0066 0.0856 0.165
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0066 0.0856 0.0855
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.077 0.0652
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Echinococcus granulosus family S9 non peptidase ue S09 family 0.006 0.077 0.0768
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1484
Echinococcus granulosus neuroligin 0.006 0.077 0.0768
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0151 0.0305
Loa Loa (eye worm) hypothetical protein 0.0073 0.0953 0.1837
Schistosoma mansoni nuclear receptor nhr-48 0.0031 0.0336 0.0213
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Onchocerca volvulus 0.006 0.077 0.8815
Brugia malayi ecdysone receptor 0.0031 0.0336 0.0647
Schistosoma mansoni ap endonuclease 0.0019 0.0151 0.0026
Schistosoma mansoni nuclear hormone receptor 0.0066 0.0856 0.074
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0066 0.0856 0.0855
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Brugia malayi Carboxylesterase family protein 0.006 0.077 0.1483
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.006 0.077 0.0768
Brugia malayi Nuclear hormone receptor E75 0.0031 0.0336 0.0647
Brugia malayi follicle stimulating hormone receptor 0.0228 0.3253 0.6269
Echinococcus multilocularis geminin 0.0368 0.5335 0.5334
Onchocerca volvulus 0.006 0.077 0.8815
Onchocerca volvulus Protein ultraspiracle homolog 0.0066 0.0856 1
Schistosoma mansoni hypothetical protein 0.0041 0.0484 0.0362
Echinococcus granulosus acetylcholinesterase 0.0358 0.5189 0.5188
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.006 0.077 1
Brugia malayi Nuclear hormone receptor-like 1 0.0035 0.0392 0.0755
Echinococcus multilocularis ubiquitin specific protease 41 0.0073 0.0953 0.0952
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0454 0.0452
Loa Loa (eye worm) hypothetical protein 0.0035 0.0392 0.0755
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Schistosoma mansoni hypothetical protein 0.0404 0.5875 0.5822
Schistosoma mansoni hypothetical protein 0.0041 0.0484 0.0362
Loa Loa (eye worm) hypothetical protein 0.006 0.077 0.1484
Schistosoma mansoni patched 1 0.0043 0.0506 0.0386
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.0277 0.0275
Echinococcus multilocularis acetylcholinesterase 0.0358 0.5189 0.5188
Echinococcus multilocularis pikachurin 0.0027 0.0277 0.0275
Loa Loa (eye worm) hypothetical protein 0.0052 0.0649 0.1251
Mycobacterium tuberculosis Carboxylesterase LipT 0.006 0.077 1
Echinococcus multilocularis protein dispatched 1 0.0049 0.0596 0.0594
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Loa Loa (eye worm) hypothetical protein 0.0043 0.0506 0.0976
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0151 0.0149
Echinococcus multilocularis BC026374 protein (S09 family) 0.006 0.077 0.0768
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0856 0.0855
Schistosoma mansoni memapsin-2 (A01 family) 0.0426 0.6203 0.6155
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.067 1
Echinococcus granulosus ecdysone induced protein 78C 0.0066 0.0856 0.0855
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.077 0.0652
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0066 0.0856 0.1651
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0336 0.0334
Brugia malayi aspartic protease BmAsp-1, identical 0.0017 0.0126 0.0242
Toxoplasma gondii exonuclease III APE 0.0019 0.0151 0.0464
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0066 0.0856 0.074
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0856 0.165
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0035 0.0392 0.027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.1719 0.1718
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1986 0.1985
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0856 0.0855
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0066 0.0856 0.165
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0066 0.0856 0.0855
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0017 0.0126 0.0124
Brugia malayi laminin alpha chain 0.0027 0.0277 0.0533
Schistosoma mansoni thyroid hormone receptor 0.0191 0.2704 0.2611
Brugia malayi nuclear receptor NHR-88 0.0031 0.0336 0.0647
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0073 0.0953 1
Schistosoma mansoni coup transcription factor 0.0066 0.0856 0.074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0066 0.0856 0.1651
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0336 0.0334
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0066 0.0856 0.165
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.006 0.077 0.0652
Brugia malayi laminin-like protein K08C7.3 precursor 0.0027 0.0277 0.0533
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0066 0.0856 0.1651
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0066 0.0856 0.074
Schistosoma mansoni cpg binding protein 0.003 0.0317 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0953 1
Brugia malayi Steroid receptor seven-up type 2 0.0066 0.0856 0.165
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.3253 0.627
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0336 0.0648
Brugia malayi CHE-14 protein 0.0043 0.0506 0.0976
Onchocerca volvulus 0.0048 0.0586 0.6301
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0035 0.0392 0.039
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0031 0.0336 0.2879
Schistosoma mansoni laminin gamma-3 chain 0.0027 0.0277 0.0153
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.1719 0.1718
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0766 0.0648
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0066 0.0856 0.165
Echinococcus multilocularis cpg binding protein 0.003 0.0317 0.0315
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0336 0.0334
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.006 0.077 0.7784
Brugia malayi nuclear receptor NHR-67 0.0031 0.0336 0.0647
Echinococcus multilocularis ecdysone induced protein 78C 0.0066 0.0856 0.0855
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0027 0.0277 0.0153
Loa Loa (eye worm) hypothetical protein 0.0066 0.0856 0.1651
Echinococcus multilocularis protein patched 0.0043 0.0506 0.0505
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0151 0.0291
Loa Loa (eye worm) hypothetical protein 0.0031 0.0336 0.0648
Brugia malayi Carboxylesterase family protein 0.0358 0.5189 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0151 0.077
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0336 0.0213
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0454 0.0452
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0856 0.0855
Schistosoma mansoni microtubule-associated protein tau 0.0682 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0336 0.0334
Loa Loa (eye worm) acetylcholinesterase 1 0.0358 0.5189 1
Schistosoma mansoni hypothetical protein 0.0041 0.0484 0.0362
Brugia malayi CXXC zinc finger family protein 0.0028 0.0293 0.0564
Brugia malayi photoreceptor-specific nuclear receptor 0.0066 0.0856 0.165
Schistosoma mansoni thyroid hormone receptor 0.0191 0.2704 0.2611
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0066 0.0856 0.165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0066 0.0856 0.165
Onchocerca volvulus 0.0031 0.0336 0.2879
Loa Loa (eye worm) hypothetical protein 0.0017 0.0126 0.0242
Brugia malayi nuclear hormone receptor family member nhr-6 0.0031 0.0336 0.0647
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0454 0.0452

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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