Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.1178 | 0.1907 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.162 | 0.2624 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.122 | 0.1975 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.122 | 0.0085 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.0152 | 0.6176 | 1 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0037 | 0.1178 | 0.0149 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.162 | 0.2624 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.122 | 0.0085 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.1178 | 0.1907 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0152 | 0.6176 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1907 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0038 | 0.122 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0038 | 0.122 | 0.1975 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0038 | 0.122 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0038 | 0.122 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.162 | 0.2624 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0037 | 0.1178 | 0.0149 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0056 | 0.2008 | 0.1661 |
Onchocerca volvulus | 0.0037 | 0.1178 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1907 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.162 | 0.2624 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.162 | 0.2624 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.1178 | 0.1907 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0038 | 0.122 | 0.0085 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1178 | 0.1907 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.1178 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.1178 | 0.0149 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.122 | 0.0085 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.0152 | 0.6176 | 1 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0056 | 0.2008 | 0.1661 |
Onchocerca volvulus | 0.0037 | 0.1178 | 1 | |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.0152 | 0.6176 | 1 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.0152 | 0.6176 | 1 |
Leishmania major | 0.0152 | 0.6176 | 1 | |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0056 | 0.2008 | 0.1661 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0038 | 0.122 | 0.1975 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.1178 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.122 | 1 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0037 | 0.1178 | 0.0149 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1178 | 0.1907 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0037 | 0.1178 | 0.0149 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.1178 | 0.0149 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 0.1178 | 0.0149 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.162 | 0.2624 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0056 | 0.2008 | 0.1661 |
Brugia malayi | beta-lactamase | 0.0037 | 0.1178 | 0.1907 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0038 | 0.122 | 0.1975 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.0152 | 0.6176 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0038 | 0.122 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0037 | 0.1178 | 0.0149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.162 | 0.2624 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1907 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.1178 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1907 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.1178 | 0.1907 |
Toxoplasma gondii | fructose-bisphospatase II | 0.0152 | 0.6176 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1178 | 0.1907 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1907 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0037 | 0.1178 | 0.0149 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0037 | 0.1178 | 0.0149 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0056 | 0.2008 | 0.1661 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1907 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0038 | 0.122 | 0.0085 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0038 | 0.122 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.162 | 0.2624 |
Loa Loa (eye worm) | inositol-1 | 0.0038 | 0.122 | 0.1975 |
Onchocerca volvulus | 0.0037 | 0.1178 | 1 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1178 | 0.1907 |
Brugia malayi | Inositol-1 | 0.0038 | 0.122 | 0.1975 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.0152 | 0.6176 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.162 | 0.2624 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.0152 | 0.6176 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.1178 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.