Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.5111 | 1 |
Loa Loa (eye worm) | sugar transporter | 0.0102 | 0.6106 | 0.6106 |
Echinococcus granulosus | ankyrin repeat and death domain containing protein | 0.0058 | 0.2109 | 0.1192 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0102 | 0.6106 | 1 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 0.6106 | 0.5702 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0046 | 0.1041 | 0.0145 |
Echinococcus multilocularis | ankyrin repeat and death domain containing protein | 0.0058 | 0.2109 | 0.132 |
Leishmania major | cytochrome P450 reductase, putative | 0.0081 | 0.417 | 0.8159 |
Brugia malayi | FAD binding domain containing protein | 0.0091 | 0.5111 | 0.5111 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.3908 | 0.3275 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0058 | 0.2109 | 0.2109 |
Brugia malayi | Protein kinase domain containing protein | 0.0058 | 0.2109 | 0.2109 |
Schistosoma mansoni | tyrosine kinase | 0.0145 | 1 | 1 |
Toxoplasma gondii | facilitative glucose transporter GT1 | 0.0102 | 0.6106 | 1 |
Echinococcus multilocularis | netrin receptor unc 5 | 0.0058 | 0.2109 | 0.132 |
Plasmodium falciparum | hexose transporter | 0.0102 | 0.6106 | 1 |
Echinococcus multilocularis | solute carrier family 2, facilitated glucose | 0.0102 | 0.6106 | 0.5717 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0091 | 0.5111 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.5111 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0091 | 0.5111 | 1 |
Plasmodium vivax | hexose transporter | 0.0102 | 0.6106 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0091 | 0.5111 | 0.4603 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.5111 | 0.4543 |
Echinococcus granulosus | netrin receptor unc 5 | 0.0058 | 0.2109 | 0.1192 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0078 | 0.3908 | 0.32 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0058 | 0.2109 | 0.129 |
Schistosoma mansoni | hypothetical protein | 0.0058 | 0.2109 | 0.129 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0078 | 0.3908 | 0.32 |
Echinococcus granulosus | General substrate transporter | 0.0088 | 0.4803 | 0.4199 |
Echinococcus granulosus | TNFR CD27 30 40 95 cysteine rich region | 0.0089 | 0.4885 | 0.4291 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0091 | 0.5111 | 0.5 |
Echinococcus granulosus | tumor necrosis factor receptor superfamily | 0.0089 | 0.4885 | 0.4291 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0046 | 0.1004 | 0.0069 |
Echinococcus multilocularis | insulin receptor | 0.0046 | 0.1041 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2109 | 0.2109 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.6106 | 0.5654 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 0.6106 | 0.5717 |
Echinococcus granulosus | Ankyrin | 0.0058 | 0.2109 | 0.1192 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0091 | 0.5111 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0046 | 0.1041 | 0.0111 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0081 | 0.417 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0091 | 0.5111 | 0.4622 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0091 | 0.5111 | 0.4622 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0091 | 0.5111 | 0.4543 |
Schistosoma mansoni | hypothetical protein | 0.0102 | 0.6106 | 0.5702 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 0.6106 | 0.5702 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.6106 | 0.5654 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0058 | 0.2109 | 0.2109 |
Schistosoma mansoni | glucose transport protein | 0.0102 | 0.6106 | 0.5702 |
Schistosoma mansoni | tyrosine kinase | 0.0078 | 0.3908 | 0.3275 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0145 | 1 | 1 |
Echinococcus multilocularis | General substrate transporter | 0.0088 | 0.4803 | 0.4283 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0081 | 0.417 | 0.6829 |
Echinococcus multilocularis | TNFR CD27 30 40 95 cysteine rich region | 0.0089 | 0.4885 | 0.4374 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.6106 | 0.5654 |
Brugia malayi | Uncoordinated protein 44 | 0.0058 | 0.2109 | 0.2109 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0056 | 0.1945 | 0.1945 |
Chlamydia trachomatis | sulfite reductase | 0.0056 | 0.1945 | 0.5 |
Echinococcus granulosus | death domain containing protein | 0.0058 | 0.2109 | 0.1192 |
Leishmania major | p450 reductase, putative | 0.0091 | 0.5111 | 1 |
Schistosoma mansoni | tumor necrosis factor receptor related | 0.0089 | 0.4885 | 0.4354 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.5111 | 0.8369 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0046 | 0.1041 | 0.1041 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | methionine synthase reductase | 0.0056 | 0.1945 | 0.1139 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0145 | 1 | 1 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0081 | 0.417 | 0.6829 |
Brugia malayi | flavodoxin family protein | 0.0091 | 0.5111 | 0.5111 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 0.6106 | 0.5717 |
Giardia lamblia | Hypothetical protein | 0.0081 | 0.417 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0091 | 0.5111 | 0.5111 |
Trypanosoma cruzi | p450 reductase, putative | 0.0091 | 0.5111 | 1 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | netrin receptor unc5 | 0.0058 | 0.2109 | 0.129 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | solute carrier family 2 facilitated glucose | 0.0102 | 0.6106 | 0.5717 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0056 | 0.1945 | 0.1108 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3833 | 0.3193 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.5111 | 0.5111 |
Schistosoma mansoni | tyrosine kinase | 0.0046 | 0.1041 | 0.0111 |
Brugia malayi | Sugar transporter family protein | 0.0102 | 0.6106 | 0.6106 |
Echinococcus multilocularis | tumor necrosis factor receptor superfamily | 0.0089 | 0.4885 | 0.4374 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0078 | 0.3908 | 0.3299 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2109 | 0.2109 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3833 | 0.3193 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0091 | 0.5111 | 1 |
Onchocerca volvulus | Netrin receptor homolog | 0.0058 | 0.2109 | 0.5 |
Echinococcus multilocularis | Ankyrin | 0.0058 | 0.2109 | 0.132 |
Echinococcus granulosus | methionine synthase reductase | 0.0056 | 0.1945 | 0.1009 |
Treponema pallidum | flavodoxin | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | ankyrin 23/unc44 | 0.0058 | 0.2109 | 0.129 |
Brugia malayi | Death domain containing protein | 0.0058 | 0.2109 | 0.2109 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0091 | 0.5111 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0077 | 0.3833 | 0.3193 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0091 | 0.5111 | 0.8369 |
Brugia malayi | Protein kinase domain containing protein | 0.0046 | 0.1041 | 0.1041 |
Entamoeba histolytica | type A flavoprotein, putative | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0091 | 0.5111 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0056 | 0.1945 | 0.1945 |
Echinococcus granulosus | solute carrier family 2 facilitated glucose | 0.0102 | 0.6106 | 0.5654 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0145 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0091 | 0.5111 | 0.8369 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.45 uM | Inhibitory activity against human neuronal nitric oxide synthase in brain (nNOS). | ChEMBL. | 9191968 |
Ki (binding) | = 1.8 uM | Inhibitory activity against human vascular endothelial nitric oxide synthase. | ChEMBL. | 9191968 |
Ki (binding) | = 2.4 uM | Inhibitory activity against human inducible nitric oxide synthase (iNOS). | ChEMBL. | 9191968 |
Selectivity index (binding) | = 4 | Selectivity index measured as the ratio of Ki eNOS to Ki nNOS. | ChEMBL. | 9191968 |
Selectivity index (binding) | = 5.3 | Selectivity index measured as the ratio of Ki iNOS to Ki nNOS. | ChEMBL. | 9191968 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.