Detailed information for compound 841900

Basic information

Technical information
  • TDR Targets ID: 841900
  • Name: N-[3-(3-methoxypropylcarbamoyl)-4,5,6,7-tetra hydro-1-benzothiophen-2-yl]-1-(3-methylphenyl )-4-oxopyridazine-3-carboxamide
  • MW: 480.579 | Formula: C25H28N4O4S
  • H donors: 2 H acceptors: 3 LogP: 4.47 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCCNC(=O)c1c(NC(=O)c2nn(ccc2=O)c2cccc(c2)C)sc2c1CCCC2
  • InChi: 1S/C25H28N4O4S/c1-16-7-5-8-17(15-16)29-13-11-19(30)22(28-29)24(32)27-25-21(23(31)26-12-6-14-33-2)18-9-3-4-10-20(18)34-25/h5,7-8,11,13,15H,3-4,6,9-10,12,14H2,1-2H3,(H,26,31)(H,27,32)
  • InChiKey: VCIQLEFWURIBKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(3-methoxypropylcarbamoyl)-4,5,6,7-tetrahydrobenzothiophen-2-yl]-1-(3-methylphenyl)-4-oxo-pyridazine-3-carboxamide
  • N-[3-[(3-methoxypropylamino)-oxomethyl]-4,5,6,7-tetrahydrobenzothiophen-2-yl]-1-(3-methylphenyl)-4-oxo-3-pyridazinecarboxamide
  • 4-keto-N-[3-(3-methoxypropylcarbamoyl)-4,5,6,7-tetrahydrobenzothiophen-2-yl]-1-(3-methylphenyl)pyridazine-3-carboxamide
  • N-[3-(3-methoxypropylcarbamoyl)-4,5,6,7-tetrahydro-1-benzothiophen-2-yl]-1-(3-methylphenyl)-4-oxo-pyridazine-3-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni zinc finger protein 0.0087 0.0224 0.0214
Onchocerca volvulus 0.0069 0.0152 0.1875
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0224 0.0214
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0181 0.02
Onchocerca volvulus 0.0039 0.0032 0.0277
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Echinococcus multilocularis lamin dm0 0.0107 0.0303 0.0343
Brugia malayi hypothetical protein 0.0039 0.0032 0.0037
Schistosoma mansoni tar DNA-binding protein 0.013 0.0396 0.0385
Loa Loa (eye worm) hypothetical protein 0.005 0.0074 0.0087
Entamoeba histolytica hypothetical protein 0.0035 0.0018 0.0089
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0049 0.0115
Echinococcus multilocularis musashi 0.0107 0.0303 0.0343
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0027 0.003
Onchocerca volvulus 0.0038 0.0027 0.0214
Schistosoma mansoni hypothetical protein 0.0074 0.0172 0.0162
Onchocerca volvulus 0.0054 0.0091 0.1073
Brugia malayi RNA recognition motif domain containing protein 0.013 0.0396 0.0464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Onchocerca volvulus 0.0069 0.0152 0.1875
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0459 0.1716 0.1707
Echinococcus multilocularis BC026374 protein (S09 family) 0.0104 0.0293 0.0332
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.008 0.0094
Onchocerca volvulus 0.0043 0.0049 0.051
Loa Loa (eye worm) beta-lactamase 0.0038 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0032
Brugia malayi steroid hormone receptor 0.0184 0.0615 0.0722
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0218 0.075 0.074
Echinococcus granulosus Nuclear hormone receptor HR96 0.0087 0.0224 0.0251
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.007 0.0069
Brugia malayi Protein-tyrosine phosphatase 1 0.0069 0.0152 0.0178
Onchocerca volvulus 0.0069 0.0152 0.1875
Echinococcus granulosus agrin 0.0037 0.0023 0.0014
Loa Loa (eye worm) hypothetical protein 0.0097 0.0266 0.0312
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0097 0.0266 0.0256
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0023 0.0027
Brugia malayi nuclear hormone receptor 0.0087 0.0224 0.0263
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.007 0.0059
Brugia malayi CHE-14 protein 0.045 0.168 0.1971
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0087 0.0224 0.0251
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0069 0.0152 0.0166
Brugia malayi Cytochrome P450 family protein 0.006 0.0115 0.0135
Schistosoma mansoni RAR-like nuclear receptor 0.0184 0.0615 0.0605
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0184 0.0615 0.071
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0184 0.0615 0.0605
Echinococcus granulosus Niemann Pick C1 protein 0.045 0.168 0.1961
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.045 0.168 0.1971
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0104 0.0293 0.0283
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0184 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Entamoeba histolytica glycogen phosphorylase, putative 0.0221 0.0762 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0087 0.0224 0.2841
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0266 0.0312
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0018 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0027
Schistosoma mansoni organic anion transporter 0.0054 0.0091 0.0081
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Onchocerca volvulus 0.0071 0.0158 0.1962
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.0203 0.0226
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.088 0.1021
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0167 0.0546 1
Onchocerca volvulus 0.0054 0.0091 0.1073
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0184 0.0615 0.071
Brugia malayi Muscleblind-like protein 0.0156 0.0501 0.0588
Mycobacterium tuberculosis Conserved protein 0.0038 0.0027 0.003
Onchocerca volvulus Protein ultraspiracle homolog 0.0184 0.0615 0.804
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0167 0.0546 0.0535
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.007 0.0069
Schistosoma mansoni hypothetical protein 0.0036 0.002 0.0009
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Schistosoma mansoni nuclear receptor 0.0087 0.0224 0.0214
Loa Loa (eye worm) dehydrogenase 0.0034 0.0011 0.0013
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0167 0.0546 0.064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0054 0.0091 0.0095
Mycobacterium ulcerans hypothetical protein 0.0039 0.0032 0.0039
Echinococcus granulosus protein tyrosine phosphatase n9 0.0069 0.0152 0.0166
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0283 0.101 0.1174
Brugia malayi nuclear hormone receptor family member odr-7 0.0087 0.0224 0.0263
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0059 0.0111 0.0521
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.007 0.0059
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0087 0.0102
Trypanosoma brucei short-chain dehydrogenase, putative 0.0034 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0344
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0032 0.0021
Onchocerca volvulus Peroxidasin homolog 0.0071 0.0158 0.1962
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0069 0.0152 0.0332
Brugia malayi Nuclear hormone receptor E75 0.0087 0.0224 0.0263
Loa Loa (eye worm) protein-tyrosine phosphatase 0.018 0.0596 0.0699
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0069 0.0152 0.1875
Brugia malayi beta-lactamase 0.0038 0.0027 0.0032
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0053 0.0088 0.1442
Brugia malayi Intermediate filament tail domain containing protein 0.0107 0.0303 0.0356
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.004 0.0094
Loa Loa (eye worm) hypothetical protein 0.0097 0.0266 0.0312
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0069 0.0152 0.0141
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0107
Schistosoma mansoni hypothetical protein 0.0053 0.0088 0.0077
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0069 0.0152 0.0178
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0184 0.0615 0.071
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0069 0.0152 0.0332
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0181 0.02
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Onchocerca volvulus 0.0069 0.0152 0.1875
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0158 0.0186
Echinococcus multilocularis microtubule associated protein 2 0.0721 0.2766 0.3237
Brugia malayi RNA binding protein 0.013 0.0396 0.0464
Trypanosoma brucei short-chain dehydrogenase, putative 0.0034 0.0011 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Schistosoma mansoni ap endonuclease 0.0059 0.0111 0.01
Loa Loa (eye worm) carboxylesterase 0.0104 0.0293 0.0344
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0049 0.0115
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0043 0.0049 0.0717
Schistosoma mansoni gabp alpha 0.0077 0.0183 0.0172
Brugia malayi dehydrogenases, short chain protein 2 0.0034 0.0011 0.0013
Brugia malayi prostaglandin transporter 0.0054 0.0091 0.0107
Echinococcus granulosus microtubule associated protein 2 0.0721 0.2766 0.3237
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0184 0.0615 0.0722
Brugia malayi hypothetical protein 0.0069 0.0152 0.0178
Echinococcus granulosus FTZ F1 alpha 0.0184 0.0615 0.071
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.0152 0.0141
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0039 0.0032 0.0024
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0032 0.0021
Schistosoma mansoni follistatin 0.0037 0.0023 0.0012
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Brugia malayi Dehydrogenases, short chain protein 30 0.0034 0.0011 0.0013
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0069 0.0152 0.0166
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.0152 0.0141
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Mycobacterium ulcerans carboxylesterase, LipT 0.0375 0.1379 0.2552
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Echinococcus multilocularis glycoprotein Antigen 5 0.0039 0.0032 0.0024
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0524 0.1977 0.1968
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0181 0.0885
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0069 0.0152 0.0178
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0018 0.0125
Loa Loa (eye worm) agrin synaptic family protein 0.0037 0.0023 0.0027
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0069 0.0152 0.0166
Brugia malayi Protein-tyrosine phosphatase containing protein 0.018 0.0596 0.0699
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0027 0.003
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0181 0.02
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Loa Loa (eye worm) protein tyrosine phosphatase 0.0069 0.0152 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0184 0.0615 0.0722
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0027 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0027 0.0084
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0077 0.0183 0.0215
Brugia malayi Trypsin-like protease protein 5 0.0039 0.0032 0.0037
Schistosoma mansoni gliotactin 0.0104 0.0293 0.0283
Loa Loa (eye worm) hypothetical protein 0.005 0.0074 0.0087
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0167 0.0546 0.2783
Onchocerca volvulus 0.0069 0.0152 0.1875
Onchocerca volvulus 0.0069 0.0152 0.1875
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.004 0.0069
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0111 0.0521
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0122 0.013
Echinococcus multilocularis acetylcholinesterase 0.0446 0.1662 0.194
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.0203 1
Toxoplasma gondii kringle domain-containing protein 0.0053 0.0088 0.2136
Onchocerca volvulus 0.0069 0.0152 0.1875
Onchocerca volvulus 0.0039 0.0032 0.0277
Brugia malayi beta-lactamase family protein 0.0038 0.0027 0.0032
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0069 0.0152 0.0166
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0087 0.0224 0.0251
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0107
Onchocerca volvulus Bile acid receptor homolog 0.0184 0.0615 0.804
Trichomonas vaginalis pten, drome, putative 0.0069 0.0152 0.0733
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0083 0.0209 0.0245
Brugia malayi Nuclear hormone receptor-like 1 0.0097 0.0266 0.0312
Brugia malayi beta-NAC-like protein 0.0035 0.0018 0.0021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0059 0.0111 0.013
Echinococcus multilocularis geminin 0.0349 0.1274 0.1484
Loa Loa (eye worm) animal heme peroxidase 0.0071 0.0158 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0027 0.0019
Schistosoma mansoni organic anion transporter 0.0054 0.0091 0.0081
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.1093 0.4259 1
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0054 0.0091 0.0107
Echinococcus granulosus BC026374 protein S09 family 0.0104 0.0293 0.0332
Loa Loa (eye worm) TK/ROR protein kinase 0.0053 0.0088 0.0103
Entamoeba histolytica hypothetical protein 0.0074 0.0172 0.215
Schistosoma mansoni pcd6 interacting protein-related 0.0069 0.0152 0.0141
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0054 0.0091 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Loa Loa (eye worm) protein-tyrosine phosphatase 0.2157 0.8523 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0181 0.04
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Onchocerca volvulus 0.0069 0.0152 0.1875
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Toxoplasma gondii exonuclease III APE 0.0059 0.0111 0.277
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Leishmania major cathepsin L-like protease 0.0067 0.0143 0.031
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0027 0.03
Schistosoma mansoni niemann-pick C1 (NPC1) 0.045 0.168 0.1671
Loa Loa (eye worm) hypothetical protein 0.0076 0.0181 0.0212
Onchocerca volvulus 0.0053 0.0088 0.1026
Loa Loa (eye worm) hypothetical protein 0.0097 0.0266 0.0312
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.009 0.0148
Loa Loa (eye worm) acetylcholinesterase 1 0.0446 0.1662 0.195
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0023 0.0027
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0069 0.0152 0.0178
Toxoplasma gondii transporter, major facilitator family protein 0.0054 0.0091 0.2232
Brugia malayi Protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0184 0.0615 0.804
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0059 0.0111 0.5204
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0181 0.02
Schistosoma mansoni ap endonuclease 0.0059 0.0111 0.01
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0344
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0032 0.0021
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.018 0.0596 0.0687
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Onchocerca volvulus Putative organic anion transporter 0.0054 0.0091 0.1073
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0167 0.0546 0.064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0184 0.0615 0.0722
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0027 0.0084
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0069 0.0152 0.0141
Brugia malayi jmjC domain containing protein 0.0061 0.0122 0.0143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0087 0.0102
Loa Loa (eye worm) animal heme peroxidase 0.0071 0.0158 0.0186
Onchocerca volvulus 0.0038 0.0027 0.0214
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0069 0.0152 0.0166
Brugia malayi photoreceptor-specific nuclear receptor 0.0184 0.0615 0.0722
Brugia malayi exodeoxyribonuclease III family protein 0.0059 0.0111 0.013
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.007 0.0069
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0344
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Echinococcus granulosus glycoprotein Antigen 5 0.0039 0.0032 0.0024
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0069 0.0152 0.0141
Echinococcus multilocularis protein dispatched 1 0.045 0.168 0.1961
Echinococcus granulosus para nitrobenzyl esterase 0.0104 0.0293 0.0332
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Brugia malayi Ets-domain containing protein 0.0077 0.0183 0.0215
Trichomonas vaginalis conserved hypothetical protein 0.045 0.168 0.8689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0184 0.0615 0.0722
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0122 0.0111
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0203 0.3594
Echinococcus multilocularis acetylcholinesterase 0.0446 0.1662 0.194
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0058 0.0107 0.0096
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0032
Schistosoma mansoni lamin 0.0107 0.0303 0.0293
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0034 0.0011 0.0013
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0039 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Schistosoma mansoni tar DNA-binding protein 0.013 0.0396 0.0385
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0513 0.1932 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0184 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Onchocerca volvulus 0.0083 0.0209 0.2632
Echinococcus multilocularis muscleblind protein 0.0156 0.0501 0.0576
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0143 0.031
Loa Loa (eye worm) hypothetical protein 0.0156 0.0501 0.0588
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0023 0.0334
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0043 0.0049 0.0045
Brugia malayi Cytochrome P450 family protein 0.0039 0.0033 0.0039
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Onchocerca volvulus 0.0069 0.0152 0.1875
Echinococcus granulosus sterol regulatory element binding protein 0.045 0.168 0.1961
Brugia malayi Trypsin family protein 0.0039 0.0032 0.0037
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0087 0.0224 0.0251
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.018 0.0596 0.0586
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Onchocerca volvulus 0.0104 0.0293 0.3759
Onchocerca volvulus 0.0104 0.0293 0.3759
Echinococcus granulosus geminin 0.0349 0.1274 0.1484
Trypanosoma brucei short-chain dehydrogenase, putative 0.0034 0.0011 0.0025
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.009 0.0093
Brugia malayi beta-lactamase family protein 0.0038 0.0027 0.0032
Schistosoma mansoni protein tyrosine phosphatase 0.0069 0.0152 0.0141
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Schistosoma mansoni coup transcription factor 0.0184 0.0615 0.0605
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.004 0.0069
Mycobacterium leprae Probable lipase LipE 0.0038 0.0027 0.0835
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Schistosoma mansoni tar DNA-binding protein 0.013 0.0396 0.0385
Brugia malayi Carboxylesterase family protein 0.0446 0.1662 0.195
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0184 0.0615 0.071
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.2157 0.8523 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0087 0.0224 0.0263
Schistosoma mansoni lamin 0.0107 0.0303 0.0293
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0181 0.2263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0037
Onchocerca volvulus 0.0054 0.0091 0.1073
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0107
Mycobacterium tuberculosis Carboxylesterase LipT 0.0375 0.1379 0.2552
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0203 0.5324
Brugia malayi ecdysone receptor 0.0087 0.0224 0.0263
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0082 0.0083
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.013 0.0222
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0069 0.0152 0.0166
Brugia malayi sodium-independent organic anion transporter family protein 0.0054 0.0091 0.0107
Loa Loa (eye worm) hypothetical protein 0.0097 0.0266 0.0312
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0069 0.0152 0.0166
Onchocerca volvulus 0.0069 0.0152 0.1875
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0097 0.0266 0.0256
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0087 0.0224 0.0263
Onchocerca volvulus 0.0039 0.0032 0.0277
Loa Loa (eye worm) trypsin family protein 0.0039 0.0032 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Schistosoma mansoni nuclear receptor 0.0087 0.0224 0.0214
Brugia malayi Carboxylesterase family protein 0.0104 0.0293 0.0344
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0033 0.0041
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0184 0.0615 0.0722
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.013 0.0119
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0054 0.0091 0.0095
Entamoeba histolytica glycogenphosphorylase, putative 0.0096 0.0259 0.3301
Onchocerca volvulus 0.0071 0.0158 0.1962
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0184 0.0615 0.071
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0184 0.0615 0.071
Onchocerca volvulus 0.0069 0.0152 0.1875
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Toxoplasma gondii protease inhibitor PI2 0.0037 0.0023 0.0334
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0069 0.0152 0.0166
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0043 0.0049 0.02
Echinococcus granulosus nuclear receptor nhr 48 0.0087 0.0224 0.0251
Echinococcus granulosus transmembrane protease serine 3 0.0039 0.0032 0.0024
Brugia malayi Carboxylesterase family protein 0.0104 0.0293 0.0344
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0181 0.0212
Brugia malayi Probable ClpP-like protease 0.0082 0.0203 0.0238
Mycobacterium tuberculosis Conserved protein 0.0038 0.0027 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0122 0.0143
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Onchocerca volvulus 0.0104 0.0293 0.3759
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0087 0.0224 0.0251
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.009 0.4127
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0107
Onchocerca volvulus 0.0069 0.0152 0.1875
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0184 0.0615 0.071
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0069 0.0152 0.0166
Echinococcus granulosus tissue type plasminogen activator 0.0053 0.0088 0.0091
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Schistosoma mansoni thyroid hormone receptor 0.0184 0.0615 0.0605
Leishmania major cytochrome p450-like protein 0.0039 0.0033 0.0052
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0104 0.0293 0.0527
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.0049 0.009
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0043 0.0049 0.0058
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0104 0.0293 0.0527
Loa Loa (eye worm) hypothetical protein 0.0446 0.1662 0.195
Onchocerca volvulus 0.0069 0.0152 0.1875
Schistosoma mansoni peroxidasin 0.0071 0.0158 0.0148
Mycobacterium ulcerans beta-lactamase 0.0038 0.0027 0.003
Brugia malayi Nuclear hormone receptor-like 1 0.0184 0.0615 0.0722
Schistosoma mansoni hypothetical protein 0.0349 0.1274 0.1265
Brugia malayi hypothetical protein 0.0034 0.0011 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0107 0.0303 0.0356
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0027 0.0084
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0069 0.0152 0.0166
Brugia malayi Trypsin family protein 0.0039 0.0032 0.0037
Brugia malayi hypothetical protein 0.0069 0.0152 0.0178
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0203 0.0359
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0018 0.0041
Schistosoma mansoni hypothetical protein 0.0104 0.0291 0.0281
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.007 0.0059
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0067 0.0056
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0037
Brugia malayi orphan nuclear receptor NR2E1 0.0087 0.0224 0.0263
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0158 0.0186
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.002 0.0024
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.0396 0.0464
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0069 0.0152 0.0141
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Trypanosoma cruzi MFS transporter, putative 0.0054 0.0091 0.019
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0167 0.0546 0.0628
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0034 0.0011 0.0013
Echinococcus multilocularis enteropeptidase 0.0039 0.0032 0.0024
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0032 0.0021
Leishmania major basic transcription factor 3a, putative 0.0035 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0184 0.0615 0.071
Loa Loa (eye worm) carboxylesterase 0.0104 0.0293 0.0344
Brugia malayi hypothetical protein 0.0097 0.0266 0.0312
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Echinococcus multilocularis microsomal glutathione S transferase 3 0.012 0.0357 0.0407
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0037
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0181 0.017
Loa Loa (eye worm) DR-78 0.0087 0.0224 0.0263
Brugia malayi Carboxylesterase family protein 0.0104 0.0293 0.0344
Schistosoma mansoni protein tyrosine phosphatase 0.0069 0.0152 0.0141
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0513 0.1932 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0059 0.0111 0.0117
Brugia malayi hypothetical protein 0.0069 0.0152 0.0178
Echinococcus multilocularis Niemann Pick C1 protein 0.045 0.168 0.1961
Loa Loa (eye worm) nuclear receptor NHR-67 0.0087 0.0224 0.0263
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0059 0.0111 0.0235
Onchocerca volvulus 0.0039 0.0032 0.0277
Brugia malayi nuclear hormone receptor family member nhr-6 0.0087 0.0224 0.0263
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.007 0.0082
Echinococcus multilocularis hypothetical protein 0.0069 0.0152 0.0166
Onchocerca volvulus 0.0069 0.0152 0.1875
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0096 0.0259 0.0463
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0069 0.0152 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0184 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0184 0.0615 0.071
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.1093 0.4259 0.4253
Trypanosoma brucei unspecified product 0.0034 0.0014 0.0032
Brugia malayi Dehydrogenases, short chain protein 2 0.0034 0.0011 0.0013
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0059 0.0111 0.026
Onchocerca volvulus 0.0104 0.0293 0.3759
Brugia malayi hypothetical protein 0.0034 0.0011 0.0013
Brugia malayi hypothetical protein 0.0097 0.0266 0.0312
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0037
Echinococcus granulosus acetylcholinesterase 0.0446 0.1662 0.194
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0018 0.0125
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0122 0.013
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Schistosoma mansoni hypothetical protein 0.0039 0.0032 0.0021
Echinococcus granulosus glycogen phosphorylase 0.0221 0.0762 0.0883
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0034 0.0011 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0184 0.0615 0.0722
Brugia malayi dehydrogenases, short chain protein 9 0.0034 0.0011 0.0013
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.0203 0.0192
Brugia malayi Trypsin family protein 0.0039 0.0032 0.0037
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0446 0.1662 0.1653
Echinococcus multilocularis lamin 0.0107 0.0303 0.0343
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0104 0.0293 0.0332
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0032
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0027 0.0063
Loa Loa (eye worm) hypothetical protein 0.0105 0.0295 0.0347
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0167 0.0546 0.2783
Schistosoma mansoni nuclear hormone receptor 0.0087 0.0224 0.0214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.007 0.0082
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Loa Loa (eye worm) steroid hormone receptor 0.0184 0.0615 0.0722
Schistosoma mansoni transcription factor btf3 0.0035 0.0018 0.0007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0087 0.0224 0.2841
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1093 0.4259 1
Loa Loa (eye worm) hypothetical protein 0.0218 0.075 0.0881
Brugia malayi jmjC domain containing protein 0.0061 0.0122 0.0143
Loa Loa (eye worm) nuclear hormone receptor 0.0087 0.0224 0.0263
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Echinococcus multilocularis ecdysone induced protein 78C 0.0184 0.0615 0.071
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0087 0.0224 0.0214
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0043 0.0049 0.0045
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0018 0.0185
Loa Loa (eye worm) animal heme peroxidase 0.0071 0.0158 0.0186
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Trichomonas vaginalis spcc417.12 protein, putative 0.0104 0.0293 0.147
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0027 0.003
Leishmania major hypothetical protein, conserved 0.0038 0.0027 0.0038
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.0203 0.5324
Onchocerca volvulus 0.0069 0.0152 0.1875
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0027
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0181 0.04
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0043 0.0049 0.051
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.004 0.0152
Loa Loa (eye worm) hypothetical protein 0.0066 0.0138 0.0162
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0184 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Loa Loa (eye worm) dehydrogenase 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0069 0.0152 0.0166
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0033 0.0052
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0034 0.0011 0.0025
Brugia malayi secreted modular calcium-binding protein 1 0.0037 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Schistosoma mansoni hypothetical protein 0.0349 0.1274 0.1265
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0018 0.0035
Loa Loa (eye worm) blistered cuticle protein 3 0.0071 0.0158 0.0186
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0014 0.0032
Mycobacterium ulcerans hypothetical protein 0.0038 0.0027 0.003
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0105 0.0123
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0027 0.003
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.1093 0.4259 0.4991
Leishmania major hypothetical protein, conserved 0.0053 0.0088 0.0182
Echinococcus granulosus muscleblind protein 0.0156 0.0501 0.0576
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0049 0.0115
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0501 0.0576
Giardia lamblia Rab geranylgeranyltransferase 0.0043 0.0049 0.02
Mycobacterium tuberculosis Probable oxidoreductase 0.1371 0.5371 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Brugia malayi carbohydrate phosphorylase 0.0221 0.0762 0.0894
Loa Loa (eye worm) hypothetical protein 0.0446 0.1662 0.195
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0069 0.0152 0.0141
Echinococcus multilocularis thyroid hormone receptor alpha 0.0184 0.0615 0.071
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0513 0.1932 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Schistosoma mansoni glycogen phosphorylase 0.0221 0.0762 0.0752
Echinococcus multilocularis FTZ F1 alpha 0.0184 0.0615 0.071
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0088 0.0182
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0069 0.0152 0.0332
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.1093 0.4259 1
Echinococcus granulosus dna polymerase kappa 0.0041 0.004 0.0034
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0023 0.0334
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0105 0.0123
Schistosoma mansoni hypothetical protein 0.0039 0.0032 0.0021
Leishmania major tyrosine specific protein phosphatase, putative 0.0069 0.0152 0.0332
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0184 0.0615 0.071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.013 0.0222
Plasmodium falciparum cysteine repeat modular protein 1 0.0053 0.0088 0.1442
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0043 0.0049 0.0115
Brugia malayi ecdysteroid receptor 0.0184 0.0615 0.0722
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0023 0.0027
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.013 0.028
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0043 0.0049 0.009
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0093 0.0097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0184 0.0615 0.0605
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0093 0.0097
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0027
Trichomonas vaginalis glycogen phosphorylase, putative 0.0221 0.0762 0.3911
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0023 0.0334
Echinococcus multilocularis tumor protein p63 0.0326 0.1184 0.1379
Giardia lamblia Glycogen phosphorylase 0.0221 0.0762 0.3911
Trypanosoma brucei RNA helicase, putative 0.0102 0.0285 0.0669
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0033 0.0039
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Echinococcus granulosus intermediate filament protein 0.0107 0.0303 0.0343
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0027 0.003
Onchocerca volvulus 4.1 G protein, putative homolog 0.0069 0.0152 0.1875
Entamoeba histolytica hypothetical protein 0.0074 0.0172 0.215
Onchocerca volvulus 0.0069 0.0152 0.1875
Loa Loa (eye worm) hypothetical protein 0.0218 0.075 0.0881
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.0152 0.0141
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0018 0.0089
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.018 0.0596 0.0687
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.0152 0.0141
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0043 0.0049 0.0717
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.018 0.0596 0.0687
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.2157 0.8523 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.0152 0.0141
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Entamoeba histolytica glycogen phosphorylase, putative 0.0096 0.0259 0.3301
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0167 0.0546 0.0628
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0172 0.0162
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0184 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0115 0.0135
Schistosoma mansoni survival motor neuron protein 0.0051 0.008 0.007
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0167 0.0546 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Echinococcus granulosus Protein patched homolog 1 0.045 0.168 0.1961
Onchocerca volvulus 0.0104 0.0293 0.3759
Loa Loa (eye worm) hypothetical protein 0.0107 0.0303 0.0356
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0032
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0167 0.0546 0.7117
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0344
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0181 0.0885
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0468 0.175 0.2053
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Brugia malayi hypothetical protein 0.0069 0.0152 0.0178
Echinococcus granulosus ecdysone induced protein 78C 0.0184 0.0615 0.071
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0122 0.013
Brugia malayi Ets-domain containing protein 0.0077 0.0183 0.0215
Loa Loa (eye worm) fli-1 protein 0.0233 0.0809 0.0949
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0181 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0184 0.0615 0.0722
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Onchocerca volvulus Peroxidase homolog 0.0071 0.0158 0.1962
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Trypanosoma cruzi cruzipain precursor, putative 0.0067 0.0143 0.031
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.004 0.0054
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0027 0.0032
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0018 0.0016
Schistosoma mansoni neuroligin 3 (S09 family) 0.0104 0.0293 0.0283
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0032 0.0021
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0087 0.0224 0.0251
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0184 0.0615 0.0722
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0143 0.031
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0049 0.009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0184 0.0615 0.0605
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Echinococcus multilocularis peroxidasin 0.0071 0.0158 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Schistosoma mansoni patched 1 0.045 0.168 0.1671
Brugia malayi nuclear receptor NHR-88 0.0087 0.0224 0.0263
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.013 0.3295
Brugia malayi Steroid receptor seven-up type 2 0.0184 0.0615 0.0722
Echinococcus granulosus tar DNA binding protein 0.013 0.0396 0.0452
Brugia malayi Protein-tyrosine phosphatase containing protein 0.2157 0.8523 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Schistosoma mansoni BC026374 protein (S09 family) 0.0104 0.0293 0.0283
Brugia malayi hypothetical protein 0.0071 0.0158 0.0186
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0069 0.0152 0.0166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0087 0.0224 0.0251
Loa Loa (eye worm) hypothetical protein 0.0048 0.0067 0.0079
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0104 0.0293 0.0283
Echinococcus granulosus transcription factor btf3 0.0035 0.0018 0.0008
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0167 0.0546 0.064
Loa Loa (eye worm) hypothetical protein 0.0051 0.0082 0.0096
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0087 0.0224 0.0214
Onchocerca volvulus Putative organic anion transporter 0.0054 0.0091 0.1073
Entamoeba histolytica glycogen phosphorylase, putative 0.0096 0.0259 0.3301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0184 0.0615 0.0722
Echinococcus granulosus neuroligin 0.0104 0.0293 0.0332
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.009 0.0148
Brugia malayi Nuclear hormone receptor E75 0.0087 0.0224 0.0263
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.013 0.014
Toxoplasma gondii hypothetical protein 0.0124 0.0372 1
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Loa Loa (eye worm) carboxylesterase 0.0446 0.1662 0.195
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0097 0.0266 0.03
Onchocerca volvulus 0.0184 0.0615 0.804
Schistosoma mansoni hypothetical protein 0.0102 0.0285 0.0274
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Mycobacterium ulcerans short chain dehydrogenase 0.1371 0.5371 1
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0034 0.0011 0.0025
Schistosoma mansoni microsomal glutathione s-transferase 0.012 0.0357 0.0347
Brugia malayi nuclear receptor RXR 0.0097 0.0266 0.0312
Onchocerca volvulus 0.0071 0.0158 0.1962
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0218 0.075 0.074
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0158 0.0186
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0023 0.0027
Schistosoma mansoni protein tyrosine phosphatase 0.0069 0.0152 0.0141
Echinococcus granulosus GA binding protein alpha chain 0.0077 0.0183 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0184 0.0615 0.0722
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.1093 0.4259 0.4998
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0184 0.0615 0.0722
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.013 0.0222
Leishmania major cathepsin L-like protease 0.0067 0.0143 0.031
Echinococcus granulosus lamin 0.0107 0.0303 0.0343
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.0023 0.0334
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Trypanosoma brucei short-chain dehydrogenase, putative 0.0034 0.0011 0.0025
Schistosoma mansoni nuclear hormone receptor 0.0184 0.0615 0.0605
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Echinococcus granulosus carboxylesterase 5A 0.0446 0.1662 0.194
Onchocerca volvulus 0.0037 0.0023 0.0161
Echinococcus multilocularis para nitrobenzyl esterase 0.0104 0.0293 0.0332
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0124 0.0372 0.1879
Echinococcus multilocularis nuclear receptor nhr 48 0.0087 0.0224 0.0251
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0018 0.0035
Brugia malayi sodium-independent organic anion transporter family protein 0.0054 0.0091 0.0107
Brugia malayi follicle stimulating hormone receptor 0.0468 0.175 0.2053
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0111 0.187
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0032
Brugia malayi hypothetical protein 0.0054 0.0091 0.0107
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.004 0.0054
Onchocerca volvulus 0.0069 0.0152 0.1875
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0033 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0181 0.0885
Echinococcus granulosus microsomal glutathione S transferase 3 0.012 0.0357 0.0407
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0167 0.0546 0.2783
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Schistosoma mansoni glycogen phosphorylase 0.0221 0.0762 0.0752
Leishmania major cathepsin L-like protease 0.0067 0.0143 0.031
Trichomonas vaginalis glycogen phosphorylase, putative 0.0221 0.0762 0.3911
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0033 0.0039
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Trypanosoma brucei oxidoreductase-like protein 0.0034 0.0011 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0027 0.0038
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0184 0.0615 0.071
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Echinococcus granulosus peroxidasin 0.0071 0.0158 0.0173
Schistosoma mansoni intermediate filament proteins 0.0107 0.0303 0.0293
Toxoplasma gondii hypothetical protein 0.0043 0.0049 0.1062
Echinococcus granulosus follistatin 0.0037 0.0023 0.0014
Schistosoma mansoni nuclear receptor nhr-48 0.0087 0.0224 0.0214
Onchocerca volvulus Glycogen phosphorylase homolog 0.0221 0.0762 1
Brugia malayi hypothetical protein 0.0104 0.0293 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Onchocerca volvulus 0.0051 0.008 0.0924
Chlamydia trachomatis glycogen phosphorylase 0.0221 0.0762 1
Echinococcus granulosus Mastin 0.0039 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0344
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0027 0.003
Brugia malayi sodium-independent organic anion transporter family protein 0.0054 0.0091 0.0107
Echinococcus multilocularis neuroligin 0.0104 0.0293 0.0332
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0186 0.0619 0.0715
Mycobacterium tuberculosis Conserved protein 0.0038 0.0027 0.003
Brugia malayi hypothetical protein 0.025 0.088 0.1032
Echinococcus multilocularis GA binding protein alpha chain 0.0077 0.0183 0.0202
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.004 0.0069
Brugia malayi Carboxylesterase family protein 0.0446 0.1662 0.195
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0344
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0069 0.0152 0.0166
Onchocerca volvulus Peroxidase homolog 0.0071 0.0158 0.1962
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.004 0.0069
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.0203 0.0226
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Onchocerca volvulus 0.0069 0.0152 0.1875
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0184 0.0615 0.0605
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0158 0.0186
Echinococcus granulosus thyroid hormone receptor alpha 0.0087 0.0224 0.0251
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0034 0.0011 0.0013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0097 0.0266 0.0312
Echinococcus multilocularis expressed protein 0.0037 0.0023 0.0014
Schistosoma mansoni retinoic acid receptor RXR 0.0283 0.101 0.1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Toxoplasma gondii ABC1 family protein 0.0038 0.0027 0.0445
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0059 0.0111 0.187
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0181 0.017
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0027 0.0016
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Echinococcus granulosus glycogen phosphorylase 0.0221 0.0762 0.0883
Loa Loa (eye worm) hypothetical protein 0.0184 0.0615 0.0722
Loa Loa (eye worm) glycogen phosphorylase 0.0221 0.0762 0.0894
Schistosoma mansoni tar DNA-binding protein 0.013 0.0396 0.0385
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0034 0.0011 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0027 0.0038
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0069 0.0152 0.0141
Brugia malayi nuclear receptor NHR-67 0.0087 0.0224 0.0263
Onchocerca volvulus 0.0218 0.075 0.9844
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0082 0.0083
Brugia malayi Peroxidasin 0.0071 0.0158 0.0186
Loa Loa (eye worm) intermediate filament protein 0.0107 0.0303 0.0356
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0069 0.0152 0.0166
Loa Loa (eye worm) hypothetical protein 0.0053 0.0087 0.0102
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0083 0.0209 0.0245
Schistosoma mansoni lipoxygenase 0.0054 0.0093 0.0082
Echinococcus multilocularis tissue type plasminogen activator 0.0053 0.0088 0.0091
Brugia malayi hypothetical protein 0.0087 0.0224 0.0263
Trypanosoma cruzi cysteine peptidase, putative 0.0067 0.0143 0.031
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0039 0.0032 0.0024
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0061 0.012 0.0256
Echinococcus multilocularis glycogen phosphorylase 0.0221 0.0762 0.0883
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0172 0.019
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0104 0.0293 0.147
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0013
Echinococcus multilocularis Mastin 0.0039 0.0032 0.0024
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Brugia malayi Carboxylesterase family protein 0.0104 0.0293 0.0344
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0059 0.0111 0.1331
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0039 0.0032 0.0037
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.0203 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0344
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0107
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0104 0.0293 0.0332
Onchocerca volvulus 0.0038 0.0027 0.0214
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Brugia malayi Protein kinase domain containing protein 0.0053 0.0088 0.0103
Schistosoma mansoni agrin 0.0037 0.0023 0.0012
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0034 0.0011 0.0025
Trypanosoma brucei protein tyrosine phosphatase 1 0.0069 0.0152 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0184 0.0615 0.0722
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.013 0.014
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.1093 0.4259 0.4998
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Schistosoma mansoni microtubule-associated protein tau 0.0721 0.2766 0.2758
Loa Loa (eye worm) RNA binding protein 0.013 0.0396 0.0464
Onchocerca volvulus 0.0087 0.0224 0.2841
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Echinococcus multilocularis transmembrane protease serine 3 0.0039 0.0032 0.0024
Onchocerca volvulus Dual oxidase homolog 0.0071 0.0158 0.1962
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0059 0.0111 0.0187
Brugia malayi Cytochrome P450 family protein 0.0039 0.0033 0.0039
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0069 0.0152 0.0166
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Onchocerca volvulus 0.0069 0.0152 0.1875
Brugia malayi nuclear receptor NHR-88 0.0184 0.0615 0.0722
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0027 0.0084
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0027 0.0019
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.0023 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0067 0.0143 0.0335
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0104 0.0293 0.0283
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0184 0.0615 0.071
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0843 0.1553
Entamoeba histolytica hypothetical protein 0.0074 0.0172 0.215
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0069 0.0152 0.0166
Mycobacterium ulcerans lipase LipD 0.0038 0.0027 0.003
Echinococcus multilocularis protein patched 0.045 0.168 0.1961
Echinococcus multilocularis agrin 0.0037 0.0023 0.0014
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.013 0.0119
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.018 0.0596 0.0687
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0087 0.0102
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.1093 0.4259 0.7927
Brugia malayi nuclear receptor RXR 0.0087 0.0224 0.0263
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.009 0.0093
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Echinococcus multilocularis L aminoadipate semialdehyde 0.0083 0.0209 0.0232
Loa Loa (eye worm) hypothetical protein 0.0037 0.0023 0.0027
Loa Loa (eye worm) oxidoreductase 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Echinococcus multilocularis glycogen phosphorylase 0.0221 0.0762 0.0883
Schistosoma mansoni ets-related 0.0233 0.0809 0.0799
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0069 0.0152 0.1875
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Schistosoma mansoni acetylcholinesterase 0.0104 0.0293 0.0283
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0181 0.04
Brugia malayi hypothetical protein 0.0069 0.0152 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0049 0.009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0059 0.0111 0.0235
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0032 0.0021
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.0152 0.0166
Toxoplasma gondii MAPEG family protein 0.012 0.0357 0.959
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0027 0.0032
Loa Loa (eye worm) hypothetical protein 0.0036 0.002 0.0024
Echinococcus granulosus tumor protein p63 0.0326 0.1184 0.1379
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0069 0.0152 0.0166
Brugia malayi TAR-binding protein 0.013 0.0396 0.0464
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0184 0.0615 0.0722
Schistosoma mansoni hypothetical protein 0.0051 0.008 0.007
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0184 0.0615 0.0722
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0043 0.0049 0.0058
Echinococcus granulosus Nuclear hormone receptor HR96 0.0087 0.0224 0.0251
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0043 0.0049 0.0045
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0069 0.0152 0.0141
Onchocerca volvulus 0.0069 0.0152 0.1875
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0069 0.0152 0.0178
Echinococcus multilocularis 0.0069 0.0152 0.0166
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0027 0.0084
Onchocerca volvulus 0.0107 0.0303 0.389
Giardia lamblia Rab geranylgeranyltransferase 0.0167 0.0546 0.2783
Echinococcus multilocularis sterol regulatory element binding protein 0.045 0.168 0.1961
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0027 0.0835
Brugia malayi hypothetical protein 0.0087 0.0224 0.0263
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.0203 0.3594
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0069 0.0152 0.0141
Onchocerca volvulus 0.0087 0.0224 0.2841
Loa Loa (eye worm) hypothetical protein 0.045 0.168 0.1971
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0107
Onchocerca volvulus 0.0039 0.0032 0.0277
Schistosoma mansoni steroid hormone receptor ad4bp 0.0184 0.0615 0.0605
Loa Loa (eye worm) hypothetical protein 0.0087 0.0224 0.0263
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0034 0.0011 0.0025
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0181 0.02
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0043 0.0049 0.009
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.2157 0.8523 0.8521
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0027 0.003
Brugia malayi Protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Echinococcus multilocularis tar DNA binding protein 0.013 0.0396 0.0452
Brugia malayi Trypsin family protein 0.0218 0.075 0.0881
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0082 0.0203 0.0238
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0172 0.019
Onchocerca volvulus 0.0069 0.0152 0.1875
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Onchocerca volvulus Putative organic anion transporter 0.0054 0.0091 0.1073
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.0071 0.0158 0.0186
Echinococcus multilocularis follistatin 0.0037 0.0023 0.0014
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.0203 0.0359
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.1093 0.4259 0.4991
Entamoeba histolytica glycogen phosphorylase, putative 0.0221 0.0762 1
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0122 0.0111
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0083 0.0209 0.0198
Echinococcus granulosus survival motor neuron protein 1 0.025 0.088 0.1021
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0181 0.0425
Echinococcus granulosus acetylcholinesterase 0.0446 0.1662 0.194
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0122 0.013
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0069 0.0152 0.0166
Onchocerca volvulus 0.0107 0.0303 0.389
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0033 0.0052
Brugia malayi Blistered cuticle protein 3 0.0071 0.0158 0.0186
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0059 0.0111 0.0117
Entamoeba histolytica hypothetical protein 0.0074 0.0172 0.215
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Loa Loa (eye worm) hypothetical protein 0.0054 0.0091 0.0107
Onchocerca volvulus 0.0069 0.0152 0.1875
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Echinococcus multilocularis dna polymerase kappa 0.0041 0.004 0.0034
Brugia malayi tailless protein 0.0087 0.0224 0.0263
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.007 0.0069
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0069 0.0152 0.0178
Onchocerca volvulus 0.0054 0.0091 0.1073
Echinococcus granulosus L aminoadipate semialdehyde 0.0083 0.0209 0.0232
Echinococcus granulosus enteropeptidase 0.0039 0.0032 0.0024
Giardia lamblia Protein tyrosine phosphatase 0.0069 0.0152 0.0733
Brugia malayi Retinol dehydrogenase 12 0.0034 0.0011 0.0013
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0039 0.0032 0.0024
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0085 0.0176
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Brugia malayi hypothetical protein 0.0074 0.0172 0.0202
Trypanosoma brucei short-chain dehydrogenase, putative 0.0034 0.0011 0.0025
Brugia malayi Fli-1 protein 0.0233 0.0809 0.0949
Schistosoma mansoni peroxidasin 0.0071 0.0158 0.0148
Brugia malayi conserved hypotetical protein 0.0087 0.0224 0.0263
Brugia malayi hypothetical protein 0.0054 0.0091 0.0107
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0184 0.0615 0.0605
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0513 0.1932 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0059 0.0111 0.0187
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.004 0.0152
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.004 0.0094
Schistosoma mansoni tar DNA-binding protein 0.013 0.0396 0.0385
Brugia malayi Animal haem peroxidase family protein 0.0071 0.0158 0.0186
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0043 0.0049 0.009
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0034 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.1093 0.4259 1
Echinococcus multilocularis transcription factor btf3 0.0035 0.0018 0.0008
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0069 0.0152 0.0178
Schistosoma mansoni cercarial elastase (S01 family) 0.0039 0.0032 0.0021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.0203 1
Loa Loa (eye worm) hypothetical protein 0.025 0.088 0.1032
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.004 0.0094
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0181 0.02
Onchocerca volvulus 0.0048 0.0067 0.0747
Loa Loa (eye worm) hypothetical protein 0.0038 0.0027 0.0032
Onchocerca volvulus Chorion peroxidase homolog 0.0071 0.0158 0.1962
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0059 0.0111 0.0235
Onchocerca volvulus 0.0054 0.0091 0.1073
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0027 0.003
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0096 0.0259 0.0463
Loa Loa (eye worm) hypothetical protein 0.0039 0.0032 0.0037
Loa Loa (eye worm) hypothetical protein 0.0097 0.0266 0.0312
Loa Loa (eye worm) hypothetical protein 0.0156 0.0501 0.0588
Brugia malayi Kringle domain containing protein 0.0053 0.0088 0.0103
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.013 0.0222
Loa Loa (eye worm) TAR-binding protein 0.013 0.0396 0.0464
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0069 0.0152 0.0178
Trichomonas vaginalis esterase, putative 0.0038 0.0027 0.0084
Echinococcus granulosus Solute carrier organic anion transporter family 0.0054 0.0091 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0184 0.0615 0.0722
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0097 0.0266 0.03
Trichomonas vaginalis ap endonuclease, putative 0.0059 0.0111 0.0521
Loa Loa (eye worm) animal heme peroxidase 0.0071 0.0158 0.0186
Loa Loa (eye worm) hypothetical protein 0.0053 0.0088 0.0103
Echinococcus multilocularis Glycosyl transferase, family 35 0.0221 0.0762 0.0883
Onchocerca volvulus 0.0069 0.0152 0.1875
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0184 0.0615 0.0605
Brugia malayi nuclear hormone receptor 0.0184 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0069 0.0152 0.0178
Brugia malayi intermediate filament protein 0.0107 0.0303 0.0356
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0069 0.0152 0.0166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0027 0.0016
Echinococcus granulosus lamin dm0 0.0107 0.0303 0.0343
Brugia malayi SPARC precursor 0.0037 0.0023 0.0027
Brugia malayi oxidoreductase 0.0034 0.0011 0.0013
Echinococcus multilocularis carboxylesterase 5A 0.0446 0.1662 0.194
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0122 0.0111
Onchocerca volvulus 0.0179 0.0594 0.7764
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0069 0.0152 0.1875
Schistosoma mansoni thyroid hormone receptor 0.0184 0.0615 0.0605
Onchocerca volvulus Peroxidasin homolog 0.0071 0.0158 0.1962
Schistosoma mansoni glycogen phosphorylase 0.0096 0.0259 0.0248
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0069 0.0152 0.0166
Echinococcus granulosus Glycosyl transferase family 35 0.0221 0.0762 0.0883
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0018 0.0021
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0043 0.0049 0.0045

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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