TDR Targets

Basic information

Technical information

TDR Targets ID: 842216
Name: 2-amino-5-bromo-N-(3-methylsulfanylphenyl)pyr idine-3-sulfonamide
MW: 374.277 | Formula: C12H12BrN3O2S2
H donors: 2 H acceptors: 3 LogP: 2.78 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CSc1cccc(c1)NS(=O)(=O)c1cc(Br)cnc1N
InChi: 1S/C12H12BrN3O2S2/c1-19-10-4-2-3-9(6-10)16-20(17,18)11-5-8(13)7-15-12(11)14/h2-7,16H,1H3,(H2,14,15)
InChiKey: STNUQTOMTJUIKX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-amino-5-bromo-N-[3-(methylthio)phenyl]-3-pyridinesulfonamide
2-amino-5-bromo-N-[3-(methylthio)phenyl]pyridine-3-sulfonamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0835	0.1682
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0835	0.0835
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0835	0.0835
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4963	1
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Echinococcus multilocularis	orexin receptor type 2	0.0021	0.0835	0.1682
Brugia malayi	putative neuropeptide receptor NPR1	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	dro:myosuppressin receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	sex peptide receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0835	0.1682
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	orexin receptor type 2	0.0021	0.0835	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0021	0.0835	0.1682
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.4963	0.4963
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0021	0.0835	0.0835
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0021	0.0835	0.0835
Echinococcus granulosus	tar DNA binding protein	0.0076	0.4963	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Brugia malayi	Dopamine receptor protein 2	0.0021	0.0835	0.0835
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	neuropeptide F-like receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	amine GPCR	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Brugia malayi	follicle stimulating hormone receptor	0.0021	0.0835	0.0835
Onchocerca volvulus		0.0021	0.0835	0.5
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	neuropeptide s receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	somatostatin receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	g-protein coupled receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	serotonin receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.4963	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0021	0.0835	0.1682
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0021	0.0835	0.1682
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4963	1
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0021	0.0835	0.1682
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0021	0.0835	0.0835
Brugia malayi	RE15519p	0.0021	0.0835	0.0835
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0835	0.1682
Brugia malayi	putative neuropeptide receptor	0.0021	0.0835	0.0835
Schistosoma mansoni	biogenic amine receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0021	0.0835	0.1682
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	allatostatin A receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	serotonin receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0021	0.0835	0.1682
Schistosoma mansoni	opsin-like receptor	0.0021	0.0835	0.1682
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0021	0.0835	0.1682
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0021	0.0835	0.0835
Brugia malayi	RNA binding protein	0.0076	0.4963	0.4963
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Brugia malayi	larval opioid receptor	0.0021	0.0835	0.0835
Echinococcus granulosus	G protein coupled receptor 139	0.0021	0.0835	0.1682
Echinococcus granulosus	neuropeptide Y receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4963	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0021	0.0835	0.1682
Brugia malayi	G protein-coupled receptor	0.0021	0.0835	0.0835
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0021	0.0835	0.1682
Loa Loa (eye worm)	neuropeptide F receptor	0.0021	0.0835	0.0835
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.4963	0.4963
Schistosoma mansoni	hypothetical protein	0.0021	0.0835	0.1682
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0021	0.0835	0.5
Brugia malayi	GnHR receptor homolog	0.0021	0.0835	0.0835
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	1	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0021	0.0835	0.1682
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	opsin-like receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0835	0.1682
Brugia malayi	G-protein coupled receptor	0.0021	0.0835	0.0835
Schistosoma mansoni	hypothetical protein	0.0021	0.0835	0.1682
Echinococcus multilocularis	fmrfamide receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Loa Loa (eye worm)	G-protein coupled receptor	0.0021	0.0835	0.0835
Echinococcus multilocularis	neuropeptide s receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Brugia malayi	Dopamine receptor protein 1	0.0021	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	dro:myosuppressin receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	hypothetical protein	0.0021	0.0835	0.1682
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Brugia malayi	G protein-coupled receptor F59B2.13	0.0021	0.0835	0.0835
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	hypothetical protein	0.0021	0.0835	0.1682
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0021	0.0835	0.0835
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0021	0.0835	0.0835
Echinococcus granulosus	7TM GPCR rhodopsin	0.0021	0.0835	0.1682
Brugia malayi	neuropeptide F receptor	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	allatostatin A receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4963	1
Brugia malayi	neuropeptide F receptor	0.0021	0.0835	0.0835
Echinococcus multilocularis	g protein coupled receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0835	0.1682
Brugia malayi	Serotonin receptor	0.0021	0.0835	0.0835
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	neuropeptides capa receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0021	0.0835	0.1682
Echinococcus multilocularis	neuropeptide receptor A26	0.0021	0.0835	0.1682
Brugia malayi	ORL1-like opioid receptor	0.0021	0.0835	0.0835
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0021	0.0835	0.0835
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Brugia malayi	Melatonin receptor type 1A	0.0021	0.0835	0.0835
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0021	0.0835	0.0835
Echinococcus multilocularis	neuropeptide receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0021	0.0835	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0021	0.0835	0.5
Echinococcus granulosus	fmrfamide receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0021	0.0835	0.1682
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0021	0.0835	0.0835
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Brugia malayi	sulfakinin receptor protein	0.0021	0.0835	0.0835
Brugia malayi	Serotonin receptor	0.0021	0.0835	0.0835
Schistosoma mansoni	amine GPCR	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Loa Loa (eye worm)	RNA binding protein	0.0076	0.4963	0.4963
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	amine GPCR	0.0021	0.0835	0.1682
Brugia malayi	TAR-binding protein	0.0076	0.4963	0.4963
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	neuropeptide receptor A26	0.0021	0.0835	0.1682
Loa Loa (eye worm)	melatonin receptor type 1A	0.0021	0.0835	0.0835
Onchocerca volvulus		0.0021	0.0835	0.5
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus granulosus	g protein coupled receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	neuropeptide receptor	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	neuropeptide f receptor 76f	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0021	0.0835	0.1682
Brugia malayi	G-protein coupled receptor	0.0021	0.0835	0.0835
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.4963	0.4963
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.4963	1
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0021	0.0835	0.1682
Brugia malayi	AKH receptor	0.0021	0.0835	0.0835
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Schistosoma mansoni	adenoreceptor	0.0021	0.0835	0.1682
Schistosoma mansoni	histamine h1 receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	g-protein coupled receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	myosin xvIII	0.0021	0.0835	0.1682
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0021	0.0835	0.1682
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	sex peptide receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	amine GPCR	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0021	0.0835	0.0835
Echinococcus granulosus	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	tm gpcr rhodopsin	0.0021	0.0835	0.1682
Echinococcus multilocularis	serotonin receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0021	0.0835	0.1682
Echinococcus multilocularis	somatostatin receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	opsin-like receptor	0.0021	0.0835	0.1682
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0021	0.0835	0.1682
Loa Loa (eye worm)	TYRA-2 protein	0.0021	0.0835	0.0835
Brugia malayi	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus granulosus	hypothetical protein	0.0021	0.0835	0.1682
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Schistosoma mansoni	amine GPCR	0.0021	0.0835	0.1682
Echinococcus multilocularis	G protein coupled receptor 139	0.0021	0.0835	0.1682
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0021	0.0835	0.0835
Echinococcus granulosus	biogenic amine 5HT receptor	0.0021	0.0835	0.1682
Echinococcus granulosus	neuropeptide receptor	0.0021	0.0835	0.1682
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0021	0.0835	0.1682
Schistosoma mansoni	growth hormone secretagogue receptor	0.0021	0.0835	0.1682
Brugia malayi	Dopamine receptor	0.0021	0.0835	0.0835
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0835	0.0835
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0021	0.0835	0.1682
Onchocerca volvulus		0.0021	0.0835	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0021	0.0835	0.1682

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	> 195 um	PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays: 2118 (Project Summary), 2098 (Primary HTS)]	ChEMBL.	No reference
Potency (functional)	0.1169 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	13.1154 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	= 35.4813 um	PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1326330
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 842216