Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0139 | 0.0107 | 0.0107 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 1 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0185 | 0.1924 | 0.1837 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Onchocerca volvulus | 0.0389 | 1 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0139 | 0.0107 | 0.0107 |
Entamoeba histolytica | protein kinase, putative | 0.0139 | 0.0107 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0139 | 0.0107 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0139 | 0.0107 | 0.0107 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0139 | 0.0107 | 0.0107 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase type | 0.0139 | 0.0107 | 0.0107 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type 1 | 0.0139 | 0.0107 | 0.0107 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0139 | 0.0107 | 0.0107 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 1 | 0.5 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase type | 0.0139 | 0.0107 | 0.0107 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0185 | 0.1924 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.9 uM | Compound is screened for cell growth inhibition against L1210 murine leukemia tumor cell line | ChEMBL. | 7783121 |
IC50 (functional) | = 0.9 uM | Compound is screened for cell growth inhibition against L1210 murine leukemia tumor cell line | ChEMBL. | 7783121 |
IC50 (functional) | = 4 uM | Compound is screened for cell growth inhibition against CCRF-CEM cell line, a human lymphoblastic leukemia line of T-cell origin | ChEMBL. | 7783121 |
IC50 (functional) | = 4 uM | Compound is screened for cell growth inhibition against CCRF-CEM cell line, a human lymphoblastic leukemia line of T-cell origin | ChEMBL. | 7783121 |
IC50 (functional) | = 5 uM | Compound is screened for cell growth inhibition against GC3/MTK-cell line, a human thymidine kinase deficient adenocarcinoma line | ChEMBL. | 7783121 |
Ki (binding) | = 0.015 uM | Inhibitory effect against recombinant human thymidylate synthase | ChEMBL. | 7783121 |
Ki (binding) | = 0.015 uM | Inhibitory effect against recombinant human thymidylate synthase | ChEMBL. | 7783121 |
Ki (binding) | = 18 uM | Inhibitory effect of the compound against E. coli thymidylate synthase | ChEMBL. | 7783121 |
Ki (binding) | = 18 uM | Inhibitory effect of the compound against E. coli thymidylate synthase | ChEMBL. | 7783121 |
Thymidine shift (functional) | = 7.7 | Compound is evaluated for thymidine shift. It is expressed as the ratio of IC50 in the presence of 10 microM thymidine divided by the IC50 with no thymidine added | ChEMBL. | 7783121 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 7783121 | |
Homo sapiens | ChEMBL23 | 7783121 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.