Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 259 aa | 254 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.054 | 0.5922 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.054 | 0.5922 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.076 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.022 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.054 | 0.5922 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.054 | 0.5922 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.054 | 0.5922 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.076 | 1 | 0.5 |
Onchocerca volvulus | 0.054 | 0.5922 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.076 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0257 | 0.068 | 0.5 |
Brugia malayi | thymidylate synthase | 0.054 | 0.5922 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0257 | 0.068 | 0.1148 |
Mycobacterium ulcerans | thymidylate synthase | 0.054 | 0.5922 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.054 | 0.5922 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.076 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.076 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0257 | 0.068 | 0.1148 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 183 nM | In vitro inhibitory activity against Steroid 5-alpha-reductase type I | ChEMBL. | 10987415 |
IC50 (binding) | = 183 nM | In vitro inhibitory activity against Steroid 5-alpha-reductase type I | ChEMBL. | 10987415 |
Inhibition (binding) | = 21.6 % | Compound was evaluated in vitro for its inhibitory activity against Steroid 5-alpha-reductase type 2 at a concentration of 40 microM | ChEMBL. | 10987415 |
Inhibition (binding) | = 21.6 % | Compound was evaluated in vitro for its inhibitory activity against Steroid 5-alpha-reductase type 2 at a concentration of 40 microM | ChEMBL. | 10987415 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.