Detailed information for compound 842451

Basic information

Technical information
  • TDR Targets ID: 842451
  • Name: 2-amino-5-bromo-N-(4-chlorophenyl)pyridine-3- sulfonamide
  • MW: 362.63 | Formula: C11H9BrClN3O2S
  • H donors: 2 H acceptors: 3 LogP: 2.9 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NS(=O)(=O)c1cc(Br)cnc1N
  • InChi: 1S/C11H9BrClN3O2S/c12-7-5-10(11(14)15-6-7)19(17,18)16-9-3-1-8(13)2-4-9/h1-6,16H,(H2,14,15)
  • InChiKey: LNLQOZSRFHRFFM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-5-bromo-N-(4-chlorophenyl)-3-pyridinesulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Brugia malayi exodeoxyribonuclease III family protein 0.0075 0.073 0.2542
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0076 0.0738 0.1293
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0449 0.3349
Loa Loa (eye worm) hypothetical protein 0.0255 0.2792 0.9914
Leishmania major cytochrome p450-like protein 0.0022 0.0116 0.0401
Schistosoma mansoni carbonic anhydrase 0.0082 0.0806 0.1675
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0076 0.0738 0.2571
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0957 0.5017
Onchocerca volvulus 0.0015 0.0043 0.0153
Brugia malayi Pre-SET motif family protein 0.0031 0.023 0.0753
Schistosoma mansoni smad 0.0016 0.0054 0.0074
Echinococcus granulosus Smad4 0.0016 0.0054 0.0115
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0121 0.1257 0.4425
Echinococcus multilocularis chromobox protein 1 0.007 0.0671 0.0671
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0353 0.1197
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0022 0.0116 0.0158
Loa Loa (eye worm) transcription factor SMAD2 0.0237 0.2591 0.9197
Echinococcus multilocularis dna polymerase kappa 0.002 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0187 0.0572
Leishmania major carbonic anhydrase-like protein 0.0174 0.1865 1
Mycobacterium ulcerans beta-lactamase 0.0076 0.0738 0.5528
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0075 0.073 0.5459
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0604 0.1244
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0043 0.0026
Toxoplasma gondii hypothetical protein 0.0082 0.0806 0.629
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0022 0.0116 0.0136
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0022 0.0116 0.0136
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0449 0.2232
Schistosoma mansoni cytochrome P450 0.0022 0.0116 0.0205
Brugia malayi latrophilin 2 splice variant baaae 0.0138 0.145 0.5116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.057 0.1208
Mycobacterium ulcerans esterase/lipase LipP 0.0076 0.0738 0.5528
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0043 0.009
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0022 0.0116 0.0158
Onchocerca volvulus Huntingtin homolog 0.0255 0.2792 1
Loa Loa (eye worm) cytochrome P450 0.0022 0.0116 0.0344
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0054 0.0124
Brugia malayi beta-lactamase family protein 0.0076 0.0738 0.2571
Schistosoma mansoni chromobox protein 0.007 0.0671 0.1388
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0022 0.0116 0.0136
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0601 0.2079
Echinococcus granulosus synaptojanin 1 0.0015 0.0043 0.009
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0407 0.1403
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0129 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0738 0.3818
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0097 0.0301
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0527 0.3986
Schistosoma mansoni chromobox protein 0.007 0.0671 0.1388
Mycobacterium tuberculosis Conserved protein 0.0076 0.0738 0.1293
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0957 0.3478
Loa Loa (eye worm) hypothetical protein 0.0202 0.2182 0.7734
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.0043 0.0026
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0015 0.0043 0.0088
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.023 0.0487
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0209 0.0678
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0022 0.0116 0.0136
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0015 0.0043 0.0088
Echinococcus granulosus geminin 0.0168 0.1793 0.3801
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0022 0.0116 0.0136
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.0043 0.0049
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0043 0.009
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0449 0.2232
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0022 0.0116 0.0158
Loa Loa (eye worm) hypothetical protein 0.0076 0.0738 0.2571
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0116 0.0401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.023 0.0448
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0484 0.5425 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0022 0.0116 0.0136
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0039 0.0317 0.1895
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0043 0.009
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.0043 0.0083
Brugia malayi Cytochrome P450 family protein 0.008 0.0787 0.2745
Brugia malayi hypothetical protein 0.0051 0.0449 0.1537
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0097 0.06
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0449 0.3349
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0022 0.0116 0.0158
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0077 0.0156
Schistosoma mansoni ap endonuclease 0.0075 0.073 0.1513
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0129 0.0129
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0015 0.0043 0.0088
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0097 0.0233
Echinococcus multilocularis dna polymerase eta 0.002 0.0097 0.0097
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0738 0.2653
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0957 0.3427
Loa Loa (eye worm) hypothetical protein 0.0076 0.0738 0.2571
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2343 0.8309
Schistosoma mansoni hypothetical protein 0.0023 0.0129 0.0233
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0121 0.1257 0.4611
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0022 0.0116 0.0136
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0079 0.0775 0.6034
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.057 0.098
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0097 0.0386
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0082 0.0806 0.2814
Echinococcus granulosus tar DNA binding protein 0.0257 0.2816 0.597
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.0043 0.0026
Schistosoma mansoni hypothetical protein 0.0168 0.1793 0.3776
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0022 0.0116 0.0158
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0097 0.0386
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0319 0.1141
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0449 0.3349
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0043 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0022 0.0116 0.0136
Schistosoma mansoni hypothetical protein 0.0049 0.0431 0.0876
Echinococcus multilocularis 0.0022 0.0116 0.0116
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0022 0.0116 0.0136
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0022 0.0116 0.0158
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0353 0.1263
Plasmodium vivax SET domain protein, putative 0.0031 0.023 0.1543
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0043 0.0043
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0121 0.1257 0.1257
Trypanosoma brucei RNA editing exonuclease 2 0.0015 0.0043 0.0088
Echinococcus multilocularis carbonic anhydrase II 0.0174 0.1865 0.1865
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0301
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0957 0.3478
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0121 0.1257 0.4611
Brugia malayi follicle stimulating hormone receptor 0.0228 0.2491 0.8838
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0957 0.3352
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0083
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0054 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0957 0.3478
Brugia malayi hypothetical protein 0.0033 0.0243 0.0801
Echinococcus multilocularis chromobox protein 1 0.007 0.0671 0.0671
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0209 0.0444
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0022 0.0116 0.0136
Trichomonas vaginalis penicillin-binding protein, putative 0.0076 0.0738 0.2653
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0083
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0121 0.1257 0.6693
Brugia malayi hypothetical protein 0.0255 0.2792 0.9914
Schistosoma mansoni ap endonuclease 0.0075 0.073 0.1513
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0121 0.1257 0.6663
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.0806 0.2814
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0043 0.0083
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0431 0.1472
Onchocerca volvulus 0.0015 0.0043 0.0153
Brugia malayi RNA binding protein 0.0257 0.2816 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0957 0.3478
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0601 0.0601
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Loa Loa (eye worm) MH2 domain-containing protein 0.0237 0.2591 0.9197
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0022 0.0116 0.0158
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0041 0.0021
Brugia malayi Pre-SET motif family protein 0.0216 0.2343 0.8309
Schistosoma mansoni tar DNA-binding protein 0.0257 0.2816 0.5953
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0097 0.0301
Echinococcus multilocularis geminin 0.0168 0.1793 0.1793
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0075 0.073 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.023 0.1543
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0353 0.1197
Leishmania major cytochrome p450-like protein 0.0022 0.0116 0.0401
Echinococcus multilocularis cpg binding protein 0.0031 0.0228 0.0228
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0957 0.3352
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0097 0.0166
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0022 0.0116 0.0158
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0075 0.073 0.3829
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0449 0.3349
Schistosoma mansoni hypothetical protein 0.0064 0.0601 0.1237
Brugia malayi Calcitonin receptor-like protein seb-1 0.0202 0.2182 0.7734
Brugia malayi Cytochrome P450 family protein 0.0022 0.0116 0.0344
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0079 0.0775 0.5847
Echinococcus multilocularis smad 0.0016 0.0054 0.0054
Onchocerca volvulus 0.003 0.0209 0.0749
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0174 0.1865 0.6599
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0957 0.5017
Loa Loa (eye worm) hypothetical protein 0.0076 0.0738 0.2571
Trichomonas vaginalis esterase, putative 0.0076 0.0738 0.2653
Echinococcus granulosus cytochrome P450 2K1 0.0022 0.0116 0.0245
Onchocerca volvulus 0.0043 0.0361 0.1294
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.004 0.0329 0.157
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0074
Leishmania major cytochrome p450-like protein 0.0039 0.0317 0.1507
Schistosoma mansoni cpg binding protein 0.003 0.0209 0.0404
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0043 0.0043
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0022 0.0116 0.0158
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0317 0.1065
Echinococcus multilocularis GPCR, family 2 0.0064 0.0601 0.0601
Echinococcus multilocularis beta LACTamase domain containing family member 0.0076 0.0738 0.0738
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0039 0.0315 0.1496
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0257 0.2816 1
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0043 0.0043
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0049
Loa Loa (eye worm) hypothetical protein 0.002 0.0097 0.0279
Schistosoma mansoni tar DNA-binding protein 0.0257 0.2816 0.5953
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.057 0.057
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0317 0.1507
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0022 0.0116 0.0136
Trypanosoma cruzi hypothetical protein, conserved 0.0076 0.0738 0.3818
Schistosoma mansoni nocturnin 0.0015 0.0043 0.0049
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0097 0.0386
Schistosoma mansoni hypothetical protein 0.0082 0.0806 0.1675
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0319 0.1068
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0174 0.1865 0.6599
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0121 0.1257 1
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0054 0.0054
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0075 0.073 0.2542
Echinococcus granulosus carbonic anhydrase 0.0082 0.0806 0.1709
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0075 0.073 0.3774
Schistosoma mansoni cpg binding protein 0.0031 0.0228 0.0445
Brugia malayi Cytochrome P450 family protein 0.0039 0.0317 0.1065
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.0806 0.2814
Brugia malayi MH1 domain containing protein 0.0016 0.0054 0.0124
Brugia malayi hypothetical protein 0.024 0.2627 0.9322
Giardia lamblia Kinase, PLK 0.0095 0.0957 0.7529
Loa Loa (eye worm) hypothetical protein 0.0039 0.0319 0.107
Leishmania major hypothetical protein, conserved 0.0076 0.0738 0.3818
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0121 0.1257 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.023 0.023
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0957 0.3478
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0738 0.2653
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.057 0.1172
Leishmania major DNA polymerase eta, putative 0.002 0.0097 0.0301
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0097 0.0233
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0077 0.0156
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.1865 1
Onchocerca volvulus 0.0031 0.0221 0.0793
Schistosoma mansoni kinase 0.0048 0.0422 0.0856
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0022 0.0116 0.0401
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Brugia malayi Smad1 0.0016 0.0054 0.0124
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.057 0.1172
Loa Loa (eye worm) hypothetical protein 0.0138 0.145 0.5116
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.023 0.023
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0082 0.0806 0.2814
Schistosoma mansoni Smad4 0.0016 0.0054 0.0074
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0076 0.0738 0.1293
Brugia malayi cytochrome P450 0.0022 0.0116 0.0344
Onchocerca volvulus 0.0245 0.2684 0.9613
Brugia malayi MH2 domain containing protein 0.0016 0.0054 0.0124
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0121 0.1257 0.6663
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0075 0.073 0.1278
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.2491 0.8838
Leishmania major DNA polymerase kappa, putative 0.002 0.0097 0.0301
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0121 0.1257 0.2634
Toxoplasma gondii exonuclease III APE 0.0075 0.073 0.5664
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0043 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0022 0.0116 0.0136
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0083
Mycobacterium ulcerans lipase LipD 0.0076 0.0738 0.5528
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0075 0.073 0.3774
Brugia malayi TAR-binding protein 0.0257 0.2816 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0097 0.0102
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0022 0.0116 0.0158
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0121 0.1257 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0041
Schistosoma mansoni synaptojanin 0.0015 0.0043 0.0049
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.0806 0.1675
Schistosoma mansoni hypothetical protein 0.0064 0.0601 0.1237
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0738 0.2653
Mycobacterium ulcerans hypothetical protein 0.0076 0.0738 0.5528
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.057 0.4343
Schistosoma mansoni hypothetical protein 0.0064 0.0601 0.1237
Echinococcus multilocularis synaptojanin 1 0.0015 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0255 0.2792 0.9914
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.023 0.0448
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0043 0.0088
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0075 0.073 0.7522
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.4717 0.4717
Plasmodium falciparum carbonic anhydrase 0.0082 0.0806 0.629
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0957 0.3478
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.0043 0.0026
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0043 0.009
Brugia malayi SET domain containing protein 0.0013 0.002 0.0004
Giardia lamblia DINP protein human, muc B family 0.002 0.0097 0.0451
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2627 0.5568
Schistosoma mansoni tar DNA-binding protein 0.0257 0.2816 0.5953
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0097 0.0206
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0601 0.2079
Brugia malayi MH2 domain containing protein 0.0016 0.0054 0.0124
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0601 0.0601
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0601 0.2079
Echinococcus granulosus GPCR family 2 0.0064 0.0601 0.1273
Mycobacterium tuberculosis Probable hydrolase 0.0076 0.0738 0.1293
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0082 0.0806 0.2814
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0022 0.0116 0.0136
Schistosoma mansoni hypothetical protein 0.0138 0.145 0.3046
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0022 0.0116 0.0158
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0054 0.0074
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0738 0.153
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0022 0.0116 0.0136
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0121 0.1257 1
Trypanosoma brucei polo-like protein kinase 0.0095 0.0957 0.5061
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.0043 0.0049
Loa Loa (eye worm) RNA binding protein 0.0257 0.2816 1
Schistosoma mansoni tar DNA-binding protein 0.0257 0.2816 0.5953
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0077 0.0156
Brugia malayi Cytochrome P450 family protein 0.0039 0.0317 0.1065
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0022 0.0116 0.0136
Loa Loa (eye worm) cytochrome P450 family protein 0.008 0.0787 0.2745
Schistosoma mansoni hypothetical protein 0.0422 0.4717 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0957 0.5017
Echinococcus granulosus chromobox protein 1 0.007 0.0671 0.1423
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0076 0.0738 0.2571
Trypanosoma brucei unspecified product 0.002 0.0097 0.0386
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Treponema pallidum exodeoxyribonuclease (exoA) 0.0075 0.073 0.5664
Echinococcus granulosus carbonic anhydrase 0.0082 0.0806 0.1709
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0042 0.035 0.0571
Brugia malayi MH1 domain containing protein 0.0016 0.0054 0.0124
Trichomonas vaginalis chromobox protein, putative 0.007 0.0671 0.24
Brugia malayi CXXC zinc finger family protein 0.003 0.0209 0.0678
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0097 0.0279
Echinococcus multilocularis Smad4 0.0016 0.0054 0.0054
Brugia malayi MH2 domain containing protein 0.0237 0.2591 0.9197
Onchocerca volvulus 0.0076 0.0738 0.2645
Echinococcus multilocularis carbonic anhydrase 0.0082 0.0806 0.0806
Schistosoma mansoni survival motor neuron protein 0.0049 0.0431 0.0876
Toxoplasma gondii cytochrome p450 superfamily protein 0.0022 0.0116 0.0602
Echinococcus granulosus dna polymerase eta 0.002 0.0097 0.0206
Loa Loa (eye worm) CYP4Cod1 0.0039 0.0317 0.1065
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.073 0.5664
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0054 0.0115
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0022 0.0116 0.0136
Mycobacterium tuberculosis Probable lipase LipE 0.0076 0.0738 0.1293
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.023 0.0448
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0041 0.0021
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0015 0.0043 0.009
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.1865 0.3928
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0957 0.2028
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0022 0.0116 0.0136
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0449 0.23
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0022 0.0116 0.0158
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0022 0.0116 0.0158
Loa Loa (eye worm) hypothetical protein 0.0051 0.0449 0.1537
Loa Loa (eye worm) hypothetical protein 0.0064 0.0601 0.2079
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Loa Loa (eye worm) hypothetical protein 0.0082 0.0806 0.2814
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0075 0.073 0.073
Echinococcus multilocularis tar DNA binding protein 0.0257 0.2816 0.2816
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0075 0.073 0.3774
Schistosoma mansoni cript-related 0.0015 0.0043 0.0049
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0022 0.0116 0.0158
Brugia malayi RNA recognition motif domain containing protein 0.0257 0.2816 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0075 0.073 0.5664
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0121 0.1257 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0601 0.1273
Echinococcus granulosus dna polymerase kappa 0.002 0.0097 0.0206
Trypanosoma cruzi cytochrome P450, putative 0.0039 0.0317 0.1507
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0601 0.1273
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.0043 0.0049
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.057 0.2894
Loa Loa (eye worm) Smad1 0.0016 0.0054 0.0124
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0022 0.0116 0.0401
Loa Loa (eye worm) TAR-binding protein 0.0257 0.2816 1
Schistosoma mansoni DNA polymerase eta 0.002 0.0097 0.0166
Toxoplasma gondii ABC1 family protein 0.0076 0.0738 0.573
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0075 0.073 0.5664
Brugia malayi beta-lactamase family protein 0.0076 0.0738 0.2571
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0082 0.0806 0.2814
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0019 0.0019
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0043 0.0088
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0082 0.0806 0.2814
Brugia malayi CCR4 0.0015 0.0043 0.0083
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0097 0.0279
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0077 0.0156
Loa Loa (eye worm) hypothetical protein 0.0082 0.0806 0.2814
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0043 0.0043
Onchocerca volvulus 0.0049 0.0431 0.1544
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0077 0.0156
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0097 0.0279
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0022 0.0116 0.0158
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0097 0.0166
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0076 0.0738 0.5528
Loa Loa (eye worm) hypothetical protein 0.0031 0.023 0.0753
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0022 0.0116 0.0401
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0121 0.1257 0.2664
Loa Loa (eye worm) beta-lactamase 0.0076 0.0738 0.2571
Brugia malayi chromobox protein homolog 3 0.0039 0.0319 0.107
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0319 0.1068
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2627 0.2627
Loa Loa (eye worm) carbonic anhydrase 3 0.0174 0.1865 0.6599
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0174 0.1865 0.6599
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.0043 0.0026
Mycobacterium leprae conserved hypothetical protein 0.0076 0.0738 1
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0121 0.1257 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0076 0.0738 0.1293
Trichomonas vaginalis D-aminoacylase, putative 0.0076 0.0738 0.2653
Loa Loa (eye worm) hypothetical protein 0.024 0.2627 0.9322
Mycobacterium tuberculosis Conserved protein 0.0076 0.0738 0.1293
Mycobacterium tuberculosis Probable lipase LipD 0.0076 0.0738 0.1293
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Trypanosoma brucei cytochrome P450, putative 0.0039 0.0317 0.1581
Echinococcus multilocularis carbonic anhydrase 0.0082 0.0806 0.0806
Brugia malayi Heterochromatin protein 1 0.007 0.0671 0.2331
Loa Loa (eye worm) hypothetical protein 0.0018 0.007 0.0181
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0015 0.0043 0.0088
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0957 1
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0043 0.0026
Loa Loa (eye worm) hypothetical protein 0.0076 0.0738 0.2571
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.0806 0.1675
Onchocerca volvulus Huntingtin homolog 0.0255 0.2792 1
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.0043 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.057 0.4076
Schistosoma mansoni hypothetical protein 0.0064 0.0601 0.1237
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0957 0.3478
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0407 0.1403
Loa Loa (eye worm) hypothetical protein 0.0076 0.0738 0.2571
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0174 0.1865 0.3928
Echinococcus granulosus smad 0.0016 0.0054 0.0115
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.073 0.2623
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0022 0.0116 0.0158
Echinococcus multilocularis carbonic anhydrase 0.0082 0.0806 0.0806
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0301
Mycobacterium leprae Probable lipase LipE 0.0076 0.0738 1
Echinococcus granulosus carbonic anhydrase 0.0082 0.0806 0.1709
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0043 0.0083
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0957 0.0957
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.0043 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.057 0.4076
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0301
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0022 0.0116 0.0158
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.057 0.4076
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.0043 0.0026
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0361 0.0728
Loa Loa (eye worm) hypothetical protein 0.0031 0.0221 0.0722
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0022 0.0116 0.0158
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0097 0.0386
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0054 0.0054
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0317 0.1065
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0054 0.0115
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0097 0.0102
Mycobacterium tuberculosis Probable esterase LipL 0.0076 0.0738 0.1293
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0671 0.2331
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0077 0.0156
Schistosoma mansoni cpg binding protein 0.0031 0.0228 0.0445
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.0043 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0187 0.0572
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0097 0.0301
Schistosoma mansoni synaptojanin 0.0015 0.0043 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0022 0.0116 0.0136
Schistosoma mansoni hypothetical protein 0.0168 0.1793 0.3776
Trichomonas vaginalis set domain proteins, putative 0.0245 0.2684 1
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.0043 0.0026
Schistosoma mansoni carbonic anhydrase-related 0.0082 0.0806 0.1675
Trypanosoma brucei hypothetical protein, conserved 0.0076 0.0738 0.3873
Schistosoma mansoni smad1 5 8 and 0.0016 0.0054 0.0074
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0022 0.0116 0.0158
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0174 0.1865 1
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0957 0.1995
Plasmodium vivax hypothetical protein, conserved 0.0076 0.0738 0.573
Echinococcus granulosus carbonic anhydrase II 0.0174 0.1865 0.3953
Trichomonas vaginalis chromobox protein, putative 0.007 0.0671 0.24
Brugia malayi glucose-6-phosphate dehydrogenase 0.0121 0.1257 0.4425
Brugia malayi beta-lactamase 0.0076 0.0738 0.2571
Echinococcus granulosus cpg binding protein 0.0031 0.0228 0.0484
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Trypanosoma brucei carbonic anhydrase-like protein 0.0174 0.1865 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0022 0.0116 0.0486
Schistosoma mansoni hypothetical protein 0.0022 0.0116 0.0205
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0121 0.1257 0.4611
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0022 0.0116 0.0158
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0076 0.0738 0.2571
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0077 0.0156
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0202 0.2182 0.7734
Mycobacterium tuberculosis Conserved protein 0.0076 0.0738 0.1293
Echinococcus granulosus chromobox protein 1 0.007 0.0671 0.1423
Schistosoma mansoni tar DNA-binding protein 0.0257 0.2816 0.5953
Echinococcus granulosus beta LACTamase domain containing family member 0.0076 0.0738 0.1565
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0022 0.0116 0.0136
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0076 0.0738 0.153
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0083
Onchocerca volvulus Putative neutral sphingomyelinase 0.0015 0.0043 0.0153
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0015 0.0043 0.0043
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0077 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0022 0.0116 0.0136
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0202 0.2182 0.7734
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.0043 0.0083
Onchocerca volvulus 0.0076 0.0738 0.2645
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0075 0.073 0.1548
Leishmania major hypothetical protein, conserved 0.0051 0.0449 0.2232
Trichomonas vaginalis ap endonuclease, putative 0.0075 0.073 0.2623
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0121 0.1257 1
Onchocerca volvulus 0.0076 0.0738 0.2645
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0097 0.0386
Echinococcus granulosus dnaJ subfamily B 0.0422 0.4717 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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