Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Bile acid receptor homolog | 0.0175 | 0.2534 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0149 | 0.1353 | 0.1353 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0339 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.012 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0339 | 1 | 1 |
Brugia malayi | ecdysteroid receptor | 0.0175 | 0.2534 | 0.2534 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.2534 | 0.2534 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.0123 | 0.0123 |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.1353 | 0.1353 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0339 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0339 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.012 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.0123 | 0.0123 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.012 | 0 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.012 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0149 | 0.1353 | 0.1353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.