TDR Targets

Basic information

Technical information

TDR Targets ID: 842885
Name: 5-phenyl-N-[3-(trifluoromethyl)phenyl]thiophe ne-2-carboxamide
MW: 347.354 | Formula: C18H12F3NOS
H donors: 1 H acceptors: 1 LogP: 5.32 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(s1)c1ccccc1)Nc1cccc(c1)C(F)(F)F
InChi: 1S/C18H12F3NOS/c19-18(20,21)13-7-4-8-14(11-13)22-17(23)16-10-9-15(24-16)12-5-2-1-3-6-12/h1-11H,(H,22,23)
InChiKey: UAZNCBBCPMEZLI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-phenyl-N-[3-(trifluoromethyl)phenyl]-2-thiophenecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	glutaminase	0.0266	0.92	1
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	amine GPCR	0.0165	0.518	0.5631
Brugia malayi	Dopamine receptor protein 1	0.0165	0.518	0.5631
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0165	0.518	0.5631
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Echinococcus multilocularis	G protein coupled receptor 139	0.0165	0.518	1
Brugia malayi	neuropeptide F receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	neuropeptides capa receptor	0.0165	0.518	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.518	1
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Onchocerca volvulus		0.0165	0.518	1
Onchocerca volvulus		0.0165	0.518	1
Echinococcus multilocularis	serotonin receptor	0.0165	0.518	1
Giardia lamblia	Fructose-bisphosphate aldolase	0.0286	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0165	0.518	0.5631
Schistosoma mansoni	opsin-like receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0165	0.518	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0165	0.518	0.5631
Onchocerca volvulus		0.0165	0.518	1
Onchocerca volvulus		0.0165	0.518	1
Schistosoma mansoni	biogenic amine receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2165	0.418
Echinococcus granulosus	neuropeptide Y receptor	0.0165	0.518	1
Onchocerca volvulus		0.0165	0.518	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0165	0.518	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0165	0.518	0.5631
Brugia malayi	glutaminase DH11.1	0.0266	0.92	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0165	0.518	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.2165	0.2354
Echinococcus multilocularis	sex peptide receptor	0.0165	0.518	1
Echinococcus granulosus	g protein coupled receptor	0.0165	0.518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0165	0.518	0.5631
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Brugia malayi	Dopamine receptor	0.0165	0.518	0.5631
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0165	0.518	0.5631
Echinococcus multilocularis	fmrfamide receptor	0.0165	0.518	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Onchocerca volvulus		0.0165	0.518	1
Echinococcus granulosus	orexin receptor type 2	0.0165	0.518	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Brugia malayi	AKH receptor	0.0165	0.518	0.5631
Echinococcus granulosus	g-protein coupled receptor	0.0165	0.518	1
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Echinococcus granulosus	neuropeptide FF receptor 2	0.0165	0.518	1
Onchocerca volvulus		0.0165	0.518	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0165	0.518	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0165	0.518	0.5631
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0511	0.0556
Schistosoma mansoni	amine GPCR	0.0165	0.518	0.5631
Echinococcus granulosus	neuropeptide receptor A26	0.0165	0.518	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0165	0.518	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0165	0.518	1
Schistosoma mansoni	amine GPCR	0.0165	0.518	0.5631
Brugia malayi	sulfakinin receptor protein	0.0165	0.518	0.5631
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0286	1	1
Loa Loa (eye worm)	glutaminase 2	0.0266	0.92	1
Brugia malayi	neuropeptide F receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Brugia malayi	Dopamine receptor protein 2	0.0165	0.518	0.5631
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0165	0.518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Echinococcus multilocularis	neuropeptide Y receptor	0.0165	0.518	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0165	0.518	0.5631
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0165	0.518	1
Onchocerca volvulus		0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0165	0.518	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0165	0.518	0.5374
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0165	0.518	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0165	0.518	0.5374
Schistosoma mansoni	biogenic amine receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	somatostatin receptor	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	g-protein coupled receptor	0.0165	0.518	1
Echinococcus granulosus	serotonin receptor	0.0165	0.518	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0165	0.518	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0165	0.518	0.5374
Echinococcus granulosus	allatostatin A receptor	0.0165	0.518	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0165	0.518	0.5631
Brugia malayi	follicle stimulating hormone receptor	0.0165	0.518	0.5631
Schistosoma mansoni	neuropeptide receptor	0.0165	0.518	0.5631
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.518	1
Onchocerca volvulus		0.0165	0.518	1
Echinococcus multilocularis	g protein coupled receptor	0.0165	0.518	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0165	0.518	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	neuropeptide F receptor	0.0165	0.518	0.5374
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Onchocerca volvulus		0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	amine GPCR	0.0165	0.518	0.5631
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.014	0.4155	1
Echinococcus granulosus	neuropeptide Y receptor	0.0165	0.518	1
Schistosoma mansoni	purine nucleoside phosphorylase	0.0127	0.3659	0.3978
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0165	0.518	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2165	0.418
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0165	0.518	0.5374
Brugia malayi	MH2 domain containing protein	0.0118	0.3307	0.3595
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0165	0.518	0.5631
Echinococcus granulosus	neuropeptide s receptor	0.0165	0.518	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0165	0.518	0.5631
Brugia malayi	Melatonin receptor type 1A	0.0165	0.518	0.5631
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0165	0.518	0.5374
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	hypothetical protein	0.0165	0.518	0.5631
Brugia malayi	G protein-coupled receptor F59B2.13	0.0165	0.518	0.5631
Brugia malayi	G-protein coupled receptor	0.0165	0.518	0.5631
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0165	0.518	0.5631
Treponema pallidum	fructose-bisphosphate aldolase	0.0286	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Brugia malayi	putative neuropeptide receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0165	0.518	0.5631
Onchocerca volvulus		0.0165	0.518	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0511	0.0556
Brugia malayi	G protein-coupled receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Echinococcus granulosus	7TM GPCR rhodopsin	0.0165	0.518	1
Schistosoma mansoni	amine GPCR	0.0165	0.518	0.5631
Schistosoma mansoni	neuropeptide receptor	0.0165	0.518	0.5631
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0165	0.518	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0165	0.518	0.5374
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0165	0.518	1
Schistosoma mansoni	myosin xvIII	0.0165	0.518	0.5631
Brugia malayi	Serotonin receptor	0.0165	0.518	0.5631
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0165	0.518	1
Brugia malayi	ORL1-like opioid receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0165	0.518	0.5374
Echinococcus granulosus	dro:myosuppressin receptor	0.0165	0.518	1
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.014	0.4155	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0165	0.518	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Echinococcus granulosus	neuropeptide receptor	0.0165	0.518	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0101	0.2606	0.5031
Echinococcus multilocularis	g protein coupled receptor	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.2165	0.418
Schistosoma mansoni	adenoreceptor	0.0165	0.518	0.5631
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2165	0.2354
Echinococcus granulosus	tm gpcr rhodopsin	0.0165	0.518	1
Echinococcus multilocularis	allatostatin A receptor	0.0165	0.518	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0165	0.518	0.5631
Brugia malayi	GnHR receptor homolog	0.0165	0.518	0.5631
Brugia malayi	G-protein coupled receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0165	0.518	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0118	0.3307	0.3218
Echinococcus multilocularis	neuropeptide receptor	0.0165	0.518	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.518	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0165	0.518	0.5631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Brugia malayi	Serotonin receptor	0.0165	0.518	0.5631
Echinococcus granulosus	hypothetical protein	0.0165	0.518	1
Schistosoma mansoni	glutaminase	0.0266	0.92	1
Echinococcus multilocularis	serotonin receptor	0.0165	0.518	1
Echinococcus granulosus	g protein coupled receptor	0.0165	0.518	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.2606	0.2411
Echinococcus granulosus	neuropeptide receptor	0.0165	0.518	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0165	0.518	0.5631
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0165	0.518	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Schistosoma mansoni	neuropeptide f receptor 76f	0.0165	0.518	0.5631
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0165	0.518	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0101	0.2606	0.5031
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0165	0.518	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	MH2 domain-containing protein	0.0118	0.3307	0.3218
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	neuropeptide receptor A26	0.0165	0.518	1
Schistosoma mansoni	neuropeptide receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	neuropeptide Y receptor	0.0165	0.518	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Brugia malayi	putative neuropeptide receptor NPR1	0.0165	0.518	0.5631
Onchocerca volvulus		0.0165	0.518	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0165	0.518	0.5631
Brugia malayi	purine nucleoside phosphorylase I, inosine and guanosine-specific family protein	0.0127	0.3659	0.3978
Echinococcus granulosus	neuropeptides capa receptor	0.0165	0.518	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0165	0.518	1
Echinococcus granulosus	inosine guanosine and xanthosine phosphorylase	0.0101	0.2606	0.5031
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Onchocerca volvulus		0.0165	0.518	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Trichomonas vaginalis	glutaminase, putative	0.0266	0.92	0.8738
Echinococcus granulosus	g protein coupled receptor	0.0165	0.518	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.2165	0.418
Echinococcus granulosus	biogenic amine 5HT receptor	0.0165	0.518	1
Echinococcus granulosus	G protein coupled receptor 139	0.0165	0.518	1
Schistosoma mansoni	biogenic amine receptor	0.0165	0.518	0.5631
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.014	0.4155	0.0895
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0165	0.518	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Onchocerca volvulus		0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	neuropeptides capa receptor	0.0165	0.518	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0165	0.518	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0165	0.518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Schistosoma mansoni	purine nucleoside phosphorylase	0.0127	0.3659	0.3978
Echinococcus granulosus	sex peptide receptor	0.0165	0.518	1
Schistosoma mansoni	opsin-like receptor	0.0165	0.518	0.5631
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Schistosoma mansoni	histamine h1 receptor	0.0165	0.518	0.5631
Brugia malayi	larval opioid receptor	0.0165	0.518	0.5631
Echinococcus multilocularis	g protein coupled receptor	0.0165	0.518	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0165	0.518	0.5631
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.2165	0.1904
Loa Loa (eye worm)	TYRA-2 protein	0.0165	0.518	0.5374
Echinococcus multilocularis	fmrfamide receptor	0.0165	0.518	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0165	0.518	1
Echinococcus multilocularis	neuropeptide receptor	0.0165	0.518	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Schistosoma mansoni	opsin-like receptor	0.0165	0.518	0.5631
Onchocerca volvulus		0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Onchocerca volvulus		0.0165	0.518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Echinococcus multilocularis	neuropeptide s receptor	0.0165	0.518	1
Echinococcus granulosus	fmrfamide receptor	0.0165	0.518	1
Schistosoma mansoni	neuropeptide receptor	0.0165	0.518	0.5631
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Echinococcus multilocularis	orexin receptor type 2	0.0165	0.518	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	G-protein coupled receptor	0.0165	0.518	0.5374
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0165	0.518	1
Echinococcus multilocularis	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Loa Loa (eye worm)	glutaminase	0.0266	0.92	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0165	0.518	1
Schistosoma mansoni	hypothetical protein	0.0165	0.518	0.5631
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.518	1
Schistosoma mansoni	hypothetical protein	0.0165	0.518	0.5631
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2165	0.2354
Brugia malayi	RE15519p	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	hypothetical protein	0.0165	0.518	0.5631
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0165	0.518	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0165	0.518	0.5631
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0286	1	1
Brugia malayi	hypothetical protein	0.0165	0.518	0.5631
Echinococcus granulosus	somatostatin receptor	0.0165	0.518	1
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Loa Loa (eye worm)	hypothetical protein	0.0165	0.518	0.5374
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.2165	0.2354
Echinococcus granulosus	purine nucleoside phosphorylase	0.0127	0.3659	0.7064
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0165	0.518	0.5631
Onchocerca volvulus		0.0165	0.518	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0165	0.518	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0165	0.518	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 842885