TDR Targets

Basic information

Technical information

TDR Targets ID: 843248
Name: N-(4-ethylphenyl)-2-(8-methyl-4H-chromeno[3,4 -d]pyrazol-1-yl)acetamide
MW: 347.41 | Formula: C21H21N3O2
H donors: 1 H acceptors: 2 LogP: 3.6 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccc(cc1)NC(=O)Cn1ncc2c1c1cc(C)ccc1OC2
InChi: 1S/C21H21N3O2/c1-3-15-5-7-17(8-6-15)23-20(25)12-24-21-16(11-22-24)13-26-19-9-4-14(2)10-18(19)21/h4-11H,3,12-13H2,1-2H3,(H,23,25)
InChiKey: BWMWJOGETNPOAF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(4-ethylphenyl)-2-(8-methyl-4H-chromeno[3,4-d]pyrazol-1-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Nuclear hormone receptor-like 1	0.0131	0.3244	0.5185
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Schistosoma mansoni	nuclear hormone receptor	0.0117	0.2886	0.2885
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0249	0.6231	0.622
Echinococcus multilocularis	cpg binding protein	0.0029	0.0649	0.0623
Brugia malayi	nuclear hormone receptor	0.0249	0.6231	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0249	0.6231	0.623
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0249	0.6231	0.622
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0249	0.6231	1
Schistosoma mansoni	nuclear hormone receptor	0.0117	0.2886	0.2885
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0117	0.2886	0.2866
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0117	0.2886	0.2866
Schistosoma mansoni	zinc finger protein	0.0117	0.2886	0.2885
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0249	0.6231	0.622
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3244	0.5185
Brugia malayi	hypothetical protein	0.0131	0.3244	0.5185
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0249	0.6231	0.622
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0117	0.2886	0.2885
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0249	0.6231	0.622
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0119	0.0092
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.006	0.0633
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0249	0.6231	0.622
Schistosoma mansoni	cpg binding protein	0.0028	0.0609	0.0608
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	0.0633
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0249	0.6231	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	0.0633
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0076	0.0074
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0117	0.2886	0.2866
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0249	0.6231	0.623
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0249	0.6231	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0119	0.0092
Entamoeba histolytica	acetyltransferase, GNAT family	0.0038	0.0864	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Onchocerca volvulus		0.0249	0.6231	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0249	0.6231	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0117	0.2886	0.4051
Loa Loa (eye worm)	DR-78	0.0117	0.2886	0.4608
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0249	0.6231	0.622
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Schistosoma mansoni	bromodomain containing protein	0.0005	0.0028	0.0026
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0141	0.3479	0.3478
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Schistosoma mansoni	cpg binding protein	0.0029	0.0649	0.0648
Schistosoma mansoni	thyroid hormone receptor	0.0249	0.6231	0.623
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0249	0.6231	0.623
Plasmodium falciparum	histone acetyltransferase GCN5	0.0038	0.0864	0.5
Brugia malayi	ecdysteroid receptor	0.0249	0.6231	1
Onchocerca volvulus	Bile acid receptor homolog	0.0249	0.6231	1
Brugia malayi	nuclear hormone receptor	0.0117	0.2886	0.4608
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Brugia malayi	nuclear receptor NHR-88	0.0249	0.6231	1
Schistosoma mansoni	nuclear hormone receptor	0.0249	0.6231	0.623
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0131	0.3244	0.5185
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0249	0.6231	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.1404	0.1403
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0116	0.0143
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0117	0.2886	0.2866
Brugia malayi	nuclear receptor RXR	0.0131	0.3244	0.5185
Onchocerca volvulus		0.0117	0.2886	0.4051
Schistosoma mansoni	RAR-like nuclear receptor	0.0249	0.6231	0.623
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0006	0.006	0.0633
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0117	0.2886	0.2866
Schistosoma mansoni	cpg binding protein	0.0029	0.0649	0.0648
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0249	0.6231	0.623
Schistosoma mansoni	bromodomain containing protein	0.0005	0.0028	0.0026
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0249	0.6231	1
Giardia lamblia	Histone acetyltransferase GCN5	0.0038	0.0864	0.5
Echinococcus granulosus	nuclear receptor nhr 48	0.0117	0.2886	0.2866
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0249	0.6231	0.623
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0117	0.2886	0.2866
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Brugia malayi	hypothetical protein	0.0117	0.2886	0.4608
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0249	0.6231	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0249	0.6231	0.623
Schistosoma mansoni	hypothetical protein	0.0397	1	1
Schistosoma mansoni	nuclear receptor	0.0117	0.2886	0.2885
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Schistosoma mansoni	coup transcription factor	0.0249	0.6231	0.623
Trichomonas vaginalis	helicase, putative	0.0006	0.006	0.0633
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0131	0.3244	0.3243
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0249	0.6231	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0076	0.0048
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0249	0.6231	0.622
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0117	0.2886	0.2866
Echinococcus granulosus	thyroid hormone receptor alpha	0.0117	0.2886	0.2866
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0076	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Schistosoma mansoni	zinc finger protein	0.0005	0.0028	0.0026
Echinococcus multilocularis	nuclear receptor nhr 48	0.0117	0.2886	0.2866
Loa Loa (eye worm)	steroid hormone receptor	0.0249	0.6231	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0249	0.6231	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0249	0.6231	0.622
Brugia malayi	nuclear receptor NHR-88	0.0117	0.2886	0.4608
Brugia malayi	tailless protein	0.0117	0.2886	0.4608
Brugia malayi	ecdysone receptor	0.0117	0.2886	0.4608
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0249	0.6231	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0249	0.6231	0.623
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0609	0.0937
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0117	0.2886	0.2866
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0249	0.6231	1
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0041	0.0952	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0041	0.0952	1
Brugia malayi	nuclear receptor NHR-67	0.0117	0.2886	0.4608
Brugia malayi	Steroid receptor seven-up type 2	0.0249	0.6231	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3244	0.5185
Brugia malayi	nuclear hormone receptor family member odr-7	0.0117	0.2886	0.4608
Schistosoma mansoni	retinoic acid receptor RXR	0.0249	0.6231	0.623
Echinococcus granulosus	ecdysone induced protein 78C	0.0249	0.6231	0.622
Loa Loa (eye worm)	acetyltransferase	0.0141	0.3479	0.5563
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	0.0633
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0249	0.6231	1
Brugia malayi	steroid hormone receptor	0.0249	0.6231	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0249	0.6231	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0249	0.6231	0.622
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0249	0.6231	1
Echinococcus granulosus	cpg binding protein	0.0029	0.0649	0.0623
Brugia malayi	Nuclear hormone receptor E75	0.0117	0.2886	0.4608
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0249	0.6231	1
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3244	0.5185
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0249	0.6231	0.622
Echinococcus multilocularis	dnaJ subfamily B	0.0397	1	1
Brugia malayi	conserved hypotetical protein	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Onchocerca volvulus		0.0117	0.2886	0.4051
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	0.0633
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0117	0.2886	0.4608
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0117	0.2886	0.2866
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0249	0.6231	0.622
Onchocerca volvulus	Protein ultraspiracle homolog	0.0249	0.6231	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0131	0.3244	0.3225
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0131	0.3244	0.3243
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0249	0.6231	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0119	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0141	0.3479	0.3461
Brugia malayi	hypothetical protein	0.0117	0.2886	0.4608
Brugia malayi	nuclear receptor RXR	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Schistosoma mansoni	nuclear receptor	0.0117	0.2886	0.2885
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0076	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3244	0.5185
Echinococcus multilocularis	FTZ F1 alpha	0.0249	0.6231	0.622
Loa Loa (eye worm)	nuclear hormone receptor	0.0117	0.2886	0.4608
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0609	0.0937
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0249	0.6231	0.622
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0137	0.3378	0.336
Schistosoma mansoni	nuclear receptor nhr-48	0.0117	0.2886	0.2885
Brugia malayi	Nuclear hormone receptor E75	0.0117	0.2886	0.4608
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0249	0.6231	1
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0076	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0249	0.6231	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0117	0.2886	0.4051
Loa Loa (eye worm)	hypothetical protein	0.0131	0.3244	0.5185
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1331	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0249	0.6231	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0249	0.6231	1
Loa Loa (eye worm)	hypothetical protein	0.0117	0.2886	0.4608
Loa Loa (eye worm)	hypothetical protein	0.0249	0.6231	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0249	0.6231	1
Brugia malayi	hypothetical protein	0.0131	0.3244	0.5185
Brugia malayi	acetyltransferase, GNAT family protein	0.0141	0.3479	0.5563
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0117	0.2886	0.4608
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0131	0.3244	0.3225
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0249	0.6231	1
Echinococcus granulosus	FTZ F1 alpha	0.0249	0.6231	0.622
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0249	0.6231	0.622
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0249	0.6231	1
Schistosoma mansoni	thyroid hormone receptor	0.0249	0.6231	0.623
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0117	0.2886	0.2885
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0041	0.0952	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0041	0.0952	0.0927
Echinococcus multilocularis	ecdysone induced protein 78C	0.0249	0.6231	0.622
Brugia malayi	Nuclear hormone receptor-like 1	0.0131	0.3244	0.5185
Trichomonas vaginalis	conserved hypothetical protein	0.0006	0.006	0.0633
Brugia malayi	orphan nuclear receptor NR2E1	0.0117	0.2886	0.4608
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0006	0.006	0.0633

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 843248