Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.2996 | 0.2996 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 1 | 0.5 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.3715 | 0.3715 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.9752 | 0.9752 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.1428 | 0.1428 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 0.5 |
Echinococcus granulosus | lamin | 0.0033 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.1428 | 0.5 |
Onchocerca volvulus | 0.0033 | 1 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.1428 | 0.1428 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2749 | 0.2749 |
Schistosoma mansoni | lamin | 0.0033 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.1428 | 0.1428 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.1428 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.1428 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.2749 | 0.2749 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.1428 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 1 | 1 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.3715 | 0.2668 |
Echinococcus multilocularis | lamin | 0.0033 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.1428 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.