Detailed information for compound 843368

Basic information

Technical information
  • TDR Targets ID: 843368
  • Name: N-[3-(dipropylamino)propyl]-2-(8-methyl-4H-ch romeno[3,4-d]pyrazol-1-yl)acetamide
  • MW: 384.515 | Formula: C22H32N4O2
  • H donors: 1 H acceptors: 2 LogP: 3.43 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(CCC)CCCNC(=O)Cn1ncc2c1c1cc(C)ccc1OC2
  • InChi: 1S/C22H32N4O2/c1-4-10-25(11-5-2)12-6-9-23-21(27)15-26-22-18(14-24-26)16-28-20-8-7-17(3)13-19(20)22/h7-8,13-14H,4-6,9-12,15-16H2,1-3H3,(H,23,27)
  • InChiKey: AOHNPGQMNPDFJM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(dipropylamino)propyl]-2-(8-methyl-4H-chromeno[3,4-d]pyrazol-1-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus acetylcholinesterase 0.0447 0.5357 1
Schistosoma mansoni hypothetical protein 0.001 0.0021 0.004
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0617 0.0617
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Echinococcus granulosus dna polymerase kappa 0.0019 0.0132 0.0246
Mycobacterium ulcerans carboxylesterase, LipT 0.0075 0.0824 0.2914
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0132 0.0218
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0025 0.0000012213
Leishmania major mitochondrial DNA polymerase beta 0.0182 0.2122 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0017 0.0115 0.0134
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0261 0.0487
Brugia malayi glutaminase DH11.1 0.0235 0.2767 0.5148
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0029 0.0018
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0115 0.2178
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0088 0.0128
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0376 0.0667
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0472 0.0882
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0198 0.1405
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0111 0.0204
Echinococcus multilocularis ETS domain containing protein Elk 1 0.001 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0042 0.041 0.0765
Loa Loa (eye worm) hypothetical protein 0.0053 0.0547 0.0987
Loa Loa (eye worm) hypothetical protein 0.0039 0.0376 0.0667
Brugia malayi steroid hormone receptor 0.001 0.0029 0.0018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Onchocerca volvulus 0.0028 0.0239 0.0753
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0001
Giardia lamblia NADH oxidase lateral transfer candidate 0.0015 0.0088 0.5838
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.1119 0.8837
Onchocerca volvulus 0.0031 0.0282 0.0905
Schistosoma mansoni thyroid hormone receptor 0.001 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.01 0.1129 0.2077
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0029 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0029 0.0015
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0029 0.0054
Loa Loa (eye worm) ets-domain-containing protein 0.001 0.0021 0.0001
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0617 0.1118
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0123 0.0357
Echinococcus multilocularis para nitrobenzyl esterase 0.0075 0.0824 0.0824
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0088 0.0296
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0099
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0198 0.1405
Echinococcus granulosus replication factor c subunit 1 0.001 0.0025 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.002 0.0038
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0193
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.001 0.0021 0.0001
Schistosoma mansoni acetylcholinesterase 0.0075 0.0824 0.1539
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0017 0.0115 0.081
Loa Loa (eye worm) hypothetical protein 0.0447 0.5357 1
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0025 0.0000031374
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0472 0.0849
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0472 0.0472
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0017 0.0115 0.0426
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0553 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0132 0.0507
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0429 0.0429
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0029 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0198 0.1565
Echinococcus multilocularis cpg binding protein 0.0029 0.0258 0.0258
Echinococcus multilocularis neuroligin 0.0075 0.0824 0.0824
Brugia malayi Carboxylesterase family protein 0.0075 0.0824 0.1509
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0282 0.0526
Echinococcus multilocularis muscleblind protein 0.0145 0.1675 0.1675
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0185
Brugia malayi Muscleblind-like protein 0.0145 0.1675 0.3103
Loa Loa (eye worm) hypothetical protein 0.0024 0.0198 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0132 0.0375
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0132 0.0211
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.1119 0.8837
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0099 0.0185
Echinococcus multilocularis dna polymerase eta 0.0019 0.0132 0.0132
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0088 0.1513
Plasmodium vivax SET domain protein, putative 0.0031 0.0282 0.6248
Echinococcus multilocularis acetylcholinesterase 0.0447 0.5357 0.5357
Loa Loa (eye worm) hypothetical protein 0.0046 0.046 0.0824
Loa Loa (eye worm) hypothetical protein 0.0145 0.1675 0.3101
Onchocerca volvulus 0.0039 0.0376 0.1238
Echinococcus granulosus ETS domain containing protein Elk 1 0.001 0.0021 0.004
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0025 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0617 0.1152
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0198 0.1565
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1129 0.2079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0029 0.0015
Plasmodium falciparum thioredoxin reductase 0.0044 0.0436 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0198 0.0335
Schistosoma mansoni ap endonuclease 0.0017 0.0115 0.0214
Brugia malayi Fli-1 protein 0.0203 0.2381 0.4425
Echinococcus granulosus RUN 0.0039 0.0376 0.0702
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0376 0.0702
Onchocerca volvulus 0.0075 0.0824 0.2819
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0185
Loa Loa (eye worm) glutaminase 2 0.0235 0.2767 0.5146
Brugia malayi hypothetical protein 0.0039 0.0376 0.0669
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0029 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0185
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0282 0.0526
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.1119 0.8837
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0472 0.0847
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0029 0.0054
Entamoeba histolytica hypothetical protein 0.0072 0.0778 0.6819
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.1254 1
Echinococcus granulosus cpg binding protein 0.0029 0.0258 0.0482
Schistosoma mansoni cpg binding protein 0.0029 0.0258 0.0482
Echinococcus multilocularis GA binding protein alpha chain 0.0067 0.0719 0.0719
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0193
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0472 0.0472
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0132 0.0132
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0123 0.2387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0099 0.0148
Toxoplasma gondii hypothetical protein 0.0029 0.0261 0.446
Plasmodium falciparum glutathione reductase 0.0015 0.0088 0.1513
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0617 0.112
Schistosoma mansoni thyroid hormone receptor 0.001 0.0029 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0617 0.1152
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0075 0.0824 0.6315
Schistosoma mansoni cpg binding protein 0.0029 0.0258 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Schistosoma mansoni DNA polymerase eta 0.0019 0.0132 0.0246
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0017 0.0115 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0169
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0029 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0198 0.0543
Loa Loa (eye worm) carboxylesterase 0.0447 0.5357 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1129 1
Echinococcus multilocularis protein C ets 2 0.001 0.0021 0.0021
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0132 0.0375
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0099 0.0148
Brugia malayi topoisomerase 0.001 0.0025 0.0012
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0029 0.0018
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0436 0.0814
Treponema pallidum exodeoxyribonuclease (exoA) 0.0017 0.0115 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0102 0.1148 0.2142
Echinococcus granulosus GPCR family 2 0.0016 0.0099 0.0185
Echinococcus multilocularis protein patched 0.0043 0.0429 0.0429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0524 0.0945
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0088 0.0296
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0026 0.0215 0.0904
Echinococcus granulosus nibrin 0.001 0.0025 0.0047
Echinococcus multilocularis nibrin 0.001 0.0025 0.0025
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0088 0.0088
Trypanosoma brucei trypanothione reductase 0.0044 0.0436 0.1957
Trichomonas vaginalis glutaminase, putative 0.0235 0.2767 0.9673
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0009
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0009
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.0088 0.1513
Brugia malayi DKFZp564C0469 protein 0.001 0.0025 0.0012
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1129 0.1129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0017 0.0115 0.0426
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0182 0.2122 1
Echinococcus granulosus muscleblind protein 0.0145 0.1675 0.3127
Loa Loa (eye worm) hypothetical protein 0.0057 0.0601 0.1087
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0198 0.063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0088 0.0296
Schistosoma mansoni ets 0.001 0.0021 0.004
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0198 0.063
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0029 0.0018
Echinococcus granulosus ewsr:fli fusion protein type 0.001 0.0021 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0111 0.0204
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0075 0.0824 0.6315
Brugia malayi nuclear receptor NHR-88 0.001 0.0029 0.0018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0524 0.0943
Brugia malayi DNA-binding protein D-ETS-3 0.001 0.0021 0.0004
Toxoplasma gondii thioredoxin reductase 0.0044 0.0436 0.7777
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0029 0.0054
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0029 0.0015
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0436 1
Brugia malayi glutathione reductase 0.0044 0.0436 0.0781
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0029 0.0018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0015 0.0088 0.0227
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0198 0.063
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0132 0.0132
Brugia malayi Ets-domain containing protein 0.001 0.0021 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.1254 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0088 0.0163
Brugia malayi Pre-SET motif family protein 0.0213 0.2502 0.4651
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0001
Echinococcus granulosus ETS transcription factor Elf 1 0.001 0.0021 0.004
Brugia malayi Carboxylesterase family protein 0.0447 0.5357 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0015 0.0088 0.0227
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0436 0.0778
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0429 0.0801
Schistosoma mansoni hypothetical protein 0.0042 0.041 0.0765
Echinococcus multilocularis expressed conserved protein 0.0094 0.1054 0.1054
Brugia malayi CHE-14 protein 0.0043 0.0429 0.0768
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0088 0.0296
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0617 0.1152
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0029 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0029 0.0029
Brugia malayi Carboxylesterase family protein 0.0075 0.0824 0.1509
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0017 0.0115 0.0177
Trypanosoma brucei unspecified product 0.0019 0.0132 0.0507
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0017 0.0115 0.0214
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0182 0.2122 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0067 0.0719 0.1309
Loa Loa (eye worm) fli-1 protein 0.0203 0.2381 0.4424
Loa Loa (eye worm) hypothetical protein 0.0075 0.0824 0.1506
Schistosoma mansoni cpg binding protein 0.0028 0.0239 0.0446
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0115 0.0315
Echinococcus granulosus dna polymerase eta 0.0019 0.0132 0.0246
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0232 0.2735 0.2735
Brugia malayi TAR-binding protein 0.0058 0.0617 0.112
Brugia malayi Ets-domain containing protein 0.0067 0.0719 0.1311
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0132 0.0246
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0029 0.0029
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0029 0.0054
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0132 0.038
Loa Loa (eye worm) carboxylesterase 0.0075 0.0824 0.1506
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0075 0.0824 0.0824
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0193
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0472 0.0882
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0198 0.0335
Schistosoma mansoni loxhd1 0.0039 0.0376 0.0702
Schistosoma mansoni lipoxygenase 0.0232 0.2735 0.5104
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0031 0.0283 0.1229
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0025 0.0047
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0088 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0282 0.0526
Loa Loa (eye worm) RNA binding protein 0.0058 0.0617 0.1118
Schistosoma mansoni rab6-interacting 0.0039 0.0376 0.0702
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0123 0.0307
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0193
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0088 0.1177
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0029 0.0015
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0029 0.0029
Onchocerca volvulus 0.0075 0.0824 0.2819
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0617 0.1152
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0029 0.0054
Trichomonas vaginalis set domain proteins, putative 0.0242 0.286 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0198 0.0543
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0088 0.0163
Echinococcus multilocularis ewsr:fli fusion protein type 0.001 0.0021 0.0021
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0088 0.0296
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0029 0.0029
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0025 0.0012
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0376 0.0376
Onchocerca volvulus 0.0242 0.286 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0029 0.0018
Echinococcus granulosus tar DNA binding protein 0.0058 0.0617 0.1152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0132 0.0209
Loa Loa (eye worm) hypothetical protein 0.0035 0.0327 0.0575
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0029 0.0054
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0436 0.1957
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0021 0.004
Leishmania major DNA polymerase eta, putative 0.0019 0.0132 0.0218
Echinococcus multilocularis ETS transcription factor Elf 1 0.001 0.0021 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0198 0.0543
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0132 0.0964
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.1119 0.8837
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0009
Brugia malayi ecdysteroid receptor 0.001 0.0029 0.0018
Schistosoma mansoni elf1 0.001 0.0021 0.004
Schistosoma mansoni patched 1 0.0043 0.0429 0.0801
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0009
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0132 0.038
Loa Loa (eye worm) hypothetical protein 0.0039 0.0376 0.0667
Mycobacterium ulcerans glutaminase 0.0235 0.2767 1
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0778 0.1452
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0029 0.0018
Schistosoma mansoni topbp1 0.001 0.0025 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0132 0.0507
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0953 0.4425
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0099 0.015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0015 0.0088 0.0227
Brugia malayi nuclear hormone receptor 0.001 0.0029 0.0018
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0132 0.0246
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0029 0.0029
Loa Loa (eye worm) hypothetical protein 0.0031 0.0282 0.049
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0029 0.0018
Trypanosoma brucei unspecified product 0.0013 0.0061 0.0169
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1655 0.3089
Mycobacterium tuberculosis Conserved hypothetical protein 0.0096 0.1072 0.8435
Treponema pallidum NADH oxidase 0.0015 0.0088 0.6948
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0099 0.015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0824 0.1539
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0088 0.6948
Echinococcus multilocularis tumor protein p63 0.0312 0.3712 0.3712
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0029 0.0054
Onchocerca volvulus 0.001 0.0029 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0088 0.0296
Schistosoma mansoni ets-related 0.001 0.0021 0.004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0029 0.0018
Brugia malayi hypothetical protein 0.001 0.0025 0.0012
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0.0088 0.6339
Onchocerca volvulus 0.0039 0.0376 0.1238
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0075 0.0824 0.1539
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0029 0.0018
Echinococcus multilocularis acetylcholinesterase 0.0447 0.5357 0.5357
Brugia malayi Ets-domain containing protein 0.0067 0.0719 0.1311
Schistosoma mansoni DNA ligase IV 0.001 0.0025 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Echinococcus granulosus neuroligin 0.0075 0.0824 0.1539
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0025 0.0000065587
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.001 0.0021 0.004
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.1119 0.8837
Brugia malayi Thioredoxin reductase 0.0044 0.0436 0.0781
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0282 0.0282
Schistosoma mansoni gabp alpha 0.0067 0.0719 0.1342
Schistosoma mansoni hypothetical protein 0.0035 0.0327 0.0611
Onchocerca volvulus 0.0075 0.0824 0.2819
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0132 0.0209
Echinococcus granulosus protein C ets 2 0.001 0.0021 0.004
Brugia malayi Carboxylesterase family protein 0.0075 0.0824 0.1509
Entamoeba histolytica hypothetical protein 0.0072 0.0778 0.6819
Brugia malayi hypothetical protein 0.0039 0.0376 0.0669
Schistosoma mansoni hypothetical protein 0.001 0.0021 0.004
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0376 0.0702
Giardia lamblia DINP protein human, muc B family 0.0019 0.0132 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0029 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0088 0.0296
Echinococcus granulosus expressed conserved protein 0.0094 0.1054 0.1968
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0.0088 0.6948
Brugia malayi Carboxylesterase family protein 0.0447 0.5357 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.002 0.002
Echinococcus multilocularis dnaJ subfamily B 0.0392 0.4689 0.4689
Loa Loa (eye worm) glutathione reductase 0.0044 0.0436 0.0778
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0169
Echinococcus multilocularis muscleblind protein 1 0.0145 0.1675 0.1675
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0472 0.0882
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0198 0.063
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0086 0.0953 0.4425
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0009
Onchocerca volvulus 0.0075 0.0824 0.2819
Schistosoma mansoni coup transcription factor 0.001 0.0029 0.0054
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0017 0.0115 0.8403
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0029 0.0054
Echinococcus granulosus tumor protein p63 0.0312 0.3712 0.6929
Echinococcus multilocularis carboxylesterase 5A 0.0447 0.5357 0.5357
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0376 0.0376
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0029 0.0054
Loa Loa (eye worm) hypothetical protein 0.0051 0.0524 0.0943
Mycobacterium ulcerans hypothetical protein 0.0024 0.0198 0.063
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0198 0.063
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0099 0.0099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0029 0.0018
Brugia malayi CXXC zinc finger family protein 0.0028 0.0239 0.0412
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0017 0.0115 0.0426
Trypanosoma brucei unspecified product 0.0013 0.0061 0.0169
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0198 0.063
Loa Loa (eye worm) hypothetical protein 0.0075 0.0824 0.1506
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0111 0.0204
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0088 0.0296
Schistosoma mansoni hypothetical protein 0.0072 0.0778 0.1452
Echinococcus multilocularis GPCR, family 2 0.0016 0.0099 0.0099
Brugia malayi exodeoxyribonuclease III family protein 0.0017 0.0115 0.0179
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0182 0.2122 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0282 0.4859
Schistosoma mansoni lipoxygenase 0.0162 0.1882 0.3514
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0429 0.0801
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0029 0.0018
Brugia malayi transcription factor E74 isoform 0.001 0.0021 0.0004
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0123 1
Brugia malayi Doublecortin family protein 0.0039 0.0376 0.0669
Entamoeba histolytica hypothetical protein 0.0072 0.0778 0.6819
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0524 0.0945
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0021 0.0021
Schistosoma mansoni rab6-interacting 0.0039 0.0376 0.0702
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.1119 0.8896
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0088 0.0296
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0026 0.0215 0.0904
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0029 0.0029
Echinococcus granulosus ETS transcription factor Elf 2 0.001 0.0021 0.004
Trichomonas vaginalis ap endonuclease, putative 0.0017 0.0115 0.0315
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0086 0.0953 0.4254
Loa Loa (eye worm) hypothetical protein 0.0075 0.0824 0.1506
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Brugia malayi hypothetical protein 0.001 0.0025 0.0012
Schistosoma mansoni hypothetical protein 0.0016 0.0099 0.0185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0472 0.0882
Loa Loa (eye worm) hypothetical protein 0.0075 0.0824 0.1506
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0111 0.0204
Loa Loa (eye worm) hypothetical protein 0.0043 0.0429 0.0765
Echinococcus granulosus BC026374 protein S09 family 0.0075 0.0824 0.1539
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0029 0.0018
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.0088 0.1513
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0376 0.0702
Schistosoma mansoni glutaminase 0.0235 0.2767 0.5165
Schistosoma mansoni ap endonuclease 0.0017 0.0115 0.0214
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0198 0.0947
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1655 0.1655
Brugia malayi hypothetical protein 0.0072 0.0778 0.1421
Echinococcus multilocularis RUN 0.0039 0.0376 0.0376
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0025 0.0000012213
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0282 0.0526
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0029 0.0054
Echinococcus granulosus dnaJ subfamily B 0.0392 0.4689 0.8753
Brugia malayi Carboxylesterase family protein 0.0075 0.0824 0.1509
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0617 0.1118
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0088 0.1513
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0029 0.0018
Echinococcus multilocularis ets variant gene 4 0.001 0.0021 0.0021
Schistosoma mansoni BC026374 protein (S09 family) 0.0075 0.0824 0.1539
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0029 0.0054
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0132 0.0507
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0376 0.0376
Schistosoma mansoni topbp1 0.001 0.0025 0.0047
Loa Loa (eye worm) hypothetical protein 0.0447 0.5357 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0132 0.0388
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.1254 1
Echinococcus multilocularis protein dispatched 1 0.0049 0.0503 0.0503
Plasmodium falciparum glutathione reductase 0.0044 0.0436 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0376 0.8547
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Schistosoma mansoni neuroligin 3 (S09 family) 0.0075 0.0824 0.1539
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0282 0.0526
Schistosoma mansoni hypothetical protein 0.0039 0.0376 0.0702
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0472 0.0882
Loa Loa (eye worm) hypothetical protein 0.0075 0.0824 0.1506
Plasmodium falciparum thioredoxin reductase 0.0015 0.0088 0.1513
Loa Loa (eye worm) carboxylesterase 0.0075 0.0824 0.1506
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0017 0.0115 0.2178
Mycobacterium tuberculosis Probable reductase 0.01 0.1119 0.8837
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0029 0.0015
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0132 0.0211
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0011 0.0039 0.0036
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0123 0.2387
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0088 0.0219
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0017 0.0115 0.0234
Echinococcus granulosus GA binding protein alpha chain 0.0067 0.0719 0.1342
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0025 0.0025
Echinococcus multilocularis ETS transcription factor Elf 5 0.001 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0198 0.0333
Loa Loa (eye worm) hypothetical protein 0.0075 0.0824 0.1506
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0198 0.0947
Loa Loa (eye worm) hypothetical protein 0.0145 0.1675 0.3101
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0088 0.0296
Mycobacterium ulcerans hypothetical protein 0.0096 0.1072 0.3817
Onchocerca volvulus 0.0024 0.0198 0.0609
Brugia malayi hypothetical protein 0.0075 0.0824 0.1509
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0327 0.0577
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0239 0.0409
Loa Loa (eye worm) hypothetical protein 0.0075 0.0824 0.1506
Leishmania major DNA polymerase kappa, putative 0.0019 0.0132 0.0218
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0029 0.0054
Echinococcus multilocularis ETS transcription factor Elf 2 0.001 0.0021 0.0021
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0429 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.001 0.0021 0.0001
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0088 0.1177
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0029 0.0018
Plasmodium vivax glutathione reductase, putative 0.0044 0.0436 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0017 0.0115 0.0115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0029 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0436 0.0436
Echinococcus granulosus acetylcholinesterase 0.0447 0.5357 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0061 0.0169
Trichomonas vaginalis spcc417.12 protein, putative 0.0075 0.0824 0.2819
Brugia malayi Pre-SET motif family protein 0.0031 0.0282 0.0492
Schistosoma mansoni nuclear hormone receptor 0.001 0.0029 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0629 0.1175
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0132 0.0388
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1129 0.2107
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0824 0.1539
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0075 0.0824 0.2819
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0029 0.0054
Onchocerca volvulus 0.0075 0.0824 0.2819
Echinococcus granulosus ETS transcription factor Elf 5 0.001 0.0021 0.004
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0436 0.2985
Onchocerca volvulus 0.0046 0.046 0.1535
Schistosoma mansoni gliotactin 0.0075 0.0824 0.1539
Loa Loa (eye worm) acetylcholinesterase 1 0.0447 0.5357 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0029 0.0054
Loa Loa (eye worm) glutaminase 0.0235 0.2767 0.5146
Schistosoma mansoni cellular tumor antigen P53 0.0046 0.046 0.0859
Loa Loa (eye worm) hypothetical protein 0.001 0.0029 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0029 0.0015
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0075 0.0824 0.1539
Echinococcus granulosus carboxylesterase 5A 0.0447 0.5357 1
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0376 0.8547
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.1254 1
Schistosoma mansoni hypothetical protein 0.0392 0.4689 0.8753
Schistosoma mansoni hypothetical protein 0.0042 0.041 0.0765
Brugia malayi RNA binding protein 0.0058 0.0617 0.112
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0132 0.0507
Loa Loa (eye worm) hypothetical protein 0.0024 0.0198 0.0333
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0132 0.0246
Schistosoma mansoni hypothetical protein 0.0042 0.041 0.0765
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0132 0.0507
Loa Loa (eye worm) hypothetical protein 0.0018 0.0123 0.0193
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0198 0.063
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0017 0.0115 0.0326
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0026 0.0215 0.0904
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0447 0.5357 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0778 0.0778
Schistosoma mansoni polycystin 1-related 0.0039 0.0376 0.0702
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0011 0.0039 0.0036
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0132 0.0507
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0778 0.1452
Echinococcus multilocularis BC026374 protein (S09 family) 0.0075 0.0824 0.0824
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.2502 0.4649
Loa Loa (eye worm) D-ets-2 protein 0.001 0.0021 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0029 0.0011
Toxoplasma gondii exonuclease III APE 0.0017 0.0115 0.1694
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0026 0.0215 0.0904
Echinococcus granulosus FTZ F1 alpha 0.001 0.0029 0.0054
Mycobacterium tuberculosis Carboxylesterase LipT 0.0075 0.0824 0.6315
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0088 0.0296
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0088 0.0219
Echinococcus granulosus para nitrobenzyl esterase 0.0075 0.0824 0.1539
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0617 0.1152
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0429 0.1424
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0029 0.0018
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0025 0.0000012213
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0198 0.0335
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0088 0.0296
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0232 0.2735 0.5104
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0282 0.0282
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0198 0.1565
Schistosoma mansoni ets-related 0.0203 0.2381 0.4445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0029 0.0015
Leishmania major trypanothione reductase 0.0044 0.0436 0.1712
Entamoeba histolytica hypothetical protein 0.0072 0.0778 0.6819

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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