Detailed information for compound 843375

Basic information

Technical information
  • TDR Targets ID: 843375
  • Name: 2-(8-methyl-4H-chromeno[3,4-d]pyrazol-1-yl)-N -(4-propan-2-ylphenyl)-N-propylacetamide
  • MW: 403.517 | Formula: C25H29N3O2
  • H donors: 0 H acceptors: 2 LogP: 5.01 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=O)Cn1ncc2c1c1cc(C)ccc1OC2)c1ccc(cc1)C(C)C
  • InChi: 1S/C25H29N3O2/c1-5-12-27(21-9-7-19(8-10-21)17(2)3)24(29)15-28-25-20(14-26-28)16-30-23-11-6-18(4)13-22(23)25/h6-11,13-14,17H,5,12,15-16H2,1-4H3
  • InChiKey: SKAIBVGFIZOQGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-isopropylphenyl)-2-(8-methyl-4H-chromeno[3,4-d]pyrazol-1-yl)-N-propyl-acetamide
  • N-(4-isopropylphenyl)-2-(8-methyl-4H-chromeno[3,4-d]pyrazol-1-yl)-N-propylacetamide
  • 2-(8-methyl-4H-chromeno[3,4-d]pyrazol-1-yl)-N-(4-propan-2-ylphenyl)-N-propyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis musashi 0.0028 0.2706 0.2491
Schistosoma mansoni aldehyde dehydrogenase 0.0062 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 1 0.5
Brugia malayi intermediate filament protein 0.0028 0.2706 0.343
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.789 0.7827
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0287 0.0363
Loa Loa (eye worm) hypothetical protein 0.0027 0.2599 0.3295
Schistosoma mansoni hypothetical protein 0.0035 0.4242 0.4073
Schistosoma mansoni aldehyde dehydrogenase 0.0062 1 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.789 0.7827
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 1 0.5
Trypanosoma brucei protein kinase, putative 0.0052 0.789 0.5
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.789 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.789 0.7827
Loa Loa (eye worm) hypothetical protein 0.0051 0.7651 0.9698
Echinococcus multilocularis lamin 0.0028 0.2706 0.2491
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.789 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.789 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.2706 0.343
Loa Loa (eye worm) hypothetical protein 0.0016 0.0287 0.0363
Loa Loa (eye worm) hypothetical protein 0.0035 0.4242 0.5377
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.789 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.789 0.5
Schistosoma mansoni lamin 0.0028 0.2706 0.2491
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 1 0.5
Echinococcus granulosus lamin dm0 0.0028 0.2706 0.2491
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.7651 0.9698
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.7651 0.9698
Echinococcus granulosus lamin 0.0028 0.2706 0.2491
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0287 0.0363
Brugia malayi MAP kinase sur-1 0.0052 0.789 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.789 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.789 0.5
Loa Loa (eye worm) intermediate filament protein 0.0028 0.2706 0.343
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.789 0.7827
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.4242 0.5377
Loa Loa (eye worm) hypothetical protein 0.0028 0.2706 0.343
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.789 0.5
Echinococcus multilocularis lamin dm0 0.0028 0.2706 0.2491
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.7651 0.9698
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.789 1
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0287 0.0363
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 1 1
Toxoplasma gondii aldehyde dehydrogenase 0.0062 1 1
Schistosoma mansoni lamin 0.0028 0.2706 0.2491
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 1 0.5
Schistosoma mansoni intermediate filament proteins 0.0028 0.2706 0.2491
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.789 0.7827
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.2706 0.343
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.789 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.789 0.5
Onchocerca volvulus 0.0028 0.2706 0.5
Echinococcus granulosus intermediate filament protein 0.0028 0.2706 0.2491
Onchocerca volvulus 0.0028 0.2706 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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