Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0014 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0014 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9186 | 0.9186 |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0014 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0014 | 0 | 0.5 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9186 | 0.9186 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0014 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | Serotonin receptor | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Brugia malayi | RE15519p | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | TYRA-2 protein | 0.0014 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0014 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Onchocerca volvulus | 0.0014 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0014 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0014 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.