Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0039 | 0.0688 | 0.2741 |
Mycobacterium leprae | Probable methionyl-tRNA synthase MetS | 0.0056 | 0.1542 | 1 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0056 | 0.1542 | 0.1743 |
Chlamydia trachomatis | phenylalanine--tRNA ligase subunit beta | 0.0028 | 0.0101 | 0.0115 |
Brugia malayi | methionyl-tRNA synthetase | 0.0056 | 0.1542 | 0.1542 |
Schistosoma mansoni | methionyl-tRNA synthetase | 0.0028 | 0.0101 | 0.0115 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0061 | 0.1788 | 0.2021 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0198 | 0.8849 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0075 | 0.2511 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0101 | 0.0404 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0061 | 0.1788 | 0.1788 |
Toxoplasma gondii | thioredoxin reductase | 0.0075 | 0.2511 | 0.844 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0075 | 0.2511 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0075 | 0.2511 | 1 |
Leishmania major | tyrosyl or methionyl-tRNA synthetase-like protein | 0.0028 | 0.0101 | 0.0404 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0101 | 0.0657 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0045 | 0.097 | 0.1096 |
Wolbachia endosymbiont of Brugia malayi | methionyl-tRNA synthetase | 0.0056 | 0.1542 | 1 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.0039 | 0.0688 | 0.4462 |
Treponema pallidum | methionyl-tRNA synthetase | 0.022 | 1 | 1 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0045 | 0.097 | 0.1096 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0056 | 0.1542 | 1 |
Mycobacterium ulcerans | methionyl-tRNA synthetase | 0.0056 | 0.1542 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.097 | 0.0358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0101 | 0.0657 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0028 | 0.0101 | 0.0404 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0198 | 0.8849 | 1 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0045 | 0.097 | 0.6291 |
Plasmodium falciparum | glutathione reductase | 0.0075 | 0.2511 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0075 | 0.2511 | 0.2313 |
Leishmania major | methionyl-tRNA synthetase, putative | 0.0056 | 0.1542 | 0.6142 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0061 | 0.1788 | 0.2021 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0045 | 0.097 | 0.097 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0056 | 0.1542 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0028 | 0.0101 | 0.0404 |
Brugia malayi | protein ZK524.3 | 0.0039 | 0.0688 | 0.0688 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0061 | 0.1788 | 0.1396 |
Echinococcus multilocularis | methionine tRNA synthetase | 0.0056 | 0.1542 | 0.1743 |
Echinococcus multilocularis | aminoacyl tRNA synthase complex interacting | 0.0028 | 0.0101 | 0.0115 |
Loa Loa (eye worm) | glutathione reductase | 0.0075 | 0.2511 | 0.2313 |
Trypanosoma brucei | tyrosyl/methionyl-tRNA synthetase, putative | 0.0028 | 0.0101 | 0.0404 |
Leishmania major | hypothetical protein | 0.0028 | 0.0101 | 0.0404 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0061 | 0.1788 | 0.2021 |
Echinococcus granulosus | tyrosyl tRNA synthetase | 0.0028 | 0.0101 | 0.0115 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0045 | 0.097 | 0.1096 |
Trypanosoma brucei | tyrosyl-tRNA synthetase, putative | 0.0028 | 0.0101 | 0.0404 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0039 | 0.0688 | 0.2313 |
Echinococcus granulosus | methionine tRNA synthetase | 0.0056 | 0.1542 | 0.1743 |
Plasmodium falciparum | thioredoxin reductase | 0.0075 | 0.2511 | 1 |
Schistosoma mansoni | tyrosyl-tRNA synthetase | 0.0028 | 0.0101 | 0.0115 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0045 | 0.097 | 0.6291 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0061 | 0.1788 | 0.1396 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0039 | 0.0688 | 0.2741 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0045 | 0.097 | 0.3864 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0032 | 0.0315 | 0.204 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0075 | 0.2511 | 1 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0056 | 0.1542 | 0.1084 |
Mycobacterium tuberculosis | Probable phenylalanyl-tRNA synthetase, beta chain PheT | 0.0028 | 0.0101 | 0.0404 |
Wolbachia endosymbiont of Brugia malayi | phenylalanyl-tRNA synthetase subunit beta | 0.0028 | 0.0101 | 0.0657 |
Plasmodium vivax | methionine-tRNA ligase, putative | 0.0028 | 0.0101 | 0.0404 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0.0101 | 0.0657 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0056 | 0.1542 | 0.6142 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.097 | 0.3864 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.0084 | 0.2975 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0198 | 0.8849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0192 | 0.8567 | 1 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0181 | 0.798 | 0.9255 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0198 | 0.8849 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0075 | 0.2511 | 0.2837 |
Mycobacterium tuberculosis | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 0.0056 | 0.1542 | 0.6142 |
Echinococcus multilocularis | tyrosyl tRNA synthetase | 0.0028 | 0.0101 | 0.0115 |
Toxoplasma gondii | tRNA binding domain-containing protein | 0.0028 | 0.0101 | 0.0341 |
Trichomonas vaginalis | methionyl-tRNA synthetase, putative | 0.0028 | 0.0101 | 0.0657 |
Brugia malayi | Thioredoxin reductase | 0.0075 | 0.2511 | 0.2511 |
Brugia malayi | glycyl-tRNA synthetase | 0.0061 | 0.1788 | 0.1788 |
Mycobacterium ulcerans | phenylalanyl-tRNA synthetase subunit beta | 0.0028 | 0.0101 | 0.0657 |
Trypanosoma brucei | methionyl-tRNA synthetase, putative | 0.0056 | 0.1542 | 0.6142 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0056 | 0.1542 | 0.6142 |
Leishmania major | trypanothione reductase | 0.0075 | 0.2511 | 1 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0056 | 0.1542 | 0.6142 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.022 | 1 | 1 |
Plasmodium falciparum | tRNA import protein tRIP | 0.0028 | 0.0101 | 0.0404 |
Echinococcus granulosus | aminoacyl tRNA synthase complex interacting | 0.0028 | 0.0101 | 0.0115 |
Brugia malayi | glutathione reductase | 0.0075 | 0.2511 | 0.2511 |
Giardia lamblia | Methionyl-tRNA synthetase | 0.0028 | 0.0101 | 0.0657 |
Leishmania major | hypothetical protein, conserved | 0.0028 | 0.0101 | 0.0404 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0075 | 0.2511 | 0.2837 |
Trypanosoma brucei | trypanothione reductase | 0.0075 | 0.2511 | 1 |
Trypanosoma cruzi | tyrosyl or methionyl-tRNA synthetase, putative | 0.0028 | 0.0101 | 0.0404 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 30 mg kg-1 | Effective dose against maximal electroshock seizure in mice after intraperitoneal administration | ChEMBL. | 8627614 |
ED50 (functional) | > 30 mg kg-1 | Effective dose against maximal electroshock seizure in mice after intraperitoneal administration | ChEMBL. | 8627614 |
ED50 (functional) | < 100 mg kg-1 | Effective dose against maximal electroshock seizure in mice after intraperitoneal administration | ChEMBL. | 8627614 |
ED50 (functional) | < 100 mg kg-1 | Effective dose against maximal electroshock seizure in mice after intraperitoneal administration | ChEMBL. | 8627614 |
TD50 (ADMET) | = 300 mg kg-1 | Neurotoxic toxicity of the compound was evaluated by rotorod test after intraperitoneal administration | ChEMBL. | 8627614 |
TD50 (ADMET) | = 300 mg kg-1 | Neurotoxic toxicity of the compound was evaluated by rotorod test after intraperitoneal administration | ChEMBL. | 8627614 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.