Detailed information for compound 843919

Basic information

Technical information
  • TDR Targets ID: 843919
  • Name: 3-(3-acetylphenyl)-1-(5-pyrrolidin-1-yl-1,3,4 -thiadiazol-2-yl)urea
  • MW: 331.393 | Formula: C15H17N5O2S
  • H donors: 2 H acceptors: 4 LogP: 1.89 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1nnc(s1)N1CCCC1)Nc1cccc(c1)C(=O)C
  • InChi: 1S/C15H17N5O2S/c1-10(21)11-5-4-6-12(9-11)16-13(22)17-14-18-19-15(23-14)20-7-2-3-8-20/h4-6,9H,2-3,7-8H2,1H3,(H2,16,17,18,22)
  • InChiKey: XRMBIEBRHJHJBM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-(3-acetylphenyl)-1-(5-1-pyrrolidinyl-1,3,4-thiadiazol-2-yl)urea
  • 3-(3-ethanoylphenyl)-1-(5-pyrrolidin-1-yl-1,3,4-thiadiazol-2-yl)urea
  • E002-1367
  • NCGC00120157-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0124 0.2584 0.2583
Brugia malayi ecdysone receptor 0.0124 0.2584 0.4595
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0048 0.5
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Schistosoma mansoni nuclear hormone receptor 0.0263 0.559 0.5589
Brugia malayi nuclear receptor NHR-88 0.0263 0.559 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0124 0.2584 0.2563
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.2584 0.3965
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0231 0.0365
Echinococcus multilocularis dnaJ subfamily B 0.0468 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.559 0.5577
Onchocerca volvulus 0.0124 0.2584 0.3965
Brugia malayi conserved hypotetical protein 0.0124 0.2584 0.4595
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0048 0.5
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0048 0.5
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0263 0.559 1
Loa Loa (eye worm) steroid hormone receptor 0.0263 0.559 1
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.2906 0.5174
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0263 0.559 0.5577
Schistosoma mansoni cpg binding protein 0.0035 0.0649 0.0648
Loa Loa (eye worm) hypothetical protein 0.0139 0.2906 0.5174
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0048 0.5
Trichomonas vaginalis helicase, putative 0.0007 0.006 0.0633
Brugia malayi nuclear hormone receptor family member nhr-6 0.0124 0.2584 0.4595
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0048 0.5
Loa Loa (eye worm) DR-78 0.0124 0.2584 0.4595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0263 0.559 1
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0048 0.5
Schistosoma mansoni retinoic acid receptor RXR 0.0263 0.559 0.5589
Schistosoma mansoni mixed-lineage leukemia protein mll 0.007 0.1404 0.1403
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0076 0.0074
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0263 0.559 0.5577
Schistosoma mansoni thyroid hormone receptor 0.0263 0.559 0.5589
Echinococcus multilocularis ecdysone induced protein 78C 0.0263 0.559 0.5577
Loa Loa (eye worm) cytochrome P450 0.0007 0.0048 0.0036
Brugia malayi Cytochrome P450 family protein 0.0025 0.0446 0.0752
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Brugia malayi Nuclear hormone receptor E75 0.0124 0.2584 0.4595
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0048 0.5
Brugia malayi Cytochrome P450 family protein 0.0007 0.0048 0.0036
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0048 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.006 0.0633
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0048 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.2584 0.2563
Echinococcus granulosus nuclear receptor nhr 48 0.0124 0.2584 0.2563
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0263 0.559 1
Schistosoma mansoni zinc finger protein 0.0124 0.2584 0.2583
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0048 0.5
Echinococcus multilocularis cpg binding protein 0.0035 0.0649 0.0623
Mycobacterium leprae putative cytochrome p450 0.0007 0.0048 0.5
Echinococcus granulosus thyroid hormone receptor alpha 0.0124 0.2584 0.2563
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0015 0.0231 1
Echinococcus multilocularis FTZ F1 alpha 0.0263 0.559 0.5577
Schistosoma mansoni hypothetical protein 0.0468 1 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.2906 0.5174
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0048 0.5
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Brugia malayi Steroid receptor seven-up type 2 0.0263 0.559 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0231 0.0365
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.2584 0.2563
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0139 0.2906 0.2886
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0166 0.3479 0.3461
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0139 0.2906 0.2905
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0124 0.2584 0.2563
Onchocerca volvulus Protein ultraspiracle homolog 0.0263 0.559 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0166 0.3479 0.3478
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0116 0.0159
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Entamoeba histolytica acetyltransferase, GNAT family 0.0045 0.0864 0.5
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.1331 1
Schistosoma mansoni nuclear receptor 0.0124 0.2584 0.2583
Schistosoma mansoni bromodomain containing protein 0.0006 0.0028 0.0026
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0048 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.0263 0.559 0.5589
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.006 0.0633
Onchocerca volvulus Bile acid receptor homolog 0.0263 0.559 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0048 0.5
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0076 0.0048
Brugia malayi steroid hormone receptor 0.0263 0.559 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0263 0.559 0.5577
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0124 0.2584 0.2563
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.559 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0263 0.559 0.5577
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0076 0.0048
Schistosoma mansoni nuclear receptor nhr-48 0.0124 0.2584 0.2583
Plasmodium falciparum histone acetyltransferase GCN5 0.0045 0.0864 0.5
Echinococcus multilocularis 0.0007 0.0048 0.002
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0263 0.559 0.5577
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0139 0.2906 0.2886
Brugia malayi cytochrome P450 0.0007 0.0048 0.0036
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0263 0.559 0.5577
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.0048 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0124 0.2584 0.2563
Loa Loa (eye worm) nuclear receptor NHR-67 0.0124 0.2584 0.4595
Schistosoma mansoni zinc finger protein 0.0006 0.0028 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0263 0.559 1
Brugia malayi Cytochrome P450 family protein 0.0015 0.0231 0.0365
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Trypanosoma brucei cytochrome P450, putative 0.0015 0.0231 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0048 0.5
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0124 0.2584 0.2563
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0952 0.7049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.559 0.5577
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0231 0.0365
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0048 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.006 0.0633
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0952 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0119 0.0092
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0263 0.559 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0263 0.559 0.5577
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0124 0.2584 0.2583
Brugia malayi CXXC zinc finger family protein 0.0033 0.0609 0.1045
Echinococcus granulosus histone acetyltransferase KAT2B 0.0161 0.3378 0.336
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0952 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0139 0.2906 0.5174
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0263 0.559 0.5589
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0048 0.5
Brugia malayi nuclear hormone receptor family member odr-7 0.0124 0.2584 0.4595
Schistosoma mansoni cytochrome P450 0.0007 0.0048 0.0046
Loa Loa (eye worm) histone methyltransferase 0.001 0.0119 0.0164
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0124 0.2584 0.2563
Schistosoma mansoni cpg binding protein 0.0033 0.0609 0.0608
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Brugia malayi hypothetical protein 0.0139 0.2906 0.5174
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0048 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.006 0.0633
Brugia malayi hypothetical protein 0.0124 0.2584 0.4595
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0139 0.2906 0.2905
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0263 0.559 1
Schistosoma mansoni nuclear receptor 0.0124 0.2584 0.2583
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0048 0.5
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Echinococcus granulosus ecdysone induced protein 78C 0.0263 0.559 0.5577
Echinococcus granulosus cpg binding protein 0.0035 0.0649 0.0623
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0124 0.2584 0.4595
Onchocerca volvulus 0.0124 0.2584 0.3965
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0263 0.559 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.006 0.0633
Brugia malayi orphan nuclear receptor NR2E1 0.0124 0.2584 0.4595
Leishmania major cytochrome p450-like protein 0.0015 0.0231 1
Brugia malayi nuclear receptor RXR 0.0139 0.2906 0.5174
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0263 0.559 1
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0231 1
Brugia malayi hypothetical protein 0.0139 0.2906 0.5174
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0263 0.559 0.5589
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0263 0.559 0.5577
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.006 0.0633
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0446 0.0752
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0124 0.2584 0.4595
Schistosoma mansoni coup transcription factor 0.0263 0.559 0.5589
Brugia malayi nuclear hormone receptor 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0263 0.559 0.5589
Loa Loa (eye worm) hypothetical protein 0.0139 0.2906 0.5174
Brugia malayi nuclear receptor RXR 0.0124 0.2584 0.4595
Schistosoma mansoni bromodomain containing protein 0.0006 0.0028 0.0026
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0263 0.559 0.5577
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0263 0.559 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0076 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0263 0.559 1
Trypanosoma cruzi cytochrome P450, putative 0.0015 0.0231 1
Echinococcus granulosus FTZ F1 alpha 0.0263 0.559 0.5577
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.559 1
Brugia malayi nuclear receptor NHR-67 0.0124 0.2584 0.4595
Schistosoma mansoni steroid hormone receptor ad4bp 0.0263 0.559 0.5589
Brugia malayi acetyltransferase, GNAT family protein 0.0166 0.3479 0.6205
Loa Loa (eye worm) acetyltransferase 0.0166 0.3479 0.6205
Giardia lamblia Histone acetyltransferase GCN5 0.0045 0.0864 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0083 0.0099
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0119 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0263 0.559 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0952 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0952 0.0927
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0048 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0263 0.559 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.006 0.0633
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0263 0.559 0.5577
Schistosoma mansoni cpg binding protein 0.0035 0.0649 0.0648
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0263 0.559 0.5589
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Brugia malayi nuclear hormone receptor 0.0124 0.2584 0.4595
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0609 0.1045
Schistosoma mansoni thyroid hormone receptor 0.0263 0.559 0.5589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0263 0.559 1
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0048 0.5
Brugia malayi tailless protein 0.0124 0.2584 0.4595
Schistosoma mansoni nuclear hormone receptor 0.0124 0.2584 0.2583
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.006 0.0633
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0263 0.559 0.5577
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0263 0.559 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0124 0.2584 0.2563
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0263 0.559 0.5589
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0076 0.0048
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0231 0.0365
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0263 0.559 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0124 0.2584 0.3965
Brugia malayi ecdysteroid receptor 0.0263 0.559 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0124 0.2584 0.2563
Loa Loa (eye worm) hypothetical protein 0.0139 0.2906 0.5174
Schistosoma mansoni hypothetical protein 0.0007 0.0048 0.0046
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0263 0.559 0.5589
Onchocerca volvulus 0.0263 0.559 1
Brugia malayi Nuclear hormone receptor E75 0.0124 0.2584 0.4595
Brugia malayi Nuclear hormone receptor-like 1 0.0139 0.2906 0.5174
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0263 0.559 0.5577
Loa Loa (eye worm) nuclear hormone receptor 0.0124 0.2584 0.4595
Brugia malayi hypothetical protein 0.0124 0.2584 0.4595
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0952 0.7049
Loa Loa (eye worm) hypothetical protein 0.0139 0.2906 0.5174
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0263 0.559 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.2584 0.4595
Brugia malayi photoreceptor-specific nuclear receptor 0.0263 0.559 1
Schistosoma mansoni nuclear hormone receptor 0.0124 0.2584 0.2583
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.006 0.0633
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0048 0.002
Brugia malayi nuclear receptor NHR-88 0.0124 0.2584 0.4595

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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