Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | carboxylesterase | 0.0973 | 0.1678 | 0.1678 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0392 | 0.0669 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0052 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0064 | 0.0064 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0973 | 0.1678 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0175 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.029 | 0.029 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0006 | 0.0006 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0045 | 0.0064 | 0.5 |
Loa Loa (eye worm) | aspartic protease BmAsp-1 | 0.0018 | 0.0018 | 0.0018 |
Brugia malayi | Pre-SET motif family protein | 0.0222 | 0.0372 | 0.0372 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0973 | 0.1678 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0041 | 0.0041 |
Echinococcus multilocularis | 0.0045 | 0.0064 | 0.0064 | |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0045 | 0.0064 | 1 |
Onchocerca volvulus | 0.0018 | 0.0018 | 0.0108 | |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Onchocerca volvulus | 0.0973 | 0.1678 | 1 | |
Onchocerca volvulus | 0.0026 | 0.0031 | 0.0187 | |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0018 | 0.0018 | 0.0018 |
Brugia malayi | Carboxylesterase family protein | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | aspartic protease BmAsp-1, identical | 0.0018 | 0.0018 | 0.0018 |
Brugia malayi | Carboxylesterase family protein | 0.0973 | 0.1678 | 0.1678 |
Echinococcus multilocularis | acetylcholinesterase | 0.5756 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0973 | 0.1678 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0052 | 0.0052 |
Onchocerca volvulus | 0.0973 | 0.1678 | 1 | |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0973 | 0.1678 | 0.1678 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0588 | 0.1009 | 0.5858 |
Brugia malayi | aspartic protease BmAsp-2, identical | 0.0018 | 0.0018 | 0.0018 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0633 | 0.1087 | 0.6338 |
Brugia malayi | Choline O-acetyltransferase | 0.0175 | 0.029 | 0.029 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.005 | 0.0191 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0026 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0973 | 0.1678 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5756 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0052 | 0.5 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0037 | 0.005 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0045 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.5756 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0031 | 0.0031 |
Onchocerca volvulus | 0.0045 | 0.0064 | 0.0379 | |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0392 | 0.0669 | 0.0669 |
Onchocerca volvulus | 0.0973 | 0.1678 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0026 | 0.0031 | 0.0031 |
Onchocerca volvulus | 0.0026 | 0.0031 | 0.0187 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0039 | 0.0054 | 0.0054 |
Onchocerca volvulus | 0.0252 | 0.0425 | 0.2534 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0973 | 0.1678 | 1 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0973 | 0.1678 | 0.1678 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0052 | 0.0052 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0052 | 0.5 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0175 | 0.029 | 0.029 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0973 | 0.1678 | 0.1678 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0032 | 0.0041 | 0.5113 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0011 | 0.0006 | 0.0006 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0045 | 0.0064 | 0.0064 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0061 | 0.0061 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0026 | 0.0031 | 0.0031 |
Schistosoma mansoni | amine oxidase | 0.0045 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0175 | 0.029 | 0.029 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0039 | 0.0054 | 0.0054 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0043 | 0.0061 | 0.0061 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | Pepsin A precursor | 0.0018 | 0.0018 | 0.0018 |
Brugia malayi | Pre-SET motif family protein | 0.0032 | 0.0041 | 0.0041 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5756 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.5756 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5756 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5756 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0045 | 0.0064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0018 | 0.0018 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0045 | 0.0064 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0175 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | carboxylesterase | 0.5756 | 1 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0026 | 0.0031 | 0.0031 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0011 | 0.0006 | 0.0006 |
Trichomonas vaginalis | set domain proteins, putative | 0.0252 | 0.0425 | 0.2452 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0392 | 0.0669 | 1 |
Echinococcus multilocularis | neuroligin | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | Carboxylesterase family protein | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0064 | 0.0064 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0052 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0973 | 0.1678 | 0.1678 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0973 | 0.1678 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0045 | 0.0064 | 0.0505 |
Onchocerca volvulus | 0.0032 | 0.0041 | 0.0247 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0018 | 0.0018 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0032 | 0.0041 | 0.0041 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0392 | 0.0669 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0973 | 0.1678 | 0.1678 |
Schistosoma mansoni | acetylcholinesterase | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0026 | 0.0031 | 0.0031 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0026 | 0.0031 | 0.0031 |
Brugia malayi | Carboxylesterase family protein | 0.0973 | 0.1678 | 0.1678 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0045 | 0.0045 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0026 | 0.0031 | 0.0031 |
Loa Loa (eye worm) | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0011 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0335 | 0.0335 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.0064 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0045 | 0.0064 | 1 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0018 | 0.0018 |
Echinococcus granulosus | voltage gated potassium channel | 0.0011 | 0.0006 | 0.0006 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0006 | 0.0006 |
Echinococcus granulosus | acetylcholinesterase | 0.5756 | 1 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0045 | 0.0064 | 0.0064 |
Plasmodium vivax | SET domain protein, putative | 0.0032 | 0.0041 | 0.5113 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0045 | 0.0064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0392 | 0.0669 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0018 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0064 | 0.0064 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0032 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | carboxylesterase | 0.0973 | 0.1678 | 0.1678 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0045 | 0.0064 | 0.0505 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | hypothetical protein | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0045 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0222 | 0.0372 | 0.0372 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0973 | 0.1678 | 0.1678 |
Echinococcus granulosus | choline O acetyltransferase | 0.0175 | 0.029 | 0.029 |
Onchocerca volvulus | 0.0018 | 0.0018 | 0.0108 | |
Schistosoma mansoni | gliotactin | 0.0973 | 0.1678 | 0.1678 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0032 | 0.0041 | 0.0041 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.0082 | 0.0082 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0045 | 0.0064 | 0.0064 |
Brugia malayi | Carboxylesterase family protein | 0.5756 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0973 | 0.1678 | 0.1678 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0032 | 0.0041 | 0.0041 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0026 | 0.0031 | 0.0031 |
Onchocerca volvulus | 0.0973 | 0.1678 | 1 | |
Onchocerca volvulus | 0.0026 | 0.0031 | 0.0187 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0045 | 0.0064 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0018 | 0.0018 | 0.0018 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.0064 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0018 | 0.0018 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0045 | 0.0064 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0052 | 0.0052 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0039 | 0.0054 | 0.0054 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0045 | 0.0064 | 0.0064 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0045 | 0.0064 | 0.0064 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0045 | 0.0064 | 0.0505 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0011 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.0973 | 0.1678 | 1 | |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0011 | 0.0006 | 0.0006 |
Brugia malayi | Eukaryotic aspartyl protease family protein | 0.0018 | 0.0018 | 0.0018 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0026 | 0.0031 | 0.0031 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0018 | 0.0018 | 0.0018 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0052 | 0.0052 |
Loa Loa (eye worm) | hypothetical protein | 0.5756 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0032 | 0.0041 | 0.0041 |
Loa Loa (eye worm) | aspartyl protease 6 | 0.0018 | 0.0018 | 0.0018 |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.046 | 0.0786 | 0.0786 |
Brugia malayi | hypothetical protein | 0.0018 | 0.0018 | 0.0018 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0045 | 0.0064 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0031 | 0.0039 | 0.0039 |
Onchocerca volvulus | 0.0026 | 0.0031 | 0.0187 | |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0039 | 0.0054 | 0.0054 |
Schistosoma mansoni | amine oxidase | 0.0045 | 0.0064 | 0.0064 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0973 | 0.1678 | 0.1678 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0045 | 0.0064 | 0.0064 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0064 | 0.0064 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0973 | 0.1678 | 0.1678 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0026 | 0.0031 | 0.0031 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0633 | 0.1087 | 0.6338 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.