Detailed information for compound 844288

Basic information

Technical information
  • TDR Targets ID: 844288
  • Name: 8-methyl-N-[(4-methylphenyl)methyl]-4,5-dihyd ro-1H-furo[5,4-g]indazole-7-carboxamide
  • MW: 321.373 | Formula: C19H19N3O2
  • H donors: 2 H acceptors: 2 LogP: 2.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)CNC(=O)c1oc2c(c1C)c1n[nH]cc1CC2
  • InChi: 1S/C19H19N3O2/c1-11-3-5-13(6-4-11)9-20-19(23)18-12(2)16-15(24-18)8-7-14-10-21-22-17(14)16/h3-6,10H,7-9H2,1-2H3,(H,20,23)(H,21,22)
  • InChiKey: CUJHQMBZSBTWCI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 8-methyl-N-(4-methylbenzyl)-4,5-dihydro-1H-furo[5,4-g]indazole-7-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0144 0.1232 0.1209
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0288 0.045
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0248 0.1685
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0206 0.3923
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0027 0.009 0.0064
Echinococcus granulosus geminin 0.0541 0.5097 0.5084
Schistosoma mansoni ran 0.0024 0.0068 0.0042
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.061 0.0585
Echinococcus granulosus lamin 0.0028 0.0105 0.0079
Mycobacterium ulcerans DNA gyrase subunit B 0.0021 0.0039 0.0073
Schistosoma mansoni importin beta-1 0.0033 0.0152 0.0126
Brugia malayi nuclear receptor NHR-67 0.0064 0.0454 0.0429
Loa Loa (eye worm) nuclear receptor NHR-67 0.0064 0.0454 0.0429
Schistosoma mansoni hypothetical protein 0.0084 0.0652 0.0627
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0143 0.1222 0.8283
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.008 0.061 0.0585
Echinococcus multilocularis thyroid hormone receptor alpha 0.0144 0.1232 0.1209
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.05 0.3401
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0144 0.1232 0.1209
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0454 0.0429
Chlamydia trachomatis DNA gyrase subunit B 0.0035 0.0173 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0029 0.0002
Loa Loa (eye worm) hypothetical protein 0.0144 0.1232 0.1209
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0027 0.009 0.0064
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0143 0.1222 0.8283
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.009 0.0064
Schistosoma mansoni RAR-like nuclear receptor 0.0144 0.1232 0.1209
Brugia malayi nuclear hormone receptor family member nhr-6 0.0064 0.0454 0.0429
Loa Loa (eye worm) hypothetical protein 0.0032 0.0147 0.0121
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0068 0.0461
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0144 0.1232 0.1209
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.0802 0.0778
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0288 0.045
Brugia malayi intermediate filament protein 0.0028 0.0105 0.0079
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0206 0.0181
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0196 0.017
Plasmodium vivax importin-beta 2, putative 0.0033 0.0152 0.2857
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1045 1 1
Brugia malayi hypothetical protein 0.008 0.061 0.0585
Brugia malayi Nuclear hormone receptor-like 1 0.0144 0.1232 0.1209
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0027 0.009 0.0064
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0168 0.147 1
Brugia malayi nuclear hormone receptor 0.0144 0.1232 0.1209
Loa Loa (eye worm) hypothetical protein 0.0043 0.0254 0.0228
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.009 0.0797
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0068 0.0862
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0047 0.0288 0.045
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.3247 0.3229
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0068 0.0042
Echinococcus multilocularis neuroligin 0.0048 0.0301 0.0276
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0144 0.1232 0.1209
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0301 0.0276
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0027 0.009 0.0064
Echinococcus granulosus transcription factor Dp 1 0.004 0.0219 0.0193
Leishmania major tyrosine specific protein phosphatase, putative 0.0027 0.009 0.0426
Loa Loa (eye worm) hypothetical protein 0.0038 0.0206 0.0181
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0067 0.0482 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0029 0.0031
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0206 0.1233
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Schistosoma mansoni zinc finger protein 0.0064 0.0454 0.0429
Brugia malayi Carboxylesterase family protein 0.0285 0.2608 0.2588
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0029 0.0031
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0143 0.1222 0.8283
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Brugia malayi hypothetical protein 0.008 0.061 0.0585
Echinococcus granulosus FTZ F1 alpha 0.0144 0.1232 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0206 0.2243
Brugia malayi nuclear receptor RXR 0.0064 0.0454 0.0429
Trichomonas vaginalis spcc417.12 protein, putative 0.0048 0.0301 0.3425
Schistosoma mansoni steroid hormone receptor ad4bp 0.0144 0.1232 0.1209
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0027 0.009 0.0426
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0144 0.1232 0.1209
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.009 0.0064
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0454 0.0429
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0301 0.0276
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0084 0.0652 0.0627
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0144 0.1232 0.1209
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0142 0.1216 0.1193
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0248 0.1519
Entamoeba histolytica DNA topoisomerase II, putative 0.0065 0.0461 0.5421
Echinococcus multilocularis musashi 0.0028 0.0105 0.0079
Loa Loa (eye worm) hypothetical protein 0.008 0.061 0.0585
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0039 0.0242
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Brugia malayi nuclear receptor NHR-88 0.0144 0.1232 0.1209
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0067 0.0482 0.567
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus granulosus Niemann Pick C1 protein 0.0205 0.1825 0.1804
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0802 0.0778
Leishmania major DNA topoisomerase ii 0.0058 0.0398 0.256
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.009 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0144 0.1232 0.1209
Onchocerca volvulus 0.0048 0.0301 0.048
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0248 0.1519
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0064 0.0454 0.0429
Echinococcus multilocularis 0.0027 0.009 0.0064
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0048 0.0301 0.0276
Loa Loa (eye worm) carboxylesterase 0.0048 0.0301 0.0276
Brugia malayi follicle stimulating hormone receptor 0.0241 0.2175 0.2154
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0473 0.0448
Mycobacterium tuberculosis Carboxylesterase LipT 0.0048 0.0301 0.1891
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0029 0.0002
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0276
Schistosoma mansoni nuclear receptor 0.0064 0.0454 0.0429
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0065 0.0461 0.0436
Brugia malayi steroid hormone receptor 0.0144 0.1232 0.1209
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0068 0.0271
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0206 0.1233
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0049
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Brugia malayi Nuclear hormone receptor E75 0.0064 0.0454 0.0429
Brugia malayi Protein-tyrosine phosphatase 1 0.0027 0.009 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Mycobacterium ulcerans carboxylesterase, LipT 0.0048 0.0301 0.1891
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.009 0.0064
Echinococcus multilocularis snurportin 1 0.0351 0.3247 0.3229
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0479 0.4487 0.4472
Loa Loa (eye worm) hypothetical protein 0.008 0.061 0.0585
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0276
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0152 0.0126
Echinococcus multilocularis lamin 0.0028 0.0105 0.0079
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0068 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0143 0.1222 0.8283
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0206 0.0181
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Brugia malayi latrophilin 2 splice variant baaae 0.0182 0.1602 0.158
Brugia malayi laminin-like protein K08C7.3 precursor 0.0025 0.0076 0.0049
Echinococcus granulosus snurportin 1 0.0351 0.3247 0.3229
Echinococcus granulosus Niemann Pick C1 protein 0.0102 0.0828 0.0804
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0027 0.009 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0045 0.0309
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0144 0.1232 0.1209
Schistosoma mansoni hypothetical protein 0.0037 0.0196 0.017
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.108 0.7297
Loa Loa (eye worm) TOPoisomerase family member 0.0065 0.0461 0.0436
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0144 0.1232 0.1209
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Schistosoma mansoni nuclear hormone receptor 0.0144 0.1232 0.1209
Brugia malayi Steroid receptor seven-up type 2 0.0144 0.1232 0.1209
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0064 0.0454 0.0429
Schistosoma mansoni hypothetical protein 0.0182 0.1602 0.158
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0144 0.1232 0.1209
Entamoeba histolytica hypothetical protein 0.0037 0.0196 0.212
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0206 0.2243
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.05 0.0475
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0473 0.0448
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0027 0.009 0.0064
Schistosoma mansoni nuclear receptor 0.0064 0.0454 0.0429
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0144 0.1232 0.1209
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0276
Loa Loa (eye worm) carboxylesterase 0.0048 0.0301 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0143 0.1222 0.8283
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0206 0.0181
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0327 0.2067
Leishmania major importin beta-1 subunit, putative 0.0027 0.0092 0.0437
Brugia malayi polk-prov protein 0.0032 0.0147 0.0121
Echinococcus granulosus thyroid hormone receptor alpha 0.0064 0.0454 0.0429
Loa Loa (eye worm) protein tyrosine phosphatase 0.0027 0.009 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0027 0.009 0.0797
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0021 0.0039 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0144 0.1232 0.1209
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Brugia malayi Carboxylesterase family protein 0.0048 0.0301 0.0276
Loa Loa (eye worm) hypothetical protein 0.0144 0.1232 0.1209
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.009 0.0064
Brugia malayi conserved hypotetical protein 0.0064 0.0454 0.0429
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0144 0.1232 0.1209
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.009 0.0064
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0206 0.2246
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.05 0.327
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0142 0.1216 0.824
Echinococcus granulosus ecdysone induced protein 78C 0.0144 0.1232 0.1209
Brugia malayi Latrophilin receptor protein 2 0.0084 0.0652 0.0627
Onchocerca volvulus 0.0064 0.0454 0.0828
Schistosoma mansoni cell polarity protein 0.0025 0.0076 0.0049
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0025 0.0076 0.0049
Brugia malayi Importin beta-1 subunit 0.0033 0.0152 0.0126
Schistosoma mansoni hypothetical protein 0.0541 0.5097 0.5084
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.061 0.0585
Leishmania major GTP-binding protein, putative 0.0024 0.0068 0.0271
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0168 0.147 1
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0142 0.1216 0.1193
Schistosoma mansoni patched 1 0.0103 0.0829 0.0805
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0027 0.009 0.0064
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0248 0.2757
Echinococcus granulosus intermediate filament protein 0.0028 0.0105 0.0079
Echinococcus granulosus expressed protein 0.0388 0.3608 0.3591
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0144 0.1232 0.1209
Brugia malayi EGF-like domain containing protein 0.0025 0.0076 0.0049
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0049
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0143 0.1222 0.8283
Brugia malayi nuclear receptor RXR 0.008 0.061 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0144 0.1232 0.1209
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0206 0.0181
Brugia malayi hypothetical protein 0.0064 0.0454 0.0429
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0147 0.0998
Onchocerca volvulus 0.0048 0.0301 0.048
Loa Loa (eye worm) carboxylesterase 0.0285 0.2608 0.2588
Leishmania major DNA polymerase kappa, putative 0.0022 0.0045 0.0116
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.05 0.0475
Brugia malayi nuclear receptor NHR-88 0.0064 0.0454 0.0429
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0168 0.147 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0144 0.1232 0.2597
Loa Loa (eye worm) hypothetical protein 0.008 0.061 0.0585
Schistosoma mansoni protein tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus multilocularis neurogenic locus notch protein 0.0025 0.0076 0.0049
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0144 0.1232 0.1209
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0142 0.1216 0.824
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.008 0.061 0.0585
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus multilocularis expressed conserved protein 0.0096 0.0768 0.0743
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0144 0.1232 0.1209
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.009 0.0064
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.05 0.5908
Schistosoma mansoni nuclear hormone receptor 0.0064 0.0454 0.0429
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0802 0.0778
Echinococcus multilocularis hypothetical protein 0.0027 0.009 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0064 0.0454 0.0429
Echinococcus granulosus acetylcholinesterase 0.0285 0.2608 0.2588
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0248 0.1685
Giardia lamblia DINP protein human, muc B family 0.0022 0.0045 0.037
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0144 0.1232 0.1209
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0266 0.2422 0.2402
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0802 0.0778
Loa Loa (eye worm) hypothetical protein 0.0144 0.1232 0.1209
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0084
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0143 0.1222 0.8283
Schistosoma mansoni ran 0.0024 0.0068 0.0042
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0248 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0144 0.1232 0.1209
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0143 0.1222 0.8283
Echinococcus multilocularis slit 2 protein 0.0025 0.0076 0.0049
Loa Loa (eye worm) hypothetical protein 0.0144 0.1232 0.1209
Echinococcus multilocularis acetylcholinesterase 0.0285 0.2608 0.2588
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0152 0.1035
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Loa Loa (eye worm) nuclear hormone receptor 0.0064 0.0454 0.0429
Echinococcus granulosus slit 2 protein 0.0025 0.0076 0.0049
Echinococcus granulosus pikachurin 0.0025 0.0076 0.0049
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0473 0.0448
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0276
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0058 0.0398 0.2705
Echinococcus multilocularis GPCR, family 2 0.0084 0.0652 0.0627
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0454 0.0429
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0143 0.1222 0.8283
Brugia malayi ecdysone receptor 0.0064 0.0454 0.0429
Schistosoma mansoni DNA topoisomerase II 0.0065 0.0461 0.0436
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Brugia malayi Carboxylesterase family protein 0.0048 0.0301 0.0276
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0473 0.0448
Onchocerca volvulus Protein ultraspiracle homolog 0.0144 0.1232 0.2597
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.1045 1 1
Loa Loa (eye worm) hypothetical protein 0.008 0.061 0.0585
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0206 0.1233
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Trypanosoma brucei DNA topoisomerase ii 0.0051 0.0327 0.2222
Trichomonas vaginalis DNA topoisomerase II, putative 0.0065 0.0461 0.5412
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0027 0.009 0.0064
Echinococcus multilocularis protein dispatched 1 0.0109 0.089 0.0866
Echinococcus multilocularis carboxylesterase 5A 0.0285 0.2608 0.2588
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Echinococcus multilocularis protein patched 0.0103 0.0829 0.0805
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0144 0.1232 0.1209
Onchocerca volvulus Bile acid receptor homolog 0.0479 0.4487 1
Echinococcus multilocularis lamin dm0 0.0028 0.0105 0.0079
Echinococcus multilocularis expressed protein 0.0388 0.3608 0.3591
Schistosoma mansoni hypothetical protein 0.0084 0.0652 0.0627
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0144 0.1232 0.1209
Brugia malayi small heat shock protein 0.0601 0.5674 0.5663
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0084 0.0652 0.0627
Loa Loa (eye worm) steroid hormone receptor 0.0144 0.1232 0.1209
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0144 0.1232 0.1209
Echinococcus granulosus neurogenic locus notch protein 0.0025 0.0076 0.0049
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0152 0.1035
Brugia malayi CHE-14 protein 0.0103 0.0829 0.0805
Schistosoma mansoni lamin 0.0028 0.0105 0.0079
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0068 0.0904
Brugia malayi Protein-tyrosine phosphatase 0.0027 0.009 0.0064
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.05 0.327
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0206 0.0181
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0143 0.1222 0.8283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0144 0.1232 0.1209
Brugia malayi orphan nuclear receptor NR2E1 0.0064 0.0454 0.0429
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0144 0.1232 0.1209
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1232 0.1209
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0802 0.0778
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.009 0.0064
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0219 0.0193
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0206 0.0181
Schistosoma mansoni thyroid hormone receptor 0.0144 0.1232 0.1209
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.009 0.0426
Brugia malayi Niemann-Pick C1 protein precursor 0.0102 0.0828 0.0804
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.0301 0.1891
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0027 0.009 0.0064
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0102 0.0828 1
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1045 1 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0144 0.1232 0.1209
Schistosoma mansoni coup transcription factor 0.0144 0.1232 0.1209
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0067 0.0482 0.567
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0168 0.147 1
Echinococcus granulosus BC026374 protein S09 family 0.0048 0.0301 0.0276
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0065 0.0461 0.0436
Loa Loa (eye worm) RNA binding protein 0.0066 0.0473 0.0448
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0064 0.0454 0.0429
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0454 0.0429
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0068 0.0042
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0168 0.147 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0068 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0144 0.1232 0.1209
Echinococcus multilocularis geminin 0.0541 0.5097 0.5084
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0027 0.009 0.0064
Brugia malayi hypothetical protein 0.0048 0.0301 0.0276
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0142 0.1216 0.824
Loa Loa (eye worm) hypothetical protein 0.0142 0.1216 0.1193
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0276
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0398 0.256
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Echinococcus granulosus expressed conserved protein 0.0096 0.0768 0.0743
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0064 0.0454 0.0429
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0196 0.017
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0143 0.1222 0.8283
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0092 0.0815
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Loa Loa (eye worm) abnormal epIthelia family member 0.0025 0.0076 0.0049
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0143 0.1222 0.8283
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0327 0.2067
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0144 0.1232 0.1209
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0065 0.0461 0.0436
Trypanosoma brucei unspecified product 0.0036 0.0181 0.1231
Brugia malayi hypothetical protein 0.0027 0.009 0.0064
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0048 0.0301 0.0276
Entamoeba histolytica hypothetical protein 0.0037 0.0196 0.212
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0027 0.009 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0144 0.1232 0.1209
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0181 0.1231
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0043 0.0254 0.0228
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.05 0.0475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0144 0.1232 0.1209
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0027 0.009 0.0064
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0206 0.2243
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0084 0.0652 0.0627
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0143 0.1222 0.8283
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.009 0.0426
Loa Loa (eye worm) hypothetical protein 0.008 0.061 0.0585
Brugia malayi TAR-binding protein 0.0066 0.0473 0.0448
Onchocerca volvulus 0.0064 0.0454 0.0828
Schistosoma mansoni acetylcholinesterase 0.0048 0.0301 0.0276
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0248 0.1519
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0473 0.0448
Echinococcus multilocularis acetylcholinesterase 0.0285 0.2608 0.2588
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.009 0.0064
Echinococcus granulosus nuclear receptor nhr 48 0.0064 0.0454 0.0429
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0142 0.1216 0.8274
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0064 0.0454 0.0429
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0048 0.0301 0.1891
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.061 0.0585
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0105 0.0079
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0144 0.1232 0.1209
Brugia malayi ecdysteroid receptor 0.0479 0.4487 0.4472
Brugia malayi hypothetical protein 0.0037 0.0196 0.017
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0143 0.1222 0.8283
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0045 0.0116
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0029 0.0195
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0027 0.009 0.0064
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0241 0.2175 0.2154
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0021 0.0039 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0301 0.0276
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0454 0.0828
Giardia lamblia DNA topoisomerase II 0.0062 0.0433 0.8931
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0144 0.1232 0.1209
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0473 0.0448
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0049
Brugia malayi Carboxylesterase family protein 0.0048 0.0301 0.0276
Giardia lamblia Protein tyrosine phosphatase 0.0027 0.009 0.1356
Loa Loa (eye worm) hypothetical protein 0.0054 0.0356 0.033
Echinococcus multilocularis para nitrobenzyl esterase 0.0048 0.0301 0.0276
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0473 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0068 0.0904
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0143 0.1222 0.8283
Loa Loa (eye worm) hypothetical protein 0.0033 0.0152 0.0126
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0143 0.1222 0.8283
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0027 0.009 0.0064
Schistosoma mansoni hypothetical protein 0.0054 0.0355 0.033
Mycobacterium ulcerans oxidoreductase 0.0128 0.108 0.7297
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Brugia malayi hypothetical protein 0.0027 0.009 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus granulosus Nuclear hormone receptor HR96 0.0064 0.0454 0.0429
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0168 0.147 1
Brugia malayi RNA binding protein 0.0066 0.0473 0.0448
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0206 0.0181
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0144 0.1232 0.1209
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0143 0.1222 0.8283
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0473 0.0448
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0084 0.0652 0.0627
Echinococcus granulosus carboxylesterase 5A 0.0285 0.2608 0.2588
Echinococcus granulosus importin subunit beta 1 0.0033 0.0152 0.0126
Echinococcus multilocularis FTZ F1 alpha 0.0144 0.1232 0.1209
Schistosoma mansoni neuroligin 3 (S09 family) 0.0048 0.0301 0.0276
Brugia malayi hypothetical protein 0.0027 0.009 0.0064
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0142 0.1216 0.824
Trichomonas vaginalis ran, putative 0.0024 0.0068 0.0517
Echinococcus multilocularis BC026374 protein (S09 family) 0.0048 0.0301 0.0276
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.05 0.0475
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0027 0.009 0.0797
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0144 0.1232 0.1209
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0048 0.0301 0.3425
Loa Loa (eye worm) hypothetical protein 0.0103 0.0829 0.0805
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Echinococcus multilocularis nuclear receptor nhr 48 0.0064 0.0454 0.0429
Loa Loa (eye worm) hypothetical protein 0.0084 0.0652 0.0627
Echinococcus multilocularis pikachurin 0.0025 0.0076 0.0049
Schistosoma mansoni hypothetical protein 0.0084 0.0652 0.0627
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Echinococcus granulosus acetylcholinesterase 0.0285 0.2608 0.2588
Loa Loa (eye worm) hypothetical protein 0.0601 0.5674 0.5663
Loa Loa (eye worm) hypothetical protein 0.0182 0.1602 0.158
Loa Loa (eye worm) latrophilin receptor protein 2 0.0084 0.0652 0.0627
Brugia malayi laminin alpha chain 0.0025 0.0076 0.0049
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0103 0.0829 0.0805
Schistosoma mansoni pcd6 interacting protein-related 0.0027 0.009 0.0064
Schistosoma mansoni nuclear receptor nhr-48 0.0064 0.0454 0.0429
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.05 0.0475
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0144 0.1232 0.1209
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0064 0.0454 0.0429
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0143 0.1222 0.8283
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0092 0.0815
Brugia malayi nuclear hormone receptor 0.0064 0.0454 0.0429
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0027 0.009 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0144 0.1232 0.1209
Schistosoma mansoni gliotactin 0.0048 0.0301 0.0276
Brugia malayi tailless protein 0.0064 0.0454 0.0429
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0068 0.0042
Trypanosoma brucei protein tyrosine phosphatase 1 0.0027 0.009 0.0613
Brugia malayi hypothetical protein 0.0027 0.009 0.0064
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1045 1 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.009 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0248 0.1519
Schistosoma mansoni hypothetical protein 0.0042 0.0244 0.0219
Loa Loa (eye worm) hypothetical protein 0.0285 0.2608 0.2588
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Onchocerca volvulus 0.0028 0.0105 0.0034
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0163 0.1413 0.1391
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0021 0.0039 0.0073
Schistosoma mansoni slit 0.0025 0.0076 0.0049
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.009 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.0802 0.0778
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0143 0.1222 0.8283
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0027 0.009 0.0064
Entamoeba histolytica Ran family GTPase 0.0024 0.0068 0.0518
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Schistosoma mansoni ap endonuclease 0.002 0.0029 0.0002
Echinococcus multilocularis sterol regulatory element binding protein 0.0103 0.0829 0.0805
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0248 0.1519
Plasmodium falciparum DNA gyrase subunit B 0.0021 0.0039 0.0242
Brugia malayi nuclear hormone receptor family member odr-7 0.0064 0.0454 0.0429
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0105 0.0079
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Echinococcus multilocularis Niemann Pick C1 protein 0.0102 0.0828 0.0804
Echinococcus multilocularis Niemann Pick C1 protein 0.0205 0.1825 0.1804
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0143 0.1222 0.8283
Plasmodium falciparum DNA topoisomerase 2 0.0065 0.0461 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0266 0.2422 0.2402
Entamoeba histolytica hypothetical protein 0.0037 0.0196 0.212
Echinococcus granulosus para nitrobenzyl esterase 0.0048 0.0301 0.0276
Plasmodium vivax DNA gyrase subunit B, putative 0.0021 0.0039 0.0242
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0144 0.1232 0.1209
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0152 0.2857
Plasmodium vivax DNA topoisomerase II, putative 0.0065 0.0461 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0144 0.1232 0.1209
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0027 0.009 0.0426
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0027 0.009 0.0064
Brugia malayi Carboxylesterase family protein 0.0285 0.2608 0.2588
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0027 0.009 0.0064
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0027 0.009 0.0064
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0248 0.1519
Onchocerca volvulus 0.0048 0.0301 0.048
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0142 0.1216 0.1193
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0248 0.2757
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0473 0.0448
Entamoeba histolytica hypothetical protein 0.0027 0.0092 0.0817
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.0802 0.0778
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0068 0.0904
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0029 0.0031
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Schistosoma mansoni hypothetical protein 0.0042 0.0244 0.0219
Echinococcus granulosus Protein patched homolog 1 0.0103 0.0829 0.0805
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0092 0.0815
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0027 0.009 0.0064
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Echinococcus granulosus protein tyrosine phosphatase n9 0.0027 0.009 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0829 1
Loa Loa (eye worm) DR-78 0.0064 0.0454 0.0429
Echinococcus granulosus neuroligin 0.0048 0.0301 0.0276
Schistosoma mansoni ap endonuclease 0.002 0.0029 0.0002
Loa Loa (eye worm) hypothetical protein 0.0144 0.1232 0.1209
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Brugia malayi Carboxylesterase family protein 0.0048 0.0301 0.0276
Onchocerca volvulus 0.0048 0.0301 0.048
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0065 0.0461 0.0436
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0206 0.0181
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0027 0.009 0.0064
Brugia malayi photoreceptor-specific nuclear receptor 0.0144 0.1232 0.1209
Entamoeba histolytica hypothetical protein 0.0037 0.0196 0.212
Schistosoma mansoni hypothetical protein 0.0541 0.5097 0.5084
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0064 0.0454 0.0429
Echinococcus granulosus lamin dm0 0.0028 0.0105 0.0079
Brugia malayi RNA, U transporter 1 0.0094 0.0742 0.0718
Loa Loa (eye worm) hypothetical protein 0.0029 0.011 0.0084
Brugia malayi Probable DNA topoisomerase II 0.0065 0.0461 0.0436
Loa Loa (eye worm) hypothetical protein 0.0028 0.01 0.0074
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0102 0.0828 0.0804
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0064 0.0454 0.0429
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0027 0.009 0.0064
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Echinococcus multilocularis ecdysone induced protein 78C 0.0144 0.1232 0.1209
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0029 0.0002
Brugia malayi hypothetical protein 0.0027 0.009 0.0064
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0027 0.009 0.0064
Trichomonas vaginalis pten, drome, putative 0.0027 0.009 0.0795
Mycobacterium leprae putative cytochrome p450 0.0143 0.1222 0.5
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Schistosoma mansoni hypothetical protein 0.0042 0.0244 0.0219
Schistosoma mansoni intermediate filament proteins 0.0028 0.0105 0.0079
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0206 0.0181
Schistosoma mansoni laminin gamma-3 chain 0.0025 0.0076 0.0049
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0029 0.0002
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0084 0.0652 0.0627
Loa Loa (eye worm) hypothetical protein 0.0285 0.2608 0.2588
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.008 0.061 0.0585
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0064 0.0454 0.0429
Onchocerca volvulus 0.0144 0.1232 0.2597
Schistosoma mansoni lamin 0.0028 0.0105 0.0079
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0143 0.1222 0.8283
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0092 0.0437
Onchocerca volvulus 0.0028 0.0105 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Toxoplasma gondii DNA topoisomerase 2, putative 0.0065 0.0461 1
Echinococcus granulosus dna polymerase kappa 0.0043 0.0248 0.0222
Schistosoma mansoni hypothetical protein 0.0351 0.3247 0.3229
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0025 0.0076 0.0049
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0067 0.0482 0.567
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0196 0.017
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0206 0.1404
Echinococcus granulosus GPCR family 2 0.0084 0.0652 0.0627
Loa Loa (eye worm) acetylcholinesterase 1 0.0285 0.2608 0.2588
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0027 0.009 0.0064
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0398 0.256
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0027 0.009 0.0064
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0058 0.0398 0.2705
Schistosoma mansoni hypothetical protein 0.0042 0.0244 0.0219
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.05 0.327
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0143 0.1222 0.8283
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.008 0.061 0.0585
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0144 0.1232 0.1209
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0144 0.1232 0.1209
Leishmania major mitochondrial DNA topoisomerase II 0.0051 0.0327 0.2067
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0105 0.0079
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0027 0.009 0.0064
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Plasmodium falciparum importin beta, putative 0.0033 0.0152 0.2857
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0142 0.1216 0.1193
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Brugia malayi Calcitonin receptor-like protein seb-1 0.0266 0.2422 0.2402
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0143 0.1222 0.8283
Loa Loa (eye worm) hypothetical protein 0.0266 0.2422 0.2402
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0144 0.1232 0.1209
Echinococcus granulosus tar DNA binding protein 0.0066 0.0473 0.0448
Schistosoma mansoni BC026374 protein (S09 family) 0.0048 0.0301 0.0276
Schistosoma mansoni retinoic acid receptor RXR 0.0144 0.1232 0.1209
Loa Loa (eye worm) hypothetical protein 0.0064 0.0454 0.0429
Onchocerca volvulus 0.0048 0.0301 0.048
Brugia malayi hypothetical protein 0.0064 0.0454 0.0429
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0048 0.0301 0.0276
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0285 0.2608 0.2588
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0064 0.0454 0.0828
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0143 0.1222 0.8283
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0045 0.0116
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0143 0.1222 0.8283
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0064
Schistosoma mansoni hypothetical protein 0.0084 0.0652 0.0627
Echinococcus granulosus sterol regulatory element binding protein 0.0103 0.0829 0.0805
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.0802 0.0778
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0147 0.0998
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.0802 0.0778
Loa Loa (eye worm) hypothetical protein 0.0144 0.1232 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0248 0.1685
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0143 0.1222 0.8283

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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