Detailed information for compound 844371

Basic information

Technical information
  • TDR Targets ID: 844371
  • Name: N-[(3-fluorophenyl)methyl]-4-methyl-2,3-dihyd ro-1,4-benzothiazine-6-carboxamide
  • MW: 316.393 | Formula: C17H17FN2OS
  • H donors: 1 H acceptors: 1 LogP: 3.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1cccc(c1)CNC(=O)c1ccc2c(c1)N(C)CCS2
  • InChi: 1S/C17H17FN2OS/c1-20-7-8-22-16-6-5-13(10-15(16)20)17(21)19-11-12-3-2-4-14(18)9-12/h2-6,9-10H,7-8,11H2,1H3,(H,19,21)
  • InChiKey: JYRDYBALTIITMK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-fluorobenzyl)-4-methyl-2,3-dihydro-1,4-benzothiazine-6-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0809 0.4132 1
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0162 0.0395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0393 0.0957
Echinococcus multilocularis somatostatin receptor 0.0018 0.0017 0.004
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.011 0.0858
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0025 0.0024
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0017 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0027 0.0028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Toxoplasma gondii transporter, major facilitator family protein 0.0028 0.007 0.0164
Schistosoma mansoni neuropeptide receptor 0.0018 0.0017 0.004
Brugia malayi hypothetical protein 0.0046 0.0162 0.0259
Schistosoma mansoni ap endonuclease 0.0038 0.0121 0.0294
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0027 0.0066
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0024 0.0039
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0408 0.2045 0.3268
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.011 0.0454
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0018
Trypanosoma brucei protein kinase, putative 0.0051 0.019 0.0476
Schistosoma mansoni endoplasmin 0.0038 0.0121 0.0295
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.0121 0.0296
Schistosoma mansoni cpg binding protein 0.0087 0.0376 0.0915
Mycobacterium tuberculosis Probable oxidoreductase 0.024 0.1175 0.9153
Echinococcus granulosus pikachurin 0.0048 0.0175 0.0426
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0096 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0253 0.0617
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0017 0.004
Echinococcus granulosus intermediate filament protein 0.0027 0.0065 0.0159
Echinococcus multilocularis dna polymerase eta 0.0019 0.0026 0.0062
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0257 0.0626
Echinococcus multilocularis GPCR, family 2 0.0019 0.0024 0.0059
Schistosoma mansoni endoplasmin 0.0038 0.0121 0.0295
Loa Loa (eye worm) hypothetical protein 0.0048 0.0175 0.0175
Echinococcus multilocularis neuropeptide receptor A26 0.0476 0.2403 0.5816
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.0583 0.0582
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0249 0.1223 0.3171
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0026 0.0061 0.0477
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0078 0.0184
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0026 0.0061 0.0117
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0017 0.004
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0408 0.2045 0.3268
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0162 0.0392
Echinococcus multilocularis neurogenic locus notch protein 0.0048 0.0175 0.0423
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0162 0.0395
Echinococcus multilocularis agrin 0.0019 0.0024 0.0059
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.006 0.0136
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Onchocerca volvulus 0.0028 0.007 0.0219
Brugia malayi hypothetical protein 0.0074 0.0309 0.0493
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0195 0.0938 0.2288
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0044 0.0153 0.0371
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0112 0.0249
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0025 0.004
Mycobacterium tuberculosis Probable sulfatase 0.0018 0.0017 0.0129
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0393 0.0957
Brugia malayi TAR-binding protein 0.0126 0.0583 0.0931
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0096 0.0427 0.1034
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0153 0.0357
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0489 0.1236
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0026 0.0061 0.0117
Brugia malayi tailless protein 0.0046 0.0162 0.0259
Schistosoma mansoni neurotransmitter gated ion channel 0.0215 0.1043 0.2543
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0028 0.007 0.0171
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0017 0.004
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.0309 0.0747
Echinococcus multilocularis sex peptide receptor 0.0018 0.0017 0.004
Schistosoma mansoni biogenic amine receptor 0.0018 0.0017 0.004
Brugia malayi EGF-like domain containing protein 0.0048 0.0175 0.028
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.011 0.0858
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0193 0.0927 0.1482
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0017 0.004
Onchocerca volvulus GPI ethanolamine phosphate transferase 1 homolog 0.0018 0.0017 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0096 0.0427 0.0683
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0112 0.0249
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0007 0.0012
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Brugia malayi Dopamine receptor protein 2 0.0018 0.0017 0.0026
Echinococcus multilocularis pikachurin 0.0048 0.0175 0.0423
Echinococcus granulosus nuclear receptor nhr 48 0.0046 0.0162 0.0395
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0062 0.0248 0.0604
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0017 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0021
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.011 0.0245
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0545 0.0544
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0049 0.0119
Echinococcus granulosus g protein coupled receptor 0.0018 0.0017 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0017 0.004
Schistosoma mansoni hypothetical protein 0.0019 0.0024 0.006
Trypanosoma cruzi MFS transporter, putative 0.0028 0.007 0.0164
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Brugia malayi Cytochrome P450 family protein 0.0036 0.011 0.0176
Schistosoma mansoni jun-related protein 0.0068 0.0279 0.0681
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0238 0.0381
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.019 0.0463
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0153 0.0357
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Schistosoma mansoni neurotransmitter gated ion channel 0.0193 0.0927 0.226
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Schistosoma mansoni laminin gamma-3 chain 0.0048 0.0175 0.0426
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0121 0.0271
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0121 0.0295
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0112
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0162 0.0596
Brugia malayi MH2 domain containing protein 0.0119 0.0545 0.0871
Echinococcus multilocularis cpg binding protein 0.0091 0.0401 0.0971
Treponema pallidum NADH oxidase 0.0033 0.0096 0.0096
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0408 0.2045 0.2045
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.019 0.0476
Brugia malayi RE15519p 0.0018 0.0017 0.0026
Onchocerca volvulus 0.0408 0.2045 0.8307
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0261 0.1284 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0193 0.0927 0.226
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0018
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0025 0.006
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0078 0.0159
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0096 0.0427 0.1041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0017 0.004
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.3694 0.8939
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0021
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0128 0.0291
Echinococcus granulosus lamin 0.0027 0.0065 0.0159
Mycobacterium ulcerans hypothetical protein 0.0036 0.0112 0.0249
Onchocerca volvulus 0.0028 0.007 0.0219
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Brugia malayi Fli-1 protein 0.0219 0.1066 0.1704
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0024 0.0039
Brugia malayi G-protein coupled receptor 0.0018 0.0017 0.0026
Echinococcus granulosus follistatin 0.0019 0.0024 0.0059
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0017 0.004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0096 0.0427 0.0683
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Loa Loa (eye worm) ACC-1 protein 0.0408 0.2045 0.2045
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0112
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0096 0.0427 0.0427
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0017 0.004
Schistosoma mansoni nuclear hormone receptor 0.0096 0.0427 0.1041
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0408 0.2045 0.4949
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0024 0.0044
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0408 0.2045 0.4985
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0096 0.0427 0.0427
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0096 0.0427 0.1034
Onchocerca volvulus 0.0487 0.2458 1
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.011 0.0269
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0024 0.0024
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0025 0.0061
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.006 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0121 0.0271
Echinococcus multilocularis endoplasmin 0.0026 0.006 0.0144
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0215 0.1043 0.2543
Echinococcus multilocularis nAChR subunit 0.0215 0.1043 0.2524
Brugia malayi hypothetical protein 0.0193 0.0927 0.1482
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi Cation transporter family protein 0.0408 0.2045 0.3268
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0096 0.0208
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0027 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0489 0.1236
Trichomonas vaginalis sensor histidine kinase, putative 0.0032 0.0091 0.0195
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0078 0.0043
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0408 0.2045 0.4985
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0408 0.2045 0.3268
Onchocerca volvulus 0.0193 0.0927 0.373
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Mycobacterium ulcerans heat shock protein 90 0.0026 0.006 0.0112
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0096 0.0427 0.1041
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0193 0.0927 0.1482
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0025 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0257 0.0628
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0017 0.0016
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0096 0.0427 0.1041
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.019 0.0463
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0121 0.0296
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0753 0.3841 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0046 0.0162 0.0395
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0216 0.1049 0.8175
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0078 0.0159
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0078 0.0043
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0026 0.0041
Mycobacterium ulcerans two component regulator - sensor kinase 0.0026 0.0061 0.0117
Echinococcus granulosus neuropeptide receptor 0.0018 0.0017 0.004
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0253 0.0617
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0303 0.15 0.15
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0017 0.004
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0025 0.0061
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0026 0.0061 0.0297
Echinococcus multilocularis heat shock protein 90 0.0026 0.006 0.0144
Echinococcus multilocularis lamin dm0 0.0027 0.0065 0.0158
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0024 0.0039
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0061
Brugia malayi conserved hypotetical protein 0.0046 0.0162 0.0259
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0096 0.0232
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0153 0.0381
Brugia malayi Sulfatase family protein 0.0018 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0408 0.2045 0.3268
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0193 0.0927 0.2244
Plasmodium falciparum glutathione reductase 0.0033 0.0096 0.0232
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0062
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0025 0.0024
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0017 0.004
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.019 0.0476
Loa Loa (eye worm) cytochrome P450 family protein 0.0093 0.0407 0.0407
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0096 0.0427 0.1041
Brugia malayi RNA binding protein 0.0126 0.0583 0.0931
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0032 0.0091 0.0195
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0112 0.0249
Loa Loa (eye worm) hypothetical protein 0.0026 0.0063 0.0062
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0026 0.0023
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0096 0.0154
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0027 0.0028
Giardia lamblia Grp94/Hsp90 0.0026 0.006 0.0112
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.0301 0.0301
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.0927 0.1482
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Brugia malayi laminin-like protein K08C7.3 precursor 0.0048 0.0175 0.028
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.011 0.0858
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0096 0.0233
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0096 0.0427 0.0427
Schistosoma mansoni amine GPCR 0.0018 0.0017 0.004
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0677 0.1083
Echinococcus multilocularis ecdysone induced protein 78C 0.0096 0.0427 0.1034
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0112 0.0249
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0044 0.0153 0.1263
Brugia malayi Steroid receptor seven-up type 2 0.0096 0.0427 0.0683
Brugia malayi nuclear receptor RXR 0.0051 0.019 0.0304
Echinococcus granulosus orexin receptor type 2 0.0018 0.0017 0.004
Echinococcus granulosus heat shock protein 90 0.0038 0.0121 0.0295
Schistosoma mansoni biogenic amine receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0257 0.0626
Echinococcus granulosus expressed protein 0.0372 0.1862 0.4539
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0024 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.019 0.0452
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0061
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0381
Onchocerca volvulus 0.0044 0.0153 0.0561
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0078 0.052
Loa Loa (eye worm) acetyltransferase 0.0145 0.0677 0.0677
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0078 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0096 0.0427 0.0683
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0017 0.004
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0026 0.0062
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0024 0.0039
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.006 0.0463
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Leishmania major cytochrome p450-like protein 0.0062 0.0248 0.0627
Onchocerca volvulus 0.0408 0.2045 0.8307
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0017 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0028
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0025 0.0021
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0096 0.0208
Mycobacterium ulcerans beta-lactamase 0.0036 0.0112 0.0249
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.0153 0.0374
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.004
Echinococcus granulosus fmrfamide receptor 0.0018 0.0017 0.004
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0489 0.4561
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0017 0.004
Brugia malayi cytochrome P450 0.0036 0.011 0.0176
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0017 0.0016
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0024 0.0044
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Echinococcus multilocularis geminin 0.0169 0.0804 0.1947
Mycobacterium ulcerans lipase LipD 0.0036 0.0112 0.0249
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.011 0.0245
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0017 0.004
Schistosoma mansoni amine GPCR 0.0018 0.0017 0.004
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0257 0.2001
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0017 0.004
Echinococcus granulosus geminin 0.0169 0.0804 0.1961
Loa Loa (eye worm) hypothetical protein 0.0044 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Schistosoma mansoni opsin-like receptor 0.0018 0.0017 0.004
Echinococcus granulosus heat shock protein 0.0038 0.0121 0.0295
Schistosoma mansoni ets-related 0.0219 0.1066 0.2599
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0121 0.0296
Trypanosoma brucei trypanothione reductase 0.0095 0.0418 0.1072
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0078 0.0184
Schistosoma mansoni nAChR subunit 0.0193 0.0927 0.226
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0753 0.3841 0.9295
Loa Loa (eye worm) hypothetical protein 0.0063 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0096 0.0232
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.011 0.0245
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0096 0.0232
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0026 0.0041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.0427 0.1034
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0017 0.004
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0017 0.004
Echinococcus granulosus g protein coupled receptor 0.0018 0.0017 0.004
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0048 0.0175 0.028
Giardia lamblia Synaptic glycoprotein SC2 0.0044 0.0153 0.0357
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0017 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.011 0.0858
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0489 0.1193
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.011 0.0858
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0096 0.0427 0.1041
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Brugia malayi bZIP transcription factor family protein 0.0084 0.0361 0.0577
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0032 0.0091 0.5212
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Schistosoma mansoni hypothetical protein 0.0803 0.4102 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0121 0.0937
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.2151 0.2151
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0017 0.004
Plasmodium vivax glutathione reductase, putative 0.0095 0.0418 0.1072
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.006
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0408 0.2045 0.3268
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0147 0.0363
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0489 0.0489
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0026 0.0047
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0381
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0121 0.094
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0026 0.0061 0.0477
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0026 0.0025
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0257 0.0628
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0408 0.2045 0.2045
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0078 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0393 0.0957
Echinococcus granulosus somatostatin receptor 0.0018 0.0017 0.004
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0025 0.006
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0121 0.0271
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0017 0.0026
Mycobacterium tuberculosis Conserved protein 0.0036 0.0112 0.0872
Brugia malayi Dopamine receptor 0.0018 0.0017 0.0026
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0248 0.0627
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0026 0.0007
Schistosoma mansoni gabp alpha 0.0072 0.0301 0.0734
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0017 0.004
Echinococcus multilocularis nAChR subunit 0.0408 0.2045 0.4949
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0147 0.0363
Schistosoma mansoni nAChR subunit 0.0408 0.2045 0.4985
Brugia malayi prostaglandin transporter 0.0028 0.007 0.0112
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0061
Echinococcus granulosus endoplasmin 0.0026 0.006 0.0146
Loa Loa (eye worm) nuclear hormone receptor 0.0046 0.0162 0.0162
Schistosoma mansoni organic anion transporter 0.0028 0.007 0.0171
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0027 0.0027
Echinococcus granulosus agrin 0.0019 0.0024 0.0059
Schistosoma mansoni acetylcholine receptor-related 0.0193 0.0927 0.226
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0017 0.004
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0017 0.004
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0408 0.2045 0.4985
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Schistosoma mansoni cell polarity protein 0.0048 0.0175 0.0426
Brugia malayi Nuclear hormone receptor-like 1 0.0096 0.0427 0.0683
Echinococcus multilocularis slit 2 protein 0.0048 0.0175 0.0423
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0193 0.0927 0.2244
Brugia malayi hypothetical protein 0.0066 0.0268 0.0428
Schistosoma mansoni cytochrome P450 0.0036 0.011 0.0269
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1119 0.8715
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0215 0.1043 0.1667
Brugia malayi neuropeptide F receptor 0.0018 0.0017 0.0026
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0017 0.0016
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0121 0.0296
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0025 0.006
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0253 0.0613
Echinococcus multilocularis dnaJ subfamily B 0.0803 0.4102 0.9928
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.011 0.0245
Brugia malayi neuropeptide F receptor 0.0018 0.0017 0.0026
Schistosoma mansoni hypothetical protein 0.0068 0.0279 0.0681
Echinococcus multilocularis musashi 0.0027 0.0065 0.0158
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Brugia malayi Cytochrome P450 family protein 0.0062 0.0248 0.0396
Trypanosoma cruzi heat shock protein 90, putative 0.0024 0.0052 0.0116
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0096 0.0234
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Loa Loa (eye worm) ACC-1 protein 0.0408 0.2045 0.2045
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0051 0.019 0.019
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0017 0.004
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0007 0.0018
Brugia malayi phosphofructokinase 0.0108 0.0489 0.0782
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.011 0.0858
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0408 0.2045 0.3268
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0153 0.0381
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0026 0.0061 0.0477
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.3694 0.9004
Onchocerca volvulus 0.0036 0.0112 0.0392
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0061
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0028 0.007 0.017
Plasmodium vivax endoplasmin, putative 0.0038 0.0121 0.0296
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0026 0.0061 0.0477
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0408 0.2045 0.4985
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0017 0.004
Schistosoma mansoni neuropeptide receptor 0.0018 0.0017 0.004
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0049 0.0119
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0216 0.1049 0.8175
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Echinococcus granulosus glycine receptor subunit alpha 1 0.0408 0.2045 0.4985
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0112 0.0274
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0489 0.1257
Echinococcus granulosus jun protein 0.0084 0.0361 0.088
Onchocerca volvulus 0.0193 0.0927 0.373
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0028 0.007 0.017
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0017 0.004
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0489 0.1193
Schistosoma mansoni cpg binding protein 0.0091 0.0401 0.0978
Brugia malayi hypothetical protein 0.0018 0.0017 0.0027
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0408 0.2045 0.2045
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0017 0.004
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0044 0.0153 0.1263
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0096 0.0232
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.0583 0.0931
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.011 0.0245
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0492 0.2482 0.6457
Onchocerca volvulus 0.0063 0.0253 0.0969
Onchocerca volvulus 0.0036 0.0112 0.0392
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0051 0.019 0.0464
Loa Loa (eye worm) steroid hormone receptor 0.0096 0.0427 0.0427
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0408 0.2045 0.4949
Echinococcus granulosus tar DNA binding protein 0.0126 0.0583 0.142
Schistosoma mansoni hypothetical protein 0.0036 0.011 0.0269
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0193 0.0927 0.1482
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0096 0.0427 0.0683
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.004
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0112 0.0249
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0112 0.0112
Schistosoma mansoni amine GPCR 0.0018 0.0017 0.004
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.0121 0.0944
Schistosoma mansoni slit 0.0048 0.0175 0.0426
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0753 0.3841 0.384
Brugia malayi beta-lactamase family protein 0.0036 0.0112 0.0179
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0019 0.0024 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0238 0.0381
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0121 0.0295
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.011 0.0858
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.011 0.0245
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.011 0.0245
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0017 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Mycobacterium leprae Probable two component sensor kinase MprB 0.0026 0.0061 0.0016
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0091 0.0195
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0408 0.2045 0.4985
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0489 0.4561
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0026 0.0061 0.0477
Echinococcus granulosus nAChR subunit 0.0408 0.2045 0.4985
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0078 0.0159
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0051 0.019 0.019
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.011 0.0245
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0026 0.0061 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0096 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.1025 0.5255 0.5254
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0147 0.0357
Entamoeba histolytica hypothetical protein 0.0074 0.0309 0.2786
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Schistosoma mansoni zinc finger protein 0.0046 0.0162 0.0395
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0028
Entamoeba histolytica hypothetical protein 0.0074 0.0309 0.2786
Brugia malayi hypothetical protein 0.0019 0.0025 0.004
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0027 0.0066
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0024 0.006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0017 0.004
Mycobacterium tuberculosis Possible arylsulfatase AtsA (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0017 0.0129
Loa Loa (eye worm) CXXC zinc finger family protein 0.0087 0.0376 0.0375
Plasmodium falciparum endoplasmin, putative 0.0025 0.0056 0.0126
Brugia malayi G-protein coupled receptor 0.0018 0.0017 0.0026
Schistosoma mansoni nAChR subunit 0.0408 0.2045 0.4985
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.0418 0.0418
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0017 0.004
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0091 0.0195
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0017 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0112 0.0273
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0025 0.006
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0112 0.0872
Trypanosoma cruzi cytochrome P450, putative 0.0062 0.0248 0.0627
Onchocerca volvulus Putative organic anion transporter 0.0028 0.007 0.0219
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0232 0.0565
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0121 0.0292
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0017 0.0016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0408 0.2045 0.4949
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0121 0.0295
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0408 0.2045 0.3268
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.004
Schistosoma mansoni hypothetical protein 0.0019 0.0024 0.006
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.011 0.0245
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0026 0.0061 0.0477
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0017 0.004
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0046 0.0162 0.0259
Loa Loa (eye worm) LGC-31 protein 0.0408 0.2045 0.2045
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0051 0.019 0.019
Schistosoma mansoni lamin 0.0027 0.0065 0.0159
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0017 0.004
Toxoplasma gondii protease inhibitor PI2 0.0019 0.0024 0.0044
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0026 0.0062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0253 0.0617
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.0418 0.1012
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.019 0.0476
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0025 0.006
Entamoeba histolytica hypothetical protein 0.0074 0.0309 0.2786
Echinococcus granulosus Nuclear hormone receptor HR96 0.0046 0.0162 0.0395
Schistosoma mansoni amine GPCR 0.0018 0.0017 0.004
Onchocerca volvulus Bile acid receptor homolog 0.0096 0.0427 0.1681
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0121 0.0295
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0096 0.0232
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0753 0.3841 1
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0017 0.004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0121 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0408 0.2045 0.3268
Schistosoma mansoni nAChR subunit 0.0408 0.2045 0.4985
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0393 0.0957
Echinococcus multilocularis serotonin receptor 0.0018 0.0017 0.004
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Brugia malayi ORL1-like opioid receptor 0.0018 0.0017 0.0026
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0357
Echinococcus granulosus neuropeptide receptor 0.0018 0.0017 0.004
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0096 0.0232
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0096 0.0232
Brugia malayi sulfakinin receptor protein 0.0018 0.0017 0.0026
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.0301 0.0734
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.011 0.0858
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0096 0.0232
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0046 0.0162 0.0395
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.011 0.0858
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0096 0.0208
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.011 0.0269
Onchocerca volvulus 0.0046 0.0162 0.0596
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0078 0.0184
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.0309 0.0752
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0026 0.0023
Echinococcus multilocularis 0.0036 0.011 0.0267
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0121 0.0294
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0753 0.3841 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0025 0.0024
Leishmania major DNA polymerase eta, putative 0.0019 0.0026 0.0047
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.011 0.0858
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.0418 0.3257
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.019 0.0304
Brugia malayi nuclear hormone receptor family member odr-7 0.0046 0.0162 0.0259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0017 0.004
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0408 0.2045 0.4985
Onchocerca volvulus 0.0028 0.007 0.0219
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0007 0.0018
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0408 0.2045 0.3268
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0583 0.142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0393 0.0957
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.019 0.0476
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.011 0.0245
Schistosoma mansoni nAChR subunit 0.0193 0.0927 0.226
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0408 0.2045 0.4949
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.024 0.1175 0.9153
Brugia malayi nuclear hormone receptor family member nhr-6 0.0046 0.0162 0.0259
Echinococcus granulosus hypothetical protein 0.0018 0.0017 0.004
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0147 0.0339
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0048 0.0175 0.0426
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0017 0.004
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.011 0.0245
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0017 0.0026
Echinococcus granulosus FTZ F1 alpha 0.0096 0.0427 0.1041
Trypanosoma brucei unspecified product 0.0019 0.0026 0.0047
Brugia malayi AKH receptor 0.0018 0.0017 0.0026
Echinococcus granulosus Solute carrier organic anion transporter family 0.0028 0.007 0.0171
Entamoeba histolytica hypothetical protein 0.0044 0.0153 0.1263
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.007 0.0112
Schistosoma mansoni retinoic acid receptor RXR 0.0195 0.0938 0.2288
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0096 0.0427 0.1681
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.0418 0.1072
Echinococcus granulosus neuropeptide s receptor 0.0476 0.2403 0.5858
Schistosoma mansoni opsin-like receptor 0.0018 0.0017 0.004
Schistosoma mansoni thyroid hormone receptor 0.0096 0.0427 0.1041
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0017 0.004
Onchocerca volvulus 0.0087 0.0376 0.147
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.011 0.0858
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0017 0.0016
Echinococcus granulosus glycine receptor subunit beta 0.0408 0.2045 0.4985
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0025 0.004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0121 0.012
Brugia malayi beta-lactamase family protein 0.0036 0.0112 0.0179
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0026 0.0047
Onchocerca volvulus 0.0046 0.0162 0.0596
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.0418 0.1072
Schistosoma mansoni nuclear receptor 0.0046 0.0162 0.0395
Echinococcus granulosus lamin dm0 0.0027 0.0065 0.0159
Brugia malayi Receptor family ligand binding region containing protein 0.0116 0.0527 0.0843
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0049 0.0118
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0017 0.004
Onchocerca volvulus 0.0096 0.0427 0.1681
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Brugia malayi glucose-6-phosphate dehydrogenase 0.0753 0.3841 0.6139
Brugia malayi intermediate filament protein 0.0027 0.0065 0.0104
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0128 0.0315
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0583 0.142
Echinococcus multilocularis lamin 0.0027 0.0065 0.0158
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0408 0.2045 0.4985
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0044 0.0153 0.0153
Echinococcus granulosus heat shock protein 90 0.0026 0.006 0.0146
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0753 0.3841 0.9362
Onchocerca volvulus Putative organic anion transporter 0.0028 0.007 0.0219
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0044 0.0153 0.0381
Loa Loa (eye worm) hypothetical protein 0.0041 0.0139 0.0139
Brugia malayi nuclear receptor NHR-88 0.0046 0.0162 0.0259
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0017 0.004
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0357
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0024 0.0039
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0026 0.0197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0096 0.0427 0.0683
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0112 0.0872
Brugia malayi hypothetical protein 0.0051 0.019 0.0304
Loa Loa (eye worm) heat shock protein 90 0.0038 0.0121 0.0121
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0026 0.0061 0.0016
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0081 0.0349 0.0349
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0539 0.273 0.7102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0051 0.019 0.0464
Mycobacterium tuberculosis Conserved protein 0.0036 0.0112 0.0872
Loa Loa (eye worm) GABA receptor subunit 0.0215 0.1043 0.1043
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0215 0.1043 0.2543
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.019 0.0452
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0096 0.5994
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0116 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trypanosoma cruzi heat shock protein 85, putative 0.0038 0.0121 0.0296
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0112 0.0273
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0112
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0545 0.0544
Loa Loa (eye worm) hypothetical protein 0.0051 0.019 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0096 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Schistosoma mansoni biogenic amine receptor 0.0018 0.0017 0.004
Trichomonas vaginalis set domain proteins, putative 0.0487 0.2458 0.6383
Brugia malayi G protein-coupled receptor 0.0018 0.0017 0.0026
Echinococcus granulosus cpg binding protein 0.0091 0.0401 0.0978
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0017 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0753 0.3841 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0051 0.019 0.019
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0361 0.088
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0046 0.0162 0.0395
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0051 0.019 0.0461
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.019 0.0463
Brugia malayi nuclear receptor RXR 0.0046 0.0162 0.0259
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0381
Echinococcus granulosus nAChR subunit 0.0215 0.1043 0.2543
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0017 0.004
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0121 0.0193
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.011 0.0858
Schistosoma mansoni hypothetical protein 0.0041 0.0139 0.034
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0078 0.0159
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.024 0.1175 0.9153
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0381
Brugia malayi hypothetical protein 0.0028 0.007 0.0112
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0078 0.0048
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.011 0.0858
Brugia malayi Cation transporter family protein 0.0408 0.2045 0.3268
Brugia malayi Thioredoxin reductase 0.0095 0.0418 0.0668
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.011 0.0269
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0017 0.004
Plasmodium falciparum thioredoxin reductase 0.0095 0.0418 0.1072
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0017 0.004
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0162 0.0395
Loa Loa (eye worm) endoplasmin 0.0038 0.0121 0.0121
Giardia lamblia DINP protein human, muc B family 0.0019 0.0026 0.0023
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0753 0.3841 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0408 0.2045 0.3268
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0024
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0257 0.0626
Mycobacterium leprae putative cytochrome p450 0.0036 0.011 0.0454
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0126 0.0583 0.0582
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.006
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.019 0.0476
Loa Loa (eye worm) hypothetical protein 0.0048 0.0175 0.0175
Schistosoma mansoni thyroid hormone receptor 0.0096 0.0427 0.1041
Trichomonas vaginalis heat shock protein, putative 0.0026 0.006 0.0112
Schistosoma mansoni nAChR subunit 0.0408 0.2045 0.4985
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0078 0.0184
Echinococcus multilocularis heat shock protein 0.0038 0.0121 0.0293
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0162 0.0259
Schistosoma mansoni steroid hormone receptor ad4bp 0.0096 0.0427 0.1041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0112 0.0179
Loa Loa (eye worm) hypothetical protein 0.0062 0.0247 0.0246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0096 0.0427 0.0683
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.011 0.0245
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0017 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.0309 0.0752
Brugia malayi Protein kinase domain containing protein 0.0015 0.0002 0.0004
Trypanosoma brucei heat shock protein 90, putative 0.0038 0.0121 0.0296
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0027 0.0044
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0753 0.3841 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0021
Brugia malayi beta-lactamase 0.0036 0.0112 0.0179
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.011 0.0858
Onchocerca volvulus 0.0408 0.2045 0.8307
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0046 0.0162 0.0392
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0753 0.3841 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0024 0.006
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.011 0.0245
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.019 0.0459
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0096 0.0208
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.019 0.0476
Onchocerca volvulus 0.0193 0.0927 0.373
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.011 0.0269
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0026 0.0061 0.0117
Echinococcus granulosus dna polymerase kappa 0.0019 0.0026 0.0062
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0153 0.0357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.0427 0.1041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0025 0.004
Schistosoma mansoni hypothetical protein 0.0074 0.0309 0.0752
Schistosoma mansoni acetylcholine receptor subunit beta 0.0193 0.0927 0.226
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0153 0.0357
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0186 0.0892 0.2174
Schistosoma mansoni intermediate filament proteins 0.0027 0.0065 0.0159
Brugia malayi putative neuropeptide receptor 0.0018 0.0017 0.0026
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.011 0.0245
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0257 0.0622
Entamoeba histolytica hypothetical protein 0.0074 0.0309 0.2786
Leishmania major cytochrome p450-like protein 0.0036 0.011 0.0269
Loa Loa (eye worm) agrin synaptic family protein 0.0019 0.0024 0.0024
Brugia malayi 6-phosphofructokinase 0.0108 0.0489 0.0782
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0017 0.004
Toxoplasma gondii ABC1 family protein 0.0036 0.0112 0.0273
Brugia malayi secreted modular calcium-binding protein 1 0.0019 0.0024 0.0039
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0147 0.0363
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.019 0.0476
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.006 0.0136
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0002 0.0004
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0253 0.0613
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0017 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0028
Echinococcus multilocularis thyroid hormone receptor alpha 0.0096 0.0427 0.1034
Loa Loa (eye worm) hypothetical protein 0.065 0.3303 0.3303
Schistosoma mansoni amine GPCR 0.0018 0.0017 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0112 0.0249
Loa Loa (eye worm) hypothetical protein 0.0027 0.0065 0.0065
Onchocerca volvulus Putative nachr subunit 0.0408 0.2045 0.8307
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0017 0.004
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0044 0.0153 0.0245
Toxoplasma gondii heat shock protein 90, putative 0.0038 0.0121 0.0296
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0489 0.0489
Schistosoma mansoni neuropeptide receptor 0.0018 0.0017 0.004
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0007 0.0056
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0489 0.0489
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0408 0.2045 0.4949
Brugia malayi follicle stimulating hormone receptor 0.0489 0.2466 0.3941
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0017 0.004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0656 0.16
Schistosoma mansoni nAChR subunit 0.0408 0.2045 0.4985
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0017 0.004
Schistosoma mansoni cpg binding protein 0.0091 0.0401 0.0978
Onchocerca volvulus 0.0408 0.2045 0.8307
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.019 0.0476
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0248 0.0247
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0024 0.0059
Schistosoma mansoni lamin 0.0027 0.0065 0.0159
Toxoplasma gondii heat shock protein HSP90 0.0038 0.0121 0.0296
Trichomonas vaginalis heat shock protein, putative 0.0026 0.006 0.0112
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0489 0.1136
Echinococcus granulosus dna polymerase eta 0.0019 0.0026 0.0062
Onchocerca volvulus 0.0019 0.0024 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0583 0.142
Schistosoma mansoni hypothetical protein 0.0169 0.0804 0.1961
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0061
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0408 0.2045 0.2045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0028
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0027 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.0418 0.1019
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0112 0.0272
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0242 0.1185 0.3073
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0112
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0017 0.004
Brugia malayi ecdysone receptor 0.0046 0.0162 0.0259
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0017 0.0016
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.011 0.0245
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0408 0.2045 0.2045
Echinococcus multilocularis FTZ F1 alpha 0.0096 0.0427 0.1034
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0216 0.1049 0.8175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0096 0.0427 0.0427
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0357
Toxoplasma gondii thioredoxin reductase 0.0095 0.0418 0.1072
Echinococcus multilocularis tar DNA binding protein 0.0126 0.0583 0.141
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Onchocerca volvulus 0.0036 0.0112 0.0392
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0017 0.004
Plasmodium falciparum polyprenol reductase, putative 0.0044 0.0153 0.0381
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0393 0.0392
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.011 0.0245
Trichomonas vaginalis endoplasmin, putative 0.0025 0.0056 0.0102
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0408 0.2045 0.3268
Plasmodium vivax SET domain protein, putative 0.0063 0.0253 0.0641
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0162 0.0395
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0096 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.019 0.0452
Onchocerca volvulus 0.0028 0.007 0.0219
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0078 0.0159
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0121 0.0161
Brugia malayi Pre-SET motif family protein 0.0063 0.0253 0.0405
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0017 0.0016
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0026 0.0062
Brugia malayi Serotonin receptor 0.0018 0.0017 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Schistosoma mansoni histamine h1 receptor 0.0018 0.0017 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0024
Trichomonas vaginalis esterase, putative 0.0036 0.0112 0.0249
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.004
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0078 0.0184
Brugia malayi Melatonin receptor type 1A 0.0018 0.0017 0.0026
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0017 0.004
Brugia malayi GnHR receptor homolog 0.0018 0.0017 0.0026
Loa Loa (eye worm) DR-78 0.0046 0.0162 0.0162
Entamoeba histolytica heat shock protein 90, putative 0.0038 0.0121 0.0944
Brugia malayi hypothetical protein 0.0249 0.1222 0.1953
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0193 0.0927 0.0927
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0489 0.3811
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0489 0.1236
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0216 0.1049 0.8175
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0753 0.3841 1
Echinococcus granulosus neurogenic locus notch protein 0.0048 0.0175 0.0426
Brugia malayi CXXC zinc finger family protein 0.0087 0.0376 0.06
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0029 0.0076 0.0186
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0017 0.004
Echinococcus granulosus neuropeptide receptor A26 0.0476 0.2403 0.5858
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0024
Schistosoma mansoni ap endonuclease 0.0038 0.0121 0.0294
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0753 0.3841 1
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.004
Plasmodium vivax heat shock protein 86, putative 0.0038 0.0121 0.0296
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0026 0.0062
Loa Loa (eye worm) hypothetical protein 0.006 0.0238 0.0238
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0096 0.0427 0.0683
Trichomonas vaginalis helicase, putative 0.002 0.0027 0.0028
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0032 0.0091 0.0195
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.011 0.0858
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0025 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0096 0.0427 0.1041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Echinococcus multilocularis expressed protein 0.0372 0.1862 0.4506
Schistosoma mansoni neuropeptide receptor 0.0018 0.0017 0.004
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0139 0.0223
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi heat shock protein 90 0.0038 0.0121 0.0193
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0078 0.0159
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0096 0.0427 0.1041
Brugia malayi glutathione reductase 0.0095 0.0418 0.0668
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0677 0.1651
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0393 0.095
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0096 0.0232
Loa Loa (eye worm) nuclear receptor NHR-67 0.0046 0.0162 0.0162
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0044 0.0153 0.0374
Echinococcus granulosus synaptic glycoprotein sc2 0.0044 0.0153 0.0374
Echinococcus granulosus ecdysone induced protein 78C 0.0096 0.0427 0.1041
Mycobacterium ulcerans hypothetical protein 0.0044 0.0153 0.0357
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0017 0.004
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0216 0.1049 0.8875
Brugia malayi hypothetical protein 0.0019 0.0025 0.004
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.011 0.0858
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.011 0.0858
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0096 0.0234
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0024
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0096 0.0232
Echinococcus multilocularis glycine receptor subunit beta 0.0408 0.2045 0.4949
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Onchocerca volvulus 0.0028 0.007 0.0219
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0408 0.2045 0.3268
Echinococcus granulosus serotonin receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0007 0.0007
Leishmania major trypanothione reductase 0.0095 0.0418 0.1072
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0162 0.0392
Brugia malayi Cation transporter family protein 0.0408 0.2045 0.3268
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0026 0.0047
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0061
Echinococcus multilocularis synaptic glycoprotein sc2 0.0044 0.0153 0.0371
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0096 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0024
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0492 0.2482 0.6448
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Brugia malayi hypothetical protein 0.0193 0.0927 0.1482
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Onchocerca volvulus 0.0027 0.0065 0.02
Brugia malayi hypothetical protein 0.0193 0.0927 0.1482
Entamoeba histolytica hypothetical protein 0.0215 0.1043 1
Brugia malayi hypothetical protein 0.0051 0.019 0.0304
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0489 0.1193
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Echinococcus multilocularis Ankyrin 0.0014 0.0001 0.0002
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0026 0.0062
Brugia malayi hypothetical protein 0.0028 0.007 0.0112
Onchocerca volvulus 0.0408 0.2045 0.8307
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0017 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0025 0.0021
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0051 0.0081
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0408 0.2045 0.3268
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0017 0.0026
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.007 0.0112
Schistosoma mansoni neurotransmitter gated ion channel 0.0193 0.0927 0.226
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0215 0.1043 0.1667
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi Nuclear hormone receptor E75 0.0046 0.0162 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0096 0.0427 0.0683
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0017 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0017 0.004
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0112 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.011 0.0858
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0112 0.0872
Schistosoma mansoni myosin xvIII 0.0018 0.0017 0.004
Plasmodium vivax polyprenol reductase, putative 0.0044 0.0153 0.0381
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0489 0.1184
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0046 0.0162 0.0162
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0017 0.004
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.011 0.0245
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0193 0.0927 0.0927
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0128 0.1014
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0677 0.1639
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0096 0.0427 0.1041
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0257 0.0651
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0017 0.004
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0489 0.3852
Brugia malayi excitatory GABA receptor EXP-1A 0.0408 0.2045 0.3268
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0112 0.0872
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0408 0.2045 0.4985
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0096 0.0092
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0489 0.1257
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0408 0.2045 0.4985
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0112 0.0274
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0024
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0065 0.0104
Brugia malayi nuclear hormone receptor 0.0046 0.0162 0.0259
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.0153 0.0374
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0489 0.1257
Echinococcus multilocularis expressed protein 0.0019 0.0024 0.0059
Loa Loa (eye worm) hypothetical protein 0.0019 0.0026 0.0025
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0096 0.0427 0.1041
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0019 0.0024 0.0039
Loa Loa (eye worm) glutathione reductase 0.0095 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0121 0.0295
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0096 0.0427 0.0427
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0175 0.0175
Brugia malayi ecdysteroid receptor 0.0096 0.0427 0.0683
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0393 0.095
Trypanosoma brucei heat shock protein, putative 0.0038 0.0121 0.0296
Brugia malayi Serotonin receptor 0.0018 0.0017 0.0026
Echinococcus granulosus glycine receptor subunit beta 0.0408 0.2045 0.4985
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0017 0.004
Schistosoma mansoni hypothetical protein 0.0019 0.0024 0.006
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) fli-1 protein 0.0219 0.1066 0.1066
Echinococcus multilocularis follistatin 0.0019 0.0024 0.0059
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0049 0.0118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0029 0.0076 0.0185
Plasmodium falciparum heat shock protein 90 0.0038 0.0121 0.0296
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0017 0.004
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0408 0.2045 0.3268
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0017 0.004
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0017 0.0016
Brugia malayi photoreceptor-specific nuclear receptor 0.0096 0.0427 0.0683
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0007 0.0018
Brugia malayi Dopamine receptor protein 1 0.0018 0.0017 0.0026
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0489 0.4561
Brugia malayi PXA domain containing protein 0.0019 0.0025 0.004
Echinococcus granulosus sex peptide receptor 0.0018 0.0017 0.004
Trypanosoma brucei Heat shock protein 83, putative 0.0038 0.0121 0.0296
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0027 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0489 0.1236
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0017 0.0026
Schistosoma mansoni DNA polymerase eta 0.0019 0.0026 0.0062
Brugia malayi MAP kinase sur-1 0.0051 0.019 0.0303
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0753 0.3841 1
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Brugia malayi hypothetical protein 0.0303 0.15 0.2398
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0393 0.0627
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0017 0.004
Schistosoma mansoni follistatin 0.0019 0.0024 0.0059
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.006 0.0112
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0001 0.0002
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0024 0.0059
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0408 0.2045 0.4949
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.019 0.0304
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0051 0.0081
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0025 0.006
Trichomonas vaginalis heat shock protein, putative 0.0038 0.0121 0.0272
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0096 0.0427 0.1034
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0121 0.0271
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0017 0.004
Brugia malayi hypothetical protein 0.0193 0.0927 0.1482
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0046 0.0162 0.0395
Echinococcus multilocularis jun protein 0.0084 0.0361 0.0874
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0096 0.0748
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0357
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0046 0.0162 0.0596
Loa Loa (eye worm) histone methyltransferase 0.0029 0.0076 0.0076
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0032 0.0091 0.0195
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0025 0.0061
Brugia malayi SPARC precursor 0.0019 0.0024 0.0039
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.019 0.0464
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0489 0.2466 0.2466
Toxoplasma gondii exonuclease III APE 0.0038 0.0121 0.0295
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Onchocerca volvulus 0.0215 0.1043 0.4204
Loa Loa (eye worm) hypothetical protein 0.0051 0.019 0.019
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.019 0.0452
Echinococcus granulosus microtubule associated protein 2 0.0725 0.3694 0.9004
Mycobacterium tuberculosis Possible hydrolase 0.0018 0.0017 0.0129
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0361 0.0874
Schistosoma mansoni nAChR subunit 0.0408 0.2045 0.4985
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0017 0.004
Onchocerca volvulus 0.0408 0.2045 0.8307
Brugia malayi Endoplasmin precursor 0.0038 0.0121 0.0193
Loa Loa (eye worm) cytochrome P450 family protein 0.0062 0.0248 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0026 0.0197
Plasmodium falciparum thioredoxin reductase 0.0033 0.0096 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0096 0.0427 0.1034
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0026 0.0061 0.0117
Brugia malayi sodium-independent organic anion transporter family protein 0.0028 0.007 0.0112
Brugia malayi steroid hormone receptor 0.0096 0.0427 0.0683
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Schistosoma mansoni adenoreceptor 0.0018 0.0017 0.004
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0408 0.2045 0.4949
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.0153 0.0381
Loa Loa (eye worm) cytochrome P450 0.0036 0.011 0.011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0096 0.0427 0.1041
Mycobacterium ulcerans two component sensor kinase MprB 0.0026 0.0061 0.0117
Leishmania major DNA polymerase kappa, putative 0.0019 0.0026 0.0047
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0583 0.142
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Schistosoma mansoni tar DNA-binding protein 0.0126 0.0583 0.142
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.1217 0.6256 1
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Brugia malayi Ets-domain containing protein 0.0072 0.0301 0.0481
Onchocerca volvulus 0.0303 0.15 0.6076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0096 0.0427 0.0683
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0112 0.0872
Schistosoma mansoni coup transcription factor 0.0096 0.0427 0.1041
Mycobacterium tuberculosis Conserved protein 0.0036 0.0112 0.0872
Schistosoma mansoni nAChR subunit 0.0408 0.2045 0.4985
Echinococcus granulosus dnaJ subfamily B 0.0803 0.4102 1
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0112 0.0872
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.0927 0.1482
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0017 0.004
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0408 0.2045 0.3268
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.011 0.0269
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0753 0.3841 0.9362
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Brugia malayi hypothetical protein 0.0193 0.0927 0.1482
Leishmania major cytochrome p450-like protein 0.0036 0.011 0.0269
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0215 0.1043 0.1667
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0408 0.2045 0.4985
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0096 0.0232
Onchocerca volvulus 0.0027 0.0065 0.02
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0112 0.0872
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0753 0.3841 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0238 0.0238
Mycobacterium tuberculosis Probable dehydrogenase 0.0216 0.1049 0.8175
Echinococcus multilocularis serotonin receptor 0.0018 0.0017 0.004
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0026 0.0023
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.019 0.0189
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0215 0.1043 0.1667
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0253 0.0617
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0408 0.2045 0.2045
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0017 0.004
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0065 0.0065
Trichomonas vaginalis receptor histidine kinase, putative 0.0032 0.0091 0.0195
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0408 0.2045 0.4949
Echinococcus multilocularis heat shock protein 90 0.0038 0.0121 0.0293
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0408 0.2045 0.4985
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0007 0.0018
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.0153 0.0357
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0193 0.0927 0.2244
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0257 0.0651
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.019 0.0459
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Schistosoma mansoni hypothetical protein 0.0018 0.0017 0.004
Brugia malayi laminin alpha chain 0.0048 0.0175 0.028
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Onchocerca volvulus 0.0215 0.1043 0.4204
Brugia malayi nuclear receptor NHR-88 0.0096 0.0427 0.0683
Schistosoma mansoni agrin 0.0019 0.0024 0.0059
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0017 0.004
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0026 0.0061 0.0117
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0753 0.3841 1
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.0301 0.0729
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0112 0.0249
Onchocerca volvulus Putative organic anion transporter 0.0028 0.007 0.0219
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.011 0.0245
Loa Loa (eye worm) hypothetical protein 0.0036 0.0112 0.0112
Plasmodium falciparum 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0381
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0096 0.0427 0.0683
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0193 0.0927 0.1482
Schistosoma mansoni heat shock protein 0.0038 0.0121 0.0295
Echinococcus granulosus GPCR family 2 0.0019 0.0024 0.006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0096 0.0427 0.0683
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0017 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0253 0.0617
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0489 0.1236
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0408 0.2045 0.4985
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0112 0.0471
Loa Loa (eye worm) hypothetical protein 0.0028 0.007 0.007
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0044 0.0153 0.1263
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0065 0.0065
Schistosoma mansoni organic anion transporter 0.0028 0.007 0.0171
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0147 0.0339
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0044 0.0153 0.0381
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Echinococcus multilocularis glycine receptor subunit beta 0.0408 0.2045 0.4949
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0026 0.0023
Brugia malayi nuclear receptor NHR-67 0.0046 0.0162 0.0259
Echinococcus granulosus glycine receptor subunit alpha 1 0.0408 0.2045 0.4985
Brugia malayi nuclear hormone receptor 0.0096 0.0427 0.0683
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0017 0.004
Brugia malayi Cytochrome P450 family protein 0.0062 0.0248 0.0396
Loa Loa (eye worm) hypothetical protein 0.1217 0.6256 0.6256
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0253 0.0641
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0112 0.0273
Mycobacterium tuberculosis Possible arylsulfatase AtsD (aryl-sulfate sulphohydrolase) (arylsulphatase) 0.0018 0.0017 0.0129
Schistosoma mansoni nuclear receptor 0.0046 0.0162 0.0395
Loa Loa (eye worm) hypothetical protein 0.0044 0.0153 0.0153
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0025 0.0061
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0017 0.0016
Echinococcus granulosus glycine receptor subunit alpha 1 0.0408 0.2045 0.4985
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.006 0.0146
Brugia malayi Cytochrome P450 family protein 0.0093 0.0407 0.0651
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0017 0.0026
Brugia malayi Synaptic glycoprotein SC2 0.0044 0.0153 0.0245
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0017 0.004
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0096 0.5994
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0096 0.0427 0.1041
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0026 0.0047
Schistosoma mansoni hypothetical protein 0.0169 0.0804 0.1961
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0307 0.0744
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Plasmodium falciparum glutathione reductase 0.0095 0.0418 0.1072
Leishmania major hypothetical protein, conserved 0.0036 0.0112 0.0273
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0027 0.0028
Brugia malayi hypothetical protein 0.0046 0.0162 0.0259
Loa Loa (eye worm) beta-lactamase 0.0036 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0018 0.0017 0.0016
Onchocerca volvulus 0.0066 0.0268 0.1028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0096 0.0427 0.0683
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0017 0.004
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0408 0.2045 0.4985
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0049 0.0119
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0193 0.0927 0.226
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.011 0.0858
Brugia malayi larval opioid receptor 0.0018 0.0017 0.0026
Giardia lamblia Heat shock protein HSP 90-alpha 0.0038 0.0121 0.0272
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0408 0.2045 0.4949
Schistosoma mansoni nuclear receptor nhr-48 0.0046 0.0162 0.0395
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0027 0.0066
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0026 0.0061 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0096 0.0427 0.0683
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0096 0.0427 0.1034
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0408 0.2045 0.4985
Brugia malayi orphan nuclear receptor NR2E1 0.0046 0.0162 0.0259
Schistosoma mansoni hypothetical protein 0.0019 0.0024 0.006
Loa Loa (eye worm) hypothetical protein 0.0193 0.0927 0.0927
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.0153 0.0381
Schistosoma mansoni heat shock protein 0.0038 0.0121 0.0295
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0096 0.0232
Loa Loa (eye worm) hypothetical protein 0.0046 0.0162 0.0162
Trichomonas vaginalis heat shock protein, putative 0.0026 0.006 0.0112
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0112 0.0273
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0017 0.004
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.019 0.0452
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.011 0.0245
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0025 0.0061
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0061
Toxoplasma gondii histone lysine methyltransferase SET1 0.017 0.0808 0.2089
Echinococcus multilocularis neuropeptide s receptor 0.0476 0.2403 0.5816
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0025 0.0061
Echinococcus granulosus slit 2 protein 0.0048 0.0175 0.0426
Brugia malayi hypothetical protein 0.0018 0.0017 0.0026
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0056 0.0102
Loa Loa (eye worm) hypothetical protein 0.0096 0.0427 0.0427
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.011 0.0245
Echinococcus multilocularis nuclear receptor nhr 48 0.0046 0.0162 0.0392
Echinococcus granulosus allatostatin A receptor 0.0018 0.0017 0.004
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0408 0.2045 0.4949
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0078 0.0159
Loa Loa (eye worm) RNA binding protein 0.0126 0.0583 0.0582
Trypanosoma cruzi Heat shock protein 83, putative 0.0038 0.0121 0.0296
Brugia malayi Ets-domain containing protein 0.0072 0.0301 0.0481
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0096 0.0208
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0017 0.004
Onchocerca volvulus Protein ultraspiracle homolog 0.0096 0.0427 0.1681
Schistosoma mansoni RAR-like nuclear receptor 0.0096 0.0427 0.1041
Mycobacterium leprae Probable lipase LipE 0.0036 0.0112 0.0471
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0144 0.0673 0.163
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0096 0.0232
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0078 0.0184
Loa Loa (eye worm) hypothetical protein 0.0019 0.0025 0.0024
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0025 0.0061
Brugia malayi 6-phosphofructokinase 0.0108 0.0489 0.0782
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0046 0.0162 0.0392
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.011 0.0858
Loa Loa (eye worm) CYP4Cod1 0.0062 0.0248 0.0247
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0017 0.004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.024 0.1175 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0028
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0026 0.0061 0.0477
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.011 0.0269
Schistosoma mansoni opsin-like receptor 0.0018 0.0017 0.004
Brugia malayi isocitrate dehydrogenase 0.0016 0.0007 0.0012
Trypanosoma brucei cytochrome P450, putative 0.0062 0.0248 0.0627
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0075 0.0119
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0753 0.3841 1
Loa Loa (eye worm) acetylcholine receptor protein 0.0193 0.0927 0.0927
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0025 0.0061
Mycobacterium tuberculosis Probable reductase 0.0216 0.1049 0.8175
Echinococcus granulosus Ankyrin 0.0014 0.0001 0.0002
Loa Loa (eye worm) abnormal epIthelia family member 0.0048 0.0175 0.0175
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0096 0.0232
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0121 0.0295
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0025 0.0061
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0028 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0408 0.2045 0.2045
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0257 0.0628
Leishmania major heat shock protein 83-1 0.0038 0.0121 0.0296
Echinococcus granulosus g protein coupled receptor 0.0018 0.0017 0.004
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0017 0.004
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0026 0.0047
Loa Loa (eye worm) hypothetical protein 0.0215 0.1043 0.1043
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.011 0.0269
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0307 0.0749
Brugia malayi Pre-SET motif family protein 0.0428 0.2151 0.3439

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) 69.506 uM PubChem BioAssay. Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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