Detailed information for compound 844709

Basic information

Technical information
  • TDR Targets ID: 844709
  • Name: ethyl 3-[[2-[methyl-[(2-methyl-1,3-benzothiaz ol-6-yl)sulfonyl]amino]acetyl]amino]benzoate
  • MW: 447.528 | Formula: C20H21N3O5S2
  • H donors: 1 H acceptors: 5 LogP: 3.05 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1cccc(c1)NC(=O)CN(S(=O)(=O)c1ccc2c(c1)sc(n2)C)C
  • InChi: 1S/C20H21N3O5S2/c1-4-28-20(25)14-6-5-7-15(10-14)22-19(24)12-23(3)30(26,27)16-8-9-17-18(11-16)29-13(2)21-17/h5-11H,4,12H2,1-3H3,(H,22,24)
  • InChiKey: IZLFWWFHPDACOB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[2-[methyl-[(2-methyl-1,3-benzothiazol-6-yl)sulfonyl]amino]-1-oxoethyl]amino]benzoic acid ethyl ester
  • 3-[[2-[methyl-[(2-methyl-1,3-benzothiazol-6-yl)sulfonyl]amino]acetyl]amino]benzoic acid ethyl ester
  • ethyl 3-[2-[methyl-[(2-methyl-1,3-benzothiazol-6-yl)sulfonyl]amino]ethanoylamino]benzoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0154 0.1021 0.7233
Brugia malayi conserved hypotetical protein 0.001 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1434 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.001 0.006
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0034 0.0124
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Onchocerca volvulus 0.001 0.001 0.006
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0085 0.0741
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.086
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0085 0.0741
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0018 0.0154
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.001 0.001 0.007
Schistosoma mansoni nuclear receptor 0.001 0.001 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0085 0.0605
Loa Loa (eye worm) hypothetical protein 0.0154 0.1021 0.7233
Echinococcus multilocularis peroxidasin 0.0026 0.0121 0.1054
Brugia malayi hypothetical protein 0.0025 0.012 0.0846
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0379 0.3287
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0085 0.0605
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.1359
Loa Loa (eye worm) histone methyltransferase 0.001 0.0012 0.0087
Schistosoma mansoni cpg binding protein 0.003 0.0156 0.1352
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0085 0.0605
Brugia malayi notch-like transmembrane receptor 0.0008 0.0000000088035 0.000000062358
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0085 0.0741
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.001 0.0084
Schistosoma mansoni thyroid hormone receptor 0.002 0.0085 0.0741
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.026 0.2253
Brugia malayi Peroxidasin 0.0026 0.0121 0.086
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0085 0.0741
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0085 0.0605
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.055 0.0723
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.001 0.0084
Brugia malayi hypothetical protein 0.0011 0.0018 0.0126
Schistosoma mansoni nuclear hormone receptor 0.002 0.0085 0.0741
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0157 0.1359
Brugia malayi nuclear receptor NHR-88 0.002 0.0085 0.0605
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0085 0.0741
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1434 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0085 0.0741
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0085 0.0605
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0085 0.0741
Loa Loa (eye worm) DR-78 0.001 0.001 0.0068
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0085 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0085 0.0605
Loa Loa (eye worm) hypothetical protein 0.0008 0.0000000088035 0.000000062358
Mycobacterium tuberculosis Probable reductase 0.0087 0.055 0.0723
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.012 0.4894
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0085 0.0605
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.012 0.0846
Schistosoma mansoni peroxidasin 0.0026 0.0121 0.1054
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0157 0.0564
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.001 0.0002
Leishmania major hypothetical protein, conserved 0.0025 0.012 0.4894
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.026 0.1839
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.026 0.2253
Brugia malayi Nuclear hormone receptor E75 0.001 0.001 0.0068
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.086
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0085 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0085 0.0605
Brugia malayi hypothetical protein 0.001 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.086
Schistosoma mansoni peroxidasin 0.0026 0.0121 0.1054
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0085 0.0741
Brugia malayi ecdysteroid receptor 0.002 0.0085 0.0605
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0404 0.2777 0.3368
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0144 0.1022
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0018 0.0126
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0034 0.0243
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0208 1
Schistosoma mansoni hypothetical protein 0.0172 0.1152 1
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0085 0.0605
Onchocerca volvulus 0.0029 0.0144 0.0894
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0085 0.0741
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0085 0.0741
Trichomonas vaginalis set domain proteins, putative 0.0238 0.1614 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.055 0.0723
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0085 0.0741
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0022 0.0188
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0096 0.0617 0.0102
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.001 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0085 0.0605
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0085 0.0605
Brugia malayi hypothetical protein 0.0026 0.0121 0.086
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.086
Echinococcus granulosus peroxidasin 0.0026 0.0121 0.1054
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0018 0.0126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.026 0.2253
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.026 0.2253
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0012 0.0082
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0157 0.1359
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0085 0.0741
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0085 0.0605
Schistosoma mansoni nuclear hormone receptor 0.001 0.001 0.0084
Trichomonas vaginalis MYB, putative 0.001 0.001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0085 0.0605
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0144 0.1254
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0085 0.0605
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.001 0.0084
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.001 0.0068
Loa Loa (eye worm) glutathione reductase 0.0038 0.0208 0.1476
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.055 0.0723
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.012 0.4894
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1029 0.7165 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0018 0.0154
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0121 0.086
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.001 0.0068
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.001 0.0084
Onchocerca volvulus 0.0026 0.0121 0.0752
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0157 0.1359
Toxoplasma gondii thioredoxin reductase 0.0038 0.0208 0.075
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.086
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.001 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0085 0.0605
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0404 0.2777 0.2753
Schistosoma mansoni cpg binding protein 0.0029 0.0144 0.1252
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.1359
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0126
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Onchocerca volvulus Peroxidase homolog 0.0026 0.0121 0.0752
Brugia malayi ecdysone receptor 0.001 0.001 0.0068
Brugia malayi glutathione reductase 0.0038 0.0208 0.1476
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0121 0.0752
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0034 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0018 0.0154
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0208 0.1476
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.055 0.0723
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.001 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0085 0.0741
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.001 0.001 0.0002
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0121 0.0752
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0085 0.0741
Echinococcus granulosus geminin 0.0172 0.1152 1
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0085 0.0741
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0085 0.0741
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0085 0.0529
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.001 0.0084
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0085 0.0529
Brugia malayi Thioredoxin reductase 0.0038 0.0208 0.1476
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Schistosoma mansoni coup transcription factor 0.002 0.0085 0.0741
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0034 0.0154
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0404 0.2777 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0096 0.0617 0.0818
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.001 0.5
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0212 0.1839
Brugia malayi nuclear receptor NHR-88 0.001 0.001 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.026 0.2253
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.012 0.4894
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0000000088035 0.000000076411
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0121 0.0752
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.001 0.0084
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0212 0.1839
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.012 0.4894
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0012 0.0107
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0018 0.0154
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.026 0.2253
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0085 0.0741
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0298
Loa Loa (eye worm) hypothetical protein 0.0031 0.0157 0.1109
Brugia malayi nuclear receptor RXR 0.001 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0085 0.0741
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0085 0.0605
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0085 0.0741
Brugia malayi Blistered cuticle protein 3 0.0026 0.0121 0.086
Brugia malayi nuclear hormone receptor 0.001 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Onchocerca volvulus 0.001 0.001 0.006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.001 0.0084
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Echinococcus granulosus cpg binding protein 0.003 0.0156 0.1352
Schistosoma mansoni nuclear receptor 0.001 0.001 0.0084
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.001 0.001 0.007
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Schistosoma mansoni cpg binding protein 0.003 0.0156 0.1352
Plasmodium falciparum glutathione reductase 0.0038 0.0208 1
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.086
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Schistosoma mansoni nuclear hormone receptor 0.001 0.001 0.0084
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0085 0.0741
Schistosoma mansoni hypothetical protein 0.0172 0.1152 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.026 0.1839
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0085 0.0529
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0085 0.0741
Plasmodium vivax SET domain protein, putative 0.0031 0.0157 0.7027
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0000000088035 0.000000054537
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0126
Brugia malayi Pre-SET motif family protein 0.0209 0.1412 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0085 0.0741
Brugia malayi nuclear hormone receptor 0.002 0.0085 0.0605
Leishmania major trypanothione reductase 0.0038 0.0208 1
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1029 0.7165 1
Onchocerca volvulus 0.0154 0.1021 0.6326
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0298
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0333 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0085 0.0605
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0085 0.0605
Echinococcus granulosus FTZ F1 alpha 0.002 0.0085 0.0741
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.001 0.0084
Schistosoma mansoni zinc finger protein 0.001 0.001 0.0084
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.001 0.0084
Brugia malayi Nuclear hormone receptor E75 0.001 0.001 0.0068
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Plasmodium vivax glutathione reductase, putative 0.0038 0.0208 1
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0018 0.0126
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0085 0.0741
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0000000088035 0.000000054537
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Brugia malayi hypothetical protein 0.001 0.001 0.0068
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.055 0.0723
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0085 0.0605
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0208 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0085 0.0741
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0157 0.1359
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.012 0.4894
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.086
Brugia malayi tailless protein 0.001 0.001 0.0068
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.001 0.0084
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0121 0.0752
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0121 0.086
Brugia malayi nuclear receptor NHR-67 0.001 0.001 0.0068
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0085 0.0741
Brugia malayi hypothetical protein 0.0011 0.0018 0.0126
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.012 0.4894
Onchocerca volvulus Peroxidase homolog 0.0026 0.0121 0.0752
Schistosoma mansoni hypothetical protein 0.0011 0.0022 0.0188
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0085 0.0605
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.001 0.001 0.0036
Onchocerca volvulus 0.002 0.0085 0.0529
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0085 0.0605
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0034 0.0154
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0404 0.2777 0.2753
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0121 0.086
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0085 0.0605
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0208 0.0244
Onchocerca volvulus 0.0238 0.1614 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.001 0.0084
Giardia lamblia Myb 1-like protein 0.001 0.001 0.2896
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.001 0.0084
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.001 0.001 0.006
Brugia malayi CXXC zinc finger family protein 0.0029 0.0144 0.1022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Trypanosoma brucei trypanothione reductase 0.0038 0.0208 1
Onchocerca volvulus 0.0031 0.0157 0.097
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0126
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.001 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.026 0.2253
Echinococcus multilocularis cpg binding protein 0.003 0.0156 0.1352
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0085 0.0741
Brugia malayi hypothetical protein 0.0016 0.0057 0.0401
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.1412 1
Loa Loa (eye worm) hypothetical protein 0.001 0.001 0.0068
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.012 0.043
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0096 0.0617 0.0818
Onchocerca volvulus 0.0026 0.0121 0.0752
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0022 0.0188
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0000000088035 0.000000076411
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0012 0.0107
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.001 0.001 0.5
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.001 0.0084
Loa Loa (eye worm) hypothetical protein 0.002 0.0085 0.0605
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.001 0.0068
Mycobacterium tuberculosis Probable oxidoreductase 0.0096 0.0617 0.0818
Brugia malayi EGF-like domain containing protein 0.0008 0.0000000088035 0.000000062358
Onchocerca volvulus 0.0026 0.0121 0.0752
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.001 0.0084
Echinococcus multilocularis geminin 0.0172 0.1152 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0157 0.1109
Plasmodium falciparum thioredoxin reductase 0.0038 0.0208 1
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0034 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0085 0.0605
Brugia malayi steroid hormone receptor 0.002 0.0085 0.0605
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0298
Loa Loa (eye worm) hypothetical protein 0.0026 0.0121 0.086
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0157 0.1359
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.1434 1 1
Brugia malayi nuclear receptor RXR 0.0011 0.0018 0.0126

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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