TDR Targets

Basic information

Technical information

TDR Targets ID: 845646
Name: N-[(2-ethoxyphenyl)methyl]-1-phenyl-5-pyrrol- 1-ylpyrazole-4-carboxamide
MW: 386.446 | Formula: C23H22N4O2
H donors: 1 H acceptors: 2 LogP: 3.73 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCOc1ccccc1CNC(=O)c1cnn(c1n1cccc1)c1ccccc1
InChi: 1S/C23H22N4O2/c1-2-29-21-13-7-6-10-18(21)16-24-22(28)20-17-25-27(19-11-4-3-5-12-19)23(20)26-14-8-9-15-26/h3-15,17H,2,16H2,1H3,(H,24,28)
InChiKey: GXCVVGIYWPGFJR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[(2-ethoxyphenyl)methyl]-1-phenyl-5-pyrrol-1-yl-pyrazole-4-carboxamide
N-[(2-ethoxyphenyl)methyl]-1-phenyl-5-(1-pyrrolyl)-4-pyrazolecarboxamide
N-(2-ethoxybenzyl)-1-phenyl-5-pyrrol-1-yl-pyrazole-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.5431	0.5
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0114	0.0114
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.1054	0.2229
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.1054	0.1768
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0114	0.0114
Brugia malayi	nuclear hormone receptor	0.001	0.1054	0.1184
Plasmodium falciparum	basic transcription factor 3b, putative	0.0035	0.5431	0.5
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0215	0.0127
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.1054	0.1768
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.8052	1
Schistosoma mansoni	zinc finger protein	0.0005	0.0114	0.0114
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.1054	0.1054
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.1054	0.1768
Entamoeba histolytica	transcription factor BTF3, putative	0.0035	0.5431	0.5
Entamoeba histolytica	hypothetical protein	0.0035	0.5431	0.5
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.1054	0.1768
Echinococcus granulosus	GPCR family 2	0.0016	0.2052	0.3645
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.5431	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.1054	0.1184
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0839	0.1364
Brugia malayi	steroid hormone receptor	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0034	0.5275	0.6501
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.1054	0.1768
Schistosoma mansoni	nuclear receptor	0.0005	0.0114	0.0114
Plasmodium vivax	basic transcription factor 3b, putative	0.0035	0.5431	0.5
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.1054	0.1768
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.2052	0.3645
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.1054	0.1768
Echinococcus granulosus	cpg binding protein	0.0031	0.4619	0.8474
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.5275	0.6501
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0215	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.5431	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.1054	0.1184
Onchocerca volvulus		0.0029	0.4331	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0531	0.0531
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0016	0.2052	0.2441
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.8052	1
Brugia malayi	beta-NAC-like protein	0.0035	0.5431	0.6698
Schistosoma mansoni	nuclear hormone receptor	0.001	0.1054	0.1054
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.1054	0.1184
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.1054	0.2229
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.2052	0.3645
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.1054	0.1184
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.1054	0.1768
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.2052	0.2441
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.1054	0.1184
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0531	0.0784
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.2052	0.3645
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0215	0.0215
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.1054	0.1184
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.1054	0.1184
Schistosoma mansoni	hypothetical protein	0.0016	0.2052	0.2052
Schistosoma mansoni	thyroid hormone receptor	0.001	0.1054	0.1054
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.1054	0.1768
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.1054	0.1184
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0531	0.0784
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0215	0.0127
Schistosoma mansoni	nuclear receptor	0.0005	0.0114	0.0114
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0215	0.0127
Brugia malayi	CXXC zinc finger family protein	0.0029	0.4331	0.5313
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.1054	0.1184
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.1054	0.1054
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.1054	0.1184
Echinococcus multilocularis	transcription factor btf3	0.0035	0.5431	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0215	0.0127
Schistosoma mansoni	transcription factor btf3	0.0035	0.5431	0.5431
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.1054	0.1184
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.1054	0.1184
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.1054	0.1184
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.1054	0.1768
Schistosoma mansoni	hypothetical protein	0.0034	0.5275	0.5275
Schistosoma mansoni	cpg binding protein	0.0031	0.4619	0.4619
Loa Loa (eye worm)	hypothetical protein	0.001	0.1054	0.1184
Schistosoma mansoni	thyroid hormone receptor	0.001	0.1054	0.1054
Loa Loa (eye worm)	ICD-1 protein	0.0035	0.5431	0.6698
Schistosoma mansoni	cpg binding protein	0.0031	0.4619	0.4619
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.1054	0.1054
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.1054	0.1184
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.1054	0.1054
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.1054	0.1184
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0215	0.0189
Loa Loa (eye worm)	hypothetical protein	0.005	0.8052	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.1054	0.1768
Schistosoma mansoni	hypothetical protein	0.0016	0.2052	0.2052
Echinococcus granulosus	transcription factor btf3	0.0035	0.5431	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.1054	0.1768
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0215	0.0127
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.1054	0.1184
Brugia malayi	ecdysteroid receptor	0.001	0.1054	0.1184
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.1054	0.1768
Schistosoma mansoni	cpg binding protein	0.0029	0.4331	0.4331
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0839	0.1364
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0215	0.0189
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0114	0.0114
Brugia malayi	hypothetical protein	0.0005	0.0215	0.0127
Trichomonas vaginalis	conserved hypothetical protein	0.0035	0.5431	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0531	0.0784
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.2052	0.2441
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.2052	0.3645
Schistosoma mansoni	hypothetical protein	0.0016	0.2052	0.2052
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.8052	1
Trypanosoma cruzi	transcription factor btf3, putative	0.0035	0.5431	0.5
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.1054	0.1054
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.1054	0.2229
Brugia malayi	nuclear receptor RXR	0.0005	0.0215	0.0127
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0114	0.0114
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0215	0.0215
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.1054	0.1768
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.1054	0.1184
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.1054	0.1768
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.1054	0.1768
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0114	0.0114
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.1054	0.1054
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.1054	0.1054
Schistosoma mansoni	hypothetical protein	0.0016	0.2052	0.2052
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.1054	0.1184
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.1054	0.1184
Brugia malayi	nuclear receptor NHR-88	0.001	0.1054	0.1184
Echinococcus multilocularis	cpg binding protein	0.0031	0.4619	0.8474
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0531	0.0784
Echinococcus granulosus	FTZ F1 alpha	0.001	0.1054	0.1768
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.8854	1
Leishmania major	basic transcription factor 3a, putative	0.0035	0.5431	0.5
Echinococcus multilocularis	GPCR, family 2	0.0016	0.2052	0.3645
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.1054	0.1054
Onchocerca volvulus		0.001	0.1054	0.2229
Brugia malayi	hypothetical protein	0.0005	0.0215	0.0127
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0819	0.0888
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0215	0.0127
Schistosoma mansoni	coup transcription factor	0.001	0.1054	0.1054
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.1054	0.1768
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0839	0.0913
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.2052	0.2441
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0215	0.0127
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.4331	0.5313
Trypanosoma brucei	transcription factor BTF3, putative	0.0035	0.5431	0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 845646