Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase eta, putative | 0.0033 | 0.4775 | 0.4775 |
Echinococcus granulosus | dna polymerase eta | 0.0048 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0033 | 0.4775 | 0.4775 |
Schistosoma mansoni | DNA polymerase eta | 0.0048 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0048 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.2319 | 0.2319 |
Leishmania major | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0048 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0033 | 0.4775 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.2319 | 0.2319 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.2319 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0021 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2319 | 0.2319 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.